Howard A. Rockman - Publications, H-index & Citations

Howard A. Rockman

duke university

79H指数

273论文数

2.3W被引数

收录论文 133

发表时间

A positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia β1AR的正性别构调节剂，具有儿茶酚胺敏感性多形性室性心动过速的拮抗活性

Journal of Clinical Investigation

IF13.6

2025-12-15

OAAI

Grogan, Alyssa; Perelli, Robin M.; Ahn, Seungkirl; Jiang, Haoran; Jyothidasan, Arun; Sood, Damini; You, Chongzhao; Israel, David I.; Shaginian, Alex; Chen, Qiuxia; Liu, Jian; Wang, Jialu; Steyaert, Jan; Kahsai, Alem W.; Landstrom, Andrew P.; Lefkowitz, Robert J.; Rockman, Howard A.

Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation 肾上腺素能高敏性驱动 Plexin 介导的心脏神经支配丧失后的室性心律失常

JACC: Clinical Electrophysiology

IF0

2025-10-02

PREAI

Ching Zhu; Takako Makita; Emilio Y. Lucero; Arun Jyothidasan; Rhea Patel; Jessica J. Wang; Yang Cao; Howard A. Rockman; Kalyanam Shivkumar

SNORD3A: a new possible circulating biomarker of human heart failure

EUROPEAN HEART JOURNAL

IF35.6

2024-10-28

PREAI

Polese, P.; Paolillo, R.; Schiattarella, G. G.; D'apice, S.; Cattaneo, F.; Lee Holley, C.; Prevete, N.; Della Corte, A.; Bancone, C.; Ioele, D.; Carotenuto, M.; Watson, M.; Esposito, G.; Rockman, H.; Perrino, C.

Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways

SCIENCE SIGNALING

IF6.6

2024-08-13

OAAI

Gareri, Clarice; Pfeiffer, Conrad T.; Jiang, Xue; Paulo, Joao A.; Gygi, Steven P.; Pham, Uyen; Chundi, Anand; Wingler, Laura M.; Staus, Dean P.; Stepniewski, Tomasz Maciej; Selent, Jana; Lucero, Emilio Y.; Grogan, Alyssa; Rajagopal, Sudarshan; Rockman, Howard A.

G Protein-Coupled Receptors: A Century of Research and Discovery

CIRCULATION RESEARCH

IF16.2

2024-06-21

PREAI

Liu, Samuel; Anderson, Preston J.; Rajagopal, Sudarshan; Lefkowitz, Robert J.; Rockman, Howard A.

Antibodies expand the scope of angiotensin receptor pharmacology

NATURE CHEMICAL BIOLOGY

IF13.7

2024-05-14

PREAI

Skiba, Meredith A.; Sterling, Sarah M.; Rawson, Shaun; Zhang, Shuhao; Xu, Huixin; Jiang, Haoran; Nemeth, Genevieve R.; Gilman, Morgan S. A.; Hurley, Joseph D.; Shen, Pengxiang; Staus, Dean P.; Kim, Jihee; McMahon, Conor; Lehtinen, Maria K.; Rockman, Howard A.; Barth, Patrick; Wingler, Laura M.; Kruse, Andrew C.

G protein-coupled receptors: from radioligand binding to cellular signaling

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2024-03-01

OAAI

Rockman, Howard A.; Lefkowitz, Robert J.

How carvedilol does not activate β2-adrenoceptors 卡维地洛如何不激活 β2-肾上腺素受体

NATURE COMMUNICATIONS

IF15.7

2023-11-30

OAAI

Lefkowitz, Robert J.; Rockman, Howard A.; Shim, Paul J.; Liu, Samuel; Ahn, Seungkirl; Pani, Biswaranjan; Rajagopal, Sudarshan; Shenoy, Sudha K.; Bouvier, Michel; Benovic, Jeffrey L.; Liggett, Stephen B.; Ruffolo, Robert R.; Bristow, Michael R.; Packer, Milton

β-arrestins Mediate Cardiac Infiltration of Cytotoxic CD8+T Cells and Macrophages in Acute CVB3 Viral Myocarditis

CIRCULATION

IF38.6

2023-11-07

PREAI

Rojas, Emilio Y. Lucero Garcia; Jiang, Haoran; D'Anniballe, Vincent; Galtes, Daniella; Grogan, Alyssa; Han, Soonbo D.; Rockman, Howard A.

