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H

Harikrishnan Balachandran

Duke University School of Medicine
H指数:17
被引数:2,119

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Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies

亲和力成熟赋予6类SARS-CoV-2广谱中和抗体强大的活性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2025-01-020
OA
Mazigi, Ohan; Langley, David B.; Henry, Jake Y.; Burnett, Deborah L.; Sobti, Meghna; Walker, GregoryJ.; Rouet, Romain; Balachandran, Harikrishnan; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Schofield, Peter; Brown, Simon H. J.; Schulz, Sebastian R.; Hoffmann, Markus; Poehlmann, Stefan; Post, Jeffrey; Martinello, Marianne; Kelleher, Anthony; Rawlinson, William D.; Turville, Stuart G.; Bull, Rowena A.; Stewart, Alastair G.; Jaeck, Hans-Martin; Goodnow, Christopher C.; Christ, Daniel
Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

通过基于表位的选择从恢复期患者中广泛中和SARS-CoV-2抗体

NATURE COMMUNICATIONS
IF15.7
2023-02-0819
OAAI
Rouet, Romain; Henry, Jake Y.; Johansen, Matt D.; Sobti, Meghna; Balachandran, Harikrishnan; Langley, David B.; Walker, Gregory J.; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Mazigi, Ohan; Schofield, Peter; Burnett, Deborah L.; Brown, Simon H. J.; Martinello, Marianne; Hudson, Bernard; Gilroy, Nicole; Post, Jeffrey J.; Kelleher, Anthony; Jaeck, Hans-Martin; Goodnow, Christopher C.; Turville, Stuart G.; Rawlinson, William D.; Bull, Rowena A.; Stewart, Alastair G.; Hansbro, Philip M.; Christ, Daniel
High activation levels maintained in receptor-binding domain-specific memory B cells in people with severe coronavirus disease 2019
IMMUNOLOGY AND CELL BIOLOGY
IF3
2022-12-013
OA
Gupta, Money; Balachandran, Harikrishnan; Louie, Raymond H. Y.; Li, Hui; Agapiou, David; Keoshkerian, Elizabeth; Christ, Daniel; Rawlinson, William; Mina, Michael M.; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Konecny, Pamela; Bartlett, Adam W.; Sasson, Sarah C.; Ahlenstiel, Golo; Dwyer, Dominic; Lloyd, Andrew R.; Martinello, Marianne; Luciani, Fabio; Bull, Rowena A.
SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents
CELL REPORTS MEDICINE
IF10.6
2022-06-0127
OAAI
Garcia-Valtanen, Pablo; Hope, Christopher M.; Masavuli, Makutiro G.; Yeow, Arthur Eng Lip; Balachandran, Harikrishnan; Mekonnen, Zelalem A.; Al-Delfi, Zahraa; Abayasingam, Arunasingam; Agapiou, David; Stella, Alberto Ospina; Aggarwal, Anupriya; Bouras, George; Gummow, Jason; Ferguson, Catherine; O'Connor, Stephanie; McCartney, Erin M.; Lynn, David J.; Maddern, Guy; Gowans, Eric J.; Reddi, Benjamin A. J.; Shaw, David; Kok-Lim, Chuan; Beard, Michael R.; Weiskopf, Daniela; Sette, Alessandro; Turville, Stuart G.; Bull, Rowena A.; Barry, Simon C.; Grubor-Bauk, Branka
Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+T cell responses

