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Synthesis of a New Purine Analogue Class with Antifungal Activity and Improved Potency against Fungal IP3-4K (vol 11, pg 940, 2025) 合成具有抗真菌活性的新型嘌呤类似物类,并提高其对真菌IP3-4K的效力(卷11,页940,2025) Desmarini, Desmarini; Truong, Daniel; Sethiya, Pooja; Liu, Guizhen; Bowring, Bethany; Jessen, Henning; Dinh, Hue; Cain, Amy K.; Thompson, Philip E.; Djordjevic, Julianne T. 分享 收藏
Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus 靶向SARS-CoV-2 Mpro的蛋白质降解剂比单纯的酶抑制作用更有效,且对耐尼玛特雷韦病毒具有活性 Pan, Baolong; Mountford, Simon J.; Kiso, Maki; Anderson, Danielle E.; Papadakis, Georgina; Jarman, Kate E.; Tilmanis, Danielle R.; Maher, Belinda; Tran, Thomas; Shortt, Jake; Yamayoshi, Seiya; Kawaoka, Yoshihiro; Thompson, Philip E.; Greenall, Sam A.; Warner, Nadia 分享 收藏
Synthesis of a New Purine Analogue Class with Antifungal Activity and Improved Potency against Fungal IP3-4K 具有抗真菌活性的新型嘌呤类似物类别的合成及其对真菌IP3-4K的增强效力 Desmarini, D; Truong, D; Sethiya, P; Liu, GZ; Bowring, B; Jessen, H; Dinh, H; Cain, AK; Thompson, PE; Djordjevic, JT 分享 收藏
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PmxPred: A data-driven approach for the identification of active polymyxin analogues against gram-negative bacteria Wang, Xiaoyu; Patil, Nitin; Li, Fuyi; Wang, Zhikang; Zhan, Haolan; Schmidt, Daniel; Thompson, Philip; Guo, Yuming; Landersdorfer, Cornelia B.; Shen, Hsin-Hui; Peleg, Anton Y.; Li, Jian; Song, Jiangning 分享 收藏
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Structure-Interaction Relationship of Polymyxins with Lung Surfactant Jiang, Xukai; Patil, Nitin A.; Xu, Yuwen; Wickremasinghe, Hasini; Zhou, Qi Tony; Zhou, Fanfan; Thompson, Philip E.; Wang, Lushan; Xiao, Min; Roberts, Kade D.; Velkov, Tony; Li, Jian 分享 收藏
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Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma 合理设计的嵌合PI3K-BET溴结构域抑制剂在MYC驱动的淋巴瘤中引起治疗反应 Oh, Danielle H.; Ma, Xiao; Hogg, Simon J.; He, Jackson; Kearney, Conor; Brasacchio, Daniella; Susanto, Olivia; Maher, Belinda; Jennings, Ian G.; Newbold, Andrea; Fraser, Peter; Gruber, Emily; Kats, Lev M.; Gregory, Gareth P.; Johnstone, Ricky W.; Thompson, Philip E.; Shortt, Jake 分享 收藏
Development of Highly Potent Clinical Candidates for Theranostic Applications against Cholecystokinin-2 Receptor Positive Cancers Corlett, Alicia; Pinson, Jo-Anne; Rahimi, Marwa N.; Van Zuylekom, Jessica; Cullinane, Carleen; Blyth, Benjamin; Thompson, Philip E.; Hutton, Craig A.; Roselt, Peter D.; Haskali, Mohammad B. 分享 收藏
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Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity Patil, Nitin A.; Ma, Wendong; Jiang, Xukai; He, Xiaoji; Yu, Heidi H.; Wickremasinghe, Hasini; Wang, Jiping; Thompson, Philip E.; Velkov, Tony; Roberts, Kade D.; Li, Jian 分享 收藏
Membrane Permeating Macrocycles: Design Guidelines from Machine Learning 膜渗透大环: 来自机器学习的设计指南 -Noonan, Billy J. Williams; Speer, Melissa N.; Le, Tu C.; Sadek, Maiada M.; Thompson, Philip E.; Norton, Raymond S.; Yuriev, Elizabeth; Barlow, Nicholas; Chalmers, David K.; Yarovsky, Irene 分享 收藏
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A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens 靶向多重耐药革兰氏阴性病原体的合成脂肽 Roberts, Kade D.; Zhu, Yan; Azad, Mohammad A. K.; Han, Mei-Ling; Wang, Jiping; Wang, Lynn; Yu, Heidi H.; Horne, Andrew S.; Pinson, Jo-Anne; Rudd, David; Voelcker, Nicolas H.; Patil, Nitin A.; Zhao, Jinxin; Jiang, Xukai; Lu, Jing; Chen, Ke; Lomovskaya, Olga; Hecker, Scott J.; Thompson, Philip E.; Nation, Roger L.; Dudley, Michael N.; Griffith, David C.; Velkov, Tony; Li, Jian 分享 收藏