Luís Zapata - Publications, H-index & Citations

Luís Zapata

The Institute of Cancer Research

35H指数

235论文数

4.5K被引数

收录论文 48

发表时间

IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial IAP拮抗剂托利那潘特（ASTX660）联合帕博利珠单抗治疗晚期实体瘤：一项I期临床试验

Nature Communications

IF15.7

2026-09-30

OAAI

Crescens Tiu; Wing Yau; Tencho Tenev; Daniel Lionarons; Ching Leung; Victoria Sanchez-Perez; Giovanni Codacci-Pisanelli; Xiaoran Lai; Anna Zachariou; Aasia Hussain; Toby Prout; Mona Parmar; Bindu Baikady; Maria Goicoechea; Scott Layzell; Naomi Guppy; Ioannis Roxanis; Thomas Lund; Diego Carlos Dos Reis; Camila Pereira Almeida; Tatiany Luiza Silveira; Ana Ferreira; Bora Gurel; Claudia Bertan; Mateus Crespo; Penny Flohr; Ann-Marie Baker; Trevor Graham; Luis Zapata; Claudio Salas; Soham Mandal; Alan Dunlop; Martin Sims; George Ward; Tomoko Smyth; Simone Jueliger; Matthew Davis; Ilya Potapov; Aram Oganesian; Danna Chan; Mattias Leino; Subham Basu; Andre Samson; James M. Murphy; Nina Tunariu; Edward W. Johnston; Alistair Ring; Nick Turner; Andrew N. J. Tutt; Amanda Swain; Anna Minchom; Adam Sharp; Alec Paschalis; Udai Banerji; Johann de Bono; Bristi Basu; Christina Yap; Syed Haider; Juanita Lopez; Pascal Meier

Distinct molecular profiles associated with early vs late genome instability in cancer 早期与晚期基因组不稳定性相关的不同分子特征

Scientific Reports

IF3.9

2026-04-06

OAAI

Lucie Gourmet; James Lam; Adam Pennycuick; Luis Zapata; Parag Mallick; Simon Walker-Samuel

Epigenetically driven and early immune evasion in colorectal cancer evolution 表观遗传驱动的结直肠癌进化中的早期免疫逃逸

Nature Genetics

IF29

2025-11-05

OAAI

Eszter Lakatos; Vinaya Gunasri; Luis Zapata; Jacob Househam; Timon Heide; Nicholas Trahearn; Ottilie Swinyard; Luis Cisneros; Claire Lynn; Maximilian Mossner; Chris Kimberley; Inmaculada Spiteri; George D. Cresswell; Gerard Llibre-Palomar; Miriam Mitchison; Carlo C. Maley; Marnix Jansen; Manuel Rodriguez-Justo; John Bridgewater; Ann-Marie Baker; Andrea Sottoriva; Trevor A. Graham

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma 食管腺癌新辅助治疗期间的肿瘤进化与免疫微环境动力学

NATURE CANCER

IF28.5

2025-05-14

OAAI

Barroux, Melissa; Househam, Jacob; Lakatos, Eszter; Ronel, Tahel; Baker, Ann-Marie; Salie, Henrike; Mossner, Maximilian; Smith, Kane; Kimberley, Chris; Nowinski, Salpie; Berner, Alison; Gunasri, Vinaya; Borgmann, Martin; Liffers, Sven; Jansen, Marnix; Caravagna, Giulio; Steiger, Katja; Slotta-Huspenina, Julia; Weichert, Wilko; Zapata, Luis; Giota, Eleftheria; Lorenzen, Sylvie; Alberstmeier, Markus; Chain, Benny; Friess, Helmut; Bengsch, Bertram; Schmid, Roland M.; Siveke, Jens T.; Quante, Michael; Graham, Trevor A.

Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer

NATURE CANCER

IF28.5

2024-07-12

OAAI

Fernandez-Mateos, Javier; Cresswell, George D.; Trahearn, Nicholas; Webb, Katharine; Sakr, Chirine; Lampis, Andrea; Stuttle, Christine; Corbishley, Catherine M.; Stavrinides, Vasilis; Zapata, Luis; Spiteri, Inmaculada; Heide, Timon; Gallagher, Lewis; James, Chela; Ramazzotti, Daniele; Gao, Annie; Kote-Jarai, Zsofia; Acar, Ahmet; Truelove, Lesley; Proszek, Paula; Murray, Julia; Reid, Alison; Wilkins, Anna; Hubank, Michael; Eeles, Ros; Dearnaley, David; Sottoriva, Andrea

Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer 均聚物开关介导错配修复缺陷型结直肠癌的适应性可变性

NATURE GENETICS

IF31.8

2024-07-03

OAAI

Kayhanian, Hamzeh; Cross, William; van der Horst, Suzanne E. M.; Barmpoutis, Panagiotis; Lakatos, Eszter; Caravagna, Giulio; Zapata, Luis; Van Hoeck, Arne; Middelkamp, Sjors; Litchfield, Kevin; Steele, Christopher; Waddingham, William; Patel, Dominic; Milite, Salvatore; Jin, Chen; Baker, Ann-Marie; Alexander, Daniel C.; Khan, Khurum; Hochhauser, Daniel; Novelli, Marco; Werner, Benjamin; van Boxtel, Ruben; Hageman, Joris H.; Buissant des Amorie, Julian R.; Linares, Josep; Ligtenberg, Marjolijn J. L.; Nagtegaal, Iris D.; Lacle, Miangela M.; Moons, Leon M. G.; Brosens, Lodewijk A. A.; Pillay, Nischalan; Sottoriva, Andrea; Graham, Trevor A.; Rodriguez-Justo, Manuel; Shiu, Kai-Keen; Snippert, Hugo J. G.; Jansen, Marnix

Immune evasion impacts the landscape of driver genes during cancer evolution

GENOME BIOLOGY

IF9.4

2024-06-26

OAAI

Gourmet, Lucie; Sottoriva, Andrea; Walker-Samuel, Simon; Secrier, Maria; Zapata, Luis

Determinants of tumour-immune evolutionary trajectory in colorectal cancer

ANNALS OF ONCOLOGY

IF65.4

2024-06-01

PREAI

Lakatos, E.; Gunasri, V.; Zapata, L.; Househam, J.; Heide, T.; Trahearn, N.; Swinyard, O.; Lynn, C.; Cresswell, G.; Mossner, M.; Kimberley, C.; Spiteri, I.; Jansen, M.; Rodriguez-Justo, M.; Bridgewater, J. A.; Baker, A-M.; Sottoriva, A.; Graham, T.

Lower incidence of small intestinal adenocarcinomas may be due to constrained copy number karyotype and increased immune surveillance

CANCER RESEARCH

IF16.6

2024-02-01

PREAI

Nowinski, Salpie; Balarajah, Vickna; Baker, Ann-Marie; Katainen, Riku; Hughes, Christine; Guo, Qingli; Zapata, Luis; Lakatos, Eszter; Kocher, Hemant M.; Graham, Trevor A.

Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors

NATURE GENETICS

IF31.8

2023-03-09

OAAI

Zapata, Luis; Caravagna, Giulio; Williams, Marc J.; Lakatos, Eszter; AbdulJabbar, Khalid; Werner, Benjamin; Chowell, Diego; James, Chela; Gourmet, Lucie; Milite, Salvatore; Acar, Ahmet; Riaz, Nadeem; Chan, Timothy A. A.; Graham, Trevor A.; Sottoriva, Andrea

One-joule 500-Hz cryogenic Yb:YAG laser driver of composite thin-disk design

OPTICS LETTERS

IF3.3

2022-12-08

PREAI

Zapata, L. E.; Pergament, M.; Schust, M.; Reuter, S.; Thesinga, J.; Zapata, C.; Kellert, M.; Demirbas, U.; Calendron, A-L; Liu, Y.; Kaertner, F. X.

