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N

Naoya Uchida

national institutes of health (nih) - usa
H指数:34
被引数:3,423

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Comparative Analysis of CRISPR-Cas9, lentiviral transduction, and base editing for sickle cell disease in a murine model

CRISPR-Cas9、慢病毒转导和碱基编辑技术在镰状细胞病小鼠模型中的比较分析

Blood Advances
IF7.1
2025-10-300
OAAI
Henna Butt; Shruti Sathish; Evan London; Anh Le; Quan Li; Bjorg Gudmundsdottir; Duck-Yeon Lee; Emma V. Burke; Bradley P. Yates; David R. Liu; Matthew Hsieh; Alexis Leonard; William A. Eaton; Naoya Uchida; Francis J. Pierciey; Gregory A. Newby; John F. Tisdale; Selami Demirci
CD117 Antibody Conditioning and Multiplex Base Editing Enable Rapid and Robust Fetal Hemoglobin Reactivation in a Rhesus Autologous Transplantation Model

CD117抗体预处理与多重碱基编辑技术实现灵长类自体移植模型中快速且稳定的胎儿血红蛋白重激活

BLOOD
IF23.1
2024-11-051
PRE
Demirci, Selami; Mondal, Nandini; Austin, Wayne; Butt, Henna; London, Evan; Sathish, Shruti; Zhang, Kathy; Wong, Jeffrey; Kromer, Hugh; Harmon, Alexander; Decker, Jeremy; Le, Anh; Essawi, Khaled; Krouse, Allen E.; Linde, N. Seth; Bonifacino, Aylin; Engels, Theresa; Golomb, Justin; Hong, So Gun; Uchida, Naoya; Gaudelli, Nicole; Hartigan, Adam J.; Mcdonagh, Charlotte F.; Chu, S. Haihua; Donahue, Robert E.; Tisdale, John
Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease
SCIENTIFIC REPORTS
IF3.9
2024-10-160
OAAI
Lessard, Samuel; Rimmele, Pauline; Ling, Hui; Moran, Kevin; Vieira, Benjamin; Lin, Yi-Dong; Rajani, Gaurav Manohar; Hong, Vu; Reik, Andreas; Boismenu, Richard; Hsu, Ben; Chen, Michael; Cockroft, Bettina M.; Uchida, Naoya; Tisdale, John; Alavi, Asif; Krishnamurti, Lakshmanan; Abedi, Mehrdad; Galeon, Isobelle; Reiner, David; Wang, Lin; Ramezi, Anne; Rendo, Pablo; Walters, Mark C.; Levasseur, Dana; Peters, Robert; Harris, Timothy; Hicks, Alexandra
Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34+cell therapy to induce fetal hemoglobin for sickle cell disease

新型Cas9基因组编辑的自体CD34细胞疗法诱导胎儿血红蛋白治疗镰状细胞病的开发和IND支持研究

MOLECULAR THERAPY
IF12
2024-10-010
OAAI
Katta, Varun; O'Keefe, Kiera; Li, Yichao; Mayuranathan, Thiyagaraj; Lazzarotto, Cicera R.; Wood, Rachael K.; Levine, Rachel M.; Powers, Alicia; Mayberry, Kalin; Manquen, Garret; Yao, Yu; Zhang, Jingjing; Jang, Yoonjeong; Nimmagadda, Nikitha; Dempsey, Erin A.; Lee, GaHyun; Uchida, Naoya; Cheng, Yong; Fazio, Frank; Lockey, Tim; Meagher, Mike; Sharma, Akshay; Tisdale, John F.; Zhou, Sheng; Yen, Jonathan S.; Weiss, Mitchell J.; Tsai, Shengdar Q.
Ex vivo culture resting time impacts transplantation outcomes of genome-edited human hematopoietic stem and progenitor cells in xenograft mouse models

离体培养静息时间影响基因组编辑的人类造血干细胞和祖细胞在异种移植小鼠模型中的移植结果

CYTOTHERAPY
IF3.2
2024-06-011
PRE
Demirci, Selami; Khan, Muhammad B. N.; Hinojosa, Gabriela; Le, Anh; Leonard, Alexis; Essawi, Khaled; Gudmundsdottir, Bjorg; Liu, Xiong; Zeng, Jing; Inam, Zaina; Chu, Rebecca; Uchida, Naoya; Araki, Daisuke; London, Evan; Butt, Henna; Bauer, Stacy A. Maitland ' Daniel E.; Wolfe, Scot A.; Larochelle, Andre; Tisdale, John F.
Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model
NATURE COMMUNICATIONS
IF15.7
2023-10-1212
OAAI
Uchida, Naoya; Stasula, Ulana; Demirci, Selami; Germino-Watnick, Paula; Hinds, Malikiya; Le, Anh; Chu, Rebecca; Berg, Alexander; Liu, Xiong; Su, Ling; Wu, Xiaolin; Krouse, Allen E.; Linde, N. Seth; Bonifacino, Aylin; Hong, So Gun; Dunbar, Cynthia E.; Lanieri, Leanne; Bhat, Anjali; Palchaudhuri, Rahul; Bennet, Bindu; Hoban, Megan; Bertelsen, Kirk; Olson, Lisa M.; Donahue, Robert E.; Tisdale, John F.
Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells

自组织的卵黄囊样类器官允许从诱导的多能干细胞可扩展地生成多能造血祖细胞

CELL REPORTS METHODS
IF4.5
2023-04-015
OAAI
Tamaoki, Naritaka; Siebert, Stefan; Maeda, Takuya; Ha, Ngoc-Han; Good, Meghan L.; Huang, Yin; Vodnala, Suman K.; Haro-Mora, Juan J.; Uchida, Naoya; Tisdale, John F.; Sweeney, Colin L.; Choi, Uimook; Brault, Julie; Koontz, Sherry; Malech, Harry L.; Yamazaki, Yasuhiro; Isonaka, Risa; Goldstein, David S.; Kimura, Masaki; Takebe, Takanori; Zou, Jizhong; Stroncek, David F.; Robey, Pamela G.; Kruhlak, Michael J.; Restifo, Nicholas P.; Vizcardo, Raul
Forced enhancer-promoter rewiring to alter in animal models
MOLECULAR THERAPY NUCLEIC ACIDS
IF6.1
2023-03-012
OAAI
Peslak, Scott A.; Demirci, Selami; Chandra, Vemika; Ryu, Byoung; Bhardwaj, Saurabh K.; Jiang, Jing; Rupon, Jeremy W.; Throm, Robert E.; Uchida, Naoya; Leonard, Alexis; Essawi, Khaled; Bonifacino, Aylin C.; Krouse, Allen E.; Linde, Nathaniel S.; Donahue, Robert E.; Ferrara, Francesca; Wielgosz, Matthew; Abdulmalik, Osheiza; Hamagami, Nicole; Germino-Watnick, Paula; Le, Anh; Chu, Rebecca; Hinds, Malikiya; Weiss, Mitchell J.; Tong, Wei; Tisdale, John F.; Blobel, Gerd A.
Sustained fetal hemoglobin induction in vivo is achieved by BCL11A interference and coexpressed truncated erythropoietin receptor
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2021-04-286
PRE
Uchida, Naoya; Ferrara, Francesca; Drysdale, Claire M.; Yapundich, Morgan; Gamer, Jackson; Nassehi, Tina; DiNicola, Julia; Shibata, Yoshitaka; Wielgosz, Matthew; Kim, Yoon-Sang; Bauler, Matthew; Throm, Robert E.; Haro-Mora, Juan J.; Demirci, Selami; Bonifacino, Aylin C.; Krouse, Allen E.; Linde, N. Seth; Donahue, Robert E.; Ryu, Byoung; Tisdale, John F.
Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models
CELL REPORTS MEDICINE
IF10.6
2021-04-0123
OAAI
Uchida, Naoya; Li, Linhong; Nassehi, Tina; Drysdale, Claire M.; Yapundich, Morgan; Gamer, Jackson; Haro-Mora, Juan J.; Demirci, Selami; Leonard, Alexis; Bonifacino, Aylin C.; Krouse, Allen E.; Linde, N. Seth; Allen, Cornell; Peshwa, Madhusudan, V; De Ravin, Suk See; Donahue, Robert E.; Malech, Harry L.; Tisdale, John F.
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells
NATURE MEDICINE
IF50
2021-03-1853
OAAI
Cromer, M. Kyle; Camarena, Joab; Martin, Renata M.; Lesch, Benjamin J.; Vakulskas, Christopher A.; Bode, Nicole M.; Kurgan, Gavin; Collingwood, Michael A.; Rettig, Garrett R.; Behlke, Mark A.; Lemgart, Viktor T.; Zhang, Yankai; Goyal, Ankush; Zhao, Feifei; Ponce, Ezequiel; Srifa, Waracharee; Bak, Rasmus O.; Uchida, Naoya; Majeti, Ravindra; Sheehan, Vivien A.; Tisdale, John F.; Dever, Daniel P.; Porteus, Matthew H.
Commentary on Winzeler et al 'Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia'
CLINICAL ENDOCRINOLOGY
IF2.4
2020-12-141
PREAI
Mayer, Balazs; Nemeth, Krisztian; Krepuska, Miklos; Myneni, Vamsee D.; Maric, Dragan; Tisdale, John F.; Hsieh, Matthew M.; Uchida, Naoya; Lee, Heon-Jin; Nemeth, Michael J.; Holmbeck, Kenn; Noguchi, Constance Tom; Rogers, Heather; Dey, Soumyadeep; Hansen, Arne; Hong, Jeffrey; Chow, Ian; Key, Sharon; Szalayova, Ildiko; Pagani, Jerome; Marko, Karoly; MacClain-Caldwell, Ian; Vitale-Cross, Lynn; Young, W. Scott, III; Brownstein, Michael J.; Mezey, Eva
Intrabone transplantation of CD34+ cells with optimized delivery does not enhance engraftment in a rhesus macaque model
BLOOD ADVANCES
IF7.1
2020-12-114
OA
Stringaris, Kate; Hoyt, Robert F., Jr.; Davidson-Moncada, Jan K.; Pantin, Jeremy M.; Tisdale, John F.; Uchida, Naoya; Raines, Lydia N.; Reger, Robert; Sato, Noriko; Dunbar, Cynthia E.; Hunt, Timothy J.; Clevenger, Randall R.; Krouse, Allen; Metzger, Mark E.; Bonifacino, Aylin C.; Telford, William; Choyke, Peter L.; Engels, Theresa; Donahue, Robert E.; Childs, Richard W.

研究方向

暂未获取到该数据
J
John F. Tisdale
H 指数:62论文数:436被引数:1.6万
M
Matthew M. Hsieh
H 指数:44论文数:248被引数:6,313
R
Robert E. Donahue
H 指数:51论文数:253被引数:1.0万
S
Selami Demirci
H 指数:28论文数:100被引数:2,316
A
Aylin Bonifacino
H 指数:27论文数:120被引数:2,307
A
Allen E. Krouse
H 指数:21论文数:94被引数:1,458
J
Juan J. Haro‐Mora
H 指数:22论文数:41被引数:1,375
A
Alexis Leonard
H 指数:24论文数:76被引数:1,409
M
Mark E. Metzger
H 指数:37论文数:155被引数:4,642
C
Claire Drysdale
H 指数:11论文数:35被引数:437