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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule Kelly, George; Kataura, Tetsushi; Panek, Johan; Ma, Gailing; Salmonowicz, Hanna; Davis, Ashley; Kendall, Hannah; Brookes, Charlotte; Ayine-Tora, Daniel Moscoh; Banks, Peter; Nelson, Glyn; Dobby, Laura; Pitrez, Patricia R.; Booth, Laura; Costello, Lydia; Richardson, Gavin D.; Lovat, Penny; Przyborski, Stefan; Ferreira, Lino; Greaves, Laura; Szczepanowska, Karolina; von Zglinicki, Thomas; Miwa, Satomi; Brown, Max; Flagler, Michael; Oblong, John E.; Bascom, Charles C.; Carroll, Bernadette; Reynisson, Johannes; Korolchuk, Viktor I. 分享 收藏
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NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy Kataura, Tetsushi; Otten, Elsje G.; Rabanal-Ruiz, Yoana; Adriaenssens, Elias; Urselli, Francesca; Scialo, Filippo; Fan, Lanyu; Smith, Graham R.; Dawson, William M.; Chen, Xingxiang; Yue, Wyatt W.; Bronowska, Agnieszka K.; Carroll, Bernadette; Martens, Sascha; Lazarou, Michael; Korolchuk, Viktor, I 分享 收藏
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner 中性粒细胞以ROS依赖的方式诱导旁分泌端粒功能障碍和衰老 Lagnado, Anthony; Leslie, Jack; Ruchaud-Sparagano, Marie-Helene; Victorelli, Stella; Hirsova, Petra; Ogrodnik, Mikolaj; Collins, Amy L.; Vizioli, Maria Grazia; Habiballa, Leena; Saretzki, Gabriele; Evans, Shane A.; Salmonowicz, Hanna; Hruby, Adam; Geh, Daniel; Pavelko, Kevin D.; Dolan, David; Reeves, Helen L.; Grellscheid, Sushma; Wilson, Colin H.; Pandanaboyana, Sanjay; Doolittle, Madison; von Zglinicki, Thomas; Oakley, Fiona; Gallage, Suchira; Wilson, Caroline L.; Birch, Jodie; Carroll, Bernadette; Chapman, James; Heikenwalder, Mathias; Neretti, Nicola; Khosla, Sundeep; Masuda, Claudio Akio; Tchkonia, Tamar; Kirkland, James L.; Jurk, Diana; Mann, Derek A.; Passos, Joao F. 分享 收藏
mTORC1 activity is supported by spatial association with focal adhesions Rabanal-Ruiz, Yoana; Byron, Adam; Wirth, Alexander; Madsen, Ralitsa; Sedlackova, Lucia; Hewitt, Graeme; Nelson, Glyn; Stingele, Julian; Wills, Jimi C.; Zhang, Tong; Zeug, Andre; Faessler, Reinhard; Vanhaesebroeck, Bart; Maddocks, Oliver D. K.; Ponimaskin, Evgeni; Carroll, Bernadette; Korolchuk, Viktor, I 分享 收藏
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity (vol 5, e11058, 201226) Carroll, Bernadette; Maetzel, Dorothea; Maddocks, Oliver D. K.; Otten, Gisela; Ratcliff, Matthew; Smith, Graham R.; Dunlop, Elaine A.; Passos, Joao F.; Davies, Owen Richard; Jaenisch, Rudolf; Tee, Andrew R.; Sarkar, Sovan; Korolchuk, Viktor I. 分享 收藏
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Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer Pennycuick, Adam; Teixeira, Vitor H.; AbdulJabbar, Khalid; Raza, Shan E. Ahmed; Lund, Tom; Akarca, Ayse U.; Rosenthal, Rachel; Kalinke, Lukas; Chandrasekharan, Deepak P.; Pipinikas, Christodoulos P.; Lee-Six, Henry; Hynds, Robert E.; Gowers, Kate H. C.; Henry, Jake Y.; Millar, Fraser R.; Hagos, Yeman B.; Denais, Celine; Falzon, Mary; Moore, David A.; Antoniou, Sophia; Durrenberger, Pascal F.; Furness, Andrew J.; Carroll, Bernadette; Marceaux, Claire; Asselin-Labat, Marie-Liesse; Larson, William; Betts, Courtney; Coussens, Lisa M.; Thakrar, Ricky M.; George, Jeremy; Swanton, Charles; Thirlwell, Christina; Campbell, Peter J.; Marafioti, Teresa; Yuan, Yinyin; Quezada, Sergio A.; McGranahan, Nicholas; Janes, Sam M. 分享 收藏
PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis Zhai, Nianhui; Liu, Kai; Li, Hu; Liu, Zixuan; Wang, Hong; Korolchuk, Viktor I.; Carroll, Bernadette; Pan, Cuiling; Gan, Fang; Huang, Kehe; Chen, Xingxiang 分享 收藏
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Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions Teixeira, Vitor H.; Pipinikas, Christodoulos P.; Pennycuick, Adam; Lee-Six, Henry; Chandrasekharan, Deepak; Beane, Jennifer; Morris, Tiffany J.; Karpathakis, Anna; Feber, Andrew; Breeze, Charles E.; Ntolios, Paschalis; Hynds, Robert E.; Falzon, Mary; Capitanio, Arrigo; Carroll, Bernadette; Durrenberger, Pascal F.; Hardavella, Georgia; Brown, James M.; Lynch, Andy G.; Farmery, Henry; Paul, Dirk S.; Chambers, Rachel C.; McGranahan, Nicholas; Navani, Neal; Thakrar, Ricky M.; Swanton, Charles; Beck, Stephan; George, Phillip Jeremy; Spira, Avrum; Campbell, Peter J.; Thirlwell, Christina; Janes, Sam M. 分享 收藏
Rapamycin improves healthspan but not inflammaging in nfb1-/- mice 雷帕霉素改善nfb1-/-小鼠的健康但不改善炎症 Correia-Melo, Clara; Birch, Jodie; Fielder, Edward; Rahmatika, Dina; Taylor, Jennifer; Chapman, James; Lagnado, Anthony; Carroll, Bernadette M.; Miwa, Satomi; Richardson, Gavin; Jurk, Diana; Oakley, Fiona; Mann, Jelena; Mann, Derek A.; Korolchuk, Viktor I.; Passos, Joao F. 分享 收藏
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Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis Carroll, Bernadette; Otten, Elsje G.; Manni, Diego; Stefanatos, Rhoda; Menzies, Fiona M.; Smith, Graham R.; Jurk, Diana; Kenneth, Niall; Wilkinson, Simon; Passos, Joao F.; Attems, Johannes; Veal, Elizabeth A.; Teyssou, Elisa; Seilhean, Danielle; Millecamps, Stephanie; Eskelinen, Eeva-Liisa; Bronowska, Agnieszka K.; Rubinsztein, David C.; Sanz, Alberto; Korolchuk, Viktor I. 分享 收藏
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