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D

David T. Scadden

Harvard University
H指数:124
被引数:6.7万

个人简介

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工作经历

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荣誉奖项

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Shifting IRES versus Cap-initiated translation during homeostatic stem cell differentiation and stress

在稳态干细胞分化和应激过程中IRES与帽启动翻译的转换

Science Advances
IF12.5
2026-05-220
OA
Michael C. Mazzola; Ting Zhao; Anna Kiem; Trine A. Kristiansen; Karin Gustafsson; Lai Ping Wong; Emily Scott-Solomon; Marissa D. Fahlberg; Christina Mayerhofer; Ernst Mayerhofer; Sarah Forward; Emane Rose Assita; Giulia Schiroli; Maris Handley; Youmna Kfoury; Tsuyoshi Fukushima; Dan Li; Samuel Keyes; Azeem Sharda; Jelena Milosevic; Hiroki Kato; Pavel Ivanov; David B. Sykes; Sheldon J. J. Kwok; Ruslan I. Sadreyev; Vijay G. Sankaran; Ya-Chieh Hsu; David T. Scadden
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity

间充质胸腺龛细胞促进成年胸腺的再生和T细胞免疫。

Nature Biotechnology
IF41.7
2025-10-300
PRE
Karin Gustafsson; Sergey Isaev; Kamdin Mirsanaye; Johanna Hofmann; Kameron A. Kooshesh; Ninib Baryawno; Anna Kiem; Nicolas Severe; Ting Zhao; Elizabeth W. Scadden; Joel A. Spencer; Christian Burns; Kumaran Akilan; Nikolaos Barkas; Hayalneh Gessessew; Konstantinos D. Kokkaliaris; Charles P. Lin; Peter V. Kharchenko; David T. Scadden
OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

OGFOD1通过调控蛋白质合成使急性髓系白血病（AML）具有化疗和营养应激抗性。

Cell Metabolism
IF30.9
2025-09-160
PRE
Christina Mayerhofer; Dan Li; Trine Kristiansen; Ernst Mayerhofer; Azeem Sharda; Giulia Schiroli; Karin Gustafsson; Lingli He; Michael Mazzola; Sam Keyes; Anna Kiem; Eve Crompton; Yanxin Xu; Sovannarith Korm; Zhixun Dou; Charles Vidoudez; Peter G. Miller; Nick van Gastel; Timothy A. Graubert; David T. Scadden
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming

去抑制核内丙酮酸脱氢酶可诱导治疗性癌细胞重编程

Cell Metabolism
IF30.9
2025-06-110
PRE
Ting Zhao; Lingli He; Lai Ping Wong; Shenglin Mei; Jun Xia; Yanxin Xu; Jonathan G. Van Vranken; Michael Mazzola; Lei Chen; Catherine Rhee; Tiancheng Fang; Tsuyoshi Fukushima; Leanne C. Sayles; Matthew Diaz; J. Alex B. Gibbons; Raul Mostoslavsky; Steven P. Gygi; Zhixun Dou; David B. Sykes; Ruslan I. Sadreyev; E. Alejandro Sweet-Cordero; David T. Scadden
AML Stem Cell Clearance By Inhibiting Selenoprotein Biosynthesis That Causes Cgas-Sting Activation and Ferroptosis

通过抑制硒蛋白生物合成，引起Cgas-Sting激活和铁死亡，从而清除AML干细胞

BLOOD
IF23.1
2024-11-050
PRE
He, Lingli; Zhao, Ting; Leong, Wei Zhong; Sharda, Azeem; Mayerhofer, Christina; Mei, Shenglin; Bonilla, Gracia M.; Menendez-Gonzalez, Juan Bautista; Gustafsson, Karin; Fukushima, Tsuyoshi; Kristiansen, Trine A.; Lee, Ji-Won; Xu, Yanxin; Budnik, Bogdan; Sadreyev, Ruslan; Dou, Zhixun; Sykes, David B.; Scadden, David
Modulating mRNA Translation Fidelity As a Novel Mechanism for AML Chemoresistance

