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D

David B. Sykes

mass general brigham cancer institute
H指数:41
被引数:6,691

个人简介

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荣誉奖项

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Shifting IRES versus Cap-initiated translation during homeostatic stem cell differentiation and stress

在稳态干细胞分化和应激过程中IRES与帽启动翻译的转换

Science Advances
IF12.5
2026-05-220
OA
Michael C. Mazzola; Ting Zhao; Anna Kiem; Trine A. Kristiansen; Karin Gustafsson; Lai Ping Wong; Emily Scott-Solomon; Marissa D. Fahlberg; Christina Mayerhofer; Ernst Mayerhofer; Sarah Forward; Emane Rose Assita; Giulia Schiroli; Maris Handley; Youmna Kfoury; Tsuyoshi Fukushima; Dan Li; Samuel Keyes; Azeem Sharda; Jelena Milosevic; Hiroki Kato; Pavel Ivanov; David B. Sykes; Sheldon J. J. Kwok; Ruslan I. Sadreyev; Vijay G. Sankaran; Ya-Chieh Hsu; David T. Scadden
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming

去抑制核内丙酮酸脱氢酶可诱导治疗性癌细胞重编程

Cell Metabolism
IF30.9
2025-06-110
PRE
Ting Zhao; Lingli He; Lai Ping Wong; Shenglin Mei; Jun Xia; Yanxin Xu; Jonathan G. Van Vranken; Michael Mazzola; Lei Chen; Catherine Rhee; Tiancheng Fang; Tsuyoshi Fukushima; Leanne C. Sayles; Matthew Diaz; J. Alex B. Gibbons; Raul Mostoslavsky; Steven P. Gygi; Zhixun Dou; David B. Sykes; Ruslan I. Sadreyev; E. Alejandro Sweet-Cordero; David T. Scadden
AML Stem Cell Clearance By Inhibiting Selenoprotein Biosynthesis That Causes Cgas-Sting Activation and Ferroptosis

通过抑制硒蛋白生物合成，引起Cgas-Sting激活和铁死亡，从而清除AML干细胞

BLOOD
IF23.1
2024-11-050
PRE
He, Lingli; Zhao, Ting; Leong, Wei Zhong; Sharda, Azeem; Mayerhofer, Christina; Mei, Shenglin; Bonilla, Gracia M.; Menendez-Gonzalez, Juan Bautista; Gustafsson, Karin; Fukushima, Tsuyoshi; Kristiansen, Trine A.; Lee, Ji-Won; Xu, Yanxin; Budnik, Bogdan; Sadreyev, Ruslan; Dou, Zhixun; Sykes, David B.; Scadden, David
Characterizing Thrombotic Risk in TEMPI Syndrome: A Retrospective Case Series

TEMPI综合征血栓风险特征的评估：一项回顾性病例系列研究

BLOOD
IF23.1
2024-11-050
PRE
Parker, Graham Blake; Cheng, Justin; Terriou, Louis; Strobl, Johanna; Iftikhar, Ayesha; Nappi, Davide; Pan, Meng; Sansen, Pierre-Yves; Diral, Elisa; Elli, Elena Maria; Schroyens, Wilfried A.; Sykes, David B.; O'Connell, Casey L.; O'Neill, Caitlin M.
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
DEVELOPMENTAL CELL
IF8.7
2024-08-011
OA
Do, Brian T.; Hsu, Peggy P.; Vermeulen, Sidney Y.; Wang, Zhishan; Hirz, Taghreed; Abbott, Keene L.; Aziz, Najihah; Replogle, Joseph M.; Bjelosevic, Stefan; Paolino, Jonathan; Nelson, Samantha A.; Block, Samuel; Darnell, Alicia M.; Ferreira, Raphael; Zhang, Hanyu; Milosevic, Jelena; Schmidt, Daniel R.; Chidley, Christopher; Harris, Isaac S.; Weissman, Jonathan S.; Pikman, Yana; Stegmaier, Kimberly; Cheloufi, Sihem; Su, Xiaofeng A.; Sykes, David B.; Vander Heiden, Matthew G.
DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

DHODH抑制通过增加癌细胞抗原呈递来增强免疫检查点阻断的功效

ELIFE
IF0
2024-07-083
OA
Mullen, Nicholas J.; Shukla, Surendra K.; Thakur, Ravi; Kollala, Sai Sundeep; Wang, Dezhen; Chaika, Nina; Santana, Juan F.; Miklavcic, William R.; Labreck, Drew A.; Mallareddy, Jayapal Reddy; Price, David H.; Natarajan, Amarnath; Mehla, Kamiya; Sykes, David B.; Hollingsworth, Michael A.; Singh, Pankaj K.
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing

亲环蛋白A支持内在无序蛋白质的翻译并影响造血干细胞的衰老

NATURE CELL BIOLOGY
IF19.1
2024-03-294
OA
Maneix, Laure; Iakova, Polina; Lee, Charles G.; Moree, Shannon E.; Lu, Xuan; Datar, Gandhar K.; Hill, Cedric T.; Spooner, Eric; King, Jordon C. K.; Sykes, David B.; Saez, Borja; Di Stefano, Bruno; Chen, Xi; Krause, Daniela S.; Sahin, Ergun; Tsai, Francis T. F.; Goodell, Margaret A.; Berk, Bradford C.; Scadden, David T.; Catic, Andre
Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic
JCI INSIGHT
IF6.1
2024-02-153
OA
Mei, Shenglin; Alchahin, Adele M.; Embaie, Bethel Tesfai; Gavriliuc, Ioana Maria; Verhoeven, Bronte Manouk; Zhao, Ting; Li, Xiangyun; Jeffries, Nathan Elias; Pepich, Adena; Sarkar, Hirak; Olsen, Thale Kristin; Wickstrom, Malin; Stenman, Jakob; Reina-Bedoya, Oscar; Kharchenko, Peter V.; Saylor, Philip J.; Johnsen, John Inge; Sykes, David B.; Kogner, Per; Baryawno, Ninib
The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG
NATURE COMMUNICATIONS
IF15.7
2023-09-212
OAAI
Kugler, Eitan; Madiwale, Shreyas; Yong, Darren; Thoms, Julie A. I.; Birger, Yehudit; Sykes, David B.; Schmoellerl, Johannes; Drakul, Aneta; Priebe, Valdemar; Yassin, Muhammad; Aqaqe, Nasma; Rein, Avigail; Fishman, Hila; Geron, Ifat; Chen, Chun-Wei; Raught, Brian; Liu, Qiao; Ogana, Heather; Liedke, Elisabeth; Bourquin, Jean-Pierre; Zuber, Johannes; Milyavsky, Michael; Pimanda, John; Prive, Gilbert G.; Izraeli, Shai

研究方向

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D
David T. Scadden
H 指数:124论文数:667被引数:6.7万
S
Shenglin Mei
H 指数:38论文数:200被引数:8,068
M
Michael K. Mansour
H 指数:38论文数:180被引数:7,877
J
Jelena Milosevic
H 指数:13论文数:46被引数:853
Y
Youmna Kfoury
H 指数:29论文数:76被引数:4,335
T
Taghreed Hirz
H 指数:13论文数:87被引数:2,539
R
Ruslan I. Sadreyev
H 指数:68论文数:402被引数:1.6万
P
Philip J. Saylor
H 指数:30论文数:205被引数:4,478
M
Mark P. Kamps
H 指数:49论文数:105被引数:1.0万
C
Chin‐Lee Wu
H 指数:76论文数:609被引数:2.8万