戴

戴一凡 (Yifan Dai)

Tsinghua University教授

H指数:38

被引数:8,297

个人简介

"戴一凡作者：基础医学院日期：2020-05-15 点击：9475 戴一凡教授理学博士博士生导师江苏省异种移植重点实验室主任科学研究方向异种移植联系方式通讯：江苏省南京市江宁区龙眠大道101号学海楼，邮编211166电邮：daiyifan@njmu.edu.cn简介戴一凡博士，国家重点研发计划首席科学家，教育部长江学者讲座教授。2012年“江苏省科技创新团队”领军人才，2012年江苏省“五一劳动荣誉奖章”获得者。现任江苏省异种器官移植重点实验室主任，南京医科大学教授，天元学者，博士生导师。入选“省双创人才”、“紫金人才”、江宁区“千百十”计划，“中国抗衰老促进会再生医学专业委员会”副主任，中华医学会器官移植学分会委员。主要研究方向是基因编辑和疾病动物模型。奖项及荣誉2010 紫金人才2011 江苏省“双创人才”2011 江苏省五一劳动荣誉奖章2018 天元学者学术兼职中国抗衰老促进会再生医学专业委员会副主任中华医学会器官移植学分会委员承担科研课题1. 2011校协同创新，心血管病大动物模型子课题、2013-2015、260万元、已结题、主持2. 中央支持地方专项经费，异种移植科研平台建设、2013-2015、1600万元、已结题、主持3. 国家自然科学基金面上项目，81570402、利用CRISPR/Cas9技术构建ApoE-/-小型猪动脉粥样硬化模型、2016.1-2019.12、132万元、已结题、主持4. 国家重点研发计划“生物医用材料研发与组织器官修复替代”专项，基因修饰的巴马小型猪和近交系五指山小型猪作为异种器官供体，2017YFC1103700，1370万，2017.7-2020.12，未结题、主持5. 国家自然科学基金面上项目，81874144、利用CRISPR/Cas9技术构建TSC1+ /-巴马小型猪作为肿瘤等疾病大动物模型、2019.1-2022.12、90万元、未结题、主持近五年代表性论文1. Wen ZH, Su YC, Lai PL, Zhang Y, Xu YF, Zhao A, Yao GY, Jia CH, Lin J, Xu S, Wang L, Wang XK, Liu AL, Jiang Y, Dai YF*, Bai XC*, Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. Oncogene. 2013 Jan 10;32(2):160-70. 2. Chen TY, Zhang ZM, Zheng XC, Wang L, Huang MJ, Qin S, Chen J, Lai PL, Yang CL, Liu J, Dai YF, Jin DD, Bai XC*，Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice. Drug Des Devel Ther. 2013 Jun 28;7:545-52. 3. Zhang Y, Xu S, Lin J, Yao G, Han Z, Liang B, Zou Z, Chen Z, Song Q, Dai Y, Gao T, Liu A, Bai X*. mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo. Breast Cancer Res Treat. 2012 Nov;136(2):379-88. doi: 10.1007/s10549-012-2270-7. Epub 2012 Sep 29.4. Hu X, Zhang F, Leak RK, Zhang W, Iwai M, Stetler RA, Dai Y, Zhao A, Gao Y, Chen J*. Transgenic overproduction of omega-3 polyunsaturated fatty acids provides neuroprotection and enhances endogenous neurogenesis after stroke. Curr Mol Med. 2013 Nov;13(9):1465-73.5. Hara H*, Witt W, Crossley T, Long C, Isse K, Fan L, Phelps CJ, Ayares D, Copper DK, Dai Y*, Starzl TE. Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T cell immune response and immune status. Immunology. 2013, 140, 39-46.6. Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC*， Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice. Ann Rheum Dis. 2014 Sep;73(9):1719-27.7. Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Gao T, Zhao A, Dai Y*, Bai X*. mTORC1/2 targeted by n-3 polyunsaturated fatty acids (PUFAs) in the prevention of mammary tumorigenesis and tumor progression. Oncogene, 2014 Sep 11;33(37):4548-57. 8. Ming Yu, Qianqian Gao, Yan Wang, Wei Zhang, Lin Li, Ying Wang*, Yifan Dai*，Unbalanced omega-6/omega-3 ratio in the red meat products in China，The Journal of Biomedical Research, 2013, 27(5):366-371.9. Zheng H, Tang H, Liu M, He M, Lai P, Dong H, Lin J, Jia C, Zhong M, Dai Y, Bai X, Wang L*. Inhibition of endometrial cancer by n-3 polyunsaturated fatty acids in preclinical models. Cancer Prev Res (Phila). 