调节mRNA翻译保真度作为一种AML化疗耐药的新机制

BLOOD
IF23.1
2024-11-050
PRE
Mayerhofer, Christina; Li, Dan; Kristiansen, Trine A.; Mayerhofer, Ernst; Sharda, Azeem; He, Lingli; Mazzola, Michael; Schiroli, Giulia; Gustafsson, Karin; Keyes, Sam; Kiem, Anna; Crompton, Eve; Xu, Yanxin; Dou, Zhixun; Vidoudez, Charles; Miller, Peter G.; Van Gastel, Nick; Scadden, David
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing

亲环蛋白A支持内在无序蛋白质的翻译并影响造血干细胞的衰老

NATURE CELL BIOLOGY
IF19.1
2024-03-294
OA
Maneix, Laure; Iakova, Polina; Lee, Charles G.; Moree, Shannon E.; Lu, Xuan; Datar, Gandhar K.; Hill, Cedric T.; Spooner, Eric; King, Jordon C. K.; Sykes, David B.; Saez, Borja; Di Stefano, Bruno; Chen, Xi; Krause, Daniela S.; Sahin, Ergun; Tsai, Francis T. F.; Goodell, Margaret A.; Berk, Bradford C.; Scadden, David T.; Catic, Andre
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate
CELL STEM CELL
IF20.4
2024-03-017
OA
Bonora, Massimo; Morganti, Claudia; van Gastel, Nick; Ito, Kyoko; Calura, Enrica; Zanolla, Ilaria; Ferroni, Letizia; Zhang, Yang; Jung, Yookyung; Sales, Gabriele; Martini, Paolo; Nakamura, Takahisa; Lasorsa, Francesco Massimo; Finkel, Toren; Lin, Charles P.; Zavan, Barbara; Pinton, Paolo; Georgakoudi, Irene; Romualdi, Chiara; Scadden, David T.; Ito, Keisuke
Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction
cardiovascular research
IF10.8
2023-12-054
OA
Zhang, Shuang; Paccalet, Alexandre; Rohde, David; Cremer, Sebastian; Hulsmans, Maarten; Lee, I-Hsiu; Mentkowski, Kyle; Grune, Jana; Schloss, Maximilian J.; Honold, Lisa; Iwamoto, Yoshiko; Zheng, Yi; Bredella, Miriam A.; Buckless, Colleen; Ghoshhajra, Brian; Thondapu, Vikas; van der Laan, Anja M.; Piek, Jan J.; Niessen, Hans W. M.; Pallante, Fabio; Carnevale, Raimondo; Perrotta, Sara; Carnevale, Daniela; Iborra-Egea, Oriol; Munoz-Guijosa, Christian; Galvez-Monton, Carolina; Bayes-Genis, Antoni; Vidoudez, Charles; Trauger, Sunia A.; Scadden, David T.; Swirski, Filip K.; Moskowitz, Michael A.; Naxerova, Kamila; Nahrendorf, Matthias

研究方向

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D
David B. Sykes
H 指数:41论文数:311被引数:6,673
N
Nicolas Sévère
H 指数:22论文数:67被引数:3,496
程
程涛
H 指数:71论文数:902被引数:2.5万
N
Ninib Baryawno
H 指数:18论文数:74被引数:3,570
Y
Youmna Kfoury
H 指数:29论文数:76被引数:4,323
F
François Mercier
H 指数:20论文数:95被引数:3,773
K
Karin Gustafsson
H 指数:18论文数:56被引数:2,749
B
Borja Sáez
H 指数:28论文数:96被引数:4,593
M
Matthias Nahrendorf
H 指数:119论文数:475被引数:5.1万
P
Peter V. Kharchenko
H 指数:80论文数:254被引数:3.7万