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J

Jim R. Hughes

University of Oxford

56H指数
219论文数
1.3W被引数
收录论文 89
发表时间
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Single-allele nanoscale mapping of regulatory variants单等位基因纳米尺度调控变异映射
errNature Genetics
IF29
err2026-10-02
err0
errOAAI
errJoseph C. Hamley; Weijiao Zhang; Daniel Willmott; Lucia Y. Chen; Vassilena Sharlandjieva; Hangpeng Li; James L. T. Dalgleish; Nicholas Denny; Gaurav Agarwal; Lance Hentges; Bora Ozcan; Roman M. Doll; Ye Wei; Simone G. Riva; Samvida S. Venkatesh; Marta Arachi; Devika Agarwal; Evgeny E. Akkuratov; Matthew Baxter; Tatjana Sauka-Spengler; Calliope A. Dendrou; Thomas A. Milne; Jim R. Hughes; James O. J. Davies
err分享
err收藏
Zone equalisation normalisation for improved alignment of epigenetic signal表观遗传信号对齐的分区均衡归一化方法
errBioinformatics
IF5.4
err2026-08-20
err0
errOAAI
errTom Wilson; Thomas A Milne; Simone G Riva; Jim R Hughes; null; null
err分享
err收藏
Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation凝聚素介导的环化挤出在分化早期增强子激活基因表达中发挥作用
errNature Communications
IF15.7
err2026-05-26
err0
errOAAI
errRosa J. Stolper; Felice H. Tsang; Emily Georgiades; Lars L. P. Hanssen; Edward A. J. Tunnacliffe; Damien J. Downes; Caroline L. Harrold; Jim R. Hughes; Robert A. Beagrie; Benjamin Davies; Mira T. Kassouf; Douglas R. Higgs
err分享
err收藏
MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemiaMYB活性驱动急性淋巴细胞白血病中增强子的涌现激活和增强子-启动子相互作用
errBlood
IF23.1
err2026-03-23
err0
PREAI
errI-Jun Lau; Gianna Bloye; Alastair L. Smith; Joe R. Harman; Joseph C. Hamley; Vassilena Sharlandjieva; Nicholas Denny; Catherine Chahrour; Hangpeng Li; Nicole E. Jackson; Paresh Vyas; James O.J. Davies; Jim R. Hughes; Nicholas T. Crump; Thomas A. Milne
err分享
err收藏
Platelets sequester extracellular DNA; capturing tumor-derived and free fetal DNA血小板隔离细胞外DNA；捕获肿瘤来源和游离胎儿DNA
errScience
IF45.8
err2025-08-14
err0
PREAI
errLauren Murphy; Jeanne Inchauspé; Giampiero Valenzano; Pamela Holland; Nikolaos Sousos; Hayley L. Belnoue-Davis; Rong Li; Natalie J. Jooss; Camelia Benlabiod; Eleanor Murphy; Zohar Etzioni; Emelie Shepherd; Lucy Denly; Sujata Biswas; Lin Chen; Jennifer O’Sullivan; Michael P. Rimmer; Abdullah O. Khan; Christina Simoglou Karali; Nadia Nasreddin; Ian S. Hitchcock; Milka Koupenova; Skirmantas Kriaucionis; Jim R. Hughes; Eric O’Neill; Manu Vatish; Paul Rees; Simon Leedham; Michael Desborough; Adam J. Mead; Benjamin Schuster-Böckler; Christopher D. Gregory; Bethan Psaila
err分享
err收藏
Active regulatory elements recruit cohesin to establish cell specific chromatin domains活性调节元件招募凝聚素以建立细胞特异性染色质结构域
errSCIENTIFIC REPORTS
IF3.9
err2025-04-06
err0
errOAAI
errGeorgiades, Emily; Harrold, Caroline; Roberts, Nigel; Kassouf, Mira; Riva, Simone G.; Sanders, Edward; Downes, Damien; Francis, Helena S.; Blayney, Joseph; Oudelaar, A. Marieke; Milne, Thomas A.; Higgs, Douglas; Hughes, Jim R.
err分享
err收藏
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis古代基因组连锁将α-球蛋白(α-globin)和Nprl3联系起来，将代谢与红细胞生成(erythropoiesis)耦合。
errNATURE COMMUNICATIONS
IF15.7
err2025-03-24
err0
errOAAI
errPreston, Alexandra E.; Frost, Joe N.; Teh, Megan R.; Badat, Mohsin; Armitage, Andrew E.; Norfo, Ruggiero; Wideman, Sarah K.; Hanifi, Muhammad; White, Natasha; Roy, Noemi BA.; Babbs, Christian; Ghesquiere, Bart; Davies, James; Howden, Andrew JM.; Sinclair, Linda V.; Hughes, Jim R.; Kassouf, Mira; Beagrie, Rob; Higgs, Douglas R.; Drakesmith, Hal
err分享
err收藏
The α-globin super-enhancer acts in an orientation-dependent manner ( vol 16, 1033 , 2025)α-球蛋白超级增强子以方向依赖性方式发挥作用（vol 16, 1033, 2025）
errNATURE COMMUNICATIONS
IF15.7
err2025-03-19
err0
errOAAI
errKassouf, Mira T.; Francis, Helena S.; Gosden, Matthew; Suciu, Maria C.; Downes, Damien J.; Harrold, Caroline; Larke, Martin; Oudelaar, Marieke; Cornell, Lucy; Blayney, Joseph; Telenius, Jelena; Xella, Barbara; Shen, Yuki; Sousos, Nikolaos; Sharpe, Jacqueline A.; Sloane-Stanley, Jacqueline; Smith, Andrew J. H.; Babbs, Christian; Hughes, Jim R.; Higgs, Douglas R.
err分享
err收藏
scATAC-seq generates more accurate and complete regulatory maps than bulk ATAC-seqScatac-seq比批量atac-seq生成更准确和完整的监管地图
errSCIENTIFIC REPORTS
IF3.9
err2025-01-29
err0
errOAAI
errGur, E. Ravza; Hughes, Jim R.
err分享
err收藏
Micro-capture-C in vessel wall cell types identifies mechanisms underlying coronary artery disease susceptibility loci
errEUROPEAN HEART JOURNAL
IF35.6
err2024-10-28
err0
PREAI
errBaxter, M.; Hamley, J.; Kyriakou, T.; Goel, A.; Watkins, H.; Hughes, J.
err分享
err收藏
Single-cell technologies meet Hi-C
errNATURE GENETICS
IF31.8
err2024-08-07
err0
PREAI
errHughes, Jim R.; Davies, James O. J.
err分享
err收藏
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes
errGENOME RESEARCH
IF5.5
err2024-07-01
err0
errOAAI
errXiang, Guanjue; He, Xi; Giardine, Belinda M.; Isaac, Kathryn J.; Taylor, Dylan J.; Mccoy, Rajiv C.; Jansen, Camden; Keller, Cheryl A.; Wixom, Alexander Q.; Cockburn, April; Miller, Amber; Qi, Qian; He, Yanghua; Li, Yichao; Lichtenberg, Jens; Heuston, Elisabeth F.; Anderson, Stacie M.; Luan, Jing; Vermunt, Marit W.; Yue, Feng; Sauria, Michael E. G.; Schatz, Michael C.; Taylor, James; Goettgens, Berthold; Hughes, Jim R.; Higgs, Douglas R.; Weiss, Mitchell J.; Cheng, Yong; Blobel, Gerd A.; Bodine, David M.; Zhang, Yu; Li, Qunhua; Mahony, Shaun; Hardison, Ross C.
err分享
err收藏
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture (vol 17, pg 445, 2022)
errNATURE PROTOCOLS
IF16
err2023-06-27
err0
errOAAI
errDownes, Damien J.; Smith, Alastair L.; Karpinska, Magdalena A.; Velychko, Taras; Rue-Albrecht, Kevin; Sims, David; Milne, Thomas A.; Davies, James O. J.; Oudelaar, A. Marieke; Hughes, Jim R.
err分享
err收藏
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells
errCELL STEM CELL
IF20.4
err2023-05-01
err7
errOAAI
errTurkalj, Sven; Jakobsen, Niels Asger; Groom, Angus; Metzner, Marlen; Riva, Simone G.; Gur, E. Ravza; Usukhbayar, Batchimeg; Salazar, Mirian Angulo; Hentges, Lance D.; Mickute, Gerda; Clark, Kevin; Sopp, Paul; Davies, James O. J.; Hughes, Jim R.; Vyas, Paresh
err分享
err收藏
Direct correction of haemoglobin E β-thalassaemia using base editors
errNATURE COMMUNICATIONS
IF15.7
err2023-04-19
err12
errOAAI
errBadat, Mohsin; Ejaz, Ayesha; Hua, Peng; Rice, Siobhan; Zhang, Weijiao; Hentges, Lance D.; Fisher, Christopher A.; Denny, Nicholas; Schwessinger, Ron; Yasara, Nirmani; Roy, Noemi B. A.; Issa, Fadi; Roy, Andi; Telfer, Paul; Hughes, Jim; Mettananda, Sachith; Higgs, Douglas R.; Davies, James O. J.
err分享
err收藏
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features
errNATURE GENETICS
IF31.8
err2022-11-04
err28
errOAAI
errRobbe, Pauline; Ridout, Kate E.; Vavoulis, Dimitrios V.; Dreau, Helene; Kinnersley, Ben; Denny, Nicholas; Chubb, Daniel; Appleby, Niamh; Cutts, Anthony; Cornish, Alex J.; Lopez-Pascua, Laura; Clifford, Ruth; Burns, Adam; Stamatopoulos, Basile; Cabes, Maite; Alsolami, Reem; Antoniou, Pavlos; Oates, Melanie; Cavalieri, Doriane; Consortium, Genomics England Research; Consortium, Cll Pilot; Gibson, Jane; Prabhu, Anika, V; Schwessinger, Ron; Jennings, Daisy; James, Terena; Maheswari, Uma; Duran-Ferrer, Marti; Carninci, Piero; Knight, Samantha J. L.; Mansson, Robert; Hughes, Jim; Davies, James; Ross, Mark; Bentley, David; Strefford, Jonathan C.; Devereux, Stephen; Pettitt, Andrew R.; Hillmen, Peter; Caulfield, Mark J.; Houlston, Richard S.; Martin-Subero, Jose, I; Schuh, Anna
err分享
err收藏
Natural and Experimental Rewiring of Gene Regulatory Regions
errannual review of genetics
IF7.9
err2022-08-31
err2
PREAI
errDownes, Damien J.; Hughes, Jim R.
err分享
err收藏
The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin
errNATURE COMMUNICATIONS
IF15.7
err2022-06-17
err23
errOAAI
errTruch, Julia; Downes, Damien J.; Scott, Caroline; Gur, E. Ravza; Telenius, Jelena M.; Repapi, Emmanouela; Schwessinger, Ron; Gosden, Matthew; Brown, Jill M.; Taylor, Stephen; Cheong, Pak Leng; Hughes, Jim R.; Higgs, Douglas R.; Gibbons, Richard J.
err分享
err收藏
Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells
errPLOS GENETICS
IF3.7
err2022-06-16
err7
errOAAI
errPavlaki, Ioanna; Shapiro, Michael; Pisignano, Giuseppina J.; Jones, Stephanie M. E. R.; Telenius, Jelena W.; Munoz-Descalzo, Silvia M.; Williams, Robert; Hughes, Jim M.; Vance, Keith
err分享
err收藏
Making connections: enhancers in cellular differentiation
errTRENDS IN GENETICS
IF16.3
err2022-04-01
err5
PREAI
errHerrmann, Jennifer C.; Beagrie, Robert A.; Hughes, Jim R.
err分享
err收藏

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