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M

Mikko Hiltunen

University of Eastern Finland

59H指数
293论文数
3.3W被引数
收录论文 115
发表时间
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PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal culturesPLCγ2下调损害突触功能并增加神经元培养物中的阿尔茨海默病标志物
errNature Genetics
IF29
err2026-08-14
err0
errOAAI
errAudrey Coulon; Florian Rabiller; Mari Takalo; Avishek Roy; Alexandre Pelletier; Henna Martiskainen; Dolores Siedlecki-Wullich; Nina Lannette-Weimann; Naďa Majerníková; Arthur Grenon; Vance Gao; Anaël Erhardt; Anne Pernodet; Morgane Lemaire; Floriane Limoge; Pauline Walle; Tiago Mendes; Karine Guyot; Célia Lemeu; Lukas-Iohan Carvalho; Ana Raquel Melo de Farias; Marc Hulsman; Chloé Najdek; Alejandra Freire-Regatillo; Orthis Saha; Philippe Amouyel; Camille Charbonnier; Jean-François Deleuze; Orio Dols-Icardo; Heli Jeskanen; Roosa-Maria Willman; Teemu Kuulasmaa; Mitja Kurki; John Hardy; Sami Heikkinen; Henne Holstege; Petra Mäkinen; Gaël Nicolas; Simon Mead; Michael Wagner; Alfredo Ramirez; Tuomas Rauramaa; Aarno Palotie; Rebecca Sims; Hilkka Soininen; John van Swieten; Julie Williams; Céline Bellenguez; Carla Gelle; Erwan Lambert; Marcos R. Costa; Julia TCW; Enrico Glaab; Anne-Marie Ayral; Florie Demiautte; Benjamin Grenier-Boley; Manon Muntaner; Delphine Eberlé; Séverine Deforges; Joel T. Haas; Devrim Kilinc; Christophe Mulle; Julien Chapuis; Mikko Hiltunen; Julie Dumont; Jean-Charles Lambert
err分享
err收藏
Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen基于生物样本库的神经退行性疾病和特发性正常压力脑积水遗传特征研究：来自FinnGen的见解与经验教训
errMolecular Psychiatry
IF10.1
err2026-06-12
err0
errOAAI
errSami Heikkinen; Valtteri Julkunen; Henna Martiskainen; Mari Takalo; Eino Solje; Ville Leinonen; Annakaisa Haapasalo; Anssi Lipponen; Mikko Hiltunen
err分享
err收藏
GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy脑脊液阿尔茨海默病生物标志物的GWAS荟萃分析揭示了调控脂质、脑容量和自噬的基因位点
errNature Communications
IF15.7
err2026-04-21
err0
errOAAI
errJigyasha Timsina; Chenyang Jiang; Daniel L. McCartney; Feifei Tao; Maria Carolina Dalmasso; Jenna Najar; Federica Anastasi; Olena Ohlei; Raquel Puerta Fuentes; Chenyu Yang; Joseph Bradley; Daniel Western; Muhammad Ali; Ciyang Wang; Chengran Yang; Ying Wu; Menghan Liu; John Budde; Julie Williams; Rebecca Mahoney; Atahualpa Castillo Morales; Timothy J. Hohman; Logan Dumitrescu; Ting-Chen Wang; Niccolo’ Tesi; Silke Kern; Margda Waern; Ingmar Skoog; Argonde van Harten; Yolande A. L. Pijnenburg; Wiesje M. van der Flier; Pascual Sánchez-Juan; Eloy Rodriguez-Rodriguez; Luca Kleineidam; Oliver Peters; Anja Schneider; Fahri Küçükali; Céline Bellenguez; Benjamin Grenier-Boley; Sami Heikkinen; Itziar de Rojas; Dan Rujescu; Norbert Scherbaum; Lucrezia Hausner; Emrah Düzel; Timo Grimmer; Jens Wiltfang; Rik Vandenberghe; Sebastiaan Engelborghs; Stefanie Heilmann-Heimbach; Matthias Schmid; Thomas Tegos; Nikolaos Scarmeas; Oriol Dols-Icardo; Fermin Moreno; Jordi Pérez-Tur; María J. Bullido; Raquel Sánchez-Valle; Victoria Álvarez; Pablo García-González; Pablo Mir; Luis M. Real; Gerard Piñol-Ripoll; Jose María García-Alberca; Harro Seelaar; Inez Ramakers; Janne Papma; Marc Hulsman; Christoph Laske; Stefan Teipel; Josef Priller; Robert Perneczky; Katharina Buerger; Markus M. Nöthen; Piotr