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Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival Kim, Jung; Vaksman, Zalman; Egolf, Laura E.; Kaufman, Rebecca; Evans, J. Perry; Conkrite, Karina L.; Danesh, Arnavaz; Lopez, Gonzalo; Randall, Michael P.; Dent, Maiah H.; Farra, Lance M.; Menghani, Neil L.; Dymek, Malwina; Desai, Heena; Hausler, Ryan; Hicks, Belynda; Auvil, Jaime Guidry; Gerhard, Daniela S.; Hakonarson, Hakon; Maxwell, Kara N.; Cole, Kristina A.; Pugh, Trevor J.; Bosse, Kristopher R.; Khan, Javed; Wei, Jun S.; Maris, John M.; Stewart, Douglas R.; Diskin, Sharon J. 分享 收藏
Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors 整合基因组分析确定跨小儿白血病和实体瘤的LncRNA调控网络 Modi, Apexa; Lopez, Gonzalo; Conkrite, Karina L.; Su, Chun; Leung, Tsz Ching; Ramanan, Sathvik; Manduchi, Elisabetta; Johnson, Matthew E.; Cheung, Daphne; Gadd, Samantha; Zhang, Jinghui; Smith, Malcolm A.; Guidry Auvil, Jaime M.; Meshinchi, Soheil; Perlman, Elizabeth J.; Hunger, Stephen P.; Maris, John M.; Wells, Andrew D.; Grant, Struan F. A.; Diskin, Sharon J. 分享 收藏
Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants 在没有ATRX突变的情况下，小儿高级别神经胶质瘤中端粒 (ALT) 的替代延长可能会发生，并且在致病性种系错配修复 (MMR) 变体的患者中富集。 Stundon, Jennifer L.; Ijaz, Heba; Gaonkar, Krutika S.; Kaufman, Rebecca S.; Jin, Run; Karras, Anastasios; Vaksman, Zalman; Kim, Jung; Corbett, Ryan J.; Lueder, Matthew R.; Miller, Daniel P.; Guo, Yiran; Santi, Mariarita; Li, Marilyn; Lopez, Gonzalo; Storm, Phillip B.; Resnick, Adam C.; Waanders, Angela J.; MacFarland, Suzanne P.; Stewart, Douglas R.; Diskin, Sharon J.; Rokita, Jo Lynne; Cole, Kristina A. 分享 收藏
GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma Dong, Zhiwei; Yeo, Kok Siong; Lopez, Gonzalo; Zhang, Cheng; Eggum, Erin N. Dankert; Rokita, Jo Lynne; Ung, Choong Yong; Levee, Taylor M.; Her, Zuag Paj; Howe, Cassie J.; Hou, Xiaonan; van Ree, Janine H.; Li, Shuai; He, Shuning; Tao, Ting; Fritchie, Karen; Torres-Mora, Jorge; Lehman, Julia S.; Meves, Alexander; Razidlo, Gina L.; Rathi, Komal S.; Weroha, S. John; Look, A. Thomas; van Deursen, Jan M.; Li, Hu; Westendorf, Jennifer J.; Maris, John M.; Zhu, Shizhen 分享 收藏
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy Rodriguez-Garcia, Alba; Lynn, Rachel C.; Poussin, Mathilde; Eiva, Monika A.; Shaw, Lauren C.; O'Connor, Roddy S.; Minutolo, Nicholas G.; Casado-Medrano, Victoria; Lopez, Gonzalo; Matsuyama, Takami; Powell, Daniel J., Jr. 分享 收藏
Somatic structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma Lopez, Gonzalo; Conkrite, Karina L.; Doepner, Miriam; Rathi, Komal S.; Modi, Apexa; Vaksman, Zalman; Farra, Lance M.; Hyson, Eric; Noureddine, Moataz; Wei, Jun S.; Smith, Malcolm A.; Asgharzadeh, Shahab; Seeger, Robert C.; Khan, Javed; Auvil, Jaime Guidry; Gerhard, Daniela S.; Maris, John M.; Diskin, Sharon J. 分享 收藏
Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma Koneru, Balakrishna; Lopez, Gonzalo; Farooqi, Ahsan; Conkrite, Karina L.; Nguyen, Thinh H.; Macha, Shawn J.; Modi, Apexa; Rokita, Jo Lynne; Urias, Eduardo; Hindle, Ashly; Davidson, Heather; Mccoy, Kristyn; Nance, Jonas; Yazdani, Vanda; Irwin, Meredith S.; Yang, Shengping; Wheeler, David A.; Maris, John M.; Diskin, Sharon J.; Reynolds, C. Patrick 分享 收藏
