George Bou–Gharios - Publications, H-index & Citations

George Bou–Gharios

university of liverpool

49H指数

269论文数

8.6K被引数

收录论文 86

发表时间

Specific knockout of kidney homogentisate 1,2-dioxygenase reveals that local metabolism of tyrosine and homogentisic acid is negligible in alkaptonuria 特异性敲除肾脏同戊二烯二酸1,2-二氧化酶揭示酪氨酸和同戊二烯二酸的局部代谢在黑酸尿症中可忽略不计

Human Molecular Genetics

IF3.2

2026-05-25

OAAI

Dominic A Rutland; Brendan P Norman; Juliette H Hughes; Peter J M Wilson; Hazel Sutherland; Rebecca L W Brown; James A Gallagher; Lakshminarayan R Ranganath; George Bou-Gharios

Loss of the RNA Binding Protein HuR in Early Murine Limb Mesenchyme Does Not Affect Development but Leads to Impaired Bone Homeostasis in Adulthood Fu, S.; Johnson, K.A.; Winstanley-Zarach, P.; Ersoy, U.; Adlmanninger, E.; McDermott, B.T.; Keenan, C.; Vasilaki, A.; Kanakis, I.; Milner, P.I.; 等. 早期小鼠肢体间充质中RNA结合蛋白HuR的缺失不影响发育，但在成年期导致骨稳态受损。FASEB J. 2025, 39, e71222. [Google Scholar] [CrossRef] [PubMed]

FASEB JOURNAL

IF4.2

2025-11-20

OAAI

Fu, Shijian; Johnson, Kirsty A.; Winstanley-zarach, Phaedra; Ersoy, Ufuk; Adlmanninger, Elena; Mcdermott, Benjamin T.; Keenan, Craig; Vasilaki, Aphrodite; Kanakis, Ioannis; Milner, Peter I.; Van't Hof, Rob J.; Kontoyiannis, Dimitris; Bou-Gharios, George; Turner, David A.; Tew, Simon R.

Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin 基质Metalloproteinase-1在成纤维细胞中的表达加速了皮肤衰老并促进了小鼠皮肤乳头状瘤的发展

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2023-09-01

OAAI

Quan, Taihao; Xia, Wei; He, Tianyuan; Calderone, Kenneth; Bou-Gharios, George; Voorhees, John J.; Dlugosz, Andrzej A.; Fisher, Gary J.

Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial

CELLS

IF5.2

2023-06-21

OAAI

Ooi, Nicola; Cooper, Ian R.; Norman, Brendan; Gallagher, James A.; Sireau, Nick; Bou-Gharios, George; Ranganath, Lakshminarayan R.; Savage, Victoria J.

ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2023-05-01

PREAI

Pekovic-Vaughan, Vanja; Sutton, Elizabeth; Carter, Alan; Fawcett, Sandra; Moore, Holly; Sarumi, Damilola; Bou-Gharios, George

Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and δEF1/ZEB1

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Ponticos, M; Partridge, T; Black, CM; Abraham, DJ; Bou-Gharios, G

Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria

METABOLITES

IF3.7

2022-09-29

OAAI

Norman, Brendan P.; Davison, Andrew S.; Hickton, Bryony; Ross, Gordon A.; Milan, Anna M.; Hughes, Andrew T.; Wilson, Peter J. M.; Sutherland, Hazel; Hughes, Juliette H.; Roberts, Norman B.; Bou-Gharios, George; Gallagher, James A.; Ranganath, Lakshminarayan R.

Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria

METABOLITES

IF3.7

2022-09-29

OAAI

Ranganath, Lakshminarayan R.; Hughes, Andrew T.; Davison, Andrew S.; Khedr, Milad; Imrich, Richard; Rudebeck, Mattias; Olsson, Birgitta; Norman, Brendan P.; Bou-Gharios, George; Gallagher, James A.; Milan, Anna M.

Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice

DISEASE MODELS & MECHANISMS

IF3.3

2022-09-28

OAAI

Lee, Katie J.; Rambault, Lisa; Bou-Gharios, George; Clegg, Peter D.; Akhtar, Riaz; Czanner, Gabriela; van't Hof, Rob; Canty-Laird, Elizabeth G.

Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria

SCIENTIFIC REPORTS

IF3.9

2022-09-27

OAAI

Ranganath, L. R.; Milan, A. M.; Hughes, A. T.; Davison, A. S.; Khedr, M.; Norman, B. P.; Bou-Gharios, G.; Gallagher, J. A.; Imrich, R.; Arnoux, J. B.; Rudebeck, M.; Olsson, B.

Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment

METABOLITES

IF3.7

2022-08-22

OAAI

Ranganath, Lakshminarayan R.; Milan, Anna M.; Hughes, Andrew T.; Davison, Andrew S.; Khedr, Milad; Imrich, Richard; Rudebeck, Mattias; Olsson, Birgitta; Norman, Brendan P.; Bou-Gharios, George; Gallagher, James A.

Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism

GENES & DISEASES

IF9.4

2022-07-01

OAAI

Norman, Brendan P.; Davison, Andrew S.; Hughes, Juliette H.; Sutherland, Hazel; Wilson, Peter JM.; Berry, Neil G.; Hughes, Andrew T.; Milan, Anna M.; Jarvis, Jonathan C.; Roberts, Norman B.; Ranganath, Lakshminarayan R.; Bou-Gharios, George; Gallagher, James A.

Laminin N-terminus α31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model 层粘连蛋白N末端 α31在发育过程中的表达是致命的，并在转基因小鼠模型中引起广泛的组织特异性缺陷

FASEB JOURNAL

IF4.2

2022-06-01

OAAI

Sugden, Conor J.; Iorio, Valentina; Troughton, Lee D.; Liu, Ke; Morais, Mychel R. P. T.; Lennon, Rachel; Bou-Gharios, George; Hamill, Kevin J.

NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2021-12-01

PREAI

Sutton, Elizabeth; Early, Jamie; Hughes, Alun; Gall, Lewis; Carter, Alan; Copple, Ian; Plagge, Antonius; Bou-Gharios, George; Leedale, Joe; Domijan, Mirela; Bechtold, David; Pekovic-Vaughan, Vanja

Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IF2.8

2021-05-01

OAAI

Tam, Angela Y. Y.; Horwell, Amy L.; Trinder, Sarah L.; Khan, Korsa; Xu, Shiwen; Ong, Voon; Denton, Christopher P.; Norman, Jill T.; Holmes, Alan M.; Bou-Gharios, George; Abraham, David J.

Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging 小鼠真皮成纤维细胞CCN1表达重述人皮肤真皮老化

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2021-04-01

OAAI

Quan, Taihao; Xiang, Yaping; Liu, Yingchun; Qin, Zhaoping; Yang, Yan; Bou-Gharios, George; Voorhees, John J.; Dlugosz, Andrzej A.; Fisher, Gary J.

Syndecan-3 enhances anabolic bone formation through WNT signaling

FASEB JOURNAL

IF4.2

2021-03-26

OAAI

Johnson de Sousa Brito, Francesca Manuela; Butcher, Andrew; Pisconti, Addolorata; Poulet, Blandine; Prior, Amanda; Charlesworth, Gemma; Sperinck, Catherine; Scotto di Mase, Michele; Liu, Ke; Bou-Gharios, George; Jurgen van 't Hof, Robert; Daroszewska, Anna

Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces

CALCIFIED TISSUE INTERNATIONAL

IF3.2

2020-10-14

OAAI

Hughes, Juliette H.; Keenan, Craig M.; Sutherland, Hazel; Edwards, Henry R.; Wilson, Peter J. M.; Ranganath, Lakshminarayan R.; Jarvis, Jonathan C.; Bou-Gharios, George; Gallagher, James A.

Modulation of the mechanical responses of synovial fibroblasts by osteoarthritis-associated inflammatory stressors 骨关节炎相关炎症应激物对滑膜成纤维细胞机械反应的调节

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IF2.8

2020-09-01

PREAI

Jamal, Juliana; Roebuck, Margaret M.; Lee, Siam-Yee; Frostick, Simon P.; Abbas, Azlina Amir; Merican, Azhar Mahmood; Teo, Seow-Hui; Wood, Amanda; Tan, Sik-Loo; Bou-Gharios, George; Wong, Pooi-Fong

Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis

CALCIFIED TISSUE INTERNATIONAL

IF3.2

2020-08-09

OAAI

Yamamoto, Kazuhiro; Wilkinson, David; Bou-Gharios, George

研究方向