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Potent Activity of Duocarmyin- and Mmaf-Conjugated FLT3-Directed Antibody-Drug Conjugates Towards Acute Myeloid Leukemia Stem Cells in Vitro and In Vivo 杜卡米恩和MMAF偶联的FLT3靶向抗体药物偶联物对急性髓系白血病干细胞在体外的强效活性及在体内的活性 Able, Marina; Kasper, Marc-Andre; Vick, Binje; Schwach, Jonathan; Gao, Xiang; Schmitt, Saskia; Tizazu, Belay; Fischer, Amrei; Kuenzl, Sarah; Leilich, Marit; Mai, Isabelle; Ochtrop, Philipp; Stengl, Andreas; de Geus, Mark A. R.; von Bergwelt-Baildon, Michael; Schumacher, Dominik; Helma, Jonas; Goetze, Katharina S. S.; Jeremias, Irmela; Feuring, Michaela; Spiekermann, Karsten 分享 收藏
Combined proteomics and CRISPR-Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo Bahrami, Ehsan; Schmid, Jan Philipp; Jurinovic, Vindi; Becker, Martin; Wirth, Anna-Katharina; Ludwig, Romina; Kreissig, Sophie; Duque Angel, Tania Vanessa; Amend, Diana; Hunt, Katharina; Oellinger, Rupert; Rad, Roland; Frenz, Joris Maximilian; Solovey, Maria; Ziemann, Frank; Mann, Matthias; Vick, Binje; Wichmann, Christian; Herold, Tobias; Jayavelu, Ashok Kumar; Jeremias, Irmela 分享 收藏
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia 单细胞转录图谱指导car-t细胞治疗急性髓系白血病的开发 Gottschlich, Adrian; Thomas, Moritz; Gruenmeier, Ruth; Lesch, Stefanie; Rohrbacher, Lisa; Igl, Veronika; Briukhovetska, Daria; Benmebarek, Mohamed-Reda; Vick, Binje; Dede, Sertac; Mueller, Katharina; Xu, Tao; Dhoqina, Dario; Maerkl, Florian; Robinson, Sophie; Sendelhofert, Andrea; Schulz, Heiko; Umut, Oeykue; Kavaka, Vladyslav; Tsiverioti, Christina Angeliki; Carlini, Emanuele; Nandi, Sayantan; Strzalkowski, Thaddaeus; Lorenzini, Theo; Stock, Sophia; Mueller, Philipp Jie; Doerr, Janina; Seifert, Matthias; Cadilha, Bruno L.; Brabenec, Ruben; Roeder, Natalie; Rataj, Felicitas; Nueesch, Manuel; Modemann, Franziska; Wellbrock, Jasmin; Fiedler, Walter; Kellner, Christian; Beltran, Eduardo; Herold, Tobias; Paquet, Dominik; Jeremias, Irmela; von Baumgarten, Louisa; Endres, Stefan; Subklewe, Marion; Marr, Carsten; Kobold, Sebastian 分享 收藏
Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia (vol 36, pg 2396, 2022) Koschade, Sebastian E.; Klann, Kevin; Shaid, Shabnam; Vick, Binje; Stratmann, Jan A.; Tholken, Marlyn; Meyer, Laura M.; Nguyen, The Duy; Campe, Julia; Moser, Laura M.; Hock, Susanna; Baker, Fatima; Meyer, Christian T.; Wempe, Frank; Serve, Hubert; Ullrich, Evelyn; Jeremias, Irmela; Muench, Christian; Brandts, Christian H. 分享 收藏
Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia Koschade, Sebastian E.; Klann, Kevin; Shaid, Shabnam; Vick, Binje; Stratmann, Jan A.; Thoelken, Marlyn; Meyer, Laura M.; The Duy Nguyen; Campe, Julia; Moser, Laura M.; Hock, Susanna; Baker, Fatima; Meyer, Christian T.; Wempe, Frank; Serve, Hubert; Ullrich, Evelyn; Jeremias, Irmela; Muench, Christian; Brandts, Christian H. 分享 收藏
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Prime-seq, efficient and powerful bulk RNA sequencing Janjic, Aleksandar; Wange, Lucas E.; Bagnoli, Johannes W.; Geuder, Johanna; Nguyen, Phong; Richter, Daniel; Vieth, Beate; Vick, Binje; Jeremias, Irmela; Ziegenhain, Christoph; Hellmann, Ines; Enard, Wolfgang 分享 收藏
Adverse stem cell clones within a single patient's tumor predict clinical outcome in AML patients Zeller, Christina; Richter, Daniel; Jurinovic, Vindi; Valtierra-Gutierrez, Ilse A.; Jayavelu, Ashok Kumar; Mann, Matthias; Bagnoli, Johannes W.; Hellmann, Ines; Herold, Tobias; Enard, Wolfgang; Vick, Binje; Jeremias, Irmela 分享 收藏
Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation Lazaro-Navarro, Juan; Pimentel-Gutierrez, Helia Judith; Gauert, Anton; Hagemann, Anja I. H.; Eisenschmid, Jassi; Goekbuget, Nicola; Vick, Binje; Jeremias, Irmela; Seyfried, Felix; Meyer, Luder Hinrich; Debatin, Klaus-Michael; Richer, Kathrin; Bultman, Miriam; Neumann, Martin; Hanzelmann, Sonja; Serve, Hubert; Astrahantseff, Kathy; Rieger, Michael A.; Eckert, Cornelia; Baldus, Claudia D.; Bastian, Lorenz 分享 收藏
