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Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes 碱基切除修复通路塑造泛癌基因组中5-甲基胞嘧啶脱氨特征 Silveira, Andre Bortolini; Houy, Alexandre; Ganier, Olivier; Ozemek, Beguem; Vanhuele, Sandra; Vincent-Salomon, Anne; Cassoux, Nathalie; Mariani, Pascale; Pierron, Gaelle; Leyvraz, Serge; Rieke, Damian; Picca, Alberto; Bielle, Franck; Yaspo, Marie-Laure 分享 收藏
A three-arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma MEK抑制剂selumetinib单独或与紫杉醇联合治疗转移性葡萄膜黑色素瘤的三臂随机II期研究 Sacco, Joseph J.; Jackson, Richard; Corrie, Pippa; Danson, Sarah; Evans, T. R. Jeffry; Ochsenreither, Sebastian; Kumar, Satish; Goodman, Andrew; Larkin, James; Karydis, Ioannis; Steven, Neil; Lorigan, Paul; Plummer, Ruth; Patel, Poulam; Psarelli, Eftychia; Olsson-Brown, Anna; Shaw, Heather; Leyvraz, Serge; Handley, Louise; Rawcliffe, Charlotte; Nathan, Paul 分享 收藏
Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas Larotrectinib在成人原肌球蛋白受体激酶融合肉瘤患者中的疗效和安全性 Kummar, Shivaani; Shen, Lin; Hong, David S.; McDermott, Ray; Keedy, Vicki L.; Casanova, Michela; Demetri, George D.; Dowlati, Afshin; Melcon, Soledad Gallego; Lassen, Ulrik N.; Leyvraz, Serge; Liu, Tianshu; Moreno, Victor; Patel, Jyoti; Patil, Tejas; Mallick, Atrayee Basu; Sousa, Nuno; Tahara, Makoto; Ziegler, David S.; Norenberg, Ricarda; Arvis, Pierre; Brega, Nicoletta; Drilon, Alexander; Tan, Daniel S. W. 分享 收藏
Tumour mutational burden and survival with molecularly matched therapy de Bortoli, Till; Benary, Manuela; Horak, Peter; Lamping, Mario; Stintzing, Sebastian; Tinhofer, Ingeborg; Leyvraz, Serge; Schaefer, Reinhold; Klauschen, Frederick; Keller, Ulrich; Stenzinger, Albrecht; Froehling, Stefan; Kurzrock, Razelle; Keilholz, Ulrich; Rieke, Damian T.; Jelas, Ivan 分享 收藏
Long-term survival follow-up of tebentafusp in previously treated metastatic uveal melanoma (mUM) Sacco, Joseph J.; Carvajal, Richard D.; Butler, Marcus O.; Shoushtari, Alexander N.; Hassel, Jessica C.; Ikeguchi, Alexandra; Hernandez-Aya, Leonel; Nathan, Paul; Hamid, Omid; Piulats, Josep M.; Rioth, Matthew; Johnson, Douglas B.; Luke, Jason J.; Espinosa, Erique; Leyvraz, Serge; Collins, Laura; Holland, Chris; McCully, Michelle L.; Sato, Takami 分享 收藏
Clinical and molecular response to tebentafusp in previously treated patients with metastatic uveal melanoma: a phase 2 trial Carvajal, Richard D.; Butler, Marcus O.; Shoushtari, Alexander N.; Hassel, Jessica C.; Ikeguchi, Alexandra; Hernandez-Aya, Leonel; Nathan, Paul; Hamid, Omid; Piulats, Josep M.; Rioth, Matthew; Johnson, Douglas B.; Luke, Jason J.; Espinosa, Enrique; Leyvraz, Serge; Collins, Laura; Goodall, Howard M.; Ranade, Koustubh; Holland, Chris; Abdullah, Shaad E.; Sacco, Joseph J.; Sato, Takami 分享 收藏
Precision oncology for resistant acral, mucosal and cutaneous melanomas: A prospective broad high throughput genomics feasibility study Leyvraz, S.; Schuette, M.; Kessler, T.; Lamping, M.; Burock, S.; Ochsenreither, S.; Amstislavskiy, V.; Risch, T.; Jelas, I.; Ulrich, C.; Dobos, G.; Klauschen, F.; Schaefer, R.; Lange, B.; Klinghammer, K.; Yaspo, M-L.; Keilholz, U. 分享 收藏
Biomarker-driven therapies for metastatic uveal melanoma: A prospective precision oncology feasibility study Leyvraz, Serge; Konietschke, Frank; Peuker, Caroline; Schuette, Moritz; Kessler, Thomas; Ochsenreither, Sebastian; Ditzhaus, Marc; Spruenken, Erin D.; Doerpholz, Gina; Lamping, Mario; Rieke, Damian T.; Klinghammer, Konrad; Burock, Susen; Ulrich, Claas; Poch, Gabriela; Schaefer, Reinhold; Klauschen, Frederick; Joussen, Antonia; Yaspo, Marie-Laure; Keilholz, Ulrich 分享 收藏
