John F. Engelhardt - Publications, H-index & Citations

John F. Engelhardt

University of Alabama at Birmingham

95H指数

432论文数

3.1W被引数

收录论文 201

发表时间

CFTR facilitates fluid secretion by ferret alveolar type 2 cells 囊性纤维化跨膜电导调节因子通过促进肺泡II型细胞分泌液体

Journal of Cystic Fibrosis

IF6

2026-05-15

PREAI

Liyuan Yang; Changfu Yao; Javahir Hajibabazade; Yabo Ma; Katherine Drake; Oluwadarasimi Atanda; Zheqing Hu; Barry R. Stripp; Xiaoming Liu; John F Engelhardt

Research updates in cystic fibrosis related diabetes: Understanding pathophysiology, expanding animal and human islet models, and advancing clinical and translational research 囊性纤维化相关糖尿病研究进展：理解发病机制、扩展动物和人类胰岛模型以及推进临床和转化研究

Journal of Cystic Fibrosis

IF6

2026-04-05

PREAI

Melissa S. Putman; Rebecca L. Hull-Meichle; Shafagh A. Waters; Katherine Tuggle; Paula Sommer; Rebecca Conway; Lee A. Borthwick; Jakob G. Knudsen; E.Danielle Dean; Sarah A. Stanley; Xingshen Sun; John F. Engelhardt; Shih-Hsing Leir; Lena Eliasson; Bibi Uhre Nielsen; Darko Stefanovski; Amanda Brennan; Charlotte K. Boughton; Andrea Kelly; Amir Moheet

Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung 氨基酸衍生的可电离脂质使吸入的碱基编辑能够在肺部进行治疗性基因校正

Nature Materials

IF38.5

2026-04-01

PREAI

Fanglin Gong; Yue Xu; Jingan Chen; Shun Zhang; Songtao Dong; Lauren Healy; Breanna Seto; Muye Zhou; Rick Xing Ze Lu; Gen Li; Tyler Thomson; Yinghua Tang; Ziyan Chen; Krista Antonio; Andrew Varley; David X. W. Chen; Craig A. Hodges; Amy P. Wong; Jim Hu; Basil P. Hubbard; John F. Engelhardt; Ziying Yan; Bowen Li

LUNAR® LNP delivery of CFTR mRNA restores channel function and improves mucociliary clearance in human and ferret cystic fibrosis airways LUNAR® LNP递送CFTR mRNA可恢复人源和雪貂囊性纤维化气道中的通道功能并改善黏液纤毛清除能力

Molecular Therapy

IF12

2025-12-24

PREAI

Xiaoming Liu; Javier Campos-Gomez; Meihui Luo; Jia Ma; Han-Chung Chen; Sourabh Shukla; Shuang Wu; Guy Snow; Yihua Pei; Stefen A. Boehme; David E. Geller; Steve M. Rowe; John F. Engelhardt

Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis 博莱霉素诱导的肺损伤雪貂模型与人类特发性肺纤维化具有共同特征

npj Regenerative Medicine

IF6.5

2025-11-21

OAAI

Shuang Wu; Ian Driver; Meihui Luo; Hikaru Miyazaki; Smitha Shambhu; Dimitry Popov; Liyuan Yang; Jing Wang; Jia Ma; Junfeng Guo; Jarron Atha; Aleksandra Tata; Eric A. Hoffman; Yujiong Wang; Purushothama Rao Tata; Martin B. Jensen; John F. Engelhardt; Vishwaraj Sontake; Xiaoming Liu

PRenatal mOdulator treatment to PrEvent CF complicaTions (PROTECT) workshop report PRenatal mOdulator治疗以预防CF并发症 (PROTECT) 工作坊报告

Journal of Cystic Fibrosis

IF6

2025-08-05

OAAI

Sylvia Szentpetery; Dara Riva; Yair J. Blumenfeld; John F. Engelhardt; Carmen Luna-Paredes; Carlos Milla; Elena K. Schneider-Futschik; Jeanne S Sheffield; Rebecca Darrah; Jane C. Davies; Patrick A Flume; Kimberly E Foil; Christopher N. Fortner; Jennifer S. Guimbellot; Anne D. Lyerly; Nicole Mayer-Hamblett; Clement L. Ren; Jacquelyn Spano; Emma M. Tillman; Aaron Trimble; Benjamin S. Wilfond; Jennifer L. Taylor-Cousar

Recombinant Adeno-Associated Virus Vector Mediated Gene Editing in Proliferating and Polarized Cultures of Human Airway Epithelial Cells 重组腺相关病毒载体介导的人气道上皮细胞增殖和极化培养中的基因编辑

gene therapy

IF4

2025-08-04

PREAI

Soo Yeun Park; Zehua Feng; Soon H. Choi; Xiujuan Zhang; Yinghua Tang; Grace N. Gasser; Donovan Richart; Feng Yuan; Jianming Qiu; John F. Engelhardt; Ziying Yan

Novel Cystic Fibrosis Ferret Model Enables Visualization of CFTR Expression Cells and Genetic CFTR Reactivation 新型囊性纤维化雪貂模型实现了CFTR表达细胞的可视化及遗传性CFTR再激活

gene therapy

IF4

2025-01-10

PREAI

Feng Yuan; Xingshen Sun; Soo Yeun Park; Yinghua Tang; Zehua Feng; Mehrnoosh Ebadi; Yaling Yi; Adriane E. Thompson; Joseph D. Karippaparambil; John F. Engelhardt; Ziying Yan

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy 人工智能引导下用于肺部基因治疗的脂质纳米粒设计

NATURE BIOTECHNOLOGY

IF41.7

2024-12-10

PREAI

Witten, Jacob; Raji, Idris; Manan, Rajith S.; Beyer, Emily; Bartlett, Sandra; Tang, Yinghua; Ebadi, Mehrnoosh; Lei, Junying; Nguyen, Dien; Oladimeji, Favour; Jiang, Allen Yujie; Macdonald, Elise; Hu, Yizong; Mughal, Haseeb; Self, Ava; Collins, Evan; Yan, Ziying; Engelhardt, John F.; Langer, Robert; Anderson, Daniel G.

