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Denise Sheer 封面图

Denise Sheer

Queen Mary University of LondonProfessor of Human Genetics
H指数:57
被引数:1.4万

个人简介

Completed a B.Sc (Hons) in Embryology and Zoology at the University of the Witwatersrand, Johannesburg, and then ran the diagnostic Cytogenetics Laboratory at the South African Institute of Medical Research for two years. She then moved to the Genetics Laboratory at the University of Oxford, where she was awarded a D.Phil. After a Post-Doctoral Research Fellowship at the Imperial Cancer Research Fund (Cancer Research UK), she became Head of the Human Cytogenetics Laboratory, where her group identified significant genetic aberrations in many different malignancies and made critical discoveries on chromosome architecture. She moved with her group to the Blizard Institute in 2006.

教育背景

暂无内容

工作经历

  • 2006.01 – 至今

    Blizard Institute

    Professor of Human Genetics

荣誉奖项

  1. Jeremy Jass Prize for Excellence in Pathology（2009）
  2. Queen Mary Innovation Proof of Concept Award（2015）
Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

作者更正：FGFR 突变和共突变的多样化景观表明儿童低级别胶质瘤中存在潜在的治疗策略

Nature Communications
IF15.7
2025-10-090
OA
April A. Apfelbaum; Eric Morin; Dominik Sturm; Georges Ayoub; Jeromy DiGiacomo; Sher Bahadur; Bhavyaa Chandarana; Phoebe C. Power; Margaret M. Cusick; Dana Novikov; Prem Prabhakar; Robert E. Jones; Jayne Vogelzang; Connor C. Bossi; Seth Malinowski; Lewis M. Woodward; Tania A. Jones; John Jeang; Sarah W. Lamson; Jared Collins; Kelly Y. Cai; Jacquelyn S. Jones; Sehee Oh; Hyesung Jeon; Jinhua Wang; Amy Cameron; Patrick Rechter; Angela De Leon; Karthikeyan Murugesan; Meagan Montesion; Lee A. Albacker; Shakti H. Ramkissoon; Cornelis M. van Tilburg; Emily C. Hardin; Philipp Sievers; Felix Sahm; Kee Kiat Yeo; Tom Rosenberg; Susan N. Chi; Karen D. Wright; Steven Hébert; Sydney Peck; Alberto Picca; Valérie Larouche; Samuele Renzi; Sara J. Buhrlage; Tejus A. Bale; Amy A. Smith; Mehdi Touat; Nada Jabado; Eric S. Fischer; Michael J. Eck; Lissa Baird; Olaf Witt; Claudia L. Kleinman; Quang-De Nguyen; Denise Sheer; Sanda Alexandrescu; David T. W. Jones; Keith L. Ligon; Pratiti Bandopadhayay
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

FGFR变异和共突变多样性的景观表明儿科低级别胶质瘤存在潜在的治疗策略

Nature Communications
IF15.7
2025-07-310
OAAI
April A. Apfelbaum; Eric Morin; Dominik Sturm; Georges Ayoub; Jeromy DiGiacomo; Sher Bahadur; Bhavyaa Chandarana; Phoebe C. Power; Margaret M. Cusick; Dana Novikov; Prem Prabhakar; Robert E. Jones; Jayne Vogelzang; Connor C. Bossi; Seth Malinowski; Lewis M. Woodward; Tania A. Jones; John Jeang; Sarah W. Lamson; Jared Collins; Kelly Y. Cai; Jacquelyn S. Jones; Sehee Oh; Hyesung Jeon; Jinhua Wang; Amy Cameron; Patrick Rechter; Angela De Leon; Karthikeyan Murugesan; Meagan Montesion; Lee A. Albacker; Shakti H. Ramkissoon; Cornelis M. van Tilburg; Emily C. Hardin; Philipp Sievers; Felix Sahm; Kee Kiat Yeo; Tom Rosenberg; Susan N. Chi; Karen D. Wright; Steven Hébert; Sydney Peck; Alberto Picca; Valérie Larouche; Samuele Renzi; Sara J. Buhrlage; Tejus A. Bale; Amy A. Smith; Mehdi Touat; Nada Jabado; Eric S. Fischer; Michael J. Eck; Lissa Baird; Olaf Witt; Claudia L. Kleinman; Quang-De Nguyen; Denise Sheer; Sanda Alexandrescu; David T. W. Jones; Keith L. Ligon; Pratiti Bandopadhayay
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma
NATURE COMMUNICATIONS
IF15.7
2021-10-2117
OAAI
Vinel, Claire; Rosser, Gabriel; Guglielmi, Loredana; Constantinou, Myrianni; Pomella, Nicola; Zhang, Xinyu; Boot, James R.; Jones, Tania A.; Millner, Thomas O.; Dumas, Anaelle A.; Rakyan, Vardhman; Rees, Jeremy; Thompson, Jamie L.; Vuononvirta, Juho; Nadkarni, Suchita; El Assan, Tedani; Aley, Natasha; Lin, Yung-Yao; Liu, Pentao; Nelander, Sven; Sheer, Denise; Merry, Catherine L. R.; Marelli-Berg, Federica; Brandner, Sebastian; Marino, Silvia
Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment

小胶质细胞通过mTOR介导的肿瘤微环境免疫抑制促进胶质母细胞瘤

EMBO JOURNAL
IF8.3
2020-06-2299
OAAI
Dumas, Anaelle A.; Pomella, Nicola; Rosser, Gabriel; Guglielmi, Loredana; Vinel, Claire; Millner, Thomas O.; Rees, Jeremy; Aley, Natasha; Sheer, Denise; Wei, Jun; Marisetty, Anantha; Heimberger, Amy B.; Bowman, Robert L.; Brandner, Sebastian; Joyce, Johanna A.; Marino, Silvia
DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas
ACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
2016-05-2717
OAAI
Jeyapalan, Jennie N.; Doctor, Gabriel T.; Jones, Tania A.; Alberman, Samuel N.; Tep, Alexander; Haria, Chirag M.; Schwalbe, Edward C.; Morley, Isabel C. F.; Hill, Alfred A.; LeCain, Magdalena; Ottaviani, Diego; Clifford, Steven C.; Qaddoumi, Ibrahim; Tatevossian, Ruth G.; Ellison, David W.; Sheer, Denise
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
NATURE GENETICS
IF31.8
2013-04-14714
OAAI
Zhang, Jinghui; Wu, Gang; Miller, Claudia P.; Tatevossian, Ruth G.; Dalton, James D.; Tang, Bo; Orisme, Wilda; Punchihewa, Chandanamali; Parker, Matthew; Qaddoumi, Ibrahim; Boop, Fredrick A.; Lu, Charles; Kandoth, Cyriac; Ding, Li; Lee, Ryan; Huether, Robert; Chen, Xiang; Hedlund, Erin; Nagahawatte, Panduka; Rusch, Michael; Boggs, Kristy; Cheng, Jinjun; Becksfort, Jared; Ma, Jing; Song, Guangchun; Li, Yongjin; Wei, Lei; Wang, Jianmin; Shurtleff, Sheila; Easton, John; Zhao, David; Fulton, Robert S.; Fulton, Lucinda L.; Dooling, David J.; Vadodaria, Bhavin; Mulder, Heather L.; Tang, Chunlao; Ochoa, Kerri; Mullighan, Charles G.; Gajjar, Amar; Kriwacki, Richard; Sheer, Denise; Gilbertson, Richard J.; Mardis, Elaine R.; Wilson, Richard K.; Downing, James R.; Baker, Suzanne J.; Ellison, David W.

研究方向

Molecular pathology of brain tumoursCancer genetics and epigeneticsProtein aggregation in neurodegenerationChromatin and nuclear organisationCell and molecular biology
T
T. Alwyn Jones
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Tim Forshew
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R
Ruth Tatevossian
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S
Silvia Marino
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N
Nicola Pomella
H 指数:11论文数:34被引数:462
G
Gabriel Rosser
H 指数:15论文数:30被引数:902
D
Diego Ottaviani
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A
Andrew Lawson
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A
Anaëlle Dumas
H 指数:15论文数:36被引数:2,192
D
David W. Ellison
H 指数:113论文数:757被引数:7.8万