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T

Tuna Mutis

Cancer Center Amsterdam
H指数:61
被引数:1.3万

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Dual targeting of BCMA and GPRC5D with the trispecific antibody ramantamig addresses antigenic heterogeneity in myeloma

双靶向BCMA和GPRC5D的trispecific antibody ramantamig解决了骨髓瘤中的抗原异质性

HemaSphere
IF14.6
2026-10-080
OAAI
Chloe O'Neill; Marloes E. C. Broekmans; Charlotte L. B. M. Korst; Maria Krevvata; Giada Dal Collo; Richard W. Groen; Bing Li; Serena R. Baglio; Ulrike Philippar; Kodandaram Pillarisetti; Sonja Zweegman; Deeksha Vishwamitra; Tuna Mutis; Niels W. C. J. van de Donk
Monocyte-mediated metabolic rewiring via CD31-CD38 interactions promotes growth and drug-resistance in multiple myeloma

单核细胞介导的代谢重编程通过CD31-CD38相互作用促进多发性骨髓瘤的生长和药物抗性

HemaSphere
IF14.6
2026-04-160
OAAI
Ramin Raoof; Giada Dal Collo; Helga Simon-Molas; Panagiota Tzortzi; Konxhe Kulaj; Elif N. Demirez; Crescenzo Massaro; Renée Poels; Charlotte L. B. M. Korst; Chloe A. O'Neill; Wassilis S. C. Bruins; Marloes E. C. Broekmans; Payam Behradkia; Maria Krevvata; Sonja Zweegman; Arnon P. Kater; Serena R. Baglio; Tuna Mutis; Niels W. C. J. van de Donk
Immune biomarkers of increased infection risk in multiple myeloma

多发性骨髓瘤中感染风险增加的免疫生物标志物

Blood
IF23.1
2026-04-011
PRE
Zabaleta, Aintzane; Tamariz-Amador, Luis-Esteban; V. Kostopoulos, Ioannis; Sklavenitis-Pistofidis, Romanos; Smits, Febe; Rodriguez-Otero, Paula; Roncal, Carmen; Aranha, Michelle P.; Zihala, David; Machu, Michaela; Tsakirakis, Nikolaos; Bakouros, Panagiotis; Tsitsilonis, Ourania; Solia, Irene; Moreno, Cristina; Maia, Catarina; Martin-Sanchez, Esperanza; Perez, Jose J.; Encinas, Cristina; Rios-Tamayo, Rafael; Oriol, Albert; Blanchard, Maria-Jesus; de Arriba, Felipe; Gonzalez, Maria-Esther; Lakhwani, Sunil; Sureda, Anna; Caban, Valentin; Escalante, Fernando; Carrillo-Cruz, Estrella; Perez-Montan, Albert; Ocio, Enrique M.; Bargay, Joan; Orfao, Alberto; Jelinek, Tomas; Ghobrial, Irene M.; Mutis, Tuna; Zweegman, Sonja; Terpos, Evangelos; Kastritis, Efstathios; Martinez-Lopez, Joaquin; Lahuerta, Juan-Jose; de Larrea, Carlos Fernandez; Rosin, Laura; Blade, Joan; Mateos, Maria-Victoria; San-Miguel, Jesus; Cedena, Maria-Teresa; Puig, Noemi; Paiva, Bruno
Pharmacokinetic and pharmacodynamic evaluation of alternative pomalidomide dosing regimens in the treatment of multiple myeloma

帕博利珠单抗替代给药方案在多发性骨髓瘤治疗中的药代动力学和药效动力学评价

British Journal of Haematology
IF3.8
2025-11-030
OAAI
M. R. Seefat; D. G. J. Cucchi; L. van Boven; N. Durdu-Rayman; K. Groen; M.-D. Levin; K. de Heer; B. de Valk; R. Wester; E. van der Spek; R. Rentenaar; C. L. B. M. Korst; M. Quik; C. A. O'Neill; P. Tzortzi; F. Smits; R. Mathot; M. R. Heerma van Voss; N. W. C. J. van de Donk; T. Mutis; I. H. Bartelink; S. Zweegman
Cytoskeletal dynamics and mitochondrial rearrangements drive cell fate upon antibody-induced complement activation in DLBCL

