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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling Graham, Keith; Lienau, Philip; Bader, Benjamin; Prechtl, Stefan; Naujoks, Jan; Lesche, Ralf; Weiske, Joerg; Kuehnlenz, Julia; Brzezinka, Krzysztof; Potze, Lisette; Zanconato, Francesca; Nicke, Barbara; Montebaur, Anna; Bone, Wilhelm; Golfier, Sven; Kaulfuss, Stefan; Kopitz, Charlotte; Pilari, Sabine; Steuber, Holger; Hayat, Sikander; Kamburov, Atanas; Steffen, Andreas; Schlicker, Andreas; Buchgraber, Philipp; Braeuer, Nico; Font, Nuria Aiguabella; Heinrich, Tobias; Kuhnke, Lara; Nowak-Reppel, Katrin; Stresemann, Carlo; Steigemann, Patrick; Walter, Annette O.; Blotta, Simona; Ocker, Matthias; Lakner, Ashley; von Nussbaum, Franz; Mumberg, Dominik; Eis, Knut; Piccolo, Stefano; Lange, Martin 分享 收藏
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Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I and Rho-GTPase signaling Graham, Keith; Lienau, Philip; Bader, Benjamin; Prechtl, Stefan; Naujoks, Jan; Lesche, Ralf; Nicke, Barbara; Bone, Wilhelm; Golfier, Sven; Brzezinka, Krzysztof; Kaulfuss, Stefan; Kopitz, Charlotte; Steuber, Holger; Braeuer, Nico; Nowak-Reppel, Katrin; Stresemann, Carlo; Steigemann, Patrick; Kuehnlenz, Julia; Potze, Lisette; Zanconato, Francesca; Montebaur, Anna; Pilari, Sabine; Hayat, Sikander; Kamburov, Atanas; Steffen, Andreas; Schlicker, Andreas; Buchgraber, Philipp; Font, Nuria Aiguabella; Heinrich, Tobias; Kuhnke, Lara; Walter, Annette O.; Blotta, Simona; Ocker, Matthias; Lakner, Ashley; Mumberg, Dominik; Eis, Knut; Piccolo, Stefano; Lange, Martin 分享 收藏
ITCC-P4, a preclinical proof-of-concept drug testing platform as a tool for pharmacological screening in pediatric tumor models ITCC-P4，一个临床前概念验证药物测试平台，作为儿科肿瘤模型药理筛选的工具 Indersie, Emilie; Branchereau, Sophie; Fresneau, Brice; Chardot, Christophe; Surdez, Didier; Saint-Charles, Alexandra; da Costa, Maria Eugenia Marques; Carcaboso, Angel M.; Scotlandi, Katia; Moro, Massimo; Kovar, Heinrich; Klusmann, Jan-Henning; Debatin, Klaus-Michael; Bomken, Simon; Chesler, Louis; Jones, Chris; Schafer, Beat; Wachtel, Marco; Gojo, Johannes; Berger, Walter; Guttke, Christina; Hattersley, Maureen; Colland, Frederic; Strougo, Ashley; Gurgen, Dennis; Hoffmann, Jens; Schueler, Julia; Aviles, Pablo M.; Guillen, Maria Jose; Federico, Aniello; Gopisetty, Apurva; Wierzbinska, Justyna Anna; Schlicker, Andreas; Colombetti, Sara; Heidenreich, Olaf; Iradier, Fatima; Huebener, Nicole; Jager, Natalie; Koster, Jan; Kool, Marcel; Schleiermacher, Gudrun; Molenaar, Jan J.; Geoerger, Birgit; Shields, David J.; Caron, Hubert N.; Stancato, Louis F.; Pfister, Stefan M.; Vassal, Gilles; Rief, Eva-Maria; Deas, Olivier 分享 收藏
The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models 完全表征的PDXs的ITCC-P4可持续平台支持高风险儿科肿瘤模型的临床前概念验证药物测试 Federico, Aniello; Gopisetty, Apurva; Surdez, Didier; Iddir, Yasmine; Saint-Charles, Alexandra; Wierzbinska, Justyna; Schlicker, Andreas; Volckmann, Richard; Zwijnenburg, Danny; Colombetti, Sara; Heidenreich, Olaf; Iradier, Fatima; Kovar, Heinrich; Klusmann, Jan-Henning; Debatin, Klaus-Michael; Bomken, Simon; Guttke, Christina; Hattersley, Maureen M.; Colland, Frederic; Strougo, Ashley; Guillen, Maria Jose; Chesler, Louis; Jones, Chris; da Costa, Maria Eugenia Marques; Scotlandi, Katia; Moro, Massimo; Schafer, Beat; Wachtel, Marco; Gojo, Johannes; Berger, Walter; Carcaboso, Angel Montero; Gurgen, Dennis; Hoffmann, Jens; Indersie, Emilie; Cairo, Stefano; Schueler, Julia; Huebener, Nicole; Schulte, Johannes H.; Molenaar, Jan J.; Geoerger, Birgit; Shields, David J.; Caron, Hubert N.; Vassal, Gilles; Stancato, Lou F.; Pfister, Stefan M.; Jager, Natalie; Koster, Jan; Kool, Marcel; Schleiermacher, Gudrun 分享 收藏
ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing Gopisetty, Apurva; Federico, Aniello; Surdez, Didier; Iddir, Yasmine; Zaidi, Sakina; Saint-Charles, Alexandra; Waterfall, Joshua; Saberi-Ansari, Elnaz; Wierzbinska, Justyna; Schlicker, Andreas; Mack, Norman; Schwalm, Benjamin; Previti, Christopher; Weiser, Lena; Buchhalter, Ivo; Bottcher, Anna-Lisa; Sill, Martin; Autry, Robert; Estermann, Frank; Jones, David; Volckmann, Richard; Zwijnenburg, Danny; Eggert, Angelika; Heidenreich, Olaf; Iradier, Fatima; Jeremias, Irmela; Kovar, Heinrich; Klusmann, Jan-Henning; Debatin, Klaus-Michael; Bomken, Simon; Hamerlik, Petra; Hattersley, Maureen; Witt, Olaf; Chesler, Louis; Mackay, Alan; Gojo, Johannes; Cairo, Stefano; Schueler, Julia; Schulte, Johannes; Geoerger, Birgit; Molenaar, Jan J.; Shields, David J.; Caron, Hubert N.; Vassal, Gilles; Stancato, Louis F.; Pfister, Stefan M.; Jaeger, Natalie; Koster, Jan; Kool, Marcel; Schleiermacher, Gudrun 分享 收藏
Immunostimulatory effects of targeted thorium-227 conjugates as single agent and in combination with anti-PD-L1 therapy Lejeune, Pascale; Cruciani, Veronique; Berg-Larsen, Axel; Schlicker, Andreas; Mobergslien, Anne; Bartnitzky, Lisa; Berndt, Sandra; Zitzmann-Kolbe, Sabine; Kamfenkel, Claudia; Stargard, Stefan; Hammer, Stefanie; Jorgensen, Jennifer S.; Jackerott, Malene; Nielsen, Carsten H.; Schatz, Christoph A.; Hennekes, Hartwig; Karlsson, Jenny; Cuthbertson, Alan S.; Mumberg, Dominik; Hagemann, Urs B. 分享 收藏
Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models Hammer, Stefanie; Schlicker, Andreas; Zitzmann-Kolbe, Sabine; Baumgart, Simon; Hagemann, Urs B.; Scholz, Arne; Haendler, Bernard; Lejeune, Pascale; Karlsson, Jenny; Ellingsen, Christine; Hennekes, Hartwig; Nielsen, Carsten H.; Juul, Mark U.; Mumberg, Dominik; Schatz, Christoph A. 分享 收藏
First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors Yap, Timothy A.; Tan, David S. P.; Terbuch, Angelika; Caldwell, Reece; Guo, Christina; Goh, Boon Cher; Heong, Valerie; Haris, Noor R. Md; Bashir, Saira; Drew, Yvette; Hong, David S.; Meric-Bernstam, Funda; Wilkinson, Gary; Hreiki, Joseph; Wengner, Antje M.; Bladt, Friedhelm; Schlicker, Andreas; Ludwig, Matthias; Zhou, Yinghui; Liu, Li; Bordia, Sonal; Plummer, Ruth; Lagkadinou, Eleni; de Bono, Johann S. 分享 收藏
PSMA-targeted thorium conjugate and darolutamide combination show synergistic anti-tumor activity and reduced expression of DNA damage repair genes in prostate cancer models Baumgart, Simon J.; Lesche, Ralf; Schlicker, Andreas; Baumgart, Urs; Haendler, Bernard; Lejeune, Pascale; Scholz, Arne; Mumberg, Dominik; Hammer, Stefanie; Schatz, Christoph A. 分享 收藏