In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets Carlet, Michela; Volse, Kerstin; Vergalli, Jenny; Becker, Martin; Herold, Tobias; Arner, Anja; Senft, Daniela; Jurinovic, Vindi; Liu, Wen-Hsin; Gao, Yuqiao; Dill, Veronika; Fehse, Boris; Baldus, Claudia D.; Bastian, Lorenz; Lenk, Lennart; Schewe, Denis M.; Bagnoli, Johannes W.; Vick, Binje; Schmid, Jan Philipp; Wilhelm, Alexander; Marschalek, Rolf; Jost, Philipp J.; Miething, Cornelius; Riecken, Kristoffer; Schmidt-Supprian, Marc; Binder, Vera; Jeremias, Irmela 分享 收藏
SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells Tahk, Siret; Vick, Binje; Hiller, Bjoern; Schmitt, Saskia; Marcinek, Anetta; Perini, Enrico D.; Leutbecher, Alexandra; Augsberger, Christian; Reischer, Anna; Tast, Benjamin; Humpe, Andreas; Jeremias, Irmela; Subklewe, Marion; Fenn, Nadja C.; Hopfner, Karl-Peter 分享 收藏
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML Kempf, Julia M.; Weser, Sabrina; Bartoschek, Michael D.; Metzeler, Klaus H.; Vick, Binje; Herold, Tobias; Voelse, Kerstin; Mattes, Raphael; Scholz, Manuela; Wange, Lucas E.; Festini, Moreno; Ugur, Enes; Roas, Maike; Weigert, Oliver; Bultmann, Sebastian; Leonhardt, Heinrich; Schotta, Gunnar; Hiddemann, Wolfgang; Jeremias, Irmela; Spiekermann, Karsten 分享 收藏
BIFUNCTIONAL SIRPα-CD123 FUSION ANTIBODY FOR THE ELIMINATION OF ACUTE MYELOID LEUKEMIA STEM CELLS Tahk, S.; Schmitt, S. M.; Vick, B.; Augsberger, C.; Ponce, L. Pascual; Jeremias, I.; Wittmann, G.; Subklewe, M.; Fenn, N. C.; Hopfner, K. 分享 收藏
41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo Libero Baroni, Matteo; Sanchez Martinez, Diego; Gutierrez Aguera, Francisco; Roca Ho, Heleia; Castella, Maria; Zanetti, Samanta; Velasco Hernandez, Talia; Diaz de la Guardia, Rafael; Castano, Julio; Anguita, Eduardo; Vives, Susana; Nomdedeu, Josep; Lapillone, Helene; Bras, Anne E.; van der Velden, Vincent H. J.; Junca, Jordi; Marin, Pedro; Bataller, Alex; Esteve, Jordi; Vick, Binje; Jeremias, Irmela; Lopez, Angel; Sorigue, Marc; Bueno, Clara; Menendez, Pablo 分享 收藏
ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells Redondo Monte, Enric; Wilding, Anja; Leubolt, Georg; Kerbs, Paul; Bagnoli, Johannes W.; Hartmann, Luise; Hiddemann, Wolfgang; Chen-Wichmann, Linping; Krebs, Stefan; Blum, Helmut; Cusan, Monica; Vick, Binje; Jeremias, Irmela; Enard, Wolfgang; Theurich, Sebastian; Wichmann, Christian; Greif, Philipp A. 分享 收藏
Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice Ebinger, Sarah; Zeller, Christina; Carlet, Michela; Senft, Daniela; Bagnoli, Johannes W.; Liu, Wen-Hsin; Rothenberg-Thurley, Maja; Enard, Wolfgang; Metzeler, Klaus H.; Herold, Tobias; Spiekermann, Karsten; Vick, Binje; Jeremias, Irmela 分享 收藏
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade Ruzicka, Michael; Koenig, Lars M.; Formisano, Simone; Boehmer, Daniel F. R.; Vick, Binje; Heuer, Eva-M.; Meinl, Hanna; Kocheise, Lorenz; Zeitlhoefler, Marcus; Ahlfeld, Julia; Kobold, Sebastian; Endres, Stefan; Subklewe, Marion; Duewell, Peter; Schnurr, Max; Jeremias, Irmela; Lichtenegger, Felix S.; Rothenfusser, Simon 分享 收藏
Loss of KDM6A confers drug resistance in acute myeloid leukemia Stief, Sophie M.; Hanneforth, Anna-Li; Weser, Sabrina; Mattes, Raphael; Carlet, Michela; Liu, Wen-Hsin; Bartoschek, Michael D.; Moreno, Helena Dominguez; Oettle, Matthias; Kempf, Julia; Vick, Binje; Ksienzyk, Bianka; Tizazu, Belay; Rothenberg-Thurley, Maja; Quentmeier, Hilmar; Hiddemann, Wolfgang; Vosberg, Sebastian; Greif, Philipp A.; Metzeler, Klaus H.; Schotta, Gunnar; Bultmann, Sebastian; Jeremias, Irmela; Leonhardt, Heinrich; Spiekermann, Karsten 分享 收藏
Gold Nanoparticles with Selective Antileukemic Activity In Vitro and In Vivo Target Mitochondrial Respiration Gaiser, Ann-Kathrin; Hafner, Susanne; Schmiech, Michael; Buchele, Berthold; Schafer, Patrick; von Arnim, Christine A.; Calzia, Enrico; Feuring-Buske, Michaela; Buske, Christian; Vick, Binje; Jeremias, Irmela; Syrovets, Tatiana; Simmet, Thomas 分享 收藏
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