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Staggered immunization with mRNA vaccines encoding SARS- CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire 编码传染性非典型肺炎CoV-2聚合酶或刺突抗原的mRNA疫苗的交错预防接种扩大了T细胞表位库 Abt, Evan R.; Lam, Alex K.; Noguchi, Miyako; Rashid, Khalid; Mclaughlin, Jami; Teng, Pu - Lin; Tran, Wendy; Cheng, Donghui; Nesterenko, Pavlo A.; Mao, Zhiyuan; Creech, Amanda L.; Sojo, Giselle Burton; Jeyachandran, Arjit Vijey; Tam, Ying K.; Henley, Jill E.; Comai, Lucio; Pardi, Norbert; Arumugaswami, Vaithilingaraja; Witte, Owen N.; Radu, Caius G.; Wu, Ting- Ting 分享 收藏
Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice Taddio, Marco F.; Doshi, Suraj; Masri, Marwan; Jeanjean, Pauline; Hikmat, Firas; Gerlach, Alana; Nyiranshuti, Lea; Rosser, Ethan W.; Schaue, Dorthe; Besserer-Offroy, Elie; Carlucci, Giuseppe; Radu, Caius G.; Czernin, Johannes; Lueckerath, Katharina; Mona, Christine E. 分享 收藏
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Adenosine inhibits STING driven anti-tumor immunity in pancreatic cancer Premji, Alykhan; Link, Jason; Yamao, Takanobu; Rashid, Khalid; Abt, Evan; Labora, Amanda; Chan, Charlotte; Le, Thuc; Wainberg, Zev; Radu, Caius; Donahue, Timothy 分享 收藏
Inhibition of KrasG12D with a novel small molecule inhibitor alters the pancreatic cancer microenvironment Kemp, Samantha B.; Cheng, Noah; Markosyan, Nune; Sor, Rina; Kim, Il-Kyu; Hallin, Jill; Shoush, Jason; Quinones, Liz; Brown, Natalie; Bassett, Jared B.; Joshi, Nikhil; Yuan, Salina; Smith, Molly; Vostrejs, William P.; Perez-Vale, Kia Z.; Kahn, Benjamin; Mo, Feiyan; Donahue, Timothy R.; Radu, Caius G.; Clendenin, Cynthia; Christensen, James G.; Vonderheide, Robert H.; Stanger, Ben Z. 分享 收藏
Immune mechanisms underlie full therapeutic efficacy of a novel inhibitor of KrasG12D in mouse models of pancreatic ductal adenocarcinoma Cheng, Noah; Kemp, Samantha B.; Markosyan, Nune; Sor, Rina; Kim, Il-Kyu; Hallin, Jill; Shoush, Jason; Quinones, Liz; Brown, Natalie V.; Bassett, Jared B.; Joshi, Nikhil; Yuan, Salina; Smith, Molly; Vostrejs, William P.; Perez-Vale, Kia Z.; Kahn, Benjamin; Mo, Feiyan; Donahue, Timothy R.; Radu, Caius G.; Clendenin, Cynthia; Christensen, James G.; Vonderheide, Robert H.; Stanger, Ben Z. 分享 收藏
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Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2-deficiency Guantay, Maria L.; Garro, Cintia A.; Siri, Sebastian; Pansa, Maria; Ghidelli-Disse, Sonja; Paviolo, Natalia; Racca, Ana; Nicotra, Viviana; Radu, Caius; Bocco, Jose L.; Felice, Rosana; Gloger, Israel; Muelbaier, Marcel; Drewes, Gerard; Madauss, Kevin; Garcia, Manuela; Gottifredi, Vanesa; Soria, Gaston 分享 收藏
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency Guantay, Laura; Garro, Cintia; Siri, Sebastian; Pansa, Maria Florencia; Ghidelli-Disse, Sonja; Paviolo, Natalia; Racca, Ana; Nicotra, Viviana; Radu, Caius; Bocco, Jose Luis; Felice, Rosana; Jansson, Keith H.; Remlinger, Katja; Amador, Alejandro; Stronach, Euan; Coleman, Kevin; Muelbaier, Marcel; Drewes, Gerard; Gloger, Isro; Madauss, Kevin; Garcia, Manuela; Gottifredi, Vanesa; Soria, Gaston 分享 收藏
