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E

Esther C.W. Breij

genmab b.v.
H指数:24
被引数:3,056

个人简介

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荣誉奖项

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Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity

六聚体抗体HexaBody-DR5/DR5在恶性实体瘤中的安全性与有效性：I/IIa期试验结果及对观察到肝毒性的转化医学见解

Clinical and Translational Science
IF2.8
2026-05-220
OAAI
Marije B. Overdijk; Kristin Strumane; Ruth Plummer; Patricia LoRusso; Jordi Rodon Ahnert; Udai Banerji; Elena Garralda; Emiliano Calvo; Han Si; Naomi Hoevenaars; Jens Thing Mortensen; Sieto Bosgra; Anders Malmberg; Merete Ellekilde-Pedersen; Teresa Ramirez-Andersen; Panagiota Diamantopoulou Reiter; Elena Favaro; Ulf Forssmann; Esther C. W. Breij; Maria Jure-Kunkel
Cytoskeletal dynamics and mitochondrial rearrangements drive cell fate upon antibody-induced complement activation in DLBCL

细胞骨架动力学和线粒体重排驱动弥漫大B细胞淋巴瘤中抗体诱导的补体激活后的细胞命运

Blood Cancer Journal
IF11.6
2025-10-060
OA
Hilma J. van der Horst; Tamás Csikós; Marjolein Quik; Jort J. van der Schans; Klaas de Lint; Gonzalo Nuñez Moreno; Meijian Guan; Kubra Karagoz; Esther C. W. Breij; Kim C. M. Santegoets; Martine E. D. Chamuleau; M. Guy Roukens; Marije B. Overdijk; Tuna Mutis
An Antibody-Drug Conjugate Directed to Tissue Factor Shows Preclinical Antitumor Activity in Head and Neck Cancer as a Single Agent and in Combination with Chemoradiotherapy

针对组织因子的抗体-药物缀合物作为单一药物并与放化疗联合在头颈癌中显示临床前抗肿瘤活性

MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-10-123
PRE
Bakema, Jantine E.; Stigter-van Walsum, Marijke; Harris, Jeffrey R.; Ganzevles, Sonja H.; Muthuswamy, Anantharaman; Houtkamp, Mischa; Plantinga, Theo S.; Bloemena, Elisabeth; Brakenhoff, Ruud H.; Breij, Esther C. W.; van de Ven, Rieneke
Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity
EBIOMEDICINE
IF10.8
2023-07-0111
OAAI
Hiemstra, Ida H.; Santegoets, Kim C. M.; Janmaat, Maarten L.; De Goeij, Bart E. C. G.; Ten Hagen, Wessel; van Dooremalen, Sanne; Boross, Peter; van den Brakel, Jeroen; Bosgra, Sieto; Andringa, Grietje; van Kessel-Welmers, Berris; Verzijl, Dennis; Hibbert, Richard G.; Frerichs, Kristine A.; Mutis, Tuna; van de Donk, Niels W. C. J.; Ahmadi, Tahamtan; Satijn, David; Sasser, A. Kate; Breij, Esther C. W.
Antibodies as drugs-a Keystone Symposia report
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
IF4.8
2022-11-163
OA
Cable, Jennifer; Saphire, Erica Ollmann; Hayday, Adrian C.; Wiltshire, Timothy D.; Mousa, Jarrod J.; Humphreys, David P.; Breij, Esther C. W.; Bruhns, Pierre; Broketa, Matteo; Furuya, Genta; Hauser, Blake M.; Mahevas, Matthieu; Carfi, Andrea; Cantaert, Tineke; Kwong, Peter D.; Tripathi, Prabhanshu; Davis, Jonathan H.; Brewis, Neil; Keyt, Bruce A.; Fennemann, Felix L.; Dussupt, Vincent; Sivasubramanian, Arvind; Kim, Philip M.; Rawi, Reda; Richardson, Eve; Leventhal, Daniel; Wolters, Rachael M.; Geuijen, Cecile A. W.; Sleeman, Matthew A.; Pengo, Niccolo; Donnellan, Francesca Rose
Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