Lewczuk; Johannes Kornhuber; Harald Hampel; Ina Giegling; Oliver Goldhardt; Janine Diehl-Schmid; Victor Andrade; Michael MT. Heneka; Lutz Frölich; Jonathan Vogelgsang; Caroline Graff; Hakan Thonberg; Abbe Ullgren; Goran Papenberg; Jean-François Deleuze; Carole Dufouil; Michael Wagner; Frank Jessen; Henne Holstege; Cornelia van Duijn; Thibaud Lebouvier; Olivier Hannon; Ville Leinonen; Hilkka Soininen; Sanna-Kaisa Herukka; Vilmantas Giedraitis; Malin Löwenmark; Lena Kilander; Patricia Genius; Blanca Rodríguez; Emma S. Luckett; Arcadi Navarro; Amanda Cano; Marta Marquié; Kaj Blennow; Henrik Zetterberg; Alberto Lleo; Mercè Boada; Agustin Ruiz; Virginia Man-Yee Lee; Vivianna M. Van Deerlin; Yuetiva Deming; Sterling C. Johnson; Corinne D. Engelman; Pau Pastor; Ignacio Alvarez; Elaine R. Peskind; Amanda J. Heslegrave; Andrew J. Saykin; Kwangsik Nho; Suzanne E. Schindler; John C. Morris; David M. Holtzman; Eric McDade; Alan E. Renton; Alison Goate; Laura Ibanez; Matthias Riemenschneider; Marilyn S. Albert; Simon M. Laws; Tenielle Porter; Eleanor K. O’Brien; Leslie M. Shaw; Betty M. Tijms; Martin Ingelsson; Pieter Jelle Visser; Mikko Hiltunen; Kristel Sleegers; Craig W. Ritchie; Rebecca Sims; Michael Belloy; Jean-Charles Lambert; Natalia Vilor-Tejedor; Maria Victoria Fernández; Qingqin S. Li; Michael W. Nagle; Riccardo E. Marioni; Alfredo Ramirez; Lars Bertram; Sven J. van der Lee; Carlos Cruchaga
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err收藏
Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial阿尔茨海默病和心血管遗传风险评分与认知功能：FINGER随机对照试验
errBrain
IF11.7
err2025-08-06
err0
errOAAI
errGazi Saadmaan; Maria Carolina Dalmasso; Maleeha Maria; Jenni Lehtisalo; Mikko Hiltunen; Minna U Kaikkonen; Esko Levälahti; Francesca Mangialasche; Markus Perola; Alfredo Ramirez; Ruth Stephen; Tiia Ngandu; Miia Kivipelto; Alina Solomon; null
err分享
err收藏
Cross-sectional study of plasma phosphorylated tau 217 in persons without dementia无痴呆人群血浆磷酸化tau 217的横断面研究
errALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
IF4.4
err2025-05-09
err0
errOAAI
errSaari, TT; Palviainen, T; Hiltunen, M; Herukka, SK; Kokkola, T; Kärkkäinen, S; Urjansson, M; Aaltonen, A; Palotie, A; Runz, H; Kaprio, J; Julkunen, V; Vuoksimaa, E
err分享
err收藏
Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2025-03-01
err0
PREAI
errVanninen, Aleksi; Erkkila, Lauri; Kokkola, Tarja; Selander, Tuomas; Koivisto, Anne M.; Kokki, Merja; Musialowicz, Tadeusz; Lipponen, Anssi; Hiltunen, Mikko; Hakumaki, Juhana; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Leinonen, Ville
err分享
err收藏
Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study
errFLUIDS AND BARRIERS OF THE CNS
IF6.2
err2025-02-13
err0
errOAAI
errRasanen, Joel; Helisalmi, Seppo; Heikkinen, Sami; Raivo, Joose; Korhonen, Ville E.; Martiskainen, Henna; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Celine; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von Und zu Fraunberg, Mikael; Lonnrot, Kimmo; Satopaa, Jarno; Perola, Markus; Koivisto, Anne M.; Julkunen, Valtteri; Portaankorva, Anne M.; Mannermaa, Arto; Soininen, Hilkka; Jaaskelainen, Juha E.; Lambert, Jean-Charles; Eide, Per K.; FinnGen, Aarno; Palotie, Aarno; Kurki, Mitja I.; Hiltunen, Mikko; Leinonen, Ville; Lipponen, Anssi