通过SARS-CoV-2-specific CD4 T细胞反应来预测感染后1年维持广泛的中和抗体和记忆b细胞

CELL REPORTS
IF6.9
2022-02-0137
OAAI
Balachandran, Harikrishnan; Phetsouphanh, Chansavath; Agapiou, David; Adhikari, Anurag; Rodrigo, Chaturaka; Hammoud, Mohamed; Shrestha, Lok Bahadur; Keoshkerian, Elizabeth; Gupta, Money; Turville, Stuart; Christ, Daniel; King, Cecile; Sasson, Sarah C.; Bartlett, Adam; Grubor-Bauk, Branka; Rawlinson, William; Aggarwal, Anupriya; Stella, Alberto Ospina; Klemm, Vera; Mina, Michael M.; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Konecny, Pam; Ahlenstiel, Golo; Dwyer, Dominic E.; Sorrell, Tania C.; Kelleher, Anthony; Tedla, Nicodemus; Lloyd, Andrew R.; Martinello, Marianne; Bull, Rowena A.
Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
IMMUNITY
IF26.3
2021-12-0137
OAAI
Burnett, Deborah L.; Jackson, Katherine J. L.; Langley, David B.; Aggrawal, Anupria; Stella, Alberto Ospina; Johansen, Matt D.; Balachandran, Harikrishnan; Lenthall, Helen; Rouet, Romain; Walker, Gregory; Saunders, Bernadette M.; Singh, Mandeep; Li, Hui; Henry, Jake Y.; Jackson, Jennifer; Stewart, Alastair G.; Witthauer, Franka; Spence, Matthew A.; Hansbro, Nicole G.; Jackson, Colin; Schofield, Peter; Milthorpe, Claire; Martinello, Marianne; Schulz, Sebastian R.; Roth, Edith; Kelleher, Anthony; Emery, Sean; Britton, Warwick J.; Rawlinson, William D.; Karl, Rudolfo; Schaefer, Simon; Winkler, Thomas H.; Brink, Robert; Bull, Rowena A.; Hansbro, Philip M.; Jaeck, Hans-Martin; Turville, Stuart; Christ, Daniel; Goodnow, Christopher C.
Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection
CELL REPORTS MEDICINE
IF10.6
2021-04-0154
OAAI
Abayasingam, Arunasingam; Balachandran, Harikrishnan; Agapiou, David; Hammoud, Mohamed; Rodrigo, Chaturaka; Keoshkerian, Elizabeth; Li, Hui; Brasher, Nicholas A.; Christ, Daniel; Rouet, Romain; Burnet, Deborah; Grubor-Bauk, Branka; Rawlinson, William; Turville, Stuart; Aggarwal, Anupriya; Stella, Alberto Ospina; Fichter, Christina; Brilot, Fabienne; Mina, Michael; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Dwyer, Dominic; Sasson, Sarah C.; Tea, Fiona; Pilli, Deepti; Kelleher, Anthony; Tedla, Nicodemus; Lloyd, Andrew R.; Martinello, Marianne; Bull, Rowena A.
Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates

