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A STAT3-STING-IFN axis controls the metastatic spread of small cell lung cancer Guanizo, Aleks C.; Luong, Quinton; Jayasekara, W. Samantha N.; de Geus, Eveline D.; Inampudi, Chaitanya; Xue, Vincent Senyang; Chen, Jasmine; de Weerd, Nicole A.; Matthews, Antony Y.; Gantier, Michael P.; Balic, Jesse J.; Arulananda, Surein; Garama, Daniel J.; Hertzog, Paul J.; Ganju, Vinod; Watkins, D. Neil; Cain, Jason E.; Gough, Daniel J. 分享 收藏
Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype Vaghjiani, Vijesh G.; Cochrane, Catherine R.; Jayasekara, W. Samantha N.; Chong, Wai Chin; Szczepny, Anette; Kumar, Beena; Martelotto, Luciano G.; Mccaw, Andrew; Carey, Kirstyn; Kansara, Maya; Thomas, David M.; Walkley, Carl; Mudge, Stuart; Gough, Daniel J.; Downie, Peter A.; Peacock, Craig D.; Matsui, William; Watkins, D. Neil; Cain, Jason E. 分享 收藏
MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat Chen, Jasmine; Guanizo, Aleks C. C.; Jakasekara, W. Samantha N.; Inampudi, Chaitanya; Luong, Quinton; Garama, Daniel J. J.; Alamgeer, Muhammad; Thakur, Nishant; DeVeer, Michael; Ganju, Vinod; Watkins, D. Neil; Cain, Jason E. E.; Gough, Daniel J. J. 分享 收藏
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Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium Chen, Jasmine; Guanizo, Aleks; Luong, Quinton; Jayasekara, W. Samantha N.; Jayasinghe, Dhilshan; Inampudi, Chaitanya; Szczepny, Anette; Garama, Daniel J.; Russell, Prudence A.; Ganju, Vinod; Cain, Jason E.; Watkins, D. Neil; Gough, Daniel J. 分享 收藏
A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma Rajal, Alvaro Gonzalez; Marzec, Kamila A.; McCloy, Rachael A.; Nobis, Max; Chin, Venessa; Hastings, Jordan F.; Lai, Kaitao; Kennerson, Marina; Hughes, William E.; Vaghjiani, Vijesh; Timpson, Paul; Cain, Jason E.; Watkins, D. Neil; Croucher, David R.; Burgess, Andrew 分享 收藏
Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling Cochrane, Catherine R.; Vaghjiani, Vijesh; Szczepny, Anette; Jayasekara, W. Samantha N.; Gonzalez-Rajal, Alvaro; Kikuchi, Kazu; McCaughan, Geoffrey W.; Burgess, Andrew; Gough, Daniel J.; Watkins, D. Neil; Cain, Jason E. 分享 收藏
Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma Hastings, Jordan F.; Rajal, Alvaro Gonzalez; Latham, Sharissa L.; Han, Jeremy Z. R.; McCloy, Rachael A.; O'Donnell, Yolande Ei; Phimmachanh, Monica; Murphy, Alexander D.; Nagrial, Adnan; Daneshvar, Dariush; Chin, Venessa; Watkins, D. Neil; Burgess, Andrew; Croucher, David R. 分享 收藏
GEAMP, a novel gastroesophageal junction carcinoma cell line derived from a malignant pleural effusion Zhang, Wei; Williams, Taylor A.; Bhagwath, Ankur S.; Hiermann, Jared S.; Peacock, Craig D.; Watkins, D. Neil; Ding, Peiguo; Park, Jason Y.; Montgomery, Elizabeth A.; Forastiere, Arlene A.; Jie, Chunfa; Cantarel, Brandi L.; Thai H Pham; Wang, David H. 分享 收藏
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Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer Kennedy, Sean P.; Han, Jeremy Z. R.; Portman, Neil; Nobis, Max; Hastings, Jordan F.; Murphy, Kendelle J.; Latham, Sharissa L.; Cadell, Antonia L.; Miladinovic, Dushan; Marriott, Gabriella R.; O'Donnell, Yolande E. I.; Shearer, Robert F.; Williams, James T.; Munoz, Amaya Garcia; Cox, Thomas R.; Watkins, D. Neil; Saunders, Darren N.; Timpson, Paul; Lim, Elgene; Kolch, Walter; Croucher, David R. 分享 收藏