In utero and postnatal ivacaftor/ lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets

JCI INSIGHT

IF6.1

2024-04-22

OAAI

Evans, Idil Apak; Sun, Xingshen; Liang, Bo; Vegter, Amber R.; Guo, Lydia; Lynch, Thomas J.; Zhang, Yan; Zhang, Yulong; Yi, Yaling; Yang, Yu; Feng, Zehua; Park, Soo Yeun; Shonka, Amanita; McCumber, Hannah; Qi, Lisi; Wu, Peipei; Liu, Guangming; Lacina, Allison; Wang, Kai; Gibson-Corley, Katherine N.; Meyerholz, David K.; Limoli, Dominique H.; Rosen, Bradley H.; Yan, Ziying; Bartels, Douglas J.; Engelhardt, John F.

Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IF19.4

2023-11-01

OAAI

Wang, Shan; Niroula, Suchan; Hoffman, Ashley; Khorrami, Melika; Khorrami, Melina; Yuan, Feng; Gasser, Grace N.; Choi, Soon; Liu, Bovey; Li, Justin; Metersky, Mark L.; Vincent, Matthew; Crum, Christopher P.; Boucher, Richard C.; Karmouty-Quintana, Harry; Huang, Howard J.; Sheshadri, Ajay; Dickey, Burton F.; Parekh, Kalpaj R.; Engelhardt, John F.; McKeon, Frank D.; Xian, Wa

Understanding and addressing the needs of people with cystic fibrosis in the era of CFTR modulator therapy

LANCET RESPIRATORY MEDICINE

IF32.8

2023-10-01

PREAI

Hisert, Katherine B.; Birket, Susan E.; Clancy, John Paul; Downey, Damian G.; Engelhardt, John F.; Fajac, Isabelle; Gray, Robert D.; Lachowicz-Scroggins, Marrah E.; Mayer-Hamblett, Nicole; Thibodeau, Patrick; Tuggle, Katherine L.; Wainwright, Claire E.; De Boeck, Kris

Sonic Hedgehog Signaling Is Essential for Pulmonary Ionocyte Specification in Human and Ferret Airway Epithelia

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2023-09-01

OAAI

Cai, Qian; Luo, Meihui; Tang, Yinghua; Yu, Miao; Yuan, Feng; Gasser, Grace N.; Liu, Xiaoming; Engelhardt, John F.

Orthotopic Ferret Tracheal Transplantation Using a Recellularized Bioengineered Graft Produces Functional Epithelia

BIOENGINEERING-BASEL

IF3.7

2023-06-29

OAAI

Pai, Albert C. C.; Swatek, Anthony M.; Lynch, Thomas J.; Ahlers, Bethany A.; Ievlev, Vitaly; Engelhardt, John F.; Parekh, Kalpaj R.

Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes

DIABETES

IF7.5

2023-05-01

OAAI

Putman, Melissa S.; Norris, Andrew W.; Hull, Rebecca L.; Rickels, Michael R.; Sussel, Lori; Blackman, Scott M.; Chan, Christine L.; Ode, Katie Larson; Daley, Tanicia; Stecenko, Arlene A.; Moran, Antoinette; Helmick, Meagan J.; Cray, Sharon; Alvarez, Jessica A.; Stallings, Virginia A.; Tuggle, Katherine L.; Clancy, John P.; Eggerman, Thomas L.; Engelhardt, John F.; Kelly, Andrea

Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2023-04-26

OAAI

Wang, Shan; Rao, Wei; Hoffman, Ashley; Lin, Jennifer; Li, Justin; Lin, Tao; Liew, Audrey-Ann; Vincent, Matthew; Mertens, Tinne C. J.; Karmouty-Quintana, Harry; Crum, Christopher P.; Metersky, Mark L.; Schwartz, David A.; Davies, Peter J. A.; Stephan, Clifford; Jyothula, Soma S. K.; Sheshadri, Ajay; Suarez, Erik Eddie; Huang, Howard J.; Engelhardt, John F.; Dickey, Burton F.; Parekh, Kalpaj R.; McKeon, Frank D.; Xian, Wa

Development and characterization of ferret ex vivo tracheal injury and cell engraftment model

FRONTIERS IN MEDICINE

IF3

2023-04-11

OAAI

Ievlev, Vitaly; Pai, Albert C.; Dillon Jr, Drew S.; Kuhl, Spencer; Lynch, Thomas J.; Freischlag, Kyle W.; Gries, Caitlyn B.; Engelhardt, John F.; Parekh, Kalpaj R.

Bile acid regulation of C/EBPβ, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

151

OAAI

Qiao, L; Han, SI; Fang, YW; Park, JS; Gupta, S; Gilfor, D; Amorino, G; Valerie, K; Sealy, L; Engelhardt, JF; Grant, S; Hylemon, PB; Dent, P

PITX2 and β-catenin interactions regulate lef-1 isoform expression

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI