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G

Gerald Grandl

Helmholtz Munich
H指数:14
被引数:1,421

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Publisher Correction: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

出版更正：GLP-1R-GIPR-PPARα/γ/δ五重激动作用可纠正小鼠的肥胖与糖尿病

Nature
IF48.5
2026-05-180
OAAI
Daniela Liskiewicz; Aaron Novikoff; Ahmed Khalil; Seun Akindehin; Jonathan E. Campbell; Pietra Candela; Russell L. Castelino; Callum Coupland; Maxime Culot; W. Scott Dodson; Jonathan D. Douros; Hannes Embring; Annette Feuchtinger; Brian Finan; Cristina Garcia-Caceres; Xiao-Bing Gao; Fabien Gosselet; Gerald Grandl; Robert M. Gutgesell; Daniel T. Haas; Martin Jastroch; Ezgi Karaoglu; Pamela Kakimoto; Anna Cristina Kaltenbach; Michaela Keuper; Christine M. Kusminski; Danielle C. Leander; Arkadiusz Liskiewicz; Xue Liu; Gandhari Maity-Kumar; Sara Martinez Martinez; Stephanie A. Mowery; Ruben Nogueiras; Marshall Paisley; Diego Perez-Tilve; Patricia S. S. Petersen; Paul T. Pfluger; Sneha Prakash; Sabine Steffens; Alberto Cebrian-Serrano; Monica Tost; Jordan Wean; Christian Weber; Junichi Yoshida; Zachary Gerhart-Hines; Tamas L. Horvath; Philipp E. Scherer; Randy J. Seeley; Richard D. DiMarchi; Matthias H. Tschöp; Natalie Krahmer; Patrick J. Knerr; Timo D. Müller
GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

GLP-1R-GIPR-PPARα/γ/δ五重激动剂纠正小鼠肥胖和糖尿病

Nature
IF48.5
2026-04-010
PRE
Liskiewicz, Daniela; Novikoff, Aaron; Khalil, Ahmed; Akindehin, Seun; Campbell, Jonathan E.; Candela, Pietra; Castelino, Russell L.; Coupland, Callum; Culot, Maxime; Dodson, W. Scott; Douros, Jonathan D.; Embring, Hannes; Feuchtinger, Annette; Finan, Brian; Garcia-Caceres, Cristina; Gao, Xiao-Bing; Gosselet, Fabien; Grandl, Gerald; Gutgesell, Robert M.; Haas, Daniel T.; Jastroch, Martin; Karaoglu, Ezgi; Kakimoto, Pamela; Kaltenbach, Anna Cristina; Keuper, Michaela; Kusminski, Christine M.; Leander, Danielle C.; Liskiewicz, Arkadiusz; Liu, Xue; Maity-Kumar, Gandhari; Martinez, Sara Martinez; Mowery, Stephanie A.; Nogueiras, Ruben; Paisley, Marshall; Perez-Tilve, Diego; Petersen, Patricia S. S.; Pfluger, Paul T.; Prakash, Sneha; Steffens, Sabine; Cebrian-Serrano, Alberto; Tost, Monica; Wean, Jordan; Weber, Christian; Yoshida, Junichi; Gerhart-Hines, Zachary; Horvath, Tamas L.; Scherer, Philipp E.; Seeley, Randy J.; DiMarchi, Richard D.; Tschop, Matthias H.; Krahmer, Natalie; Knerr, Patrick J.; Muller, Timo D.
Loss of GIPR in glutamatergic neurons does not impair acceleration of GLP-1-induced weight loss by GIPR antagonism

谷氨酸能神经元中GIPR的缺失不会损害GIPR拮抗作用对GLP-1诱导的体重减轻的加速效果

Molecular Metabolism
IF6.6
2026-01-010
OA
Russell L. Castelino; Ahmed Khalil; Gandhari Maity‐Kumar; Shiqi Zang; Ophélia Le Thuc; Aaron Novikoff; Daniela Liśkiewicz; Robert M. Gutgesell; Xue Liu; Callum Coupland; Ezgi Karaoglu; Gerald Grandl; Susanna M. Hofmann; Alberto Cebrian-Serrano; Stephanie A. Mowery; Richard diMarchi; Jonathan D. Douros; Patrick J. Knerr; Arkadiusz Liśkiewicz; Timo D. Müller
Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism

E2共轭GLP-1的雌激素活性由细胞内内体溶酶体酸化和雌酮代谢介导

MOLECULAR METABOLISM
IF6.6
2025-06-010
OAAI
Coupland, Callum; Sun, Na; Khalil, Ahmed; Karaoglu, Oezuem Ezgi; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Grandl, Gerald; Akindehin, Seun; Maity, Gandhari; Yang, Bin; Finan, Brian; Knerr, Patrick; Douros, Jonathan D.; Walch, Axel; Dimarchi, Richard; Tschoep, Matthias H.; Mueller, Timo D.; Novikoff, Aaron
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice (Apr, 10.1038/s42255-025-01294-x, 2024)

