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D

Dale J. Kempf

Abbott Laboratories
H指数:59
被引数:1.2万

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Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2023-04-182
OAAI
Hulverson, Matthew A.; Choi, Ryan; Schaefer, Deborah A.; Betzer, Dana P.; McCloskey, Molly C.; Whitman, Grant R.; Huang, Wenlin; Lee, Sangun; Pranata, Andy; McLeod, Malcolm D.; Marsh, Kennan C.; Kempf, Dale J.; LeRoy, Bruce E.; Zafiratos, Mark T.; Bielinski, Aimee L.; Hackman, Robert C.; Ojo, Kayode K.; Arnold, Samuel L. M.; Barrett, Lynn K.; Tzipori, Saul; Riggs, Michael W.; Fan, Erkang; Van Voorhis, Wesley C.
The Tuberculosis Drug Accelerator at year 10: what have we learned?
NATURE MEDICINE
IF50
2021-07-0539
OAAI
Aldridge, Bree B.; Barros-Aguirre, David; Barry, Clifton E., III; Bates, Robert H.; Berthel, Steven J.; Boshoff, Helena I.; Chibale, Kelly; Chu, Xin-Jie; Cooper, Christopher B.; Dartois, Veronique; Duncan, Ken; Fotouhi, Nader; Gusovsky, Fabian; Hipskind, Philip A.; Kempf, Dale J.; Lelievre, Joel; Lenaerts, Anne J.; McNamara, Case W.; Mizrahi, Valerie; Nathan, Carl; Olsen, David B.; Parish, Tanya; Petrassi, H. Michael; Pym, Alexander; Rhee, Kyu Y.; Robertson, Gregory T.; Rock, Jeremy Michael; Rubin, Eric J.; Russell, Betsy; Russell, David G.; Sacchettini, James C.; Schnappinger, Dirk; Schrimpf, Michael; Upton, Anna M.; Warner, Peter; Wyatt, Paul Graham; Yuan, Ying
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