Rationale and design of ON TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib ON TRK的原理和设计: larotrectinib治疗TRK融合癌患者的一项新的前瞻性非干预性研究 Yang, James C. H.; Brose, Marcia S.; Castro, Gilberto; Kim, Edward S.; Lassen, Ulrik N.; Leyvraz, Serge; Pappo, Alberto; Lopez-Rios, Fernando; Reeves, John A.; Fellous, Marc; Penault-Llorca, Frederique; Rudzinski, Erin R.; Tabatabai, Ghazaleh; Vassal, Gilles; Drilon, Alexander; Trent, Jonathan 分享 收藏
Updated efficacy and ctDNA analysis of patients with TRK fusion lung cancer treated with larotrectinib Moreno, V.; Lin, J. J.; Tan, D. S. W.; Lassen, U. N.; Leyvraz, S.; Liu, Y.; Patel, J.; Rosen, L.; Solomon, B.; Rudolph, M.; Norenberg, R.; Schulz, A.; Fellous, M.; Brega, N.; Shen, L.; Kummar, S.; Drilon, A. 分享 收藏
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Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase (TRK) fusion cancer Brose, M. S.; Shen, L.; Tan, D. S. W.; Kummar, S.; Lin, J. J.; McDermott, R.; Berlin, J.; Tahara, M.; Lassen, U. N.; Leyvraz, S.; Patel, J. D.; Norenberg, R.; Dima, L.; Brega, N.; Hong, D. S.; Drilon, A. 分享 收藏
Genomic and transcriptomic landscape of conjunctival melanoma Cisarova, Katarina; Folcher, Marc; El Zaoui, Ikram; Pescini-Gobert, Rosanna; Peter, Virginie G.; Royer-Bertrand, Beryl; Zografos, Leonidas; Schalenbourg, Ann; Nicolas, Michael; Rimoldi, Donata; Leyvraz, Serge; Riggi, Nicole; Moulin, Alexandre P.; Rivolta, Carlo 分享 收藏
A phase (ph) II, multi-center study of the safety and efficacy of tebentafusp (tebe) (IMCgp100) in patients (pts) with metastatic uveal melanoma (mUM) Sacco, J. J.; Carvajal, R.; Butler, M. O.; Shoushtari, A. N.; Hassel, J. C.; Ikeguchi, A.; Hernandez-Aya, L.; Nathan, P.; Hamid, O.; Piulats Rodriguez, J. M.; Rioth, M.; Johnson, D. B.; Luke, J. J.; Espinosa, E.; Leyvraz, S.; Goodall, H. M.; Holland, C.; Abdullah, S.; Sato, T. 分享 收藏
ON-TRK: A non-interventional study of larotrectinib in patients with TRK fusion cancer Leyvraz, S.; Yang, J. C-H.; Casali, P. G.; Castro, G.; Kim, E. S.; Lassen, U. N.; Lopez-Rios, F.; Penault-Llorca, F.; Pappo, A.; Rudzinski, E. R.; Tabatabai, G.; Vassal, G.; Reeves, J. A.; Nogai, H.; Fellous, M.; Drilon, A.; Brose, M. S.; Trent, J. 分享 收藏
Efficacy and safety of larotrectinib in patients with tropomyosin receptor kinase (TRK) fusion lung cancer Drilon, A.; Moreno, V.; Patel, J.; Lassen, U. N.; Solomon, B.; Rosen, L.; Leyvraz, S.; Tan, D. S. W.; Reeves, J. A.; Dima, L.; Brega, N.; Kummar, S.; Farago, A. F. 分享 收藏
Treatment of metastatic uveal melanoma (mUM) through genomic profiling Leyvraz, S.; Schuette, M.; Kessler, T.; Risch, T.; Doerpholz, G.; Ochsenreither, S.; Rieke, D. T.; Amstislavskiy, V.; Wierling, C.; Klauschen, F.; Peuker, C. A.; Lamping, M.; Jelas, I.; Burock, S.; Schaefer, R.; Lange, B.; Ulrich, C.; Joussen, A.; Keilholz, U.; Yaspo, M-L. 分享 收藏
Larotrectinib treatment of advanced TRK fusion thyroid cancer Cabanillas, M. E.; Drilon, A.; Farago, A. F.; Brose, M. S.; McDermott, R.; Sohal, D.; Oh, D-Y.; Almubarak, M.; Bauman, J.; Chu, E.; Kummar, S.; Leyvraz, S.; Park, K.; Reeves, J. A.; Dima, L.; Maeda, P.; Rodrigues, L.; Brega, N.; Hong, D. S.; Waguespack, S. G. 分享 收藏
Validation of a Prognostic Staging for Metastatic Uveal Melanoma: A Collaborative Study of the European Ophthalmic Oncology Group (vol 168, pg 217, 2020) Kivela, Tero; Piperno-Neumann, Sophie; Desjardins, Laurence; Schmittel, Alexander; Bechrakis, Nikolaos; Midena, Edoardo; Leyvraz, Serge; Zografos, Leonidas; Grange, Jean -Daniel; Ract-Madoux, Guillaume; Marshall, Ernest; Damato, Bertil; Eskelin, Sebastian 分享 收藏
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