GIPR激动和拮抗通过不同的机制降低雄性小鼠的体重和食物摄入量（Apr, 10.1038/s42255-025-01294-x, 2024）

NATURE METABOLISM
IF20.8
2025-05-130
OA
Gutgesell, Robert M.; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D.; Knerr, Patrick J.; Finan, Brian; DiMarchi, Richard D.; Sloop, Kyle W.; Samms, Ricardo J.; Theis, Fabian J.; Tschop, Matthias H.; Muller, Timo D.
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

GIPR激动和拮抗通过不同的机制降低雄性小鼠的体重和食物摄入量。

NATURE METABOLISM
IF20.8
2025-04-291
OA
Gutgesell, Robert M.; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D.; Knerr, Patrick J.; Finan, Brian; DiMarchi, Richard D.; Sloop, Kyle W.; Samms, Ricardo J.; Theis, Fabian J.; Tschoep, Matthias H.
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

LEPR细胞中GIPR的丢失会损害GIP和GIP的葡萄糖控制: GLP-1共同激动而不影响小鼠的体重和食物摄入量

MOLECULAR METABOLISM
IF6.6
2024-05-012
OAAI
Akindehin, Seun; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Bernecker, Miriam; Garcia-Caceres, Cristina; Drucker, Daniel J.; Finan, Brian; Grandl, Gerald; Gutgesell, Robert; Hofmann, Susanna M.; Khalil, Ahmed; Liu, Xue; Cota, Perla; Bakhti, Mostafa; Czarnecki, Oliver; Lickert, Heiko; Kang, Lingru; Maity, Gandhari; Novikoff, Aaron; Parlee, Sebastian; Pathak, Ekta; Schriever, Sonja C.; Sterr, Michael; Ussar, Siegfried; Zhang, Qian; DiMarchi, Richard; Tschoep, Matthias H.; Pfluger, Paul T.; Douros, Jonathan D.; Mueller, Timo D.
Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity
NATURE METABOLISM
IF20.8
2024-02-281
OAAI
Grandl, Gerald; Collden, Gustav; Feng, Jin; Bhattacharya, Sreya; Klingelhuber, Felix; Schomann, Leopold; Bilekova, Sara; Xu, Weiwei; Far, Fataneh Fathi; Tost, Monica; Gruber, Tim; Bastidas-Ponce, Aimee; Zhang, Qian; Novikoff, Aaron; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Garcia-Caceres, Cristina; Feuchtinger, Annette; Tschoep, Matthias H.; Krahmer, Natalie; Lickert, Heiko; Mueller, Timo D.
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice
NATURE METABOLISM
IF20.8
2023-11-0921
OA
Liskiewicz, Arkadiusz; Khalil, Ahmed; Liskiewicz, Daniela; Novikoff, Aaron; Grandl, Gerald; Maity-Kumar, Gandhari; Gutgesell, Robert M.; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Czarnecki, Oliver; Makris, Konstantinos; Lickert, Heiko; Feuchtinger, Annette; Tost, Monica; Coupland, Callum; Staender, Lisa; Akindehin, Seun; Prakash, Sneha; Abrar, Faiyaz; Castelino, Russell L.; He, Yantao; Knerr, Patrick J.; Yang, Bin; Hogendorf, Wouter F. J.; Zhang, Shiqi; Hofmann, Susanna M.; Finan, Brian; Dimarchi, Richard D.; Tschoep, Matthias H.; Douros, Jonathan D.; Mueller, Timo D.
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

GLP-1-mediated递送tesaglitazar改善雄性小鼠的肥胖和葡萄糖代谢

NATURE METABOLISM
IF20.8
2022-08-2216
OAAI
Quarta, Carmelo; Stemmer, Kerstin; Novikoff, Aaron; Yang, Bin; Klingelhuber, Felix; Harger, Alex; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Bauge, Eric; Campbell, Jonathan E.; Capozzi, Megan; Clemmensen, Christoffer; Collden, Gustav; Cota, Perla; Douros, Jon; Drucker, Daniel J.; DuBois, Barent; Feuchtinger, Annette; Garcia-Caceres, Cristina; Grandl, Gerald; Hennuyer, Nathalie; Herzig, Stephan; Hofmann, Susanna M.; Knerr, Patrick J.; Kulaj, Konxhe; Lalloyer, Fanny; Lickert, Heiko; Liskiewicz, Arek; Liskiewicz, Daniela; Maity, Gandhari; Perez-Tilve, Diego; Prakash, Sneha; Sanchez-Garrido, Miguel A.; Zhang, Qian; Staels, Bart; Krahmer, Natalie; DiMarchi, Richard D.; Tschoep, Matthias H.; Finan, Brian; Mueller, Timo D.
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

