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R

Richard D. DiMarchi

university of munich
H指数:72
被引数:1.9万

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Publisher Correction: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

出版更正：GLP-1R-GIPR-PPARα/γ/δ五重激动作用可纠正小鼠的肥胖与糖尿病

Nature
IF48.5
2026-05-180
OAAI
Daniela Liskiewicz; Aaron Novikoff; Ahmed Khalil; Seun Akindehin; Jonathan E. Campbell; Pietra Candela; Russell L. Castelino; Callum Coupland; Maxime Culot; W. Scott Dodson; Jonathan D. Douros; Hannes Embring; Annette Feuchtinger; Brian Finan; Cristina Garcia-Caceres; Xiao-Bing Gao; Fabien Gosselet; Gerald Grandl; Robert M. Gutgesell; Daniel T. Haas; Martin Jastroch; Ezgi Karaoglu; Pamela Kakimoto; Anna Cristina Kaltenbach; Michaela Keuper; Christine M. Kusminski; Danielle C. Leander; Arkadiusz Liskiewicz; Xue Liu; Gandhari Maity-Kumar; Sara Martinez Martinez; Stephanie A. Mowery; Ruben Nogueiras; Marshall Paisley; Diego Perez-Tilve; Patricia S. S. Petersen; Paul T. Pfluger; Sneha Prakash; Sabine Steffens; Alberto Cebrian-Serrano; Monica Tost; Jordan Wean; Christian Weber; Junichi Yoshida; Zachary Gerhart-Hines; Tamas L. Horvath; Philipp E. Scherer; Randy J. Seeley; Richard D. DiMarchi; Matthias H. Tschöp; Natalie Krahmer; Patrick J. Knerr; Timo D. Müller
GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

GLP-1R-GIPR-PPARα/γ/δ五重激动剂纠正小鼠肥胖和糖尿病

Nature
IF48.5
2026-04-010
PRE
Liskiewicz, Daniela; Novikoff, Aaron; Khalil, Ahmed; Akindehin, Seun; Campbell, Jonathan E.; Candela, Pietra; Castelino, Russell L.; Coupland, Callum; Culot, Maxime; Dodson, W. Scott; Douros, Jonathan D.; Embring, Hannes; Feuchtinger, Annette; Finan, Brian; Garcia-Caceres, Cristina; Gao, Xiao-Bing; Gosselet, Fabien; Grandl, Gerald; Gutgesell, Robert M.; Haas, Daniel T.; Jastroch, Martin; Karaoglu, Ezgi; Kakimoto, Pamela; Kaltenbach, Anna Cristina; Keuper, Michaela; Kusminski, Christine M.; Leander, Danielle C.; Liskiewicz, Arkadiusz; Liu, Xue; Maity-Kumar, Gandhari; Martinez, Sara Martinez; Mowery, Stephanie A.; Nogueiras, Ruben; Paisley, Marshall; Perez-Tilve, Diego; Petersen, Patricia S. S.; Pfluger, Paul T.; Prakash, Sneha; Steffens, Sabine; Cebrian-Serrano, Alberto; Tost, Monica; Wean, Jordan; Weber, Christian; Yoshida, Junichi; Gerhart-Hines, Zachary; Horvath, Tamas L.; Scherer, Philipp E.; Seeley, Randy J.; DiMarchi, Richard D.; Tschop, Matthias H.; Krahmer, Natalie; Knerr, Patrick J.; Muller, Timo D.
A once-daily GLP-1/GIP/glucagon receptor triagonist (NN1706) lowers body weight in rodents, monkeys and humans

一种每日一次的GLP-1/GIP/胰高血糖素受体三激动剂（NN1706）可降低啮齿动物、猴和人体的体重。

MOLECULAR METABOLISM
IF6.6
2025-06-010
OAAI
Finan, Brian; Douros, Jonathan D.; Goldwater, Ronald; Hansen, Ann Maria Kruse; Hjerpsted, Julie B.; Hjollund, Karina Rahr; Kankam, Martin K.; Knerr, Patrick J.; Konkar, Anish; Mowery, Stephanie A.; Mueller, Timo D.; Nielsen, John Romer; Nygard, Sune Boris; Perez-Tilve, Diego; Raun, Kirsten; Yang, Bin; Tschop, Matthias H.; DiMarchi, Richard D.
Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism

E2共轭GLP-1的雌激素活性由细胞内内体溶酶体酸化和雌酮代谢介导

MOLECULAR METABOLISM
IF6.6
2025-06-010
OAAI
Coupland, Callum; Sun, Na; Khalil, Ahmed; Karaoglu, Oezuem Ezgi; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Grandl, Gerald; Akindehin, Seun; Maity, Gandhari; Yang, Bin; Finan, Brian; Knerr, Patrick; Douros, Jonathan D.; Walch, Axel; Dimarchi, Richard; Tschoep, Matthias H.; Mueller, Timo D.; Novikoff, Aaron
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice (Apr, 10.1038/s42255-025-01294-x, 2024)