A Novel Allosteric Modulator Of The ß 1AR Identified By DNA-encoded Small Molecule Library Screening Demonstrates Unique Pharmacology And Function

CIRCULATION RESEARCH

IF16.2

2023-08-04

PREAI

Grogan, Alyssa; Ahn, Seungkirl; Israel, David; Shaginian, Alex; Chen, Qiuxia; Liu, Jian; Wilkey, Max; Wang, Jialu; Kahsai, Alem; Lefkowitz, Robert J.; Rockman, Howard A.

G protein-coupled receptor signaling: transducers and effectors

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2022-09-01

OAAI

Jiang, Haoran; Galtes, Daniella; Wang, Jialu; Rockman, Howard A.

β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection Β-抑制蛋白偏向性变构调节剂增强卡维地洛刺激的 β 肾上腺素能受体的心脏保护作用

MOLECULAR PHARMACOLOGY

IF3

2021-12-01

OAAI

Wang, Jialu; Pani, Biswaranjan; Gokhan, Ilhan; Xiong, Xinyu; Kahsai, Alem W.; Jiang, Haoran; Ahn, Seungkirl; Lefkowitz, Robert J.; Rockman, Howard A.

Mapping Angiotensin II Type 1 Receptor-Biased Signaling Using Proximity Labeling and Proteomics Identifies Diverse Actions of Biased Agonists 使用邻近标记和蛋白质组学绘制血管紧张素II 1型受体偏向信号，确定偏向激动剂的多种作用

JOURNAL OF PROTEOME RESEARCH

IF3.6

2021-05-05

OAAI

Pfeiffer, Conrad T.; Wang, Jialu; Paulo, Joao A.; Jiang, Xue; Gygi, Steven P.; Rockman, Howard A.

Synthetic nanobodies as angiotensin receptor blockers 合成纳米抗体作为血管紧张素受体阻滞剂

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-08-04

OAAI

McMahon, Conor; Staus, Dean P.; Wingler, Laura M.; Wang, Jialu; Skiba, Meredith A.; Elgeti, Matthias; Hubbell, Wayne L.; Rockman, Howard A.; Kruse, Andrew C.; Lefkowitz, Robert J.

Development of β-arrestin-biased Positive Allosteric Modulators for the β1 Adrenergic Receptor

CIRCULATION RESEARCH

IF16.2

2020-07-31

PREAI

Wang, Jialu; Gokhan, Ilhan; Xiong, Xinyu; Kahsai, Alem W.; Jiang, Haoran; Pfeiffer, Conrad T.; Tian, William; Pani, Biswaranjan; Ahn, Seungkirl; Lefkowitz, Robert J.; Rockman, Howard A.

β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19

CIRCULATION

IF38.6

2020-07-28

OAAI

Manglik, Aashish; Wingler, Laura M.; Rockman, Howard A.; Lefkowitz, Robert J.

The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility Β-抑制蛋白偏向性 β-肾上腺素能受体阻滞剂卡维地洛增强骨骼肌收缩力

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-05-15

OAAI

Kim, Jihee; Grotegut, Chad A.; Wisler, James W.; Mao, Lan; Rosenberg, Paul B.; Rockman, Howard A.; Lefkowitz, Robert J.

The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling 去泛素酶泛素特异性蛋白酶20是心肌 β1-肾上腺素能受体表达和信号传导的正调节剂

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-02-01

OAAI

Yu, Samuel Mon-Wei; Jean-Charles, Pierre-Yves; Abraham, Dennis M.; Kaur, Suneet; Gareri, Clarice; Mao, Lan; Rockman, Howard A.; Shenoy, Sudha K.

The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2018-10-02

OAAI

Abraham, Dennis M.; Lee, Teresa E.; Watson, Lewis J.; Mao, Lan; Chandok, Gurangad; Wang, Hong-Gang; Frangakis, Stephan; Pitt, Geoffrey S.; Shah, Svati H.; Wolf, Matthew J.; Rockman, Howard A.

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 用siRNA和CRISPR/Cas9阐明 β-arrestins在GPCR信号传导中的多重作用

SCIENCE SIGNALING

IF6.6

2018-09-25

168

OAAI

Luttrell, Louis M.; Wang, Jialu; Plouffe, Bianca; Smith, Jeffrey S.; Yamani, Lama; Kaur, Suneet; Jean-Charles, Pierre-Yves; Gauthier, Christophe; Lee, Mi-Hye; Pani, Biswaranjan; Kim, Jihee; Ahn, Seungkirl; Rajagopal, Sudarshan; Reiter, Eric; Bouvier, Michel; Shenoy, Sudha K.; Laporte, Stephane A.; Rockman, Howard A.; Lefkowitz, Robert J.

研究方向