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I

Iain Uings

gsk, stevenage, uk
H指数:27
被引数:2,624

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荣誉奖项

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Clinical and Molecular Effect of the Anti–IL-18 Antibody Aletekitug in Adults With Atopic Dermatitis

抗IL-18抗体Aletekitug在成人特应性皮炎中的临床与分子效应

Allergy
IF12
2025-12-180
OAAI
Joanne Ellis; Léa Fortunato; Hannah Wajdner; Ester Del Duca; Joanna Barnard; Joanna C. Betts; Swaroop Bose; John Browning; Núria Buil-Bruna; Scott Van Buren; Eden David; Scott Dinehart; Puneet Dhawan; Yeriel Estrada; Parima Ghafoori; Kiranmai Gumireddy; Zhenghong Li; Wei Jing Loo; Fiona Lovegrove; Jenny Lowe; Lawrence Charles Parish; Will Powley; Naveen Prasad; Joel Correa Da Rosa; Marieta Ruseva; Neda Shokrian; Farhat Syed; Chun-Hang Tang; Gabriel K. Wong; John B. Kelly; Nicolas Wisniacki; Iain Uings; Emma Guttman-Yassky
Design and Mechanistic Analysis of a Potent Bivalent Inhibitor of Transthyretin Amyloid Fibrillogenesis

设计和机制分析：一种强效的双价转甲状腺素蛋白淀粉样纤维形成抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-270
OA
Mangione, P. Patrizia; Verona, Guglielmo; Cantarutti, Cristina; Nocerino, Paola; Mimmi, Maria Chiara; Swain, Christopher J.; Canetti, Diana; Giorgetti, Sofia; Uings, Iain; Gillmore, Julian D.; Taylor, Graham W.; Pepys, Mark B.; Bellotti, Vittorio; Corazza, Alessandra
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis
CELL REPORTS
IF6.9
2023-08-016
OA
Hayes, Alastair J.; Zheng, Xiaozhong; O'Kelly, James; Neyton, Lucile P. A.; Bochkina, Natalia A.; Uings, Iain; Liddle, John; Baillie, J. Kenneth; Just, George; Binnie, Margaret; Homer, Natalie Z. M.; Murray, Toby B. J.; Baily, James; McGuire, Kris; Skouras, Christos; Garden, O. James; Webster, Scott P.; Iredale, John P.; Howie, Sarah E. M.; Mole, Damian J.
Assessment of the safety, pharmacokinetics and pharmacodynamics of GSK3335065, an inhibitor of kynurenine monooxygenase, in a randomised placebo-controlled first-in-human study in healthy volunteers
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
IF3
2021-08-223
OAAI
Fernando, Disala; Dimelow, Richard; Gorey, Ciara; Zhu, Xinyi; Muya, Catherine; Parker, Connie; Wright, Wayne; Soleman, Sara; Walsh, Sarah; Crause, Madelein; Vlasakakis, Georgios; Guiney, William; Robertson, Nicola; Bergeal, Marylise; Cui, Yi; Krug, Alexander W.; Uings, Iain
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
EMBO MOLECULAR MEDICINE
IF8.3
2021-01-2928
OAAI
Lomas, David A.; Irving, James A.; Arico-Muendel, Christopher; Belyanskaya, Svetlana; Brewster, Andrew; Brown, Murray; Chung, Chun-wa; Dave, Hitesh; Denis, Alexis; Dodic, Nerina; Dossang, Anthony; Eddershaw, Peter; Klimaszewska, Diana; Haq, Imran; Holmes, Duncan S.; Hutchinson, Jonathan P.; Jagger, Alistair M.; Jakhria, Toral; Jigorel, Emilie; Liddle, John; Lind, Ken; Marciniak, Stefan J.; Messer, Jeff; Neu, Margaret; Olszewski, Allison; Ordonez, Adriana; Ronzoni, Riccardo; Rowedder, James; Ruediger, Martin; Skinner, Steve; Smith, Kathrine J.; Terry, Rebecca; Trottet, Lionel; Uings, Iain; Wilson, Steve; Zhu, Zhengrong; Pearce, Andrew C.
CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-04-2919
OAAI
Ketley, Ami; Wojciechowska, Marzena; Ghidelli-Disse, Sonja; Bamborough, Paul; Ghosh, Tushar K.; Morato, Marta Lopez; Sedehizadeh, Saam; Malik, Naveed Altaf; Tang, Zhenzhi; Powalowska, Paulina; Tanner, Matthew; Billeter-Clark, Rudolf; Trueman, Rebecca C.; Geiszler, Philippine C.; Agostini, Alessandra; Othman, Othman; Bosche, Markus; Bantscheff, Marcus; Rudiger, Martin; Mossakowska, Danuta E.; Drewry, David H.; Zuercher, William J.; Thornton, Charles A.; Drewes, Gerard; Uings, Iain; Hayes, Christopher J.; Brook, J. David
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-2830
PREAI
Liddle, John; Hutchinson, Jonathan P.; Kitchen, Semra; Rowland, Paul; Neu, Margarete; Cecconie, Ted; Holmes, Duncan S.; Jones, Emma; Korczynska, Justyna; Koumantou, Despoina; Lea, Jonathan D.; Nickels, Leng; Pemberton, Michelle; Phillipou, Alex; Schneck, Jessica L.; Sheehan, Hester; Tinworth, Christopher P.; Uings, Iain; Wojno-Picon, Justyna; Young, Robert J.; Stratikos, Efstratios
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-04-1125
OAAI
Walker, Ann L.; Ancellin, Nicolas; Beaufils, Benjamin; Bergeal, Marylise; Binnie, Margaret; Bouillot, Anne; Clapham, David; Denis, Alexis; Haslan, Carl P.; Holmes, Duncan S.; Hutchinson, Jonathan P.; Liddle, John; McBride, Andrew; Mirguet, Olivier; Mowat, Christopher G.; Rowland, Paul; Tiberghien, Nathalie; Trottett, Lionel; Uings, Iain; Webster, Scott P.; Zheng, Xiaozhong; Mole, Damian J.
Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis
SCIENTIFIC REPORTS
IF3.9
2016-09-2727
OAAI
Skouras, Christos; Zheng, Xiaozhong; Binnie, Margaret; Homer, Natalie Z. M.; Murray, Toby B. J.; Robertson, Darren; Briody, Lesley; Paterson, Finny; Spence, Heather; Derr, Lisa; Hayes, Alastair J.; Tsoumanis, Andreas; Lyster, Dawn; Parks, Rowan W.; Garden, O. James; Iredale, John P.; Uings, Iain J.; Liddle, John; Wright, Wayne L.; Dukes, George; Webster, Scott P.; Mole, Damian J.
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
NATURE MEDICINE
IF50
2016-01-11132
OAAI
Mole, Damian J.; Webster, Scott P.; Uings, Iain; Zheng, Xiaozhong; Binnie, Margaret; Wilson, Kris; Hutchinson, Jonathan P.; Mirguet, Olivier; Walker, Ann; Beaufils, Benjamin; Ancellin, Nicolas; Trottet, Lionel; Beneton, Veronique; Mowat, Christopher G.; Wilkinson, Martin; Rowlands, Paul; Haslam, Carl; McBride, Andrew; Homer, Natalie Z. M.; Baily, James E.; Sharp, Matthew G. F.; Garden, O. James; Hughes, Jeremy; Howie, Sarah E. M.; Holmes, Duncan S.; Liddle, John; Iredale, John P.
Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2013-09-25289
PREAI
Mirguet, Olivier; Gosmini, Romain; Toum, Jerome; Clement, Catherine A.; Barnathan, Melanie; Brusq, Jean-Marie; Mordaunt, Jacqueline E.; Grimes, Richard M.; Crowe, Miriam; Pineau, Olivier; Ajakane, Myriam; Daugan, Alain; Jeffrey, Phillip; Cutler, Leanne; Haynes, Andrea C.; Smithers, Nicholas N.; Chung, Chun-wa; Bamborough, Paul; Uings, Iain J.; Lewis, Antonia; Witherington, Jason; Parr, Nigel; Prinjha, Rab K.; Nicodeme, Edwige
Discovery and Characterizatlion of Small Molecule Inhibitors of the BET Family Bromodomains
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2011-05-13395
PREAI
Chung, Chun-wa; Coste, Herve; White, Julia H.; Mirguet, Olivier; Wilde, Jonathan; Gosmini, Romain L.; Delves, Chris; Magny, Sylvie M.; Woodward, Robert; Hughes, Stephen A.; Boursier, Eric V.; Flynn, Helen; Bouillot, Anne M.; Bamborough, Paul; Brusq, Jean-Marie G.; Gellibert, Francoise J.; Jones, Emma J.; Riou, Alizon M.; Homes, Paul; Martin, Sandrine L.; Uings, Iain J.; Toum, Jerome; Clement, Catherine A.; Boullay, Anne-Benedicte; Grimley, Rachel L.; Blande, Florence M.; Prinjha, Rab K.; Lee, Kevin; Kirilovsky, Jorge; Nicodeme, Edwige
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2009-10-2767
OAAI
Biggadike, Keith; Bledsoe, Randy K.; Coe, Diane M.; Cooper, Tony W. J.; House, David; Iannone, Marie A.; Macdonald, Simon J. F.; Madauss, Kevin P.; McLay, Iain M.; Shipley, Tracy J.; Taylor, Simon J.; Tran, Thuy B.; Uings, Iain J.; Weller, Victoria; Williams, Shawn P.
Nonsteroidal glucocorticoid agonists: Tetrahydronaphthalenes with alternative steroidal a-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2007-11-2748
PREAI
Biggadike, Keith; Boudjelal, Mohamed; Clackers, Margaret; Coe, Diane M.; Demaine, Derek A.; Hardy, George W.; Humphreys, Davina; Inglis, Graham G. A.; Johnston, Michael J.; Jones, Haydn T.; House, David; Loiseau, Richard; Needham, Deborah; Skone, Philip A.; Uings, Iain; Veitch, Gemma; Weingarten, Gordon G.; McLay, Iain M.; Macdonald, Simon J. F.

研究方向

暂未获取到该数据
J
John Liddle
H 指数:35论文数:141被引数:5,351
S
Scott P. Webster
H 指数:31论文数:111被引数:2,726
D
Damian J. Mole
H 指数:29论文数:144被引数:4,535
D
Duncan S. Holmes
H 指数:24论文数:62被引数:1,492
J
Jonathan P. Hutchinson
H 指数:18论文数:44被引数:811
C
Chun‐wa Chung
H 指数:48论文数:141被引数:1.2万
O
Olivier Mirguet
H 指数:20论文数:50被引数:3,407
X
Xiaozhong Zheng
H 指数:34论文数:176被引数:5,089
M
Margaret Binnie
H 指数:20论文数:47被引数:1,263
P
Paul Rowland
H 指数:29论文数:113被引数:3,585