未登录 Rat and dog quad-culture liver chip models: characterization and use to interrogate a potential flavin-containing monooxygenase-mediated, species-specific toxicity of a histamine receptor antagonist 大鼠和犬四菌共培养肝脏芯片模型：表征及其用于探究一种组胺受体拮抗剂潜在的黄素依赖性单加氧酶介导的种属特异性毒性 Kukla, David A.; Sharapova, Tatiana A.; Ciurlionis, Rita; Van Vleet, Terry; Wetter, Jill M.; Peterkin, Vincent C.; Lee, Anthony J.; Marsh, Kennan C.; Wang, Yueting; Mahalingaiah, Prathap Kumar S.; Stresser, David M. 分享 收藏
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Pharmacokinetics and Safety of Navitoclax in Hepatic Impairment Navitoclax的药代动力学和安全性研究（肝功能不全患者） Patel, Maulik; Potluri, Jalaja; Marbury, Thomas; Lawitz, Eric; Rondon, Juan Carlos; Hoffman, David M.; Siddani, Satya R.; Marsh, Kennan C.; Kim, Elaine J.; Uddin, Muhammad Erfan; Menon, Rajeev M.; Polepally, Akshanth R. 分享 收藏
Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates Greenberg, Edward F.; Voorbach, Martin J.; Smith, Alexandra; Reuter, David R.; Zhuang, Yuchuan; Wang, Ji-Quan; Wooten, Dustin W.; Asque, Elizabeth; Hu, Min; Hoft, Carolin; Duggan, Ryan; Townsend, Matthew; Orsi, Karin; Dalecki, Karen; Amberg, Willi; Duggan, Lori; Knight, Heather; Spina, Joseph S.; He, Yupeng; Marsh, Kennan; Zhao, Vivian; Ybarra, Suzanne; Mollon, Jennifer; Fang, Yuni; Vasanthakumar, Aparna; Westmoreland, Susan; Droescher, Mathias; Finnema, Sjoerd J.; Florian, Hana 分享 收藏
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A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity Alami, Negar; Carter, David; Kwatra, Nisha R.; Zhao, Weihan E.; Snodgrass, Linda E.; Porcalla, Ariel; Klein, Cheri; Cohen, Daniel A.; Gallenberg, Loretta C.; Neenan, Melina J.; Carr, Robert; Marsh, Kennan; Kempf, Dale 分享 收藏
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis Hulverson, Matthew A.; Choi, Ryan; Schaefer, Deborah A.; Betzer, Dana P.; McCloskey, Molly C.; Whitman, Grant R.; Huang, Wenlin; Lee, Sangun; Pranata, Andy; McLeod, Malcolm D.; Marsh, Kennan C.; Kempf, Dale J.; LeRoy, Bruce E.; Zafiratos, Mark T.; Bielinski, Aimee L.; Hackman, Robert C.; Ojo, Kayode K.; Arnold, Samuel L. M.; Barrett, Lynn K.; Tzipori, Saul; Riggs, Michael W.; Fan, Erkang; Van Voorhis, Wesley C. 分享 收藏
Expanding the Repertoire for Large Small Molecules: Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers Salem, Ahmed Hamed; Tao, Zhi-Fu; Bueno, Orlando F.; Chen, Jie; Chen, Shuang; Edalji, Rohinton; Elmore, Steven W.; Fournier, Keith M.; Harper, Kaid C.; Hong, Richard; Jenkins, Gary J.; Ji, Jianguo; Judge, Russell A.; Kalvass, John C.; Klix, Russell C.; Ku, Yi-Yin; Leverson, Joel D.; Marks, Richard A.; Marsh, Kennan C.; Menon, Rajeev M.; Park, Chang H.; Phillips, Darren C.; Pu, Yu-Ming; Rosenberg, Saul H.; Sanzgiri, Yeshwant D.; Sheikh, Ahmad Y.; Shi, Yi; Stolarik, Deanne; Suleiman, Ahmed A.; Wang, Xilu; Zhang, Geoff G. Z.; Catron, Nathaniel D.; Souers, Andrew J. 分享 收藏
Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis Hulverson, Matthew A.; Choi, Ryan; Vidadala, Rama S. R.; Whitman, Grant R.; Vidadala, Venkata Narayana; Ojo, Kayode K.; Barrett, Lynn K.; Lynch, James J.; Marsh, Kennan; Kempf, Dale J.; Maly, Dustin J.; Van Voorhis, Wesley C. 分享 收藏
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned Choi, Ryan; Hulverson, Matthew A.; Huang, Wenlin; Vidadala, Rama S. R.; Whitman, Grant R.; Barrett, Lynn K.; Schaefer, Deborah A.; Betzer, Dana P.; Riggs, Michael W.; Doggett, J. Stone; Hemphill, Andrew; Ortega-Mora, Luis Miguel; McCloskey, Molly C.; Arnold, Samuel L. M.; Hackman, Robert C.; Marsh, Kennan C.; Lynch, James J.; Freiberg, Gail M.; Leroy, Bruce E.; Kempf, Dale J.; Choy, Robert K. M.; de Hostos, Eugenio L.; Maly, Dustin J.; Fan, Erkang; Ojo, Kayode K.; Van Voorhis, Wesley C. 分享 收藏
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Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats Lynch, James J., III; Rossignol, Emilie; Moehrle, Joerg J.; Van Vleet, Terry R.; Marsh, Kennan C.; Parman, Toufan; Mirsalis, Jon; Ottinger, Sean E.; Segreti, Jason A.; Rao, Mohan; Mittelstadt, Scott W. 分享 收藏
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae Huebner, Marc P.; Koschel, Marianne; Struever, Dominique; Nikolov, Venelin; Frohberger, Stefan J.; Ehrens, Alexandra; Fendler, Martina; Johannes, Iliana; von Geldern, Thomas W.; Marsh, Kennan; Turner, Joseph D.; Taylor, Mark J.; Ward, Stephen A.; Pfarr, Kenneth; Kempf, Dale J.; Hoerauf, Achim 分享 收藏
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Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis Taylor, Mark J.; von Geldern, Thomas W.; Ford, Louise; Huebner, Marc P.; Marsh, Kennan; Johnston, Kelly L.; Sjoberg, Hanna T.; Specht, Sabine; Pionnier, Nicolas; Tyrer, Hayley E.; Clare, Rachel H.; Cook, Darren A. N.; Murphy, Emma; Steven, Andrew; Archer, John; Bloemker, Dominique; Lenz, Franziska; Koschel, Marianne; Ehrens, Alexandra; Metuge, Haelly M.; Chunda, Valerinne C.; Chounna, Patrick W. Ndongmo; Njouendou, Abdel J.; Fombad, Fanny F.; Carr, Robert; Morton, Howard E.; Aljayyoussi, Ghaith; Hoerauf, Achim; Wanji, Samuel; Kempf, Dale J.; Turner, Joseph D.; Ward, Stephen A. 分享 收藏
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity von Geldern, Thomas W.; Morton, Howard E.; Clark, Rick F.; Brown, Brian S.; Johnston, Kelly L.; Ford, Louise; Specht, Sabine; Carr, Robert A.; Stolarik, Deanne F.; Ma, Junli; Rieser, Matthew J.; Struever, Dominique; Frohberger, Stefan J.; Koschel, Marianne; Ehrens, Alexandra; Turner, Joseph D.; Huebner, Marc P.; Hoerauf, Achim; Taylor, Mark J.; Ward, Stephen A.; Marsh, Kennan; Kempf, Dale J. 分享 收藏