选定的受体单和双激动剂诱导的时空GLP-1和GIP受体信号传导和运输/循环动力学

MOLECULAR METABOLISM
IF6.6
2021-07-0153
OAAI
Novikoff, Aaron; O'Brien, Shannon L.; Bernecker, Miriam; Grandl, Gerald; Kleinert, Maximilian; Knerr, Patrick J.; Stemmer, Kerstin; Klingenspor, Martin; Zeigerer, Anja; DiMarchi, Richard; Tschoep, Matthias H.; Finan, Brian; Calebiro, Davide; Mueller, Timo D.
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes (vol 9, 4304, 2018)
NATURE COMMUNICATIONS
IF15.7
2018-11-203
OAAI
Clemmensen, Christoffer; Jall, Sigrid; Kleinert, Maximilian; Quarta, Carmelo; Gruber, Tim; Reber, Josefine; Sachs, Stephan; Fischer, Katrin; Feuchtinger, Annette; Karlas, Angelos; Simonds, Stephanie E.; Grandl, Gerald; Loher, Daniela; Sanchez-Quant, Eva; Keipert, Susanne; Jastroch, Martin; Hofmann, Susanna M.; Nascimento, Emmani B. M.; Schrauwen, Patrick; Ntziachristos, Vasilis; Cowley, Michael A.; Finan, Brian; Mueller, Timo D.; Tschoep, Matthias H.
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
NATURE COMMUNICATIONS
IF15.7
2018-10-2342
OAAI
Clemmensen, Christoffer; Jail, Sigrid; Kleinert, Maximilian; Quarta, Carmelo; Gruber, Tim; Reber, Josefine; Sachs, Stephan; Fischer, Katrin; Feuchtinger, Annette; Karlas, Angelos; Simonds, Stephanie E.; Grandl, Gerald; Loher, Daniela; Sanchez-Quant, Eva; Keipert, Susanne; Jastroch, Martin; Hofmann, Susanna M.; Nascimento, Emmani B. M.; Schrauwen, Patrick; Ntziachristos, Vasilis; Cowley, Michael A.; Finan, Brian; Mueller, Timo D.; Tschoep, Matthias H.
Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring (vol 24, pg 1372, 2018)
NATURE MEDICINE
IF50
2018-08-071
OAAI
Sun, Wenfei; Dong, Hua; Becker, Anton S.; Dapito, Dianne H.; Modica, Salvatore; Grandl, Gerald; Opitz, Lennart; Efthymiou, Vissarion; Straub, Leon G.; Sarker, Gitalee; Balaz, Miroslav; Balazova, Lucia; Perdikari, Aliki; Kiehlmann, Elke; Bacanovic, Sara; Zellweger, Caroline; Peleg-Raibstein, Daria; Pelczar, Pawel; Reik, Wolf; Burger, Irene A.; von Meyenn, Ferdinand; Wolfrum, Christian
Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring (vol 24, pg 1372, 2018)
NATURE MEDICINE
IF50
2018-08-073
OAAI
Sun, Wenfei; Dong, Hua; Becker, Anton S.; Dapito, Dianne H.; Modica, Salvatore; Grandl, Gerald; Opitz, Lennart; Efthymiou, Vissarion; Straub, Leon G.; Sarker, Gitalee; Balaz, Miroslav; Balazova, Lucia; Perdikari, Aliki; Kiehlmann, Elke; Bacanovic, Sara; Zellweger, Caroline; Peleg-Raibstein, Daria; Pelczar, Pawel; Reik, Wolf; Burger, Irene A.; von Meyenn, Ferdinand; Wolfrum, Christian
Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring
NATURE MEDICINE
IF50
2018-07-0981
OAAI
Sun, Wenfei; Dong, Hua; Becker, Anton S.; Dapito, Dianne H.; Modica, Salvatore; Grandl, Gerald; Opitz, Lennart; Efthymiou, Vissarion; Straub, Leon G.; Sarker, Gitalee; Balaz, Miroslav; Balazova, Lucia; Perdikari, Aliki; Kiehlmann, Elke; Bacanovic, Sara; Zellweger, Caroline; Peleg-Raibstein, Daria; Pelczar, Pawel; Reik, Wolf; Burger, Irene A.; von Meyenn, Ferdinand; Wolfrum, Christian

研究方向

暂未获取到该数据
T
Timo D. Müller
H 指数:63论文数:282被引数:1.8万
A
Aaron Novikoff
H 指数:12论文数:37被引数:635
D
Daniela Liśkiewicz
H 指数:13论文数:39被引数:545
A
Arkadiusz Liśkiewicz
H 指数:15论文数:42被引数:635
R
Richard D. DiMarchi
H 指数:72论文数:294被引数:1.9万
B
Brian Finan
H 指数:46论文数:124被引数:1.0万
C
Christian Wolfrum
H 指数:63论文数:346被引数:1.7万
J
Jonathan D. Douros
H 指数:20论文数:53被引数:2,018
R
Robert M. Gutgesell
H 指数:10论文数:16被引数:688
C
Callum Coupland
H 指数:3论文数:8被引数:243