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Ryotaro Ohkuma

Showa Medical University
H指数:13
被引数:518

个人简介

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工作经历

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荣誉奖项

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Efficacy and biomarker analysis for nivolumab in cancer of unknown primary: results from an investigator-initiated expanded access program

纳武利尤单抗治疗未知原发灶癌症的疗效与生物标志物分析：来自研究者发起的扩展性准入项目的结果

International Journal of Clinical Oncology
IF2.8
2026-09-240
OAAI
Junko Tanizaki; Kan Yonemori; Yuichi Takiguchi; Kohei Akiyoshi; Keigo Komine; Yusuke Onozawa; Mariko Sato; Kenro Hirata; Takuma Onoe; Ryotaro Ohkuma; Yosuke Horita; Hironobu Minami; Kazunori Honda; Koichi Suyama; Akihiko Ito; Yasutaka Chiba; Hiroko Watanabe; Yosuke Togashi; Kazuko Sakai; Kazuto Nishio; Kazuhiko Nakagawa; Hidetoshi Hayashi
Association of Prior Local Therapy with Outcomes Within Systemic Therapy Regimen Cohorts in Advanced Soft Tissue Sarcoma: A Retrospective Cohort Study

先前局部治疗与系统性治疗方案队列中高级别软组织肉瘤预后的相关性：一项回顾性队列研究

Cancers
IF4.4
2026-08-290
OA
Ryotaro Ohkuma; Tomoyuki Ishiguro; Hirotsugu Ariizumi; Masahiro Shimokawa; Go Ikeda; Takahiro Yoshizawa; Yuya Hirasawa; Risako Suzuki; Toshiaki Tsurui; Emiko Mura; Rika Sasaki; Shuichi Komori; Kosuke Toyofuku; Masako Kato; Kanae Shimada; Shingo Miyamoto; Kouzou Murakami; Yoshihiro Nakagami; Kazuhiko Oshinomi; Yutaro Kubota; Hiroo Ishida; Takeshi Aoki; Masahiko Murakami; Kiyoshi Yoshimura; Satoshi Wada; Katsuhito Takahashi; Takuya Tsunoda; Atsushi Horiike
Association of Intratumoral Macrophage Subsets with Treatment Outcomes in Patients with Stage IV Solid Tumors

肿瘤内巨噬细胞亚群与IV期实体瘤患者治疗结局的关联

Laboratory Investigation
IF4.2
2026-08-120
OAAI
Ryotaro Ohkuma; Nobuyuki Onishi; Aya Misawa; Makoto Watanabe; Jian Jin; Hirotsugu Ariizumi; Masahiro Shimokawa; Go Ikeda; Risako Suzuki; Toshiaki Tsurui; Yutaro Kubota; Yosuke Sasaki; Mayumi Homma; Kiyoshi Yoshimura; Toshiko Yamochi; Shinichi Kobayashi; Takuya Tsunoda; Atsushi Horiike; Satoshi Wada
Elevated plasma IgG is associated with improved treatment response and survival in advanced non‑small cell lung cancer patients treated with anti‑PD‑1 therapy

血浆IgG升高与接受抗PD-1治疗晚期非小细胞肺癌患者的治疗反应改善及生存率提高相关

Scientific Reports
IF3.9
2026-04-200
OAAI
Ryotaro Ohkuma; Nobuyuki Onishi; Makoto Watanabe; Jian Jin; Hirotsugu Ariizumi; Masahiro Shimokawa; Go Ikeda; Tomoyuki Ishiguro; Risako Suzuki; Toshiaki Tsurui; Yutaro Kubota; Kiyoshi Yoshimura; Shinichi Kobayashi; Takuya Tsunoda; Atsushi Horiike; Satoshi Wada
Correction: Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression

