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GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice GLP-1R-GIPR-PPARα/γ/δ五重激动剂纠正小鼠肥胖和糖尿病 Liskiewicz, Daniela; Novikoff, Aaron; Khalil, Ahmed; Akindehin, Seun; Campbell, Jonathan E.; Candela, Pietra; Castelino, Russell L.; Coupland, Callum; Culot, Maxime; Dodson, W. Scott; Douros, Jonathan D.; Embring, Hannes; Feuchtinger, Annette; Finan, Brian; Garcia-Caceres, Cristina; Gao, Xiao-Bing; Gosselet, Fabien; Grandl, Gerald; Gutgesell, Robert M.; Haas, Daniel T.; Jastroch, Martin; Karaoglu, Ezgi; Kakimoto, Pamela; Kaltenbach, Anna Cristina; Keuper, Michaela; Kusminski, Christine M.; Leander, Danielle C.; Liskiewicz, Arkadiusz; Liu, Xue; Maity-Kumar, Gandhari; Martinez, Sara Martinez; Mowery, Stephanie A.; Nogueiras, Ruben; Paisley, Marshall; Perez-Tilve, Diego; Petersen, Patricia S. S.; Pfluger, Paul T.; Prakash, Sneha; Steffens, Sabine; Cebrian-Serrano, Alberto; Tost, Monica; Wean, Jordan; Weber, Christian; Yoshida, Junichi; Gerhart-Hines, Zachary; Horvath, Tamas L.; Scherer, Philipp E.; Seeley, Randy J.; DiMarchi, Richard D.; Tschop, Matthias H.; Krahmer, Natalie; Knerr, Patrick J.; Muller, Timo D. 分享 收藏
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A High-Potency Protein That Normalizes Body Weight in DIO Mice through Triple Agonism at FGF21, GLP1, and GIP Receptors 一种通过FGF21、GLP1和GIP受体三重激动作用来调节DIO小鼠体重的高效蛋白 Brunel, Florence M.; Parlee, Sebastian D.; Li, Pengyun; Lu, Wei; Chabenne, Joseph; Perez-Tilve, Diego; Finan, Brian; Kharitonenkov, Alexei; Dimarchi, Richard D. 分享 收藏
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Bile Acid Binding Resins Improve Glucagon Receptor Agonist-Mediated Weight Loss in Diet-Induced Obese Mice 胆汁酸结合树脂可改善胰高血糖素受体激动剂介导的饮食诱导肥胖小鼠的体重减轻 Kim, Teayoun; Pearson, Mackenzie J.; Hong, Huixian; Nason, Shelly; Seck, Khadija; Antipenko, Jessica; Presedo, Natalie; DiMarchi, Richard; Roell, William C.; Habegger, Kirk 分享 收藏
A once-daily GLP-1/GIP/glucagon receptor triagonist (NN1706) lowers body weight in rodents, monkeys and humans 一种每日一次的GLP-1/GIP/胰高血糖素受体三激动剂（NN1706）可降低啮齿动物、猴和人体的体重。 Finan, Brian; Douros, Jonathan D.; Goldwater, Ronald; Hansen, Ann Maria Kruse; Hjerpsted, Julie B.; Hjollund, Karina Rahr; Kankam, Martin K.; Knerr, Patrick J.; Konkar, Anish; Mowery, Stephanie A.; Mueller, Timo D.; Nielsen, John Romer; Nygard, Sune Boris; Perez-Tilve, Diego; Raun, Kirsten; Yang, Bin; Tschop, Matthias H.; DiMarchi, Richard D. 分享 收藏
Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism E2共轭GLP-1的雌激素活性由细胞内内体溶酶体酸化和雌酮代谢介导 Coupland, Callum; Sun, Na; Khalil, Ahmed; Karaoglu, Oezuem Ezgi; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Grandl, Gerald; Akindehin, Seun; Maity, Gandhari; Yang, Bin; Finan, Brian; Knerr, Patrick; Douros, Jonathan D.; Walch, Axel; Dimarchi, Richard; Tschoep, Matthias H.; Mueller, Timo D.; Novikoff, Aaron 分享 收藏
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice (Apr, 10.1038/s42255-025-01294-x, 2024) GIPR激动和拮抗通过不同的机制降低雄性小鼠的体重和食物摄入量（Apr, 10.1038/s42255-025-01294-x, 2024） Gutgesell, Robert M.; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D.; Knerr, Patrick J.; Finan, Brian; DiMarchi, Richard D.; Sloop, Kyle W.; Samms, Ricardo J.; Theis, Fabian J.; Tschop, Matthias H.; Muller, Timo D. 分享 收藏
