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Alexandre Puissant

Université Paris-Cité
H指数:39
被引数:5,170

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Oncogenic modulation of MAPK signaling in leukemia via SPNS2-driven sphingolipid metabolism and membrane nanodomains remodeling

通过SPNS2驱动的鞘脂代谢和膜纳米域重塑对白血病中MAPK信号通路的致癌性调控

Nature Communications
IF15.7
2026-10-280
OAAI
Gaetano Sodaro; Khansa Saadallah; Swann Bredin; Michel Kahi; Frank Ling; Paul-Arthur Meslin; Hélène Pasquer; Christopher F. Bassil; Jonathan Paz Montoya; Jean Andrea Maillat; Julie Lesieur; Chloé Zédouard; Nario Tomishige; Nina Fenouille; Matthieu Duchmann; Raphaël Itzykson; Arnaud Jacquel; Patrick Auberger; Kris C. Wood; Toshihide Kobayashi; Camille Lobry; Giovanni D’Angelo; Lina Benajiba; Alexandre Puissant
FANCM is required for the PAX3::FOXO1-driven oncogenic program in rhabdomyosarcoma

FANCM在横纹肌肉瘤中对于PAX3::FOXO1驱动的癌基因程序是必需的

Cell Reports
IF6.9
2026-09-010
OAAI
Delaney, Christopher D.; Lu, Min; Zimmerman, Seth P.; Meng, Yingying; Vaganay, Camille; Cerda-Smith, Christian G.; Liu, Annie; Hoj, Jacob P.; Killarney, Shane T.; Dillon, Kerry; Stewart, Amy E.; Huang, Kevin; Caci, Julia D.; White, Olivia; Puissant, Alexandre; Root, David E.; Shern, Jack F.; Eyler, Christine E.; Chen, Chun-Wei David; Counter, Christopher M.; Linardic, Corinne M.; Zou, Lee; Wood, Kris C.
Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in human and mouse acute myeloid leukemia

剪接相关网络PAK1-CLK1/4-SRRM1是人类和小鼠急性髓系白血病克服化疗耐药的易感靶点

Science Translational Medicine
IF14.6
2026-07-080
PRE
Camille Vaganay; Frank Ling; Lois M. Kelly; Juliette Charles; Paul-Arthur Meslin; Hélène Pasquer; Rathana Kim; Marie Passet; Matthieu Duchmann; Léa Pelissier-Menjaud; Séverine Lecourt; Angela H. Su; Emmanuelle Latour; Christopher F. Bassil; Gabriela Alexe; Gael Fortin; Duong Ho Nhat; Cécile Culeux; Carine Legrand; Sofiane Fodil; Tony Huynh; Khansa Saadallah; Azucena Ramos; Bérangère Lombard; Damarys Loew; Christopher D. Delaney; Catherine Lonchamp; Morgane Fontaine; Kim Pacchiardi; Anja Kocijancic; Lisa Aziez; Nina Fenouille; Marie Sebert; Lionel Adès; Emmanuel Raffoux; Michael T. Hemann; Emmanuelle Clappier; Lina Benajiba; Kimberly Stegmaier; Kris C. Wood; Raphaël Itzykson; Antoine Forget; Camille Lobry; Alexandre Puissant
EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge

EGFR抑制剂抗性肺癌对一种共价、半胱氨酸非依赖性的KEAP1寡聚化分子桥具有交叉敏感性

Nature Communications
IF15.7
2026-01-140
OAAI
Christopher F. Bassil; Kerry Dillon; Gray R. Anderson; Benjamin Mayro; Kayleigh N. Askin; Peter S. Winter; Stefan Harry; Samuel Gruber; Tierney M. Hall; Jacob P. Hoj; Christian Cerda-Smith; Haley M. Hutchinson; Shane T. Killarney; Ava Heffernan; Caroline Teddy; Katherine R. Singleton; Li Qin; Kévin Jubien-Girard; Cécile Favreau; Guillaume Robert; Barr Tivon; Ella Livnah; Nir London; Rachid Benhida; Patrick Auberger; Ann Marie Pendergast; Liron Bar-Peled; David M. Lonard; Anthony R. Martin; Alexandre Puissant; Kris C. Wood
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia

通路共必需性分析显示，复合物II对于急性髓系白血病中的从头嘌呤生物合成是必需的。

Nature Metabolism
IF20.8
2025-12-050
OAAI
Amy E. Stewart; Derek K. Zachman; Pol Castellano-Escuder; Lois M. Kelly; Ben Zolyomi; Michael D. I. Aiduk; Christopher D. Delaney; Ian C. Lock; Claudie Bosc; John Bradley; Shane T. Killarney; J. Darren Stuart; Paul A. Grimsrud; Olga R. Ilkayeva; Christopher B. Newgard; Navdeep S. Chandel; Alexandre Puissant; Kris C. Wood; Matthew D. Hirschey
JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms

JAK2 抑制介导了骨髓增殖性肿瘤中 RAS 通路突变的克隆选择。

Nature Communications
IF15.7
2025-07-080
OAAI
Nabih Maslah; Nina Kaci; Blandine Roux; Gabriela Alexe; Raphael Marie; Hélène Pasquer; Emmanuelle Verger; Rafael Daltro De Oliveira; Cécile Culeux; Bochra Mlayah; Nicolas Gauthier; Fanny Gonzales; Lin-Pierre Zhao; Saravanan Ganesan; Panhong Gou; Frank Ling; Juliette Soret-Dulphy; Nathalie Parquet; William Vainchenker; Emmanuel Raffoux; Rose Ann Padua; Stéphane Giraudier; Caroline Marty; Isabelle Plo; Camille Lobry; Kimberly Stegmaier; Alexandre Puissant; Jean-Jacques Kiladjian; Bruno Cassinat; Lina Benajiba
Targeting a lineage-specific PI3Kγ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule

使用异双功能降解剂分子靶向急性髓性白血病中的谱系特异性PI3Kγ-Akt信号模块

NATURE CANCER
IF28.5
2024-05-302
PRE
Kelly, Lois M.; Rutter, Justine C.; Lin, Kevin H.; Ling, Frank; Duchmann, Matthieu; Latour, Emmanuelle; Arang, Nadia; Pasquer, Helene; Nhat, Duong Ho; Charles, Juliette; Killarney, Shane T.; Ang, Hazel X.; Namor, Federica; Culeux, Cecile; Lombard, Berangere; Loew, Damarys; Swaney, Danielle L.; Krogan, Nevan J.; Brunel, Luc; Carretero, Elodie; Verdie, Pascal; Amblard, Muriel; Fodil, Sofiane; Huynh, Tony; Sebert, Marie; Ades, Lionel; Raffoux, Emmanuel; Fenouille, Nina; Itzykson, Raphael; Lobry, Camille; Benajiba, Lina; Forget, Antoine; Martin, Anthony R.; Wood, Kris C.; Puissant, Alexandre
Favorable pharmacokinetic and pharmacodynamic properties of gilteritinib in cerebrospinal fluid: a potential effective treatment in relapsing meningeal acute myeloid leukemia FLT3-ITD patients
HAEMATOLOGICA
IF7.9
2023-02-165
OAAI
Vignal, Nicolas; Kelly, Lois; Lengline, Etienne; Cabannes-Hamy, Aurelie; Siavellis, Justine; Ghez, David; Sauvageon, Helene; Braun, Thorsten; Jacqz-Aigrain, Evelyne; Kohn, Milena; Rousselot, Philippe; Puissant, Alexandre; Raffoux, Emmanuel; Mourah, Samia; Goldwirt, Lauriane
Relative Mitochondrial Priming Predicts Survival in Older AML Patients Treated Intensively
HEMASPHERE
IF14.6
2023-01-013
OAAI
Dal Bello, Reinaldo; Pacchiardi, Kim; Chauvel, Clementine; Ades, Lionel; Braun, Thorsten; Pasanisi, Justine; Fournier, Elise; Berthon, Celine; Clappier, Emmanuelle; Raffoux, Emmanuel; Lebon, Delphine; Cluzeau, Thomas; Roumier, Christophe; Plesa, Adriana; Celli-Lebras, Karine; Dombret, Herve; Preudhomme, Claude; Mathis, Stephanie; Puissant, Alexandre; Gardin, Claude; Itzykson, Raphael
Hematopoietic differentiation at single-cell resolution in NPM1-mutated AML
BLOOD CANCER JOURNAL
IF11.6
2022-09-236
OAAI
Duchmann, Matthieu; Joudinaud, Romane; Boudry, Augustin; Pasanisi, Justine; Di Feo, Giuseppe; Kim, Rathana; Bucci, Maxime; Chauvel, Clementine; Chat, Laureen; Larcher, Lise; Pacchiardi, Kim; Mathis, Stephanie; Raffoux, Emmanuel; Ades, Lionel; Berthon, Celine; Clappier, Emmanuelle; Roumier, Christophe; Puissant, Alexandre; Preudhomme, Claude; Duployez, Nicolas; Itzykson, Raphael
A multiparametric niche-like drug screening platform in acute myeloid leukemia
BLOOD CANCER JOURNAL
IF11.6
2022-06-249
OAAI
Dal Bello, Reinaldo; Pasanisi, Justine; Joudinaud, Romane; Duchmann, Matthieu; Pardieu, Bryann; Ayaka, Paolo; Di Feo, Giuseppe; Sodaro, Gaetano; Chauvel, Clementine; Kim, Rathana; Vasseur, Loic; Chat, Laureen; Ling, Frank; Pacchiardi, Kim; Vaganay, Camille; Berrou, Jeannig; Benaksas, Chaima; Boissel, Nicolas; Braun, Thorsten; Preudhomme, Claude; Dombret, Herve; Raffoux, Emmanuel; Fenouille, Nina; Clappier, Emmanuelle; Ades, Lionel; Puissant, Alexandre; Itzykson, Raphael
P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia
NATURE CANCER
IF28.5
2022-06-0620
OA
Lin, Kevin H.; Rutter, Justine C.; Xie, Abigail; Killarney, Shane T.; Vaganay, Camille; Benaksas, Chaima; Ling, Frank; Sodaro, Gaetano; Meslin, Paul-Arthur; Bassil, Christopher F.; Fenouille, Nina; Hoj, Jacob; Washart, Rachel; Ang, Hazel X.; Cerda-Smith, Christian; Chaintreuil, Paul; Jacquel, Arnaud; Auberger, Patrick; Forget, Antoine; Itzykson, Raphael; Lu, Min; Lin, Jiaxing; Pierobon, Mariaelena; Sheng, Zhecheng; Li, Xinghai; Chilkoti, Ashutosh; Owzar, Kouros; Rizzieri, David A.; Pardee, Timothy S.; Benajiba, Lina; Petricoin, Emanuel; Puissant, Alexandre; Wood, Kris C.
Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia
LEUKEMIA
IF13.4
2022-04-2637
OA
Pardieu, Bryann; Pasanisi, Justine; Ling, Frank; Dal Bello, Reinaldo; Penneroux, Justine; Su, Angela; Joudinaud, Romane; Chat, Laureen; Wu, Hsin Chieh; Duchmann, Matthieu; Sodaro, Gaetano; Chauvel, Clementine; Castelli, Florence A.; Vasseur, Loic; Pacchiardi, Kim; Belloucif, Yannis; Laiguillon, Marie-Charlotte; Meduri, Eshwar; Vaganay, Camille; Alexe, Gabriela; Berrou, Jeannig; Benaksas, Chaima; Forget, Antoine; Braun, Thorsten; Gardin, Claude; Raffoux, Emmanuel; Clappier, Emmanuelle; Ades, Lionel; de The, Hugues; Fenaille, Francois; Huntly, Brian J.; Stegmaier, Kimberly; Dombret, Herve; Fenouille, Nina; Lobry, Camille; Puissant, Alexandre; Itzykson, Raphael

研究方向

暂未获取到该数据
P
Patrick Auberger
H 指数:60论文数:370被引数:2.6万
G
Guillaume Robert
H 指数:46论文数:348被引数:7,410
N
Nina Fenouille
H 指数:23论文数:143被引数:2,391
K
Kimberly Stegmaier
H 指数:64论文数:757被引数:2.2万
R
Raphaël Itzykson
H 指数:55论文数:415被引数:1.5万
A
Arnaud Jacquel
H 指数:40论文数:173被引数:4,713
G
Gabriela Alexe
H 指数:47论文数:402被引数:8,435
L
Lina Benajiba
H 指数:21论文数:183被引数:3,940
F
Frédéric Luciano
H 指数:37论文数:154被引数:1.5万
C
Christopher F. Bassil
H 指数:11论文数:81被引数:1,390