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The bispecific antibody targeting VISTA and PD-L1 shows enhanced tumor inhibitory activity in pancreatic, endometrial and breast cancers compared to mono- and combination immune checkpoint blockade 靶向VISTA和PD-L1的双特异性抗体与单药及联合免疫检查点阻断相比，在胰腺癌、子宫内膜癌和乳腺癌中显示出增强的肿瘤抑制作用。 Bielski, Przemyslaw; Barczynski, Jan; Mikitiuk, Michal; Myrcha, Maja; Rykala, Kamil; Boon, Louis; Gasior, Wiktoria; Hec-Galazka, Aleksandra; Holak, Tad A.; Sitar, Tomasz 分享 收藏
CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not? (vol 24, 2804, 2019) Musielak, Bogdan; Kocik, Justyna; Skalniak, Lukasz; Magiera-Mularz, Katarzyna; Sala, Dominik; Czub, Miroslawa; Stec, Malgorzata; Siedlar, Maciej; Holak, Tad A.; Plewka, Jacek 分享 收藏
Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein (vol 27, 8282, 2022) Romero, Atilio Reyes; Kubica, Katarzyna; Kitel, Radoslaw; Rodriguez, Ismael; Magiera-Mularz, Katarzyna; Domling, Alexander; Holak, Tad A.; Surmiak, Ewa 分享 收藏
C2-Symmetrical Terphenyl Derivatives as Small Molecule Inhibitors of Programmed Cell Death 1/Programmed Death Ligand 1 Protein-Protein Interaction Klimek, Joanna; Kruc, Oskar; Ceklarz, Joanna; Kaminska, Beata; Musielak, Bogdan; van der Straat, Robin; Domling, Alexander; Holak, Tad A.; Muszak, Damian; Kalinowska-Tluscik, Justyna; Skalniak, Lukasz; Surmiak, Ewa 分享 收藏
Nonsymmetrically Substituted 1,1′-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction Hec-Galazka, Aleksandra; Tyrcha, Urszula; Barczynski, Jan; Bielski, Przemyslaw; Mikitiuk, Michal; Gudz, Ganna P.; Kitel, Radoslaw; Musielak, Bogdan; Plewka, Jacek; Sitar, Tomasz; Holak, Tad A. 分享 收藏
1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists van der Straat, Robin; Draijer, Rosalie; Surmiak, Ewa; Butera, Roberto; Land, Lennart; Magiera-Mularz, Katarzyna; Musielak, Bogdan; Plewka, Jacek; Holak, Tad A.; Domling, Alexander 分享 收藏
Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m-Terphenyl Derivatives Surmiak, Ewa; Zaber, Julia; Plewka, Jacek; Wojtanowicz, Grzegorz; Kocik-Krol, Justyna; Kruc, Oskar; Muszak, Damian; Rodriguez, Ismael; Musielak, Bogdan; Viviano, Monica; Castellano, Sabrina; Skalniak, Lukasz; Magiera-Mularz, Katarzyna; Holak, Tad A.; Kalinowska-Tluscik, Justyna 分享 收藏
Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction Kitel, Radoslaw; Surmiak, Ewa; Borggraefe, Jan; Kalinowska-Tluscik, Justyna; Golik, Przemyslaw; Czub, Miroslawa; Uzar, Wiktor; Musielak, Bogdan; Madej, Mariusz; Popowicz, Grzegorz M.; Dubin, Grzegorz; Holak, Tad A. 分享 收藏
IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins 基于IGF2肽的LYTACs靶向降解细胞外和跨膜蛋白 Mikitiuk, Michal; Barczynski, Jan; Bielski, Przemyslaw; Arciniega, Marcelino; Tyrcha, Urszula; Hec, Aleksandra; Lipinska, Andrea D.; Rychlowski, Michal; Holak, Tad A.; Sitar, Tomasz 分享 收藏
Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies Rodriguez, Ismael; Kocik-Krol, Justyna; Skalniak, Lukasz; Musielak, Bogdan; Wisniewska, Aneta; Ciesiolkiewicz, Agnieszka; Berlicki, Lukasz; Plewka, Jacek; Grudnik, Przemyslaw; Stec, Malgorzata; Siedlar, Maciej; Holak, Tad A.; Magiera-Mularz, Katarzyna 分享 收藏
Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors Wazynska, Marta A. A.; Butera, Roberto; Requesens, Marta; Plat, Annechien; Zarganes-Tzitzikas, Tryfon; Neochoritis, Constantinos G. G.; Plewka, Jacek; Skalniak, Lukasz; Kocik-Krol, Justyna; Musielak, Bogdan; Magiera-Mularz, Katarzyna; Rodriguez, Ismael; Blok, Simon N. N.; de Bruyn, Marco; Nijman, Hans W. W.; Elsinga, Philip H. H.; Holak, Tad A. A.; Domling, Alexander 分享 收藏
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Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments Kitel, Radoslaw; Rodriguez, Ismael; del Corte, Xabier; Atmaj, Jack; Zarnik, Magdalena; Surmiak, Ewa; Muszak, Damian; Magiera-Mularz, Katarzyna; Popowicz, Grzegorz M.; Holak, Tad A.; Musielak, Bogdan 分享 收藏
Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe Malicki, Stanislaw; Pucelik, Barbara; Zyla, Edyta; Benedyk-Machaczka, Malgorzata; Galan, Wojciech; Golda, Anna; Sochaj-Gregorczyk, Alicja; Kaminska, Marta; Encarnacao, Joao Crispim; Chruscicka, Barbara; Marti, Hans-Peter; Chen, Tony Jialiang; Magiera-Mularz, Katarzyna; Zieba, Bartosz; Holak, Tad A.; Dabrowski, Janusz M.; Czarna, Anna; Koziel, Joanna; Mydel, Piotr; Dubin, Grzegorz 分享 收藏
Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction Shaabani, Shabnam; Gadina, Louis; Surmiak, Ewa; Wang, Zefeng; Zhang, Bidong; Butera, Roberto; Zarganes-Tzitzikas, Tryfon; Rodriguez, Ismael; Kocik-Krol, Justyna; Magiera-Mularz, Katarzyna; Skalniak, Lukasz; Domling, Alexander; Holak, Tad A. 分享 收藏
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A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity Romero, Atilio Reyes; Lunev, Serjey; Popowicz, Grzegorz M.; Calderone, Vito; Gentili, Matteo; Sattler, Michael; Plewka, Jacek; Taube, Michal; Kozak, Maciej; Holak, Tad A.; Domling, Alexander S. S.; Groves, Matthew R. 分享 收藏
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