2014 Aug;7(8):824-34. 10. Li J, Li FR, Wei D, Jia W, Kang JX, Stefanovic-Racic M, Dai Y*, Zhao AZ*. Endogenous ω-3 polyunsaturated fatty acid production confers resistance to obesity, dyslipidemia, and diabetes in mice. Mol Endocrinol. 2014 Aug;28(8):1316-28.11. Gao Z, Wang Y, Ren Z, Li Q, Wang Y*, Dai Y*，Genome-wide screen for serum microRNA expression profile in mfat-1 transgenic mice. Tumour Biol. 2014 Oct;35(10):9717-23.12. Cheng J, Wang Y, Zhang Z, Jin Y, Li Q, Want R, Wang Y, Li X, Xiong Q, Zhang M, Li R*, Dai Y*., Dominant-negative inhibition of glucose-dependent insulinotropic polypeptide impairs function of β cells in transgenic pigs. J Biomed Res. 2015 Nov;29(6):512-4. 13. Chen F, Wang Y, Yuan Y, Zhang W, Ren Z, Jin Y, Liu X, Xiong Q, Chen Q, Zhang M, Li X, Zhao L, Li Z, Wu Z, Zhang Y, Hu F, Huang J, Li R*, Dai Y*.,Generation of B cell-deficient pigs by highly efficient CRISPR/Cas9-mediated gene targeting. J Genet Genomics. 2015 Aug 20;42(8):437-44.14. Sheng T, Zhang X, Wang S, Zhang J, Lu W*, Dai Y*.,Endothelin-1-induced mini-stroke in the dorsal hippocampus or lateral amygdala results in deficits in learning and memory., J Biomed Res. 2015 Sep;29(5):362-9. 15. Iwase H, Ekser B, Satyananda V, Zhou H, Hara H, Bajona P, Wijkstrom M, Bhama JK, Long C, Veroux M, Wang Y, Dai Y, Phelps C, Ayares D, Ezzelarab MB, Cooper DK*., Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs. Transpl Immunol. 2015 Mar;32(2):99-108.16. Zhang Y, Yuan Y, Sheng M, Zhang W, Wang Y, Zhang X*, Yifan Dai*, Generation of monoclonal antibodies against n-3 fatty acid desaturase., J Biomed Res. 2015 May 28, 29(6), 515-7.17. Hou DR, Jin Y, Nie XW, Zhang ML, Ta N, Zhao LH, Yang N, Chen Y, Wu ZQ, Jiang HB, Li YR, Sun QY, Dai YF, Li RF*, Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos. Sci Rep. 2016 May 13;6:25838. doi: 10.1038/srep25838.18. Zhou M, Hara H, Dai Y, Mou L, Cooper DK, Wu C, Cai Z*., Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation. Int J Mol Sci. 2016 Aug 1;17(8).19. Dong X, Hara H, Wang Y, Wang L, Zhang Y, Cooper DK, Dai Y*, Pan Z*, Initial study of α1,3-galactosyltransferase gene-knockout/CD46 pig full-thickness corneal xenografts in rhesus monkeys. Xenotransplantation. 2017 Jan 5. 24 (1), e12282. 20. Liu L, Gao H, Hong C, He C, Pan D, Dai Y, Hara H, Cooper DK, Li Z, Cai Z, Mou L*., Klotho attenuated antibody-mediated porcine endothelial cell activation and injury. Xenotransplantation. 2017 Jan 28. doi: 10.1111/xen.12286. [Epub ahead of print]21. Gao H, Zhao C, Xiang X, Li Y, Zhao Y, Li Z, Pan D, Dai Y, Ha"