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P

Paul Rowland

GlaxoSmithKline
H指数:29
被引数:3,585

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荣誉奖项

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Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-11-061
OAAI
Hryczanek, Ross P.; Hackett, Andrew S.; Rowland, Paul; Chung, Chun-wa; Convery, Maire A.; Holmes, Duncan S.; Hutchinson, Jonathan P.; Kitchen, Semra; Korczynska, Justyna; Law, Robert P.; Lea, Jonathan D.; Liddle, John; Lonsdale, Richard; Neu, Margarete; Nickels, Leng; Phillipou, Alex; Rowedder, James E.; Schneck, Jessica L.; Scott-Stevens, Paul; Sheehan, Hester; Tayler, Chloe L.; Temponeras, Ioannis; Tinworth, Christopher P.; Walker, Ann L.; Wojno-Picon, Justyna; Young, Robert J.; Lindsay, David M.; Stratikos, Efstratios
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-289
OAAI
Thomas, Michael G.; McGonagle, Kate; Rowland, Paul; Robinson, David A.; Dodd, Peter G.; Camino-Diaz, Isabel; Campbell, Lorna; Cantizani, Juan; Castaneda, Pablo; Conn, Daniel; Craggs, Peter D.; Edwards, Darren; Ferguson, Liam; Fosberry, Andrew; Frame, Laura; Goswami, Panchali; Hu, Xiao; Korczynska, Justyna; MacLean, Lorna; Martin, Julio; Mutter, Nicole; Osuna-Cabello, Maria; Paterson, Christy; Pena, Imanol; Pinto, Erika G.; Pont, Caterina; Riley, Jennifer; Shishikura, Yoko; Simeons, Frederick R. C.; Stojanovski, Laste; Thomas, John; Wrobel, Karolina; Young, Robert J.; Zmuda, Filip; Zuccotto, Fabio; Read, Kevin D.; Gilbert, Ian H.; Marco, Maria; Miles, Timothy J.; Manzano, Pilar; De Rycker, Manu
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-12-208
PRE
Wellaway, Christopher R.; Baldwin, Ian R.; Bamborough, Paul; Barker, Daniel; Bartholomew, Michelle A.; Chung, Chun-wa; Dumpelfeld, Birgit; Evans, John P.; Fazakerley, Neal J.; Homes, Paul; Keeling, Steven P.; Lewell, Xiao Q.; McNab, Finlay W.; Morley, Joanne; Needham, Deborah; Neu, Margarete; van Oosterhout, Antoon J. M.; Pal, Anshu; Reinhard, Friedrich B. M.; Rianjongdee, Francesco; Robertson, Craig M.; Rowland, Paul; Shah, Rishi R.; Sherriff, Emma B.; Sloan, Lisa A.; Teague, Simon; Thomas, Daniel A.; Wellaway, Natalie; Wojno-Picon, Justyna; Woolven, James M.; Coe, Diane M.
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-09-113
PRE
Down, Kenneth; Amour, Augustin; Anderson, Niall A.; Barton, Nick; Campos, Sebastien; Cannons, Edward P.; Clissold, Cole; Convery, Maire A.; Coward, John J.; Doyle, Kevin; Duempelfeld, Birgit; Edwards, Christopher D.; Goldsmith, Michael D.; Krause, Jana; Mallett, David N.; McGonagle, Grant A.; Patel, Vipulkumar K.; Rowedder, James; Rowland, Paul; Sharpe, Andrew; Sriskantharajah, Srividya; Thomas, Daniel A.; Thomson, Douglas W.; Uddin, Sorif; Hamblin, J. Nicole; Hessel, Edith M.
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-2830
PREAI
Liddle, John; Hutchinson, Jonathan P.; Kitchen, Semra; Rowland, Paul; Neu, Margarete; Cecconie, Ted; Holmes, Duncan S.; Jones, Emma; Korczynska, Justyna; Koumantou, Despoina; Lea, Jonathan D.; Nickels, Leng; Pemberton, Michelle; Phillipou, Alex; Schneck, Jessica L.; Sheehan, Hester; Tinworth, Christopher P.; Uings, Iain; Wojno-Picon, Justyna; Young, Robert J.; Stratikos, Efstratios
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target

