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Mehdi Derhourhi

Lille University Hospital
H指数:13
被引数:483

个人简介

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教育背景

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工作经历

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荣誉奖项

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Human genetic evidence challenges NCOA1 as a monogenic obesity gene

人类遗传学证据挑战NCOA1作为单基因肥胖基因

Cell Reports Medicine
IF10.6
2026-10-080
OAAI
Jérôme Delplanque; Audrey Leloire; Lauriane Le Collen; Hélène Loiselle; Bénédicte Toussaint; Emmanuel Vaillant; Frédéric Allegaert; Timothée Beke; Guillaume Charpentier; Sylvia Franc; Beverley Balkau; Michel Marre; Emma Henriques; Emmanuel Buse Falay; Mehdi Derhourhi; Philippe Froguel; Amélie Bonnefond
Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes

表观遗传景观在人类胰腺胰岛中揭示了对年龄和2型糖尿病适应性转变的不同驱动因素

Nature Communications
IF15.7
2026-06-030
OAAI
Lucas Maurin; Lorella Marselli; Mathilde Boissel; Vincent Pascat; Mara Suleiman; Emma Henriques; Carmela De Luca; Lijiao Ning; Marie Fourcot; Marta Tesi; Bénédicte Toussaint; Souhila Amanzougarene; Mehdi Derhourhi; Frédérik Oger; Frederic Burdet; Mickael Canouil; Miriam Cnop; Mark Ibberson; Amélie Bonnefond; Piero Marchetti; Philippe Froguel; Amna Khamis
Exploring the role of readthrough-inducing molecule 2,6-diaminopurine to increase immune response against cancer cells

探索readthrough-inducing molecule 2,6-diaminopurine在增强抗肿瘤细胞免疫反应中的作用

Molecular Therapy
IF12
2025-09-120
OAAI
Carmen Sandoval Pacheco; Alice M. Leroy; Mehdi Derhourhi; Tristan Cardon; Catherine Leroy; Nathalie Jouy; Emmanuelle Com; Blandine Guevel; Roland Bourette; Julie Carrard; Daniela Barros; Belinda Duchêne; Bénédicte Toussaint; Philippe Froguel; Nicolas Jonckheere; Thierry Chassat; Isabelle Van Seuningen; Régis Lavigne; Charles Pineau; Philippe Pierre; Fabrice Soncin; Michel Salzet; Amélie Bonnefond; Fabrice Lejeune
Biallelic pathogenic variants in POMC can cause combined pituitary hormonal deficiency associated with severe obesity

POMC基因的双等位基因致病性变异可导致伴有严重肥胖的垂体联合性激素缺乏症。

EUROPEAN JOURNAL OF ENDOCRINOLOGY
IF5.2
2025-07-010
PRE
Vitellius, Geraldine; Poitou, Christine; Clement, Karine; Petit, Jean Michel; Gatta Cherifi, Blandine; Amanzougarene, Souhila; Derhourhi, Mehdi; Saveanu, Alexandru; Froguel, Philippe; Bonnefond, Amelie; Delemer, Brigitte; Le Collen, Lauriane
Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease

微生物组衍生的马尿酸盐的肝内水平与改善的代谢功能障碍相关的脂肪性肝病相关

MOLECULAR METABOLISM
IF6.6
2025-02-010
OAAI
Deslande, Maxime; Puig-Castellvi, Francesc; Castro-Dionicio, Ines; Pacheco-Tapia, Romina; Raverdy, Violeta; Caiazzo, Robert; Lassailly, Guillaume; Leloire, Audrey; Andrikopoulos, Petros; Kahoul, Yasmina; Zaibi, Nawel; Toussaint, Benedicte; Oger, Frederik; Gambardella, Nicolas; Lefebvre, Philippe; Derhourhi, Mehdi; Amanzougarene, Souhila; Staels, Bart; Pattou, Francois; Froguel, Philippe; Bonnefond, Amelie; Dumas, Marc-Emmanuel
PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism
DIABETES
IF7.5
2024-08-131
PRE
Maurin, Lucas; Marselli, Lorella; Boissel, Mathilde; Ning, Lijiao; Boutry, Raphael; Fernandes, Justine; Suleiman, Mara; De Luca, Carmela; Leloire, Audrey; Pascat, Vincent; Toussaint, Benedicte; Amanzougarene, Souhila; Derhourhi, Mehdi; Joerns, Anne; Lenzen, Sigurd; Pattou, Francois; Kerr-Conte, Julie; Canouil, Mickael; Marchetti, Piero; Bonnefond, Amelie; Froguel, Philippe; Khamis, Amna
Characteristics and impact of infiltration of B-cells from systemic sclerosis patients in a 3D healthy skin model