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer Saad, Mohamed I.; Alhayyani, Sultan; McLeod, Louise; Yu, Liang; Alanazi, Mohammad; Deswaerte, Virginie; Tang, Ke; Jarde, Thierry; Smith, Julian A.; Prodanovic, Zdenka; Tate, Michelle D.; Balic, Jesse J.; Watkins, D. Neil; Cain, Jason E.; Bozinovski, Steven; Algar, Elizabeth; Kohmoto, Tomohiro; Ebi, Hiromichi; Ferlin, Walter; Garbers, Christoph; Ruwanpura, Saleela; Sagi, Irit; Rose-John, Stefan; Jenkins, Brendan J. 分享 收藏
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing 刺猬通过在小鼠皮肤伤口愈合过程中产生诱导性真皮来刺激毛囊新生 Lim, Chae Ho; Sun, Qi; Ratti, Karan; Lee, Soung-Hoon; Zheng, Ying; Takeo, Makoto; Lee, Wendy; Rabbani, Piul; Plikus, Maksim V.; Cain, Jason E.; Wang, David H.; Watkins, D. Neil; Millar, Sarah; Taketo, M. Mark; Myung, Peggy; Cotsarelis, George; Ito, Mayumi 分享 收藏
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer Leong, Tracy L.; Gayevskiy, Velimir; Steinfort, Daniel P.; De Massy, Marc R.; Gonzalez-Rajal, Alvaro; Marini, Kieren D.; Stone, Emily; Chin, Venessa; Havryk, Adrian; Plit, Marshall; Irving, Louis B.; Jennings, Barton R.; McCloy, Rachael A.; Jayasekara, W. Samantha N.; Alamgeer, Muhammad; Boolell, Vishal; Field, Andrew; Russell, Prudence A.; Kumar, Beena; Gough, Daniel J.; Szczepny, Anette; Ganju, Vinod; Rossello, Fernando J.; Cain, Jason E.; Papenfuss, Anthony T.; Asselin-Labat, Marie-Liesse; Cowley, Mark J.; Watkins, D. Neil 分享 收藏
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy Marini, Kieren D.; Croucher, David R.; McCloy, Rachael A.; Vaghjiani, Vijesh; Gonzalez-Rajal, Alvaro; Hastings, Jordan F.; Chin, Venessa; Szczepny, Anette; Kostyrko, Kaja; Marquez, Cesar; Jayasekara, W. Samantha N.; Alamgeer, Muhammad; Boolell, Vishal; Han, Jeremy Z. R.; Waugh, Todd; Lee, Hong Ching; Oakes, Samantha R.; Kumar, Beena; Harrison, Craig A.; Hedger, Mark P.; Lorensuhewa, Nirmal; Kita, Badia; Barrow, Ross; Robinson, Bruce W.; de Kretser, David M.; Wu, Jianmin; Ganju, Vinod; Sweet-Cordero, E. Alejandro; Burgess, Andrew; Martelotto, Luciano G.; Rossello, Fernando J.; Cain, Jason E.; Watkins, D. Neil 分享 收藏
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer 靶向基质重塑和癌症干细胞可塑性克服了三阴性乳腺癌的化学抗性 Cazet, Aurelie S.; Hui, Mun N.; Elsworth, Benjamin L.; Wu, Sunny Z.; Roden, Daniel; Chan, Chia-Ling; Skhinas, Joanna N.; Collot, Raphael; Yang, Jessica; Harvey, Kate; Johan, M. Zahied; Cooper, Caroline; Nair, Radhika; Herrmann, David; McFarland, Andrea; Deng, Niantao; Ruiz-Borrego, Manuel; Rojo, Federico; Trigo, Jose M.; Bezares, Susana; Caballero, Rosalia; Lim, Elgene; Timpson, Paul; O'Toole, Sandra; Watkins, D. Neil; Cox, Thomas R.; Samuel, Michael S.; Martin, Miguel; Swarbrick, Alexander 分享 收藏
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p53 and RB regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis Cain, Jason E.; Cochrane, Catherine R.; Vaghjiani, Vijesh; Szczepny, Anette; Mccaw, Andrew; Carey, Kirstyn; Martelotto, Luciano; Kansara, Maya; Thomas, David; Walkley, Carl; Matsui, William H.; Watkins, David N. 分享 收藏
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