Murray C.H. Clarke

university of cambridge

H指数:27

被引数:5,315

个人简介

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教育背景

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荣誉奖项

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Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis.

常见克隆性造血驱动突变对巨噬细胞细胞因子、克隆扩增和动脉粥样硬化具有不同影响。

JCI Insight

IF6.1

2026-02-090

Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilizing fibrous cap

血栓受体刺激的血管平滑肌细胞转分化生成斑块稳定纤维帽的细胞轮廓绘制

CARDIOVASCULAR RESEARCH

IF13.3

2025-07-010

OAAI

A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction

CD4+ T细胞内源性补体C5aR2-前列环素-IL-1R2轴调控Th1细胞的收缩

Immunity

IF26.3

2025-05-300

Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β

人血管平滑肌细胞利用糜酶进行白介素-1β 的非典型裂解和激活

ATHEROSCLEROSIS

IF5.7

2024-03-013

OAAI

Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1

T滤泡调节细胞源性IL-1R2的丧失通过增加IL-1而增加生发中心反应

JCI INSIGHT

IF6.1

2024-02-083

OAAI

Expansion of fibroblast-like cells may explain the CANTOS meta-analysis findings for patients with clonal hematopoiesis

cardiovascular research

IF10.8

2024-01-170

PRE

Clonal Hematopoiesis Driver Mutations Have Disparate Effects on Macrophage Cytokine Profiles and Only Modestly Drive Atherogenesis at Pathophysiological Levels

CIRCULATION

IF38.6

2023-11-070

PRE

PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models

PLK1抑制抑制炎症性疾病模型中NLRP3炎性体引起的反应

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2023-11-012

OAAI

Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease

FRONTIERS IN IMMUNOLOGY

IF5.9

2020-12-18103

OAAI

Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells

细胞因子对凋亡诱导的血管平滑肌细胞凋亡和凋亡诱导的细胞增殖的调节

APOPTOSIS

IF8.1

2020-07-0528

OAAI

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

NATURE COMMUNICATIONS

IF15.7

2020-01-1672

OAAI

Senescence utilises inflammatory caspases to drive the SASP

AGING-US

IF3.9

2019-06-1711

OAAI

Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire

IMMUNITY

IF26.3

2019-06-0113

OAAI

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

IMMUNITY

IF26.3

2019-04-01163

OAAI

IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype

AGING CELL

IF7.1

2019-03-2792

OAAI

SENESCENT VASCULAR SMOOTH MUSCLE CELLS DRIVE INFLAMMATION THROUGH AN INTERLEUKIN-1α-DEPENDENT SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE

ATHEROSCLEROSIS

IF5.7

2016-01-012

OAAI

Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

血管平滑肌细胞衰老促进动脉粥样硬化及斑块易损性特征

CIRCULATION

IF38.6

2015-11-17290

OAAI

Interleukin-1 a Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2 IMPLICATIONS FOR ALLOGRAFT REJECTION

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-10-0125

OAAI

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1a-Dependent Senescence Associated Secretory Phenotype

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IF7.4

2015-09-01228

OAAI

VASCULAR SMOOTH MUSCLE CELL SENESCENCE PROMOTES ATHEROSCLEROSIS AND FEATURES OF PLAQUE VULNERABILITY

ATHEROSCLEROSIS

IF5.7

2015-07-011

OAAI

Murray C.H. Clarke

个人简介

教育背景

工作经历

荣誉奖项

研究方向