err分享
err收藏
Exploring the Association Between Visual Field Testing and CERAD Neuropsychological Battery in Idiopathic Normal Pressure Hydrocephalus Patients
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2024-06-25
err1
PREAI
errKemilainen, Benjam; Tiainen, Sonja; Rauramaa, Tuomas; Luikku, Antti J.; Herukka, Sanna-Kaisa; Koivisto, Anne; Hiltunen, Mikko; Verdooner, Steven; Johnson, Ken; Chambers, Mieko; Kaarniranta, Kai; Leinonen, Ville
err分享
err收藏
Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial手指生活方式试验中的阿尔茨海默病遗传风险评分和神经影像学
errALZHEIMERS & DEMENTIA
IF11.1
err2024-04-22
err0
errOAAI
errSaadmaan, Gazi; Dalmasso, Maria Carolina; Ramirez, Alfredo; Hiltunen, Mikko; Kemppainen, Nina; Lehtisalo, Jenni; Mangialasche, Francesca; Ngandu, Tiia; Rinne, Juha; Soininen, Hilkka; Stephen, Ruth; Kivipelto, Miia; Solomon, Alina
err分享
err收藏
DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-01-18
err5
errOAAI
errKaarijaervi, Roosa; Kaljunen, Heidi; Nappi, Lucia; Fazli, Ladan; Kung, Sonia H. Y.; Hartikainen, Jaana M.; Paakinaho, Ville; Capra, Janne; Rilla, Kirsi; Malinen, Marjo; Maekinen, Petri I.; Ylae-Herttuala, Seppo; Zoubeidi, Amina; Wang, Yuzhuo; Gleave, Martin E.; Hiltunen, Mikko; Ketola, Kirsi
err分享
err收藏
Cognitive and biomarker responses in healthy older adults to a 18-hole golf round and different walking types: a randomised cross-over study
errBMJ OPEN SPORT & EXERCISE MEDICINE
IF3.2
err2023-10-12
err2
errOAAI
errKettinen, Julia; Tikkanen, Heikki; Hiltunen, Mikko; Murray, Andrew; Horn, Nils; Taylor, William R.; Venojaervi, Mika
err分享
err收藏
Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2023-07-18
err2
errOAAI
errVanninen, Aleksi; Lukkarinen, Heikki; Kokkola, Tarja; Koivisto, Anne M.; Kokki, Merja; Musialowicz, Tadeusz; Hiltunen, Mikko; Zetterberg, Henrik; Leinonen, Ville; Herukka, Sanna-Kaisa; Rauramaa, Tuomas
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err收藏
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates成年TAU病小鼠的器官型海马切片培养物和纳米材料磷酸-TAU抗体缀合物的治疗评估
errCELLS
IF5.2
err2023-05-18
err0
errOAAI
errKemppainen, Susanna; Huber, Nadine; Willman, Roosa-Maria; Zamora, Ana; Makinen, Petra; Martiskainen, Henna; Takalo, Mari; Haapasalo, Annakaisa; Sobrino, Tomas; Gomez, Manuel Antonio Gonzalez; Pineiro, Yolanda; Rivas, Jose; Himmelreich, Uwe; Hiltunen, Mikko
err分享
err收藏
Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err30
errOAAI
errSarajarvi, Timo; Tuusa, Jussi T.; Haapasalo, Annakaisa; Lackman, Jarkko J.; Sormunen, Raija; Helisalmi, Seppo; Roehr, Johannes T.; Parrado, Antonio R.; Makinen, Petra; Bertram, Lars; Soininen, Hilkka; Tanzi, Rudolph E.; Petaja-Repo, Ulla E.; Hiltunen, Mikko
err分享
err收藏
Concordance of Alzheimer's Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2023-01-03
err2
errOAAI
errLukkarinen, Heikki; Vanninen, Aleksi; Tesseur, Ina; Pemberton, Darrel; Van der Ark, Peter; Kokkola, Tarja; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville
err分享
err收藏
Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice
errLIFE SCIENCES
IF5.1
err2022-12-01
err6
errOAAI
errMontaser, Ahmed B.; Kuiri, Janita; Natunen, Teemu; Hruska, Pavel; Potesil, David; Auriola, Seppo; Hiltunen, Mikko; Terasaki, Tetsuya; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M.