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice GIPR激动和拮抗通过不同的机制降低雄性小鼠的体重和食物摄入量。 Gutgesell, Robert M.; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D.; Knerr, Patrick J.; Finan, Brian; DiMarchi, Richard D.; Sloop, Kyle W.; Samms, Ricardo J.; Theis, Fabian J.; Tschoep, Matthias H. 分享 收藏
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Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy Sanchez-Garrido, Miguel A.; Serrano-Lopez, Victor; Ruiz-Pino, Francisco; Vazquez, Maria Jesus; Rodriguez-Martin, Andrea; Torres, Encarnacion; Velasco, Inmaculada; Rodriguez, Ana Belen; Chicano-Galvez, Eduardo; Mora-Ortiz, Marina; Ohlsson, Claes; Poutanen, Matti; Pinilla, Leonor; Gaytan, Francisco; Douros, Jonathan D.; Yang, Bin; Mueller, Timo D.; Dimarchi, Richard D.; Tschoep, Matthias H.; Finan, Brian; Tena-Sempere, Manuel 分享 收藏
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease( vol 22 , 217 , 2023) 在心脏代谢疾病的临床前小鼠模型中，GIP受体激动作用可改善血脂异常和动脉粥样硬化，而与体重减轻无关 (第22卷，217，2023) Sachs, Stephan; Goetz, Anna; Finan, Brian; Feuchtinger, Annette; Dimarchi, Richard D.; Doering, Yvonne; Weber, Christian; Tschoep, Matthias H.; Mueller, Timo D.; Hofmann, Susanna M. 分享 收藏
A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression Chrudinova, Martina; Kirk, Nicholas S.; Chuard, Aurelien; Venugopal, Hari; Zhang, Fa; Lubos, Marta; Gelfanov, Vasily; Panikova, Terezie; Zakova, Lenka; Cutone, Julianne; Mojares, Matthew; DiMarchi, Richard; Jiracek, Jiri; Altindis, Emrah 分享 收藏
Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation Zaykov, Alexander N.; Gelfanov, Vasily M.; Tagmose, Tina M.; Demozay, Damien; Manfe, Valentina; Rohlfs, Rebecca; Rivir, Marita; Perez-Tilve, Diego; Finan, Brian; DiMarchi, Richard D. 分享 收藏
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice Liskiewicz, Arkadiusz; Khalil, Ahmed; Liskiewicz, Daniela; Novikoff, Aaron; Grandl, Gerald; Maity-Kumar, Gandhari; Gutgesell, Robert M.; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Czarnecki, Oliver; Makris, Konstantinos; Lickert, Heiko; Feuchtinger, Annette; Tost, Monica; Coupland, Callum; Staender, Lisa; Akindehin, Seun; Prakash, Sneha; Abrar, Faiyaz; Castelino, Russell L.; He, Yantao; Knerr, Patrick J.; Yang, Bin; Hogendorf, Wouter F. J.; Zhang, Shiqi; Hofmann, Susanna M.; Finan, Brian; Dimarchi, Richard D.; Tschoep, Matthias H.; Douros, Jonathan D.; Mueller, Timo D. 分享 收藏
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GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease 在心脏代谢疾病的临床前小鼠模型中，GIP受体激动可独立于体重减轻而改善血脂异常和动脉粥样硬化 Sachs, Stephan; Goetz, Anna; Finan, Brian; Feuchtinger, Annette; DiMarchi, Richard D.; Doering, Yvonne; Weber, Christian; Tschoep, Matthias H.; Mueller, Timo D.; Hofmann, Susanna M. 分享 收藏
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome Maity-Kumar, Gandhari; Staender, Lisa; DeAngelis, Meri; Lee, Sooyeon; Molenaar, Anna; Becker, Lore; Garrett, Lillian; Amerie, Oana, V; Hoelter, Sabine M.; Wurst, Wolfgang; Fuchs, Helmut; Feuchtinger, Annette; Gailus-Durner, Valerie; Garcia-Caceres, Cristina; Othman, Ahmed E.; Brockmann, Caroline; Schoeffling, Vanessa, I; Beiser, Katja; Krude, Heiko; Mroz, Piotr A.; Hofmann, Susanna; Tuckermann, Jan; DiMarchi, Richard D.; de Angelis, Martin Hrabe; Tschoep, Matthias H.; Pfluger, Paul T.; Mueller, Timo D. 分享 收藏
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