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria (vol 62, e00012-18, 2018 Brunschwig, Christel; Lawrence, Nina; Taylor, Dale; Abay, Efrem; Njoroge, Mathew; Basarab, Gregory S.; Le Manach, Claire; Paquet, Tanya; Cabrera, Diego Gonzalez; Nchinda, Aloysius T.; de Kock, Carmen; Wiesner, Lubbe; Denti, Paolo; Waterson, David; Blasco, Benjamin; Leroy, Didier; Witty, Michael J.; Donini, Cristina; Duffy, James; Wittlin, Sergio; White, Karen L.; Charman, Susan A.; Jimenez-Diaz, Maria Belen; Angulo-Barturen, Inigo; Herreros, Esperanza; Gamo, Francisco Javier; Rochford, Rosemary; Mancama, Dalu; Coetzer, Theresa L.; van der Watt, Mariette E.; Reader, Janette; Birkholtz, Lyn-Marie; Marsh, Kennan C.; Solapure, Suresh M.; Burke, John E.; McPhail, Jacob A.; Vanaerschot, Manu; Fidock, David A.; Fish, Paul V.; Siegl, Peter; Smith, Dennis A.; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N.; Marfurt, Jutta; Silue, Kigbafori D.; Street, Leslie J.; Chibale, Kelly 分享 收藏
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria Brunschwig, Christel; Lawrence, Nina; Taylor, Dale; Abay, Efrem; Njoroge, Mathew; Basarab, Gregory S.; Le Manach, Claire; Paquet, Tanya; Cabrera, Diego Gonzalez; Nchinda, Aloysius T.; de Kock, Carmen; Wiesner, Lubbe; Denti, Paolo; Waterson, David; Blasco, Benjamin; Leroy, Didier; Witty, Michael J.; Donini, Cristina; Duffy, James; Wittlin, Sergio; White, Karen L.; Charman, Susan A.; Belen Jimenez-Diaz, Maria; Angulo-Barturen, Inigo; Herreros, Esperanza; Javier Gamo, Francisco; Rochford, Rosemary; Mancama, Dalu; Coetzer, Theresa L.; van der Watt, Mariette E.; Reader, Janette; Birkholtz, Lyn-Marie; Marsh, Kennan C.; Solapure, Suresh M.; Burke, John E.; McPhail, Jacob A.; Vanaerschot, Manu; Fidock, David A.; Fish, Paul V.; Siegl, Peter; Smith, Dennis A.; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N.; Marfurt, Jutta; Silue, Kigbafori D.; Street, Leslie J.; Chibale, Kelly 分享 收藏
Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study McCarthy, James S.; Lotharius, Julie; Ruckle, Thomas; Chalon, Stephan; Phillips, Margaret A.; Elliott, Suzanne; Sekuloski, Silvana; Griffin, Paul; Ng, Caroline L.; Fidock, David A.; Marquart, Louise; Williams, Noelle S.; Gobeau, Nathalie; Bebrevska, Lidiya; Rosario, Maria; Marsh, Kennan; Mohrle, Jorg J. 分享 收藏
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase Paquet, Tanya; Le Manach, Claire; Cabrera, Diego Gonzalez; Younis, Yassir; Henrich, Philipp P.; Abraham, Tara S.; Lee, Marcus C. S.; Basak, Rajshekhar; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Bantscheff, Marcus; Ruecker, Andrea; Blagborough, Andrew M.; Zakutansky, Sara E.; Zeeman, Anne-Marie; White, Karen L.; Shackleford, David M.; Mannila, Janne; Morizzi, Julia; Scheurer, Christian; Angulo-Barturen, Inigo; Martinez, Maria Santos; Ferrer, Santiago; Sanz, Laura Maria; Gamo, Francisco Javier; Reader, Janette; Botha, Mariette; Dechering, Koen J.; Sauerwein, Robert W.; Tungtaeng, Anchalee; Vanachayangkul, Pattaraporn; Lim, Chek Shik; Burrows, Jeremy; Witty, Michael J.; Marsh, Kennan C.; Bodenreider, Christophe; Rochford, Rosemary; Solapure, Suresh M.; Jimenez-Diaz, Mara Belen; Wittlin, Sergio; Charman, Susan A.; Donini, Cristina; Campo, Brice; Birkholtz, Lyn-Marie; Hanson, Kirsten K.; Drewes, Gerard; Kocken, Clemens H. M.; Delves, Michael J.; Leroy, Didier; Fidock, David A.; Waterson, David; Street, Leslie J.; Chibale, Kelly 分享 收藏
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