3D健康皮肤模型中系统性硬化症患者b细胞浸润的特征和影响

FRONTIERS IN IMMUNOLOGY
IF5.9
2024-08-091
OAAI
Le Maitre, Mathilde; Guerrier, Thomas; Collet, Aurore; Derhourhi, Mehdi; Meneboo, Jean-Pascal; Toussaint, Benedicte; Bonnefond, Amelie; Villenet, Celine; Sebda, Sheherazade; Bongiovanni, Antonino; Tardivel, Meryem; Simon, Myriam; Jendoubi, Manel; Daunou, Blanche; Largy, Alexis; Figeac, Martin; Dubucquoi, Sylvain; Launay, David
Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function
NATURE COMMUNICATIONS
IF15.7
2024-08-050
OAAI
Meulebrouck, Sarah; Merrheim, Judith; Queniat, Gurvan; Bourouh, Cyril; Derhourhi, Mehdi; Boissel, Mathilde; Yi, Xiaoyan; Badreddine, Alaa; Boutry, Raphael; Leloire, Audrey; Toussaint, Benedicte; Amanzougarene, Souhila; Vaillant, Emmanuel; Durand, Emmanuelle; Loiselle, Helene; Huyvaert, Marlene; Dechaume, Aurelie; Scherrer, Victoria; Marchetti, Piero; Balkau, Beverley; Charpentier, Guillaume; Franc, Sylvia; Marre, Michel; Roussel, Ronan; Scharfmann, Raphael; Cnop, Miriam; Canouil, Mickael; Baron, Morgane; Froguel, Philippe; Bonnefond, Amelie
Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD
JHEP REPORTS
IF7.5
2024-01-012
OAAI
Johanns, Manuel; Haas, Joel T.; Raverdy, Violetta; Vandel, Jimmy; Chevalier-Dubois, Julie; Guille, Loic; Derudas, Bruno; Legendre, Benjamin; Caiazzo, Robert; Verkindt, Helene; Gnemmi, Viviane; Leteurtre, Emmanuelle; Derhourhi, Mehdi; Bonnefond, Amelie; Froguel, Philippe; Eeckhoute, Jerome; Lassailly, Guillaume; Mathurin, Philippe; Pattou, Francois; Staels, Bart; Lefebvre, Philippe
Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics
MOLECULAR METABOLISM
IF6.6
2024-01-011
OAAI
Dance, Arnaud; Fernandes, Justine; Toussaint, Benedicte; Vaillant, Emmanuel; Boutry, Raphael; Baron, Morgane; Loiselle, Helene; Balkau, Beverley; Charpentier, Guillaume; Franc, Sylvia; Ibberson, Mark; Marre, Michel; Gernay, Marie; Fadeur, Marjorie; Paquot, Nicolas; Vaxillaire, Martine; Boissel, Mathilde; Amanzougarene, Souhila; Derhourhi, Mehdi; Khamis, Amna; Froguel, Philippe; Bonnefond, Amelie
Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity
NATURE METABOLISM
IF20.8
2023-09-1416
OA
Gao, Wenwen; Liu, Lei; Huh, Eunna; Gbahou, Florence; Cecon, Erika; Oshima, Masaya; Houze, Ludivine; Katsonis, Panagiotis; Hegron, Alan; Fan, Zhiran; Hou, Guofei; Charpentier, Guillaume; Boissel, Mathilde; Derhourhi, Mehdi; Marre, Michel; Balkau, Beverley; Froguel, Philippe; Scharfmann, Raphael; Lichtarge, Olivier; Dam, Julie; Bonnefond, Amelie; Liu, Jianfeng; Jockers, Ralf
Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use

POMC中的杂合致病变异与单基因肥胖无关: 对MC4R激动剂使用的影响

GENETICS IN MEDICINE
IF6.2
2023-07-015
PRE
Le Collen, Lauriane; Delemer, Brigitte; Poitou, Christine; Vaxillaire, Martine; Toussaint, Benedicte; Dechaume, Aurelie; Badreddine, Alaa; Boissel, Mathilde; Derhourhi, Mehdi; Clement, Karine; Petit, Jean M.; Mau-Them, Frederic Tran; Bruel, Ange-Line; Thauvin-Robinet, Christel; Saveanu, Alexandru; Cherifi, Blandine Gatta; Le Beyec-Le Bihan, Johanne; Froguel, Philippe; Bonnefond, Amelie
β-Cell-Specific E2f1 Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion
DIABETES
IF7.5
2023-05-223
OA
Oger, Frederik; Bourouh, Cyril; Friano, Marika Elsa; Courty, Emilie; Rolland, Laure; Gromada, Xavier; Moreno, Maeva; Carney, Charlene; Rabhi, Nabil; Durand, Emmanuelle; Amanzougarene, Souhila; Berberian, Lionel; Derhourhi, Mehdi; Blanc, Etienne; Hannou, Sarah Anissa; Denechaud, Pierre-Damien; Benfodda, Zohra; Meffre, Patrick; Fajas, Lluis; Kerr-Conte, Julie; Pattou, Francois; Froguel, Philippe; Pourcet, Benoit; Bonnefond, Amelie; Collombat, Patrick; Annicotte, Jean-Sebastien

研究方向

暂未获取到该数据
A
Amélie Bonnefond
H 指数:61论文数:358被引数:1.7万
P
Philippe Froguel
H 指数:163论文数:1,176被引数:13.1万
B
Bénédicte Toussaint
H 指数:10论文数:46被引数:340
E
Emmanuel Vaillant
H 指数:23论文数:99被引数:4,308
M
Mathilde Boissel
H 指数:16论文数:56被引数:3,322
S
Souhila Amanzougarene
H 指数:8论文数:53被引数:201
E
Emmanuelle Durand
H 指数:32论文数:144被引数:8,510
M
Michel Marre
H 指数:93论文数:862被引数:5.0万
A
Alaa Badreddine
H 指数:8论文数:20被引数:170
A
Aurélie Dechaume
H 指数:24论文数:73被引数:2,575