Investigating the concordance in molecular subtypes of primary colorectal tumors and their matched synchronous liver metastasis 原发性结直肠肿瘤分子亚型与同期肝转移的一致性研究 Schlicker, Andreas; Ellappalayam, Architha; Beumer, Ines J.; Snel, Mireille H. J.; Mittempergher, Lorenza; Diosdado, Begona; Dreezen, Christa; Tian, Sun; Salazar, Ramon; Loupakis, Fotios; Pietrantonio, Filippo; Santos Vivas, Cristina; Mercedes Martinez-Villacampa, Maria; Villanueva, Alberto; Sanjuan, Xavier; Schirripa, Marta; Fassan, Matteo; Martinetti, Antonia; Fuca, Giovanni; Lonardi, Sara; Keilholz, Ulrich; Glas, Annuska M.; Bernards, Rene; Vecchione, Loredana 分享 收藏
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models Wengner, Antje M.; Siemeister, Gerhard; Luecking, Ulrich; Lefranc, Julien; Wortmann, Lars; Lienau, Philip; Bader, Benjamin; Boemer, Ulf; Moosmayer, Dieter; Eberspaecher, Uwe; Golfier, Sven; Schatz, Christoph A.; Baumgart, Simon J.; Haendler, Bernard; Lejeune, Pascale; Schlicker, Andreas; von Nussbaum, Franz; Brands, Michael; Ziegelbauer, Karl; Mumberg, Dominik 分享 收藏
Anetumab ravtansine has monotherapy efficacy in mesothelin positive patient-derived NSCLC tumor models and in a syngeneic tumor model in immunocompetent mice Sommer, Anette; Lejeune, Pascale; Hoff, Sabine; Walter, Annette O.; Berndt, Sandra; Roese, Lars; Schlicker, Andreas; Wick, Michael J.; Elbi, Cem; Mumberg, Dominik; Schatz, Christoph 分享 收藏
Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance 新型单羧酸转运蛋白1抑制剂BAY-8002和相关耐药标志物的临床前疗效 Quanz, Maria; Bender, Eckhard; Kopitz, Charlotte; Gruenewald, Sylvia; Schlicker, Andreas; Schwede, Wolfgang; Eheim, Ashley; Toschi, Luisella; Neuhaus, Roland; Richter, Carmen; Toedling, Joern; Merz, Claudia; Lesche, Ralf; Kamburov, Atanas; Siebeneicher, Holger; Bauser, Marcus; Haegebarth, Andrea 分享 收藏
Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death Klutzny, Saskia; Lesche, Ralf; Keck, Matthias; Kaulfuss, Stefan; Schlicker, Andreas; Christian, Sven; Sperl, Carolyn; Neuhaus, Roland; Mowat, Jeffrey; Steckel, Michael; Riefke, Bjoern; Prechtl, Stefan; Parczyk, Karsten; Steigemann, Patrick 分享 收藏
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ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder Cancers with Excellent Response to Neoadjuvant Chemotherapy ERBB2突变是对新辅助化疗反应良好的肌肉浸润性膀胱癌亚组的特征 Groenendijk, Floris H.; de Jong, Jeroen; van de Putte, Elisabeth E. Fransen; Michaut, Magali; Schlicker, Andreas; Peters, Dennis; Velds, Arno; Nieuwland, Marja; van den Heuvel, Michel M.; Kerkhoven, Ron M.; Wessels, Lodewijk F.; Broeks, Annegien; van Rhijn, Bas W. G.; Bernards, Rene; van der Heijden, Michiel S. 分享 收藏
Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer Michaut, Magali; Chin, Suet-Feung; Majewski, Ian; Severson, Tesa M.; Bismeijer, Tycho; de Koning, Leanne; Peeters, Justine K.; Schouten, Philip C.; Rueda, Oscar M.; Bosma, Astrid J.; Tarrant, Finbarr; Fan, Yue; He, Beilei; Xue, Zheng; Mittempergher, Lorenza; Kluin, Roelof J. C.; Heijmans, Jeroen; Snel, Mireille; Pereira, Bernard; Schlicker, Andreas; Provenzano, Elena; Ali, Hamid Raza; Gaber, Alexander; O'Hurley, Gillian; Lehn, Sophie; Muris, Jettie J. F.; Wesseling, Jelle; Kay, Elaine; Sammut, Stephen John; Bardwell, Helen A.; Barbet, Aurelie S.; Bard, Floriane; Lecerf, Caroline; O'Connor, Darran P.; Vis, Daniel J.; Benes, Cyril H.; McDermott, Ultan; Garnett, Mathew J.; Simon, Iris M.; Jirstrom, Karin; Dubois, Thierry; Linn, Sabine C.; Gallagher, William M.; Wessels, Lodewyk F. A.; Caldas, Carlos; Bernards, Rene 分享 收藏
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