具有改善的hERG和细胞毒性特征的Spirocycle MmpL3抑制剂作为结核分枝杆菌生长的抑制剂

ACS OMEGA
IF4.3
2021-01-1325
OAAI
Ray, Peter C.; Huggett, Margaret; Turner, Penelope A.; Taylor, Malcolm; Cleghorn, Laura A. T.; Early, Julie; Kumar, Anuradha; Bonnett, Shilah A.; Flint, Lindsay; Joerss, Douglas; Johnson, James; Korkegian, Aaron; Mullen, Steven; Moure, Abraham L.; Davis, Susan H.; Murugesan, Dinakaran; Mathieson, Michael; Caldwell, Nicola; Engelhart, Curtis A.; Schnappinger, Dirk; Epemolu, Ola; Zuccotto, Fabio; Riley, Jennifer; Scullion, Paul; Stojanovski, Laste; Massoudi, Lisa; Robertson, Gregory T.; Lenaerts, Anne J.; Freiberg, Gail; Kempf, Dale J.; Masquelin, Thierry; Hipskind, Philip A.; Odingo, Joshua; Read, Kevin D.; Green, Simon R.; Wyatt, Paul G.; Parish, Tanya
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
INTERNATIONAL JOURNAL FOR PARASITOLOGY
IF3.2
2020-05-0140
OAAI
Choi, Ryan; Hulverson, Matthew A.; Huang, Wenlin; Vidadala, Rama S. R.; Whitman, Grant R.; Barrett, Lynn K.; Schaefer, Deborah A.; Betzer, Dana P.; Riggs, Michael W.; Doggett, J. Stone; Hemphill, Andrew; Ortega-Mora, Luis Miguel; McCloskey, Molly C.; Arnold, Samuel L. M.; Hackman, Robert C.; Marsh, Kennan C.; Lynch, James J.; Freiberg, Gail M.; Leroy, Bruce E.; Kempf, Dale J.; Choy, Robert K. M.; de Hostos, Eugenio L.; Maly, Dustin J.; Fan, Erkang; Ojo, Kayode K.; Van Voorhis, Wesley C.
Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2019-03-1359
OAAI
Taylor, Mark J.; von Geldern, Thomas W.; Ford, Louise; Huebner, Marc P.; Marsh, Kennan; Johnston, Kelly L.; Sjoberg, Hanna T.; Specht, Sabine; Pionnier, Nicolas; Tyrer, Hayley E.; Clare, Rachel H.; Cook, Darren A. N.; Murphy, Emma; Steven, Andrew; Archer, John; Bloemker, Dominique; Lenz, Franziska; Koschel, Marianne; Ehrens, Alexandra; Metuge, Haelly M.; Chunda, Valerinne C.; Chounna, Patrick W. Ndongmo; Njouendou, Abdel J.; Fombad, Fanny F.; Carr, Robert; Morton, Howard E.; Aljayyoussi, Ghaith; Hoerauf, Achim; Wanji, Samuel; Kempf, Dale J.; Turner, Joseph D.; Ward, Stephen A.
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity
PLOS NEGLECTED TROPICAL DISEASES
IF3.4
2019-02-2827
OAAI
von Geldern, Thomas W.; Morton, Howard E.; Clark, Rick F.; Brown, Brian S.; Johnston, Kelly L.; Ford, Louise; Specht, Sabine; Carr, Robert A.; Stolarik, Deanne F.; Ma, Junli; Rieser, Matthew J.; Struever, Dominique; Frohberger, Stefan J.; Koschel, Marianne; Ehrens, Alexandra; Turner, Joseph D.; Huebner, Marc P.; Hoerauf, Achim; Taylor, Mark J.; Ward, Stephen A.; Marsh, Kennan; Kempf, Dale J.
In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2018-01-0169
OAAI
Ng, Teresa I.; Tripathi, Rakesh; Reisch, Thomas; Lu, Liangjun; Middleton, Timothy; Hopkins, Todd A.; Pithawalla, Ron; Irvin, Michelle; Dekhtyar, Tatyana; Krishnan, Preethi; Schnell, Gretja; Beyer, Jill; McDaniel, Keith F.; Ma, Jun; Wang, Guoqiang; Jiang, Li-Juan; Or, Yat Sun; Kempf, Dale; Pilot-Matias, Tami; Collins, Christine
Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis
INTERNATIONAL JOURNAL FOR PARASITOLOGY
IF3.2
2017-10-0130
OAAI
Hulverson, Matthew A.; Choi, Ryan; Arnold, Samuel L. M.; Schaefer, Deborah A.; Hemphill, Andrew; McCloskey, Molly C.; Betzer, Dana P.; Mueller, Joachim; Vidadala, Rama S. R.; Whitman, Grant R.; Rivas, Kasey L.; Barrett, Lynn K.; Hackman, Robert C.; Love, Melissa S.; McNamara, Case W.; Shaughnessy, Thomas K.; Kondratiuk, Alison.; Kurnick, Matthew; Banfor, Patricia N.; Lynch, James J.; Freiberg, Gail M.; Kempf, Dale J.; Maly, Dustin J.; Riggs, Michael W.; Ojo, Kayode K.; Van Voorhis, Wesley C.
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis
ACS INFECTIOUS DISEASES
IF3.8
2016-10-1781
OAAI
Park, Yumi; Pacitto, Angela; Bayliss, Tracy; Cleghorn, Laura A. T.; Wang, Zhe; Hartman, Travis; Arora, Kriti; Ioerger, Thomas R.; Sacchettini, Jim; Rizzi, Menico; Donini, Stefano; Blundell, Tom L.; Ascher, David B.; Rhee, Kyu; Breda, Ardala; Zhou, Nian; Dartois, Veronique; Jonnala, Surendranadha Reddy; Via, Laura E.; Mizrahi, Valerie; Epemolu, Ola; Stojanovski, Laste; Simeons, Fred; Osuna-Cabello, Maria; Ellis, Lucy; MacKenzie, Claire J.; Smith, Alasdair R. C.; Davis, Susan H.; Murugesan, Dinakaran; Buchanan, Kirsteen I.; Turner, Penelope A.; Huggett, Margaret; Zuccotto, Fabio; Jose Rebollo-Lopez, Maria; Jose Lafuente-Monasterio, Maria; Sanz, Olalla; Santos Diaz, Gracia; Lelievre, Joel; Ballell, Lluis; Selenski, Carolyn; Axtman, Matthew; Ghidelli-Disse, Sonja; Pflaumer, Hannah; Boesche, Markus; Drewes, Gerard; Freiberg, Gail M.; Kurnick, Matthew D.; Srikumaran, Myron; Kempf, Dale J.; Green, Simon R.; Ray, Peter C.; Read, Kevin; Wyatt, Paul; Barry, Clifton E., III; Boshoff, Helena I.
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-07-0178
OAAI
Vidadala, Rama Subba Rao; Rivas, Kasey L.; Ojo, Kayode K.; HuIverson, Matthew A.; Zambriski, Jennifer A.; Bruzual, Igor; Schultz, Tracey L.; Huang, Wenlin; Zhang, Zhongsheng; Scheele, Suzanne; DeRocher, Amy E.; Choi, Ryan; Barrett, Lynn K.; Siddaramaiah, Latha Kallur; Hol, Wim G. J.; Fan, Erkang; Merritt, Ethan A.; Parsons, Marilyn; Freiberg, Gail; Marsh, Kennan; Kempf, Dale J.; Carruthers, Vern B.; Isoherranen, Nina; Doggett, J. Stone; Van Voorhis, Wesley C.; Maly, Dustin J.
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2015-10-2636
OAAI
Huang, Wenlin; Ojo, Kayode K.; Zhang, Zhongsheng; Rivas, Kasey; Vidadala, Rama Subba Rao; Scheele, Suzanne; DeRocher, Amy E.; Choi, Ryan; Hulverson, Matthew A.; Barrett, Lynn K.; Bruzual, Igor; Siddaramaiah, Latha Kallur; Kerchner, Keshia M.; Kurnick, Matthew D.; Freiberg, Gail M.; Kempf, Dale; Hol, Wim G. J.; Merritt, Ethan A.; Neckermann, Georg; de Hostos, Eugenio L.; Isoherranen, Nina; Maly, Dustin J.; Parsons, Marilyn; Doggett, J. Stone; Van Voorhis, Wesley C.; Fang, Erkang

研究方向

暂未获取到该数据
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Kennan C. Marsh
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Akhteruzzaman Molla
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W
Warren M. Kati
H 指数:40论文数:250被引数:6,072
L
Larry L. Klein
H 指数:26论文数:106被引数:1,669
K
Kent D. Stewart
H 指数:42论文数:138被引数:5,246
D
Daniel W. Norbeck
H 指数:34论文数:101被引数:6,167
D
David A. DeGoey
H 指数:16论文数:44被引数:1,414
E
Eugene Sun
H 指数:37论文数:96被引数:7,440
T
Tatyana Dekhtyar
H 指数:18论文数:64被引数:1,217
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Liangjun Lu
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