病毒1型包膜疫苗接种和非人灵长类动物的猿猴-人免疫缺陷病毒攻击的NYVAC素蛋白增强人类免疫缺陷的免疫原性

JOURNAL OF VIROLOGY
IF3.8
2018-04-157
OAAI
Saunders, Kevin O.; Santra, Sampa; Parks, Robert; Yates, Nicole L.; Sutherland, Laura L.; Scearce, Richard M.; Balachandran, Harikrishnan; Bradley, Todd; Goodman, Derrick; Eaton, Amanda; Stanfield-Oakley, Sherry A.; Tartaglia, James; Phogat, Sanjay; Pantaleo, Giuseppe; Esteban, Mariano; Gomez, Carmen E.; Perdiguero, Beatriz; Jacobs, Bertram; Kibler, Karen; Korber, Bette; Montefiori, David C.; Ferrari, Guido; Vandergrift, Nathan; Liao, Hua-Xin; Tomaras, Georgia D.; Haynes, Barton F.
Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
NATURE COMMUNICATIONS
IF15.7
2017-06-08125
OAAI
Bradley, Todd; Pollara, Justin; Santra, Sampa; Vandergrift, Nathan; Pittala, Srivamshi; Bailey-Kellogg, Chris; Shen, Xiaoying; Parks, Robert; Goodman, Derrick; Eaton, Amanda; Balachandran, Harikrishnan; Mach, Linh V.; Saunders, Kevin O.; Weiner, Joshua A.; Scearce, Richard; Sutherland, Laura L.; Phogat, Sanjay; Tartaglia, Jim; Reed, Steven G.; Hu, Shiu-Lok; Theis, James F.; Pinter, Abraham; Montefiori, David C.; Kepler, Thomas B.; Peachman, Kristina K.; Rao, Mangala; Michael, Nelson L.; Suscovich, Todd J.; Alter, Galit; Ackerman, Margaret E.; Moody, M. Anthony; Liao, Hua-Xin; Tomaras, Georgia; Ferrari, Guido; Korber, Bette T.; Haynes, Barton F.
Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques
MOLECULAR THERAPY
IF12
2016-11-0131
OAAI
Negri, Donatella; Blasi, Maria; LaBranche, Celia; Parks, Robert; Balachandran, Harikrishnan; Lifton, Michelle; Shen, Xiaoying; Denny, Thomas; Ferrari, Guido; Vescio, Maria Fenicia; Andersen, Hanne; Montefiori, David C.; Tomaras, Georgia D.; Liao, Hua-Xin; Santra, Sampa; Haynes, Barton F.; Klotman, Mary E.; Cara, Andrea
Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine
OPEN FORUM INFECTIOUS DISEASES
IF3.8
2016-02-1112
OAAI
Chamcha, Venkateswarlu; Kannanganat, Sunil; Gangadhara, Sailaja; Nabi, Rafiq; Kozlowski, Pamela A.; Montefiori, David C.; LaBranche, Celia C.; Wrammert, Jens; Keele, Brandon F.; Balachandran, Harikrishnan; Sahu, Sujata; Lifton, Michelle; Santra, Sampa; Basu, Rahul; Moss, Bernard; Robinson, Harriet L.; Amara, Rama Rao
Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost
JOURNAL OF VIROLOGY
IF3.8
2015-06-1540
OAAI
Hulot, Sandrine L.; Korber, Bette; Giorgi, Elena E.; Vandergrift, Nathan; Saunders, Kevin O.; Balachandran, Harikrishnan; Mach, Linh V.; Lifton, Michelle A.; Pantaleo, Giuseppe; Tartaglia, Jim; Phogat, Sanjay; Jacobs, Bertram; Kibler, Karen; Perdiguero, Beatriz; Gomez, Carmen E.; Esteban, Mariano; Rosati, Margherita; Felber, Barbara K.; Pavlakis, George N.; Parks, Robert; Lloyd, Krissey; Sutherland, Laura; Scearce, Richard; Letvin, Norman L.; Seaman, Michael S.; Alam, S. Munir; Montefiori, David; Liao, Hua-Xin; Haynes, Barton F.; Santra, Sampa
Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2011-05-04190
OAAI
Letvin, Norman L.; Rao, Srinivas S.; Montefiori, David C.; Seaman, Michael S.; Sun, Yue; Lim, So-Yon; Yeh, Wendy W.; Asmal, Mohammed; Gelman, Rebecca S.; Shen, Ling; Whitney, James B.; Seoighe, Cathal; Lacerda, Miguel; Keating, Sheila; Norris, Philip J.; Hudgens, Michael G.; Gilbert, Peter B.; Buzby, Adam P.; Mach, Linh V.; Zhang, Jinrong; Balachandran, Harikrishnan; Shaw, George M.; Schmidt, Stephen D.; Todd, John-Paul; Dodson, Alan; Mascola, John R.; Nabel, Gary J.
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
NATURE MEDICINE
IF50
2010-02-21258
OAAI
Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin; Muldoon, Mark; Watson, Sydeaka; Fischer, Will; Theiler, James; Szinger, James; Balachandran, Harikrishnan; Buzby, Adam; Quinn, David; Parks, Robert J.; Tsao, Chun-Yen; Carville, Angela; Mansfield, Keith G.; Pavlakis, George N.; Felber, Barbara K.; Haynes, Barton F.; Korber, Bette T.; Letvin, Norman L.

研究方向

暂未获取到该数据
S
Sampa Santra
H 指数:45论文数:106被引数:1.0万
R
Rowena A. Bull
H 指数:42论文数:205被引数:6,756
M
Marianne Martinello
H 指数:32论文数:159被引数:3,166
D
David C. Montefiori
H 指数:142论文数:1,167被引数:8.6万
B
Barton F. Haynes
H 指数:144论文数:835被引数:7.7万
W
William D. Rawlinson
H 指数:80论文数:635被引数:2.3万
S
Stuart Turville
H 指数:45论文数:211被引数:6,336
D
Daniel Christ
H 指数:41论文数:167被引数:6,563
J
Jeffrey J. Post
H 指数:31论文数:165被引数:3,293
R
Robert Parks
H 指数:58论文数:165被引数:1.1万