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L

Lukas Chávez

Sanford Burnham Prebys Medical Discovery Institute
H指数:50
被引数:1.5万

个人简介

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教育背景

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工作经历

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荣誉奖项

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A Living Multi-Omics PDX Biobank of High-Risk Sarcomas Reveals ecDNA-Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

高风险肉瘤的活体多组学PDX生物银行揭示了骨肉瘤中环状染色体外DNA驱动的癌基因扩增，并支持临床前精准肿瘤学

Advanced Science
IF14.1
2026-10-130
OAAI
Weisong Zhao; Zhiwei Cheng; Kai Tian; Mengxiong Sun; Zhuoying Wang; Ming Jiao; Jens Luebeck; Kaiyuan Zhu; Xiao Zhang; Dongqing Zuo; Hongsheng Wang; Chongren Wang; Jiakang Shen; Xiaojun Ma; Gangyang Wang; Zongyi Wang; Jing Han; Kaiyuan Liu; Haoran Mu; Weiqi Ma; Yongyong Ren; Shibing Guo; Huangxin Tu; Lingfeng Yu; Yining Tao; Yu Lv; Hui Lu; Owen S. Chapman; Rishaan Kenkre; Lukas Chavez; Zhengdong Cai; Yuqin Yang; Wei Sun; Yafei Jiang; Yingqi Hua
Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency 不同小脑髓母细胞瘤染色质状态揭示KDM2B为一种选择性依赖

Nature Genetics
IF29
2026-09-240
OA
Ran Tao; Serap Erkek-Ozhan; Beisi Xu; Yurika Matsui; Priya Mittal; Kyle S. Smith; Yiran Li; David Filipovic; Ruijie Xu; Qingsong Gao; Emily Darrow; Rahul Kumar; Nadhir Djekidel; Richa Bajpai; Jennifer Hadley; Melissa Batts; Sara A. Lewis; Taha Soliman; Colleen Reilly; Natarajan V. Bhanu; Leena Paul; Hong Lin; Brian Gudenas; Kim Lowe; Marc Zapatka; Laura Sieber; David T. W. Jones; Marcel Kool; Sebastian M. Waszak; Volker Hovestadt; Ivo Buchhalter; Marina Ryzhova; Andrey Korshunov; Peter Lichter; Lukas Chavez; Lena M. Kutscher; Benjamin A. Garcia; Shondra M. Pruett-Miller; Xin Zhou; Brent A. Orr; Giles W. Robinson; Gang Wu; Jan O. Korbel; Jamy C. Peng; Stefan M. Pfister; Paul A. Northcott
Combinatorial targeting of avapritinib-driven MAPK activation in pediatric high-grade glioma

阿伐普利尼布诱导的MAPK激活在儿童高级别胶质瘤中的组合靶向治疗

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Schwark, Kallen; Miclea, Madeline; Patel, Tirth; Kong, Seongbae; Stanczak, Alina; Lau, Benison; Cartaxo, Rodrigo; Messinger, Dana; Doherty, Robert; Ji, Sunjong; Wadden, Jack; Clausen, Madison; Momen, Fareen; Adam, Tiffany; Wink, Kelsey; Hutchinson, Aria; Niculcea, Michael; Serhan, Habib; Merrill, Nathan; Edmonds, Amy; Mayr, Lisa; Neyazi, Sina; Munoz, Denise; Nuechterlein, Nicholas; Fernandez, Ester Calvo; Califano, Andrea; Pavisic, Jovana; Garton, Hugh; Rao, Rama; Upadhyaya, Santhosh; Skrypek, Mary; Bendel, Anne; Lobbous, Mina; Klawinski, Darren; Merajver, Sofia; Koptyra, Mateusz; Resnick, Adam; Nazarian, Javad; Venneti, Sriram; Waszak, Sebastian; Chavez, Lukas; Beck, Alexander; Gojo, Johannes; Filbin, Mariella; Coppe, Jean-Philippe; Koschmann, Carl
Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
DEVELOPMENTAL CELL
IF8.7
2024-09-011
PRE
Shiraishi, Ryo; Cancila, Gabriele; Kumegawa, Kohei; Torrejon, Jacob; Basili, Irene; Bernardi, Flavia; Silva, Patricia Benites Goncalves da; Wang, Wanchen; Chapman, Owen; Yang, Liying; Jami, Maki; Nishitani, Kayo; Arai, Yukimi; Xiao, Zhize; Yu, Hua; Lo Re, Valentina; Marsaud, Veronique; Talbot, Julie; Lombard, Berangere; Loew, Damarys; Jingu, Maho; Okonechnikov, Konstantin; Sone, Masaki; Motohashi, Norio; Aoki, Yoshitsugu; Pfister, Stefan M.; Chavez, Lukas; Hoshino, Mikio; Maruyama, Reo; Ayrault, Olivier; Kawauchi, Daisuke
MULTI-OMICS AND FUNCTIONAL PRECISION MEDICINE FOR NEWLY DIAGNOSED AND RECURRENT PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS
NEURO-ONCOLOGY
IF13.4
2024-06-180
OAAI
Crawford, John R.; Lo, Yan Yuen; Pagadala, Meghana S.; Chapman, Owen S.; Sridhar, Sunita; Juarez, Edwin F.; Tzaridis, Theophilos; Chau, Lianne Q.; Wang, Jun; Eisemann, Tanja; Masihi, Meher Beigi; Chambers, Kendall R.; Dixit, Deobrat; Koubourli, Daphne; Larson, Jon D.; Guidugli, Lucia; Hammer, Monia; Wong, Terence; Abdullaev, Zied; Quezado, Martha; Martins, Timothy J.; Reich, Michael; Sears, Timothy; Hobbs, Charlotte; Kingsmore, Stephen F.; Levy, Michael L.; Gonda, David; Malicki, Denise M.; Snuderl, Matija; Becker, Pamela S.; Tamayo, Pablo; Elster, Jennifer D.; Aldape, Kenneth; Carter, Hannah; Paul, Megan R.; Mesirov, Jill P.; Chavez, Lukas; Wechsler-Reya, Robert J.
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

