未登录 A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, Peter; Glaser, Stefan P.; Han, Jing; Popa, Alexandra; Pisarsky, Laura; Feng, Ningping; Geyer, Antonia; Haderk, Franziska; Alpar, Donat; Bristow, Christopher; Schmittner, Susanne; Traexler, Paula-Elena; Mahendra, Mikhila; Poehn, Birgit; Gandhi, Poojabahen; Fiorelli, Roberto; Awate, Sanket; Budano, Nicole; Martin, Florian; Albrecht, Christoph; Drobits-Handl, Barbara; Anand, Sathanandam S.; Kasturirangan, Srinath; Trapani, Francesca; Schweifer, Norbert; Marszalek, Joseph R.; Tontsch-Grunt, Ulrike; Pearson, Mark; Heffernan, Timothy P.; Kraut, Norbert; Vellano, Christopher P.; Garcia-Martinez, Juan Manuel 分享 收藏
A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, P.; Glaser, S. P.; Han, J.; Popa, A.; Pisarsky, L.; Feng, N.; Geyer, A.; Haderk, F.; Alpar, D.; Bristow, C.; Drobits-Handl, B.; Kasturirangan, S.; Trapani, F.; Marszalek, J. R.; Tontsch-Grunt, U.; Pearson, M.; Heffernan, T. P.; Kraut, N.; Vellano, C. P.; Garcia-Martinez, J. M. 分享 收藏
Zongertinib (BI1810631), an irreversible HER2 TKI spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers Neumueller, R.; Wilding, B.; Augsten, M.; Baum, A.; Chylinski, K.; Waizenegger, I.; Woelflingseder, L.; Solca, F.; Kraut, N. 分享 收藏
KRASmulti inhibition and checkpoint targeting therapy show strong combination potential in KRAS wild-type and KRASG12V-driven syngeneic mouse models of pancreatic cancer Ebner, F.; Krolo, A.; Artemov, A.; Hubmann, M.; Hajto, A.; Oslislok, M.; Baumann, I.; Egermann, W.; Chylinski, K.; Tedeschi, A.; Lipp, J.; Kraut, N.; Pearson, M.; Pisarsky, L.; Rudolph, D.; Aichinger, M. 分享 收藏
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, A.; Peng, D. H.; Schischlik-Siegl, F.; Schaaf, O.; Gerlach, D.; Rocchetti, F.; Popow, J.; Broeker, J.; Wunberg, T.; Boghossian, A. S.; Rees, M. G.; Ronan, M. M.; Roth, J. A.; Williams, M.; Vellano, C.; Marszalek, J. R.; Heffernan, T. P.; Pearson, M.; Kraut, N.; Dorothea, R. 分享 收藏
Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules Gollner, Andreas; Rudolph, Dorothea; Weyer-Czernilofsky, Ulrike; Baumgartinger, Rosa; Jung, Peter; Weinstabl, Harald; Ramharter, Jurgen; Grempler, Rolf; Quant, Jens; Rinnenthal, Jorg; Pitarch, Alejandro Perez; Golubovic, Bojana; Gerlach, Daniel; Bader, Gerd; Wetzel, Kristiane; Otto, Sebastian; Mandl, Christian; Boehmelt, Guido; Mcconnell, Darryl B.; Kraut, Norbert; Sini, Patrizia 分享 收藏
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance 共靶向SOS1通过解决内在和获得性耐药增强KRASG12C抑制剂的抗肿瘤作用 Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H. 分享 收藏
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Development and characterisation of KRASmulti inhibitors for the treatment of KRAS mutant pancreatic ductal adenocarcinoma Tedeschi, Antonio; Schaaf, Otmar; Gmachl, Michael; Herdeis, Lorenz; Rocchetti, Francesca; Popow, Johannes; Schischlik, Fiorella; Gerlach, Daniel; Lipp, Jesse; Broker, Joachim; Mantoulidis, Andreas; Smethurst, Chris; Kessler, Dirk; Boettcher, Jark; Wunberg, Tobias; Santoro, Valeria; Waterson, Alex; Phan, Jason; Little, Andrew; Abbott, Jason; Sun, Qi; Fesik, Stephen; Mcconnell, Darryl; Pearson, Mark A.; Kraut, Norbert; Rudolph, Dorothea 分享 收藏
Determinants of sensitivity to BI KRASmulti inhibitor using high-throughput in-vitro drug screens Schischlik, Fiorella; Tedeschi, Antonio; Rudolph, Dorothea; Gerlach, Daniel; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Herdeis, Lorenz; Broeker, Joachim; Wunberg, Tobias; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Haslinger, Christian; Lipp, Jesse 分享 收藏
BI 907828: A highly potent MDM2-p53 antagonist suitable for intermittent dose schedules Gollner, Andreas; Sini, Patrizia; Rudolph, Dorothea; Weinstabl, Harald; Ramharter, Juergen; Weyer-Czernilofsky, Ulrike; Golubovic, Bojana; Grempler, Rolf; Pitarch, Alejandro Perez; Sailer, Reinhard; McConnell, Darryl B.; Kraut, Norbert 分享 收藏
Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition Hofmann, Irmgard; Baum, Anke; Hofmann, Marco H.; Trapani, Francesca; Reichel-Voda, Claudia; Ehrensperger, Diane; Aichinger, Martin; Ebner, Florian; Budano, Nicole; Schweifer, Norbert; Sykora, Martina; Depla, Erik; Boucneau, Joachim; Gschwind, Andreas; Kraut, Norbert; Hilberg, Frank; Kunkele, Klaus-Peter 分享 收藏
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling 发现对HER2外显子20插入驱动的肿瘤有效的和选择性的HER2抑制剂，其保留野生型EGFR信号传导 Wilding, Birgit; Scharn, Dirk; Boese, Dietrich; Baum, Anke; Santoro, Valeria; Chetta, Paolo; Schnitzer, Renate; Botesteanu, Dana A.; Reiser, Christoph; Kornigg, Stefan; Knesl, Petr; Hoermann, Alexandra; Koeferle, Anna; Corcokovic, Maja; Lieb, Simone; Scholz, Guido; Bruchhaus, Jens; Spina, Markus; Balla, Josef; Peric-Simov, Biljana; Zimmer, Jasmin; Mitzner, Sophie; Fett, Thomas N.; Beran, Alexandra; Lamarre, Lyne; Gerstberger, Thomas; Gerlach, Daniel; Bauer, Markus; Bergner, Andreas; Schlattl, Andreas; Bader, Gerd; Treu, Matthias; Engelhardt, Harald; Zahn, Stephan; Fuchs, Julian E.; Zuber, Johannes; Ettmayer, Peter; Pearson, Mark; Petronczki, Mark; Kraut, Norbert; McConnell, Darryl B.; Solca, Flavio; Neumuller, Ralph A. 分享 收藏
Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses Zettl, Markus; Wurm, Melanie; Schaaf, Otmar; Mostbock, Sven; Tirapu, Inigo; Apfler, Ilse; Lorenz, Ivo C.; Frego, Lee; Kenny, Cynthia; Thibodeau, Michael; Cifuentes, Elisa Oquendo; Reschke, Markus; Moll, Jurgen; Kraut, Norbert; Vogt, Anne; Sedgwick, Jonathon D.; Waizenegger, Irene C. 分享 收藏
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One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS 一个原子就能改变一切: 在SOS1和KRAS之间进门 Ramharter, Juergen; Kessler, Dirk; Ettmayer, Peter; Hofmann, Marco H.; Gerstberger, Thomas; Gmachl, Michael; Wunberg, Tobias; Kofink, Christiane; Sanderson, Michael; Arnhof, Heribert; Bader, Gerd; Rumpel, Klaus; Zoephel, Andreas; Schnitzer, Renate; Boettcher, Jark; O'Connell, Jonathan C.; Mendes, Rachel L.; Richard, David; Pototschnig, Nikolai; Weiner, Irene; Hela, Wolfgang; Hauer, Katja; Haering, Daniela; Lamarre, Lyne; Wolkerstorfer, Bernhard; Salamon, Christian; Werni, Patrick; Munico-Martinez, Silvia; Meyer, Reiner; Kennedy, Matthew D.; Kraut, Norbert; McConnell, Darryl B. 分享 收藏
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition BI-3406是一种有效的选择性SOS1-KRAS相互作用抑制剂，通过联合MEK抑制对KRAS驱动的癌症有效 Hofmann, Marco H.; Gmachl, Michael; Ramharter, Juergen; Savarese, Fabio; Gerlach, Daniel; Marszalek, Joseph R.; Sanderson, Michael P.; Kessler, Dirk; Trapani, Francesca; Arnhof, Heribert; Rumpel, Klaus; Botesteanu, Dana-Adriana; Ettmayer, Peter; Gerstberger, Thomas; Kofink, Christiane; Wunberg, Tobias; Zoephel, Andreas; Fu, Szu-Chin; Teh, Jessica L.; Boettcher, Jark; Pototschnig, Nikolai; Schachinger, Franziska; Schipany, Katharina; Lieb, Simone; Vellano, Christopher P.; O'Connell, Jonathan C.; Mendes, Rachel L.; Moll, Jurgen; Petronczki, Mark; Heffernan, Timothy P.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert 分享 收藏
Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist Garcia-Martinez, Juan Manuel; Wang, Shirley; Weishaeupl, Cordula; Wernitznig, Andreas; Chetta, Paolo; Pinto, Catarina; Ho, Jason; Dutcher, Darrin; Gorman, Philip N.; Kroe-Barrett, Rachel; Rinnenthal, Joerg; Giragossian, Craig; Impagnatiello, Maria Antonietta; Tirapu, Inigo; Hilberg, Frank; Kraut, Norbert; Pearson, Mark; Kuenkele, Klaus Peter 分享 收藏
CLIFF, a bioinformatics software tool to explore molecular differences between two sets of cancer cell lines Wernitznig, Andreas; Lipp, Jesse J.; Zichner, Thomas; Gerlach, Daniel; Bauer, Markus J.; Voss, Tilman; Schlattl, Andreas; Haslinger, Christian; Montgomery, Philip G.; Zamanighomi, Mahdi; Sellers, William R.; Kraut, Norbert 分享 收藏
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