更正：Akkermansia muciniphila在PD-L1低表达的非小细胞肺癌患者中预测对免疫检查点抑制剂的临床反应

Frontiers in Immunology
IF5.9
2026-03-270
OAAI
TS Takashi Shimizu; RO Ryotaro Ohkuma; MH Mayumi Homma; SN Shingo Nakayama; YS Yosuke Sasaki; SM Satoshi Muto; KI Katsuaki Ieguchi; MW Makoto Watanabe; AT Akashi Taguchi; DT Daisuke Takayanagi; YW Youichiro Wada; AH Atsushi Horiike; YK Yutaro Kubota; HA Hirotsugu Ariizumi; MS Masahiro Shimokawa; YH Yuya Hirasawa; TI Tomoyuki Ishiguro; RS Risako Suzuki; NI Nana Iriguchi; EM Emiko Mura; KY Kiyoshi Yoshimura; MT Mayumi Tsuji; YK Yuji Kiuchi; HS Hiroyuki Suzuki; TY Toshiko Yamochi
Neoadjuvant immune checkpoint blockade before chemoradiation for cervical squamous carcinoma (GINECO window-of-opportunity COLIBRI study): a phase II trial

新辅助免疫检查点阻断在宫颈鳞癌患者化疗放疗前的应用（GINECO window-of-opportunity COLIBRI研究）：一项II期临床试验

Nature Communications
IF15.7
2026-01-050
OAAI
Isabelle Ray-Coquard; Marie-Christine Kaminsky-Forrett; Ryotaro Ohkuma; Aymeric de Montfort; Florence Joly; Isabelle Treilleux; Sarah Ghamry-Barrin; Diana Bello-Roufai; Pierre Saintigny; Antoine Angelergues; Lucas Michon; Anne-Claire Hardy-Bessard; Valéry Attignon; Jessie Auclair; Gabriel Chemin; Alexandra Lainé; Hélène Péré; David Veyer; Aude-Marie Savoye; Justine Berthet; Christophe Caux; Fabrice Lecuru; Bertrand Dubois; Sarah Bétrian
Vinegar intake in patients undergoing immune checkpoint inhibitor therapy: food frequency questionnaire study

接受免疫检查点抑制剂治疗的患者醋摄入情况：食物频率问卷调查研究

Frontiers in Immunology
IF5.9
2025-12-110
OAAI
Hirotsugu Ariizumi; Miyuki Shimazui; Chisato Ogawa; Mika Kaneki; Nanaho Saito; Emiko Mura; Risako Suzuki; Toshiaki Tsurui; Nana Iriguchi; Tomoyuki Ishiguro; Yuya Hirasawa; Masahiro Shimokawa; Ryotaro Ohkuma; Yutaro Kubota; Atsushi Horiike; Satoshi Wada; Kiyoshi Yoshimura; Kouzou Murakami; Takuya Tsunoda
Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression

Akkermansia muciniphila在PD-L1低表达的非小细胞肺癌患者中预测对免疫检查点抑制剂的临床反应

Frontiers in Immunology
IF5.9
2025-09-080
OA
Takashi Shimizu; Ryotaro Ohkuma; Mayumi Homma; Shingo Nakayama; Yosuke Sasaki; Satoshi Muto; Katsuaki Ieguchi; Makoto Watanabe; Akashi Taguchi; Daisuke Takayanagi; Youichiro Wada; Atsushi Horiike; Yutaro Kubota; Hirotsugu Ariizumi; Masahiro Shimokawa; Yuya Hirasawa; Tomoyuki Ishiguro; Risako Suzuki; Nana Iriguchi; Emiko Mura; Kiyoshi Yoshimura; Mayumi Tsuji; Yuji Kiuchi; Hiroyuki Suzuki; Toshiko Yamochi
Inosine shapes PD-1 blockade responses and synergizes with dual PD-1/CTLA-4 immunotherapy to enhance antitumor immunity

次黄苷塑造PD-1阻断反应，并与双重PD-1/CTLA-4免疫疗法协同作用以增强抗肿瘤免疫。

cancer immunology immunotherapy
IF0
2025-08-190
OAAI
Yoichiro Narikawa; Atsuo Kuramasu; Masahiro Hosonuma; Masakazu Murayama; Eiji Funayama; Akiko Sasaki; Yuta Baba; Hitoshi Toyoda; Junya Isobe; Kohei Tajima; Rie Nakashima; Aya Sasaki; Yuki Maruyama; Yoshitaka Yamazaki; Midori Shida; Toshiaki Tsurui; Yuya Hirasawa; Hirotsugu Ariizumi; Tomoyuki Ishiguro; Risako Suzuki; Ryotaro Ohkuma; Yutaro Kubota; Takehiko Sambe; Mayumi Tsuji; Satoshi Wada; Atsushi Horiike; Shinichi Kobayashi; Takuya Tsunoda; Sei Kobayashi; Hitome Kobayashi; Tatsunori Oguchi; Toshikazu Shimane; Yuji Kiuchi; Kiyoshi Yoshimura
Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8+ T cells as a predictor of clinical benefit