口服可生物利用的PI3Kδ 抑制剂的优化和Vps34作为关键选择性靶标的鉴定

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-12-1919
PREAI
Henley, Zoe A.; Amour, Augustin; Barton, Nick; Bantscheff, Marcus; Bergamini, Giovanna; Bertrand, Sophie M.; Convery, Maire; Down, Kenneth; Duempelfeld, Birgit; Edwards, Chris D.; Grandi, Paola; Gore, Paul M.; Keeling, Steve; Livia, Stefano; Mallett, David; Maxwell, Aoife; Price, Mark; Rau, Christina; Reinhard, Friedrich B. M.; Rowedder, James; Rowland, Paul; Taylor, Jonathan A.; Thomas, Daniel A.; Hessel, Edith M.; Hamblin, J. Nicole
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-04-08115
OAAI
Wyllie, Susan; Brand, Stephen; Thomas, Michael; De Rycker, Manu; Chung, Chun-wa; Pena, Imanol; Bingham, Ryan P.; Bueren-Calabuig, Juan A.; Cantizani, Juan; Cebrian, David; Craggs, Peter D.; Ferguson, Liam; Goswami, Panchali; Hobrath, Judith; Howe, Jonathan; Jeacock, Laura; Ko, Eun-Jung; Korczynska, Justyna; MacLean, Lorna; Manthri, Sujatha; Martinez, Maria S.; Mata-Cantero, Lydia; Moniz, Sonia; Nuhs, Andrea; Osuna-Cabello, Maria; Pinto, Erika; Riley, Jennifer; Robinson, Sharon; Rowland, Paul; Simeons, Frederick R. C.; Shishikura, Yoko; Spinks, Daniel; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Gaza, Elisabet Viayna; Wall, Richard J.; Zuccotto, Fabio; Horn, David; Ferguson, Michael A. J.; Fairlamb, Alan H.; Fiandor, Jose M.; Martin, Julio; Gray, David W.; Miles, Timothy J.; Gilbert, Ian H.; Read, Kevin D.; Marco, Maria; Wyatt, Paul G.
Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
ACS OMEGA
IF4.3
2018-08-1525
OAAI
Kokkonda, Sreekanth; El Mazouni, Farah; White, Karen L.; White, John; Shackleford, David M.; Jose Lafuente-Monasterio, Maria; Rowland, Paul; Manjalanagara, Krishne; Joseph, Jayan T.; Garcia-Perez, Adolfo; Fernandez, Jorge; Javier Gamo, Francisco; Waterson, David; Burrows, Jeremy N.; Palmer, Michael J.; Charman, Susan A.; Rathod, Pradipsinh K.; Phillips, Margaret A.
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-04-1125
OAAI
Walker, Ann L.; Ancellin, Nicolas; Beaufils, Benjamin; Bergeal, Marylise; Binnie, Margaret; Bouillot, Anne; Clapham, David; Denis, Alexis; Haslan, Carl P.; Holmes, Duncan S.; Hutchinson, Jonathan P.; Liddle, John; McBride, Andrew; Mirguet, Olivier; Mowat, Christopher G.; Rowland, Paul; Tiberghien, Nathalie; Trottett, Lionel; Uings, Iain; Webster, Scott P.; Zheng, Xiaozhong; Mole, Damian J.
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
NATURE MEDICINE
IF50
2016-01-11132
OAAI
Mole, Damian J.; Webster, Scott P.; Uings, Iain; Zheng, Xiaozhong; Binnie, Margaret; Wilson, Kris; Hutchinson, Jonathan P.; Mirguet, Olivier; Walker, Ann; Beaufils, Benjamin; Ancellin, Nicolas; Trottet, Lionel; Beneton, Veronique; Mowat, Christopher G.; Wilkinson, Martin; Rowlands, Paul; Haslam, Carl; McBride, Andrew; Homer, Natalie Z. M.; Baily, James E.; Sharp, Matthew G. F.; Garden, O. James; Hughes, Jeremy; Howie, Sarah E. M.; Holmes, Duncan S.; Liddle, John; Iredale, John P.
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-09-03127
PREAI
Down, Kenneth; Amour, Augustin; Baldwin, Ian R.; Cooper, Anthony W. J.; Deakin, Angela M.; Felton, Leigh M.; Guntrip, Stephen B.; Hardy, Charlotte; Harrison, Zoe A.; Jones, Katherine L.; Jones, Paul; Keeling, Suzanne E.; Le, Joelle; Livia, Stefano; Lucas, Fiona; Lunniss, Christopher J.; Parr, Nigel J.; Robinson, Ed; Rowland, Paul; Smith, Sarah; Thomas, Daniel A.; Vitulli, Giovanni; Washio, Yoshiaki; Hamblin, J. Nicole

研究方向

暂未获取到该数据
J
John Liddle
H 指数:35论文数:141被引数:5,351
C
Chun‐wa Chung
H 指数:48论文数:141被引数:1.2万
D
Daniel A. Thomas
H 指数:14论文数:51被引数:1,488
D
Duncan S. Holmes
H 指数:24论文数:62被引数:1,492
J
Jonathan P. Hutchinson
H 指数:18论文数:44被引数:811
M
Margarete Neu
H 指数:23论文数:57被引数:1,689
M
M.A. Convery
H 指数:26论文数:155被引数:2,162
A
Anthony W. J. Cooper
H 指数:15论文数:59被引数:1,021
H 指数:0论文数:50被引数:695
N
Natalie Wellaway
H 指数:9论文数:25被引数:306