圆形染色体外DNA促进高危髓母细胞瘤的肿瘤异质性

NATURE GENETICS
IF31.8
2023-11-098
OAAI
Chapman, Owen S.; Luebeck, Jens; Sridhar, Sunita; Wong, Ivy Tsz-Lo; Dixit, Deobrat; Wang, Shanqing; Prasad, Gino; Rajkumar, Utkrisht; Pagadala, Meghana S.; Larson, Jon D.; He, Britney Jiayu; Hung, King L.; Lange, Joshua T.; Dehkordi, Siavash R.; Chandran, Sahaana; Adam, Miriam; Morgan, Ling; Wani, Sameena; Tiwari, Ashutosh; Guccione, Caitlin; Lin, Yingxi; Dutta, Aditi; Lo, Yan Yuen; Juarez, Edwin; Robinson, James T.; Korshunov, Andrey; Michaels, John-Edward A.; Cho, Yoon-Jae; Malicki, Denise M.; Coufal, Nicole G.; Levy, Michael L.; Hobbs, Charlotte; Scheuermann, Richard H.; Crawford, John R.; Pomeroy, Scott L.; Rich, Jeremy N.; Zhang, Xinlian; Chang, Howard Y.; Dixon, Jesse R.; Bagchi, Anindya; Deshpande, Aniruddha J.; Carter, Hannah; Fraenkel, Ernest; Mischel, Paul S.; Wechsler-Reya, Robert J.; Bafna, Vineet; Mesirov, Jill P.; Chavez, Lukas
Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

转录延伸机制是一种药物依赖性，可增强胶质母细胞瘤干细胞的免疫治疗

CANCER DISCOVERY
IF33.3
2022-02-0945
OA
Qiu, Zhixin; Zhao, Linjie; Shen, Jia Z.; Liang, Zhengyu; Wu, Qiulian; Yang, Kailin; Min, Lihua; Gimple, Ryan C.; Yang, Qiyuan; Bhargava, Shruti; Jin, Chunyu; Kim, Cheryl; Hinz, Denise; Dixit, Deobrat; Bernatchez, Jean A.; Prager, Briana C.; Zhang, Guoxin; Dong, Zhen; Lv, Deguan; Wang, Xujun; Kim, Leo J. Y.; Zhu, Zhe; Jones, Katherine A.; Zheng, Ye; Wang, Xiuxing; Siqueira-Neto, Jair L.; Chavez, Lukas; Fu, Xiang-Dong; Spruck, Charles; Rich, Jeremy N.
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies
CANCER DISCOVERY
IF33.3
2020-11-0233
OAAI
Prager, Briana C.; Vasudevan, Harish N.; Dixit, Deobrat; Bernatchez, Jean A.; Wu, Qiulian; Wallace, Lisa C.; Bhargava, Shruti; Lee, Derrick; King, Bradley H.; Morton, Andrew R.; Gimple, Ryan C.; Pekmezci, Melike; Zhu, Zhe; Siqueira-Neto, Jair L.; Wang, Xiuxing; Xie, Qi; Chen, Clark; Barnett, Gene H.; Vogelbaum, Michael A.; Mack, Stephen C.; Chavez, Lukas; Perry, Arie; Raleigh, David R.; Rich, Jeremy N.

研究方向

暂未获取到该数据
S
Stefan M. Pfister
H 指数:159论文数:2,105被引数:12.8万
M
Marcel Kool
H 指数:119论文数:957被引数:8.4万
A
Andrey Korshunov
H 指数:127论文数:831被引数:7.3万
D
David Jones
H 指数:144论文数:1,486被引数:10.4万
A
Anjana Rao
H 指数:127论文数:413被引数:7.3万
O
Owen Chapman
H 指数:6论文数:46被引数:230
D
David Capper
H 指数:95论文数:648被引数:4.3万
J
Jill P. Mesirov
H 指数:85论文数:473被引数:22.4万
T
Tanvi Sharma
H 指数:29论文数:117被引数:3,714
R
Robert J. Wechsler‐Reya
H 指数:60论文数:485被引数:1.7万