靶向PD-L1和4-1BB (GEN1046) 的双特异性抗体在晚期难治性实体瘤患者中的临床前特征和I期试验结果

CANCER DISCOVERY
IF33.3
2022-02-1761
OAAI
Muik, Alexander; Garralda, Elena; Altintas, Isil; Gieseke, Friederike; Geva, Ravit; Ben-Ami, Eytan; Maurice-Dror, Corinne; Calvo, Emiliano; LoRusso, Patricia M.; Alonso, Guzman; Rodriguez-Ruiz, Maria E.; Schoedel, Kristina B.; Blum, Jordan M.; Sanger, Bianca; Salcedo, Theodora W.; Burm, Saskia M.; Stanganello, Eliana; Verzijl, Dennis; Vascotto, Fulvia; Sette, Angelica; Quinkhardt, Juliane; Plantinga, Theo S.; Toker, Aras; van den Brink, Edward N.; Fereshteh, Mark; Diken, Mustafa; Satijn, David; Kreiter, Sebastian; Breij, Esther C. W.; Bajaj, Gaurav; Lagkadinou, Eleni; Sasser, Kate; Tureci, Ozlem; Forssmann, Ulf; Ahmadi, Tahamtan; Sahin, Ugur; Jure-Kunkel, Maria; Melero, Ignacio
Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism
MOLECULAR CANCER THERAPEUTICS
IF5.5
2020-10-0240
OAAI
Overdijk, Marije B.; Strumane, Kristin; Beurskens, Frank J.; Buijsse, Antonio Ortiz; Vermot-Desroches, Claudine; Vuillermoz, Boris S.; Kroes, Thessa; de Jong, Bart; Hoevenaars, Naomi; Hibbert, Richard G.; Lingnau, Andreas; Forssmann, UIf; Schuurman, Janine; Parren, Paul W. H., I; de Jong, Rob N.; Breij, Esther C. W.
Multifaceted mechanism of action of DuoHexaBody-CD37 involves both complement- and Fc gamma receptor-mediated cytotoxicity in pre-clinical B-cell lymphoma models
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Kil, Laurens P.; Oostindie, Simone C.; Strumane, Kristin; van der Horst, Hilma J.; van Kessel, Berris; Overdijk, Marije B.; Lingnau, Andreas; Brandhorst, Marcel; van den Brakel, Jeroen; Lindorfer, Margaret A.; Taylor, Ronald P.; Chamuleau, Martine E.; Mutis, Tuna; Sasser, A. Kate; Schuurman, Janine; Parren, Paul W.; Beurskens, Frank J.; Breij, Esther C.
DuoHexaBody-CD37(R), a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies
BLOOD CANCER JOURNAL
IF11.6
2020-04-2847
OAAI
Oostindie, Simone C.; van der Horst, Hilma J.; Kil, Laurens P.; Strumane, Kristin; Overdijk, Marije B.; van den Brink, Edward N.; van den Brakel, Jeroen H. N.; Rademaker, Hendrik J.; van Kessel, Berris; van den Noort, Juliette; Chamuleau, Martine E. D.; Mutis, Tuna; Lindorfer, Margaret A.; Taylor, Ronald P.; Schuurman, Janine; Parren, Paul W. H. I.; Beurskens, Frank J.; Breij, Esther C. W.
DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing
EBIOMEDICINE
IF10.8
2020-02-0196
OAAI
Engelberts, Patrick J.; Hiemstra, Ida H.; de Jong, Bart; Schuurhuis, Danita H.; Meesters, Joyce; Hernandez, Irati Beltran; Oostindie, Simone C.; Neijssen, Joost; van den Brink, Edward N.; Horbach, G. Jean; Verploegen, Sandra; Labrijn, Aran F.; Salcedo, Theodora; Schuurman, Janine; Parren, Paul W. H., I; Breij, Esther C. W.

研究方向

暂未获取到该数据
P
Paul W.H.I. Parren
H 指数:96论文数:474被引数:3.1万
J
Janine Schuurman
H 指数:46论文数:167被引数:9,407
M
Marije B. Overdijk
H 指数:20论文数:81被引数:2,106
F
Frank J. Beurskens
H 指数:35论文数:110被引数:5,793
D
David Satijn
H 指数:26论文数:98被引数:3,683
T
Tuna Mutis
H 指数:61论文数:344被引数:1.3万
A
Andreas Lingnau
H 指数:15论文数:58被引数:1,033
K
Kristin Strumane
H 指数:16论文数:69被引数:2,585
M
Martine E.D. Chamuleau
H 指数:27论文数:227被引数:3,084
H
Hilma J. van der Horst
H 指数:10论文数:16被引数:404