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Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design Rokita, Jo Lynne; Rathi, Komal S.; Cardenas, Maria F.; Upton, Kristen A.; Jayaseelan, Joy; Cross, Katherine L.; Pfeil, Jacob; Egolf, Laura E.; Way, Gregory P.; Farrel, Alvin; Kendsersky, Nathan M.; Patel, Khushbu; Gaonkar, Krutika S.; Modi, Apexa; Berko, Esther R.; Lopez, Gonzalo; Vaksman, Zalman; Mayoh, Chelsea; Nance, Jonas; McCoy, Kristyn; Haber, Michelle; Evans, Kathryn; McCalmont, Hannah; Bendak, Katerina; Boehm, Julia W.; Marshall, Glenn M.; Tyrrell, Vanessa; Kalletla, Karthik; Braun, Frank K.; Qi, Lin; Du, Yunchen; Zhang, Huiyuan; Lindsay, Holly B.; Zhao, Sibo; Shu, Jack; Baxter, Patricia; Morton, Christopher; Kurmashev, Dias; Zheng, Siyuan; Chen, Yidong; Bowen, Jay; Bryan, Anthony C.; Leraas, Kristen M.; Coppens, Sara E.; Doddapaneni, HarshaVardhan; Momin, Zeineen; Zhang, Wendong; Sacks, Gregory, I; Hart, Lori S.; Krytska, Kateryna; Mosse, Yael P.; Gatto, Gregory J.; Sanchez, Yolanda; Greene, Casey S.; Diskin, Sharon J.; Vaske, Olena Morozova; Haussler, David; Gastier-Foster, Julie M.; Kolb, E. Anders; Gorlick, Richard; Li, Xiao-Nan; Reynolds, C. Patrick; Kurmasheva, Raushan T.; Houghton, Peter J.; Smith, Malcolm A.; Lock, Richard B.; Raman, Pichai; Wheeler, David A.; Maris, John M. 分享 收藏
Pediatric high-grade glioma resources from the Children's Brain Tumor Tissue Consortium 来自儿童脑肿瘤组织联盟的小儿高级神经胶质瘤资源 Ijaz, Heba; Koptyra, Mateusz; Gaonkar, Krutika S.; Rokita, Jo Lynne; Baubet, Valerie P.; Tauhid, Lamiya; Zhu, Yuankun; Brown, Miguel; Lopez, Gonzalo; Zhang, Bo; Diskin, Sharon J.; Vaksman, Zalman; Mason, Jennifer L.; Appert, Elizabeth; Lilly, Jena; Lulla, Rishi; De Raedt, Thomas; Heath, Allison P.; Felmeister, Alex; Raman, Pichai; Nazarian, Javad; Santi, Maria Rita; Storm, Phillip B.; Resnick, Adam; Waanders, Angela J.; Cole, Kristina A. 分享 收藏
Germline 16p11.2 Microdeletion Predisposes to Neuroblastoma Egolf, Laura E.; Vaksman, Zalman; Lopez, Gonzalo; Rokita, Jo Lynne; Modi, Apexa; Basta, Patricia, V; Hakonarson, Hakon; Olshan, Andrew F.; Diskin, Sharon J. 分享 收藏
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Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma Boboila, Shuobo; Lopez, Gonzalo; Yu, Jiyang; Banerjee, Debarshi; Kadenhe-Chiweshe, Angela; Connolly, Eileen P.; Kandel, Jessica J.; Rajbhandari, Presha; Silva, Jose M.; Califano, Andrea; Yamashiro, Darrell J. 分享 收藏
Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma 跨队列分析确定TEAD4-MYCN正反馈回路为高危神经母细胞瘤的核心调控元件 Rajbhandari, Presha; Lopez, Gonzalo; Capdevila, Claudia; Salvatori, Beatrice; Yu, Jiyang; Rodriguez-Barrueco, Ruth; Martinez, Daniel; Yarmarkovich, Mark; Weichert-Leahey, Nina; Abraham, Brian J.; Alvarez, Mariano J.; Iyer, Archana; Harenza, Jo Lynne; Oldridge, Derek; De Preter, Katleen; Koster, Jan; Asgharzadeh, Shahab; Seeger, Robert C.; Wei, Jun S.; Khan, Javed; Vandesompele, Jo; Mestdagh, Pieter; Versteeg, Rogier; Look, A. Thomas; Young, Richard A.; Iavarone, Antonio; Lasorella, Anna; Silva, Jose M.; Maris, John M.; Califano, Andrea 分享 收藏
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HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma Tavana, Omid; Li, Dawei; Dai, Chao; Lopez, Gonzalo; Banerjee, Debarshi; Kon, Ning; Chen, Chao; Califano, Andrea; Yamashiro, Darrell J.; Sun, Hongbin; Gu, Wei 分享 收藏
Selective cross-cohort discovery of transcriptional mechanisms presiding over high-risk neuroblastoma subtype state maintenance Rajbhandari, Presha; Lopez, Gonzalo; Yu, Jiyang; Rodriguez-Barrueco, Ruth; Alvarez, Mariano; Martinez, Daniel; Yarmarkovich, Mark; Vandesompele, Jo; Mestdagh, Pieter; Silva, Jose M.; Lasorella, Anna; Lavarone, Antonio; Mans, John M.; Califano, Andrea 分享 收藏
Oncogenic dysregulations in neuroblastoma are associated with distal large chromosomal aberrations Lopez, Gonzalo; Alvarez, Mariano; Chen, James; Rajbhandari, Presha; Cole, Kristina A.; Attiyeh, Edward F.; Diskin, Sharon; Mestdagh, Pieter; Vandesompele, Jo; Maris, John M.; Califano, Andrea 分享 收藏
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