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err收藏
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients反映特发性正常压力脑积水患者临床症状的脑脊液生物标志物
errFLUIDS AND BARRIERS OF THE CNS
IF6.2
err2022-02-05
err18
errOAAI
errLukkarinen, Heikki; Jeppsson, Anna; Wikkelso, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M.; Herukka, Sanna-Kaisa; Hiltunen, Mikko; Rauramaa, Tuomas; Nagga, Katarina; Leinonen, Ville; Tullberg, Mats
err分享
err收藏
Challenges at the APOE locus: a robust quality control approach for accurate APOE genotypingAPOE基因座的挑战: 准确的APOE基因分型的稳健质量控制方法
errALZHEIMERS RESEARCH & THERAPY
IF7.6
err2022-02-04
err7
errOAAI
errBelloy, Michael E.; Eger, Sarah J.; Le Guen, Yann; Damotte, Vincent; Ahmad, Shahzad; Ikram, M. Arfan; Ramirez, Alfredo; Tsolaki, Anthoula C.; Rossi, Giacomina; Jansen, Iris E.; de Rojas, Itziar; Parveen, Kayenat; Sleegers, Kristel; Ingelsson, Martin; Hiltunen, Mikko; Amin, Najaf; Andreassen, Ole; Sanchez-Juan, Pascual; Kehoe, Patrick; Amouyel, Philippe; Sims, Rebecca; Frikke-Schmidt, Ruth; van der Flier, Wiesje M.; Lambert, Jean-Charles; He, Zihuai; Han, Summer S.; Napolioni, Valerio; Greicius, Michael D.
err分享
err收藏
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5
errNEUROBIOLOGY OF DISEASE
IF5.6
err2022-02-01
err10
errOAAI
errFerreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M. A.; Takalo, Mari; Makinen, Petra; Leppanen, Luukas; Miranda-Lourenco, Catarina; Fonseca-Gomes, Joao; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastiao, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luisa V.; de Mendonca, Alexandre; Diogenes, Maria Jose; Hiltunen, Mikko
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Novel Rare SORL1 Variants in Early-Onset Dementia
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2021-07-21
err3
PREAI
errKorpioja, Anita; Kruger, Johanna; Koivuluoma, Susanna; Pylkas, Katri; Moilanen, Virpi; Helisalmi, Seppo; Hiltunen, Mikko; Remes, Anne M.
err分享
err收藏

研究方向

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合作学者
合作期刊
J
John Q. Trojanowski
H 指数: 255 · 论文数: 1.8K
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Cornelia M. van Duijn
H 指数: 238 · 论文数: 1.9K
A
André G. Uitterlinden
H 指数: 234 · 论文数: 2.0K
D
Dennis W. Dickson
H 指数: 218 · 论文数: 2.3K
E
Eric Boerwinkle
H 指数: 215 · 论文数: 2.0K
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