Immunization of Mice with Virus-Like Vesicles of Kaposi Sarcoma-Associated Herpesvirus Reveals a Role for Antibodies Targeting ORF4 in Activating Complement-Mediated Neutralization Lam, Alex K.; Roshan, Romin; Miley, Wendell; Labo, Nazzarena; Zhen, James; Kurland, Andrew P.; Cheng, Celine; Huang, Haigen; Teng, Pu-Lin; Harelson, Claire; Gong, Danyang; Tam, Ying K.; Radu, Caius G.; Epeldegui, Marta; Johnson, Jeffrey R.; Zhou, Z. Hong; Whitby, Denise; Wu, Ting-Ting 分享 收藏
Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer KrasG12D小分子抑制剂在胰腺癌免疫活性模型中的疗效 Kemp, Samantha B.; Cheng, Noah; Markosyan, Nune; Sor, Rina; Kim, Il-Kyu; Hallin, Jill; Shoush, Jason; Quinones, Liz; Brown, Natalie V.; Bassett, Jared B.; Joshi, Nikhil; Yuan, Salina; Smith, Molly; Vostrejs, William P.; Perez-Vale, Kia Z.; Kahn, Benjamin; Mo, Feiyan; Donahue, Timothy R.; Radu, Caius G.; Clendenin, Cynthia; Christensen, James G.; Vonderheide, Robert H.; Stanger, Ben Z. 分享 收藏
Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity Abt, Evan R.; Rashid, Khalid; Le, Thuc M.; Li, Suwen; Lee, Hailey R.; Lok, Vincent; Li, Luyi; Creech, Amanda L.; Labora, Amanda N.; Mandl, Hanna K.; Lam, Alex K.; Cho, Arthur; Rezek, Valerie; Wu, Nanping; Abril-Rodriguez, Gabriel; Rosser, Ethan W.; Mittelman, Steven D.; Hugo, Willy; Mehrling, Thomas; Bantia, Shanta; Ribas, Antoni; Donahue, Timothy R.; Crooks, Gay M.; Wu, Ting-Ting; Radu, Caius G. 分享 收藏
18F-FDG PET Visualizes Systemic STING Agonist-Induced Lymphocyte Activation in Preclinical Models Le, Thuc M.; Lee, Hailey R.; Abt, Evan R.; Rashid, Khalid; Creech, Amanda L.; Liang, Keke; Cui, Jing; Cho, Arthur; Wei, Liu; Labora, Amanda; Chan, Charlotte; Sanchez, Eric; Kriti, Kriti; Karin, Daniel; Li, Luyi; Wu, Nanping; Mona, Christine; Carlucci, Giuseppe; Hugo, Willy; Wu, Ting-Ting; Donahue, Timothy R.; Czernin, Johannes; Radu, Caius G. 分享 收藏
Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Pancreatic Cancer Aguilera, Kristina Y.; Le, Thuc; Riahi, Rana; Lay, Anna R.; Hinz, Stefan; Saadat, Edris A.; Vashisht, Ajay A.; Wohlschlegel, James; Donahue, Timothy R.; Radu, Caius G.; Dawson, David W. 分享 收藏
Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair Li, Shen; Yokota, Tomohiro; Wang, Ping; Hoeve, Johanna ten; Ma, Feiyang; Le, Thuc M.; Abt, Evan R.; Zhou, Yonggang; Wu, Rimao; Nanthavongdouangsy, Maxine; Rodriguez, Abraham; Wang, Yijie; Lin, Yen-Ju; Muranaka, Hayato; Sharpley, Mark; Braddock, Demetrios T.; MacRae, Vicky E.; Banerjee, Utpal; Chiou, Pei-Yu; Seldin, Marcus; Huang, Dian; Teitell, Michael; Gertsman, Ilya; Jung, Michael; Bensinger, Steven J.; Damoiseaux, Robert; Faull, Kym; Pellegrini, Matteo; Lusis, Aldons J.; Graeber, Thomas G.; Radu, Caius G.; Deb, Arjun 分享 收藏
Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells Abt, Evan R.; Le, Thuc M.; Dann, Amanda M.; Capri, Joseph R.; Poddar, Soumya; Lok, Vincent; Li, Luyi; Liang, Keke; Creech, Amanda L.; Rashid, Khalid; Kim, Woosuk; Wu, Nanping; Cui, Jing; Cho, Arthur; Lee, Hailey Rose; Rosser, Ethan W.; Link, Jason M.; Czernin, Johannes; Wu, Ting-Ting; Damoiseaux, Robert; Dawson, David W.; Donahue, Timothy R.; Radu, Caius G. 分享 收藏
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