GIPR激动和拮抗通过不同的机制降低雄性小鼠的体重和食物摄入量（Apr, 10.1038/s42255-025-01294-x, 2024）

NATURE METABOLISM
IF20.8
2025-05-130
OA
Gutgesell, Robert M.; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D.; Knerr, Patrick J.; Finan, Brian; DiMarchi, Richard D.; Sloop, Kyle W.; Samms, Ricardo J.; Theis, Fabian J.; Tschop, Matthias H.; Muller, Timo D.
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

GIPR激动和拮抗通过不同的机制降低雄性小鼠的体重和食物摄入量。

NATURE METABOLISM
IF20.8
2025-04-291
OA
Gutgesell, Robert M.; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D.; Knerr, Patrick J.; Finan, Brian; DiMarchi, Richard D.; Sloop, Kyle W.; Samms, Ricardo J.; Theis, Fabian J.; Tschoep, Matthias H.
Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
NATURE COMMUNICATIONS
IF15.7
2024-10-010
OAAI
Sanchez-Garrido, Miguel A.; Serrano-Lopez, Victor; Ruiz-Pino, Francisco; Vazquez, Maria Jesus; Rodriguez-Martin, Andrea; Torres, Encarnacion; Velasco, Inmaculada; Rodriguez, Ana Belen; Chicano-Galvez, Eduardo; Mora-Ortiz, Marina; Ohlsson, Claes; Poutanen, Matti; Pinilla, Leonor; Gaytan, Francisco; Douros, Jonathan D.; Yang, Bin; Mueller, Timo D.; Dimarchi, Richard D.; Tschoep, Matthias H.; Finan, Brian; Tena-Sempere, Manuel
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease( vol 22 , 217 , 2023)

在心脏代谢疾病的临床前小鼠模型中，GIP受体激动作用可改善血脂异常和动脉粥样硬化，而与体重减轻无关 (第22卷，217，2023)

CARDIOVASCULAR DIABETOLOGY
IF10.6
2024-09-120
OAAI
Sachs, Stephan; Goetz, Anna; Finan, Brian; Feuchtinger, Annette; Dimarchi, Richard D.; Doering, Yvonne; Weber, Christian; Tschoep, Matthias H.; Mueller, Timo D.; Hofmann, Susanna M.
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice
NATURE METABOLISM
IF20.8
2023-11-0921
OA
Liskiewicz, Arkadiusz; Khalil, Ahmed; Liskiewicz, Daniela; Novikoff, Aaron; Grandl, Gerald; Maity-Kumar, Gandhari; Gutgesell, Robert M.; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Czarnecki, Oliver; Makris, Konstantinos; Lickert, Heiko; Feuchtinger, Annette; Tost, Monica; Coupland, Callum; Staender, Lisa; Akindehin, Seun; Prakash, Sneha; Abrar, Faiyaz; Castelino, Russell L.; He, Yantao; Knerr, Patrick J.; Yang, Bin; Hogendorf, Wouter F. J.; Zhang, Shiqi; Hofmann, Susanna M.; Finan, Brian; Dimarchi, Richard D.; Tschoep, Matthias H.; Douros, Jonathan D.; Mueller, Timo D.
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease

在心脏代谢疾病的临床前小鼠模型中，GIP受体激动可独立于体重减轻而改善血脂异常和动脉粥样硬化

CARDIOVASCULAR DIABETOLOGY
IF10.6
2023-08-176
OAAI
Sachs, Stephan; Goetz, Anna; Finan, Brian; Feuchtinger, Annette; DiMarchi, Richard D.; Doering, Yvonne; Weber, Christian; Tschoep, Matthias H.; Mueller, Timo D.; Hofmann, Susanna M.
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome
MOLECULAR METABOLISM
IF6.6
2022-12-014
OAAI
Maity-Kumar, Gandhari; Staender, Lisa; DeAngelis, Meri; Lee, Sooyeon; Molenaar, Anna; Becker, Lore; Garrett, Lillian; Amerie, Oana, V; Hoelter, Sabine M.; Wurst, Wolfgang; Fuchs, Helmut; Feuchtinger, Annette; Gailus-Durner, Valerie; Garcia-Caceres, Cristina; Othman, Ahmed E.; Brockmann, Caroline; Schoeffling, Vanessa, I; Beiser, Katja; Krude, Heiko; Mroz, Piotr A.; Hofmann, Susanna; Tuckermann, Jan; DiMarchi, Richard D.; de Angelis, Martin Hrabe; Tschoep, Matthias H.; Pfluger, Paul T.; Mueller, Timo D.

研究方向

暂未获取到该数据
B
Brian Finan
H 指数:46论文数:124被引数:1.0万
D
Diego Pérez–Tilve
H 指数:56论文数:153被引数:1.4万
T
Timo D. Müller
H 指数:63论文数:281被引数:1.8万
V
Vasily M. Gelfanov
H 指数:25论文数:69被引数:4,813
M
Matthias H. Tschöp
H 指数:112论文数:621被引数:5.5万
K
Kirk M. Habegger
H 指数:34论文数:103被引数:6,712
M
Matthias Tschoep
H 指数:8论文数:33被引数:455
J
John P. Mayer
H 指数:32论文数:104被引数:4,092
S
Susanna M. Hofmann
H 指数:41论文数:112被引数:9,063
P
Paul T. Pfluger
H 指数:61论文数:194被引数:1.5万