细胞骨架动力学和线粒体重排驱动弥漫大B细胞淋巴瘤中抗体诱导的补体激活后的细胞命运

Blood Cancer Journal
IF11.6
2025-10-060
OA
Hilma J. van der Horst; Tamás Csikós; Marjolein Quik; Jort J. van der Schans; Klaas de Lint; Gonzalo Nuñez Moreno; Meijian Guan; Kubra Karagoz; Esther C. W. Breij; Kim C. M. Santegoets; Martine E. D. Chamuleau; M. Guy Roukens; Marije B. Overdijk; Tuna Mutis
Immune signatures in older patients with newly diagnosed multiple myeloma are associated with survival outcomes of first-line therapy irrespective of frailty levels

老年新诊断多发性骨髓瘤患者的免疫特征与一线治疗的生存结局相关，且与脆弱性水平无关。

HemaSphere
IF14.6
2025-10-050
OAAI
Wassilis S. C. Bruins; Febe Smits; Carolien Duetz; Kazem Nasserinejad; Kazimierz Groen; Charlotte L. B. M. Korst; A. Vera de Jonge; Rosa Rentenaar; Tamara Hageman; Meliha Cosovic; Merve Eken; Inoka Twickler; Paola M. Homan-Weert; Christie P. M. Verkleij; Kristine Frerichs; Mark-David Levin; Ellen van der Spek; Inger S. Nijhof; Roel van Kampen; Niels W. C. J. van de Donk; Sonja Zweegman; Tuna Mutis
A T-cell-based metric of immune age predicts outcomes in elderly myeloma patients receiving daratumumab-based therapy

基于T细胞的免疫年龄指标可预测接受达雷木单抗为基础疗法的老年骨髓瘤患者的结局

Blood
IF23.1
2025-08-210
PRE
Wassilis S. C. Bruins; Febe Smits; Carolien Duetz; Kaz Groen; Charlotte L. B. M. Korst; A. Vera de Jonge; Christie P. M. Verkleij; Rosa Rentenaar; Meliha Cosovic; Merve Eken; Inoka Twickler; Paola M. Homan-Weert; Pieter Sonneveld; Philippe Moreau; Jürgen Claesen; Niels W. C. J. van de Donk; Sonja Zweegman; Tuna Mutis
Immunosuppressed Tumor Microenvironment in MYC-Rearranged High-Grade B-Cell Lymphomas Compared to Diffuse Large B-Cell Lymphomas, Not Otherwise Specified

MYC重排的高级别B细胞淋巴瘤与未特别指明的弥漫性大B细胞淋巴瘤相比的免疫抑制性肿瘤微环境

BLOOD
IF23.1
2024-11-050
PRE
De Jonge, A.; Noordenbos, Troy; De Groen, Ruben A. L.; De Groot, Fleur A.; De Haan-Treurniet, Lorraine M.; Jansen, Patty M.; Fu, Liping; de Heer, Koen; Klerk, Clara; Sandberg, Yorick; Fijnheer, Rob; Mutsaers, Pim; Beeker, Aart; Bohmer, Lara H.; Wang, Steven; Strobbe, Leonie; Boersma, Rinske; Oosterveld, Margriet; Koene, Harry R.; De Miranda, Noel; van den Berg, Anke; Nijland, Marcel; Roemer, Margaretha G. M.; Mutis, Tuna; Chamuleau, Martine E. D.; Vermaat, Joost S. P.
Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity
EBIOMEDICINE
IF10.8
2023-07-0111
OAAI
Hiemstra, Ida H.; Santegoets, Kim C. M.; Janmaat, Maarten L.; De Goeij, Bart E. C. G.; Ten Hagen, Wessel; van Dooremalen, Sanne; Boross, Peter; van den Brakel, Jeroen; Bosgra, Sieto; Andringa, Grietje; van Kessel-Welmers, Berris; Verzijl, Dennis; Hibbert, Richard G.; Frerichs, Kristine A.; Mutis, Tuna; van de Donk, Niels W. C. J.; Ahmadi, Tahamtan; Satijn, David; Sasser, A. Kate; Breij, Esther C. W.
NK Cell Phenotype Is Associated With Response and Resistance to Daratumumab in Relapsed/Refractory Multiple Myeloma
HEMASPHERE
IF14.6
2023-05-0117
OAAI
Verkleij, Christie P. M.; Frerichs, Kristine A.; Broekmans, Marloes E. C.; Duetz, Carolien; O'Neill, Chloe A.; Bruins, Wassilis S. C.; Homan-Weert, Paola M.; Minnema, Monique C.; Levin, Mark-David; Broijl, Annemiek; Bos, Gerard M. J.; Kersten, Marie Jose; Klein, Saskia K.; Shikhagaie, Medya M.; Casneuf, Tineke; Abraham, Yann; Smets, Tina; Vanhoof, Greet; Cortes-Selva, Diana; van Steenbergen, Laure; Ramos, Elena; Verona, Raluca I.; Krevvata, Maria; Sonneveld, Pieter; Zweegman, Sonja; Mutis, Tuna; van de Donk, Niels W. C. J.
Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