Very large hidden genetic diversity in one single tumor: evidence for tumors-in-tumor 单个肿瘤中非常大的隐藏遗传多样性: 肿瘤中肿瘤的证据

NATIONAL SCIENCE REVIEW

IF17.1

2022-11-11

OAAI

Chen, Bingjie; Wu, Xianrui; Ruan, Yongsen; Zhang, Yulin; Cai, Qichun; Zapata, Luis; Wu, Chung-, I; Lan, Ping; Wen, Haijun

Parameter sensitivities in tilted-pulse-front based terahertz setups and their implications for high-energy terahertz source design and optimization

OPTICS EXPRESS

IF3.3

2022-06-22

OAAI

Kroh, Tobias; Rohwer, Timm; Zhang, Dongfang; Demirbas, Umit; Cankaya, Huseyin; Hemmer, Michael; Hua, Yi; Zapata, Luis E.; Pergament, Mikhail; Kartner, Franz X.; Matlis, Nicholas H.

Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells

NATURE COMMUNICATIONS

IF15.7

2020-10-28

OAAI

Tarbier, Marcel; Mackowiak, Sebastian D.; Frade, Joao; Catuara-Solarz, Silvina; Biryukova, Inna; Gelali, Eleni; Menendez, Diego Barcena; Zapata, Luis; Ossowski, Stephan; Bienko, Magda; Gallant, Caroline J.; Friedlander, Marc R.

Evolutionary dynamics of neoantigens in growing tumors

NATURE GENETICS

IF31.8

2020-09-14

OAAI

Lakatos, Eszter; Williams, Marc J.; Schenck, Ryan O.; Cross, William C. H.; Househam, Jacob; Zapata, Luis; Werner, Benjamin; Gatenbee, Chandler; Robertson-Tessi, Mark; Barnes, Chris P.; Anderson, Alexander R. A.; Sottoriva, Andrea; Graham, Trevor A.

Subclonal reconstruction of tumors by using machine learning and population genetics

NATURE GENETICS

IF31.8

2020-09-02

OAAI

Caravagna, Giulio; Heide, Timon; Williams, Marc J.; Zapata, Luis; Nichol, Daniel; Chkhaidze, Ketevan; Cross, William; Cresswell, George D.; Werner, Benjamin; Acar, Ahmet; Chesler, Louis; Barnes, Chris P.; Sanguinetti, Guido; Graham, Trevor A.; Sottoriva, Andrea

The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissues

GENOME MEDICINE

IF11.2

2020-05-27

OAAI

Muyas, Francesc; Zapata, Luis; Guigo, Roderic; Ossowski, Stephan

Geospatial immune variability illuminates differential evolution of lung adenocarcinoma 地理空间免疫变异性揭示肺腺癌的差异演变

NATURE MEDICINE

IF50

2020-05-27

191

OAAI

AbdulJabbar, Khalid; Raza, Shan E. Ahmed; Rosenthal, Rachel; Jamal-Hanjani, Mariam; Veeriah, Selvaraju; Akarca, Ayse; Lund, Tom; Moore, David A.; Salgado, Roberto; Al Bakir, Maise; Zapata, Luis; Hiley, Crispin T.; Officer, Leah; Sereno, Marco; Smith, Claire Rachel; Loi, Sherene; Hackshaw, Allan; Marafioti, Teresa; Quezada, Sergio A.; McGranahan, Nicholas; Le Quesne, John; Swanton, Charles; Yuan, Yinyin

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

ELIFE

IF0

2020-03-30

OAAI

Williams, Marc J.; Zapata, Luis; Werner, Benjamin; Barnes, Chris P.; Sottoriva, Andrea; Graham, Trevor A.

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

NATURE COMMUNICATIONS

IF15.7

2020-03-27

OAAI

Cresswell, George D.; Nichol, Daniel; Spiteri, Inmaculada; Tari, Haider; Zapata, Luis; Heide, Timon; Maley, Carlo C.; Magnani, Luca; Schiavon, Gaia; Ashworth, Alan; Barry, Peter; Sottoriva, Andrea

研究方向