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M

Marco H. Hofmann

Boehringer Ingelheim
H指数:18
被引数:2,239

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Disentangling effects of the DR and DQ isomers encoded by the HLA class II haplotype DRB1*15:01/DQB1*06:02 to help establish the true risk allele for FVIII inhibitor development in Hemophilia A

区分由HLA-II类单倍型DRB1*15:01/DQB1*06:02编码的DR和DQ异构体的效应，以帮助确定血友病A中FVIII抑制剂发展的真实风险等位基因。

FRONTIERS IN GENETICS
IF2.8
2025-04-090
OA
Diego, Vincent P.; Luu, Bernadette W.; Almeida, Marcio A.; Rajalingam, Raja; Hofmann, Marco; Galan, Jacob A.; Manusov, Eron G.; Powell, Jerry S.; Dinh, Long V.; Mead, Henry; Huynh, Huy; Verhagen, Anne M.; Peralta, Juan M.; Lehmann, Paul V.; Kumar, Satish; Fine, Eli J.; Curran, Joanne E.; Goring, Harald H.; Escobar, Miguel A.; Williams-Blangero, Sarah; Maraskovsky, Eugene; Blangero, John; Howard, Tom E.
SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRASG12D inhibitor in KRAS LUAD

SOS1抑制剂BI-3406显示出类似基因敲除的在体抗肿瘤活性，并能与KRASG12D抑制剂协同作用，用于KRAS LUAD。

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2025-03-120
OA
Baltanas, Fernando C.; Kramer-Drauberg, Maximilian; Garcia-Navas, Rosula; Patrucco, Enrico; Petrini, Ettore; Arnhof, Heribert; Olarte-SanJuan, Andrea; Rodriguez-Ramos, Pablo; Borrajo, Javier; Calzada, Nuria; Castellano, Esther; Mair, Barbara; Kostyrko, Kaja; Hofmann, Marco H.
Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma

同时抑制SOS1和MEK抑制NF1-null黑色素瘤的信号传导和生长

CELL REPORTS MEDICINE
IF10.6
2024-11-010
OAAI
Marasco, Michelangelo; Kumar, Dinesh; Seale, Tessa; Borrego, Santiago Garcia; Kaplun, Esther; Aricescu, Ilinca; Cole, Soren; Qeriqi, Besnik; Qiu, Juan; Chen, Xiaoping; Bahr, Amber; Fidele, Deborah; Hofmann, Marco H.; Gerlach, Daniel; Savarese, Fabio; Merghoub, Taha; Wolchok, Jedd D.; Yao, Zhan; de Stanchina, Elisa; Solit, David; Misale, Sandra; Rosen, Neal
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

共靶向SOS1通过解决内在和获得性耐药增强KRASG12C抑制剂的抗肿瘤作用

NATURE CANCER
IF28.5
2024-08-051
OA
Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H.
Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-145
PRE
Kuttruff, Christian A. A.; Fleck, Martin; Carotta, Sebastian; Arnhof, Heribert; Bretschneider, Tom; Dahmann, Georg; Gremel, Gabriela; Grube, Achim; Handschuh, Sandra; Heimann, Annekatrin; Hofmann, Marco H. H.; Impagnatiello, Maria A. A.; Nar, Herbert; Rast, Georg; Schaaf, Otmar; Schmidt, Esther; Oost, Thorsten
Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2023-03-018
OAAI
Hofmann, Irmgard; Baum, Anke; Hofmann, Marco H.; Trapani, Francesca; Reichel-Voda, Claudia; Ehrensperger, Diane; Aichinger, Martin; Ebner, Florian; Budano, Nicole; Schweifer, Norbert; Sykora, Martina; Depla, Erik; Boucneau, Joachim; Gschwind, Andreas; Kraut, Norbert; Hilberg, Frank; Kunkele, Klaus-Peter
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS

一个原子就能改变一切: 在SOS1和KRAS之间进门

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-1540
PRE
Ramharter, Juergen; Kessler, Dirk; Ettmayer, Peter; Hofmann, Marco H.; Gerstberger, Thomas; Gmachl, Michael; Wunberg, Tobias; Kofink, Christiane; Sanderson, Michael; Arnhof, Heribert; Bader, Gerd; Rumpel, Klaus; Zoephel, Andreas; Schnitzer, Renate; Boettcher, Jark; O'Connell, Jonathan C.; Mendes, Rachel L.; Richard, David; Pototschnig, Nikolai; Weiner, Irene; Hela, Wolfgang; Hauer, Katja; Haering, Daniela; Lamarre, Lyne; Wolkerstorfer, Bernhard; Salamon, Christian; Werni, Patrick; Munico-Martinez, Silvia; Meyer, Reiner; Kennedy, Matthew D.; Kraut, Norbert; McConnell, Darryl B.
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

BI-3406是一种有效的选择性SOS1-KRAS相互作用抑制剂，通过联合MEK抑制对KRAS驱动的癌症有效

CANCER DISCOVERY
IF33.3
2021-01-06276
OAAI
Hofmann, Marco H.; Gmachl, Michael; Ramharter, Juergen; Savarese, Fabio; Gerlach, Daniel; Marszalek, Joseph R.; Sanderson, Michael P.; Kessler, Dirk; Trapani, Francesca; Arnhof, Heribert; Rumpel, Klaus; Botesteanu, Dana-Adriana; Ettmayer, Peter; Gerstberger, Thomas; Kofink, Christiane; Wunberg, Tobias; Zoephel, Andreas; Fu, Szu-Chin; Teh, Jessica L.; Boettcher, Jark; Pototschnig, Nikolai; Schachinger, Franziska; Schipany, Katharina; Lieb, Simone; Vellano, Christopher P.; O'Connell, Jonathan C.; Mendes, Rachel L.; Moll, Jurgen; Petronczki, Mark; Heffernan, Timothy P.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert
Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist
CANCER RESEARCH
IF16.6
2020-08-155
PRE
Gremel, Gabriela; Impagnatiello, Maria A.; Carotta, Sebastian; Schaaf, Otmar; Chetta, Paolo M.; Oost, Thorsten; Zichner, Thomas; Hofmann, Marco; Blake, Sophia; Bretschneider, Tom; Fleck, Martin; Grube, Achim; Nar, Herbert; Rast, Georg; Schmidt, Esther; Klinkhardt, Ute; Arndt-Schmitz, Kirsten; Laux, Thorsten; Zinzalla, Vittoria; Sedgwick, Jonathon; Kraut, Norbert
BI-3406 and BI 1701963: Potent and selective SOS1::KRAS inhibitors induce regressions in combination with MEK inhibitors or irinotecan

BI-3406和BI 1701963: 有效和选择性的SOS1::KRAS抑制剂与MEK抑制剂或伊立替康联合诱导消退

CANCER RESEARCH
IF16.6
2020-08-1530
PRE
Gerlach, Daniel; Gmachl, Michael; Ramharter, Juergen; Teh, Jessica; Fu, Szu-Chin; Trapani, Francesca; Kessler, Dirk; Rumpel, Klaus; Botesteanu, Dana-Adriana; Ettmayer, Peter; Arnhof, Heribert; Gerstberger, Thomas; Kofink, Christiane; Wunberg, Tobias; Vellano, Christopher P.; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert; Hofmann, Marco H.

研究方向

暂未获取到该数据
N
Norbert Kraut
H 指数:41论文数:264被引数:1.0万
H
Heribert Arnhof
H 指数:16论文数:88被引数:2,050
D
Daniel Gerlach
H 指数:33论文数:177被引数:9,051
M
Mark Pearson
H 指数:44论文数:261被引数:8,831
D
Darryl B. McConnell
H 指数:33论文数:155被引数:4,819
T
Thomas Gerstberger
H 指数:21论文数:65被引数:3,452
K
Kaja Kostyrko
H 指数:14论文数:133被引数:1,089
M
Michael P. Sanderson
H 指数:21论文数:96被引数:3,544
F
Francesca Trapani
H 指数:20论文数:122被引数:3,867
F
Fabio Savarese
H 指数:16论文数:88被引数:1,760