结合CAR和嵌合共刺激受体可增强T细胞对低抗原密度的敏感性并促进持久性

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2021-12-0862
OA
Katsarou, Afroditi; Sjostrand, Maria; Naik, Jyoti; Mansilla-Soto, Jorge; Kefala, Dionysia; Kladis, Georgios; Nianias, Alexandros; Ruiter, Ruud; Poels, Renee; Sarkar, Irene; Patankar, Yash R.; Merino, Elena; Reijmers, Rogier M.; Frerichs, Kristine A.; Yuan, Huipin; de Bruijn, Joost; Stroopinsky, Dina; Avigan, David; van de Donk, Niels W. C. J.; Zweegman, Sonja; Mutis, Tuna; Sadelain, Michel; Groen, Richard W. J.; Themeli, Maria
Efficacy and safety of daratumumab combined with all-trans retinoic acid in relapsed/refractory multiple myeloma

达雷妥尤单抗联合全反式维甲酸治疗复发/难治性多发性骨髓瘤的疗效和安全性

BLOOD ADVANCES
IF7.1
2021-12-0625
OAAI
Frerichs, Kristine A.; Minnema, Monique C.; Levin, Mark-David; Broijl, Annemiek; Bos, Gerard M. J.; Kersten, Marie Jose; Mutis, Tuna; Verkleij, Christie P. M.; Nijhof, Inger S.; Maas-Bosman, Patricia W. C.; Klein, Saskia K.; Zweegman, Sonja; Sonneveld, Pieter; van de Donk, Niels W. C. J.
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma

GPRC5DxCD3双特异性抗体talquetamab在多发性骨髓瘤中的临床前活性和反应决定因素

BLOOD ADVANCES
IF7.1
2021-04-23101
OA
Verkleij, Christie P. M.; Broekmans, Marloes E. C.; van Duin, Mark; Frerichs, Kristine A.; Kuiper, Rowan; de Jonge, A. Vera; Kaiser, Martin; Morgan, Gareth; Axel, Amy; Boominathan, Rengasamy; Sendecki, Jocelyn; Wong, Amy; Verona, Raluca, I; Sonneveld, Pieter; Zweegman, Sonja; Adams, Homer C., III; Mutis, Tuna; van de Donk, Niels W. C. J.

研究方向

暂未获取到该数据
N
Niels W.C.J. van de Donk
H 指数:78论文数:628被引数:2.5万
S
Sonja Zweegman
H 指数:87论文数:772被引数:3.2万
R
Richard W.J. Groen
H 指数:36论文数:197被引数:4,853
H
Hilma J. van der Horst
H 指数:10论文数:16被引数:404
A
Anton C. Martens
H 指数:39论文数:229被引数:7,443
H
H M Lokhorst
H 指数:45论文数:170被引数:6,233
E
Esther C.W. Breij
H 指数:24论文数:153被引数:3,056
J
Joost D. de Bruijn
H 指数:60论文数:238被引数:1.2万
K
Kristine A. Frerichs
H 指数:17论文数:40被引数:911
H
Huipin Yuan
H 指数:17论文数:62被引数:2,036