Ki-67表达在程序性死亡蛋白-1抗体结合的CD8+ T细胞中作为临床获益的预测指标

DISCOVER ONCOLOGY
IF2.9
2025-03-180
OA
Tsurui, Toshiaki; Hosonuma, Masahiro; Sasaki, Aya; Maruyama, Yuuki; Amari, Yasunobu; Funayama, Eiji; Tajima, Kohei; Toyoda, Hitoshi; Isobe, Junya; Yamazaki, Yoshitaka; Baba, Yuta; Shida, Midori; Udaka, Yuko; Mura, Emiko; Suzuki, Risako; Iriguchi, Nana; Ishiguro, Tomoyuki; Hirasawa, Yuya; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Kubota, Yutaro; Horiike, Atsushi; Wada, Satoshi; Kuramasu, Atsuo; Tsuji, Mayumi; Kiuchi, Yuji; Tsunoda, Takuya; Yoshimura, Kiyoshi
Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors

免疫应激诱导的肿瘤突变负荷及新抗原表达在4T1乳腺癌细胞中的作用：长期存活于接受免疫检查点抑制剂治疗患者的一种潜在机制

CANCER GENOMICS & PROTEOMICS
IF2.6
2024-12-270
OA
Ishiguro, Tomoyuki; Takeda, Kazuyuki; Takayanagi, Daisuke; Mura, Emiko; Suzuki, Risako; Tsurui, Toshiaki; Iriguchi, Nana; Hirasawa, Yuya; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Kubota, Yutaro; Horiike, Atsushi; Izumizaki, Masahiko; Wada, Satoshi; Yoshimura, Kiyoshi; Hoffman, Robert m.; Tsunoda, Takuya
Chemotherapy combined with immune checkpoint inhibitors may overcome the detrimental effect of high neutrophil-to-lymphocyte ratio prior to treatment in esophageal cancer patients
FRONTIERS IN ONCOLOGY
IF3.3
2024-10-110
OAAI
Hirasawa, Yuya; Kubota, Yutaro; Mura, Emiko; Suzuki, Risako; Tsurui, Toshiaki; Iriguchi, Nana; Ishiguro, Tomoyuki; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Horiike, Atsushi; Wada, Satoshi; Yamashita, Takeshi; Ariyoshi, Tomotake; Goto, Satoru; Otsuka, Koji; Murakami, Masahiko; Kiuchi, Yuji; Yoshimura, Kiyoshi; Tsunoda, Takuya
Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody

异丁酸增强anti-PD-1抗体的抗肿瘤作用

SCIENTIFIC REPORTS
IF3.9
2024-05-177
OAAI
Murayama, Masakazu; Hosonuma, Masahiro; Kuramasu, Atsuo; Kobayashi, Sei; Sasaki, Akiko; Baba, Yuta; Narikawa, Yoichiro; Toyoda, Hitoshi; Isobe, Junya; Funayama, Eiji; Tajima, Kohei; Sasaki, Aya; Maruyama, Yuki; Yamazaki, Yoshitaka; Shida, Midori; Hamada, Kazuyuki; Hirasawa, Yuya; Tsurui, Toshiaki; Ariizumi, Hirotsugu; Ishiguro, Tomoyuki; Suzuki, Risako; Ohkuma, Ryotaro; Kubota, Yutaro; Horiike, Atsushi; Sambe, Takehiko; Tsuji, Mayumi; Wada, Satoshi; Kobayashi, Shinichi; Shimane, Toshikazu; Tsunoda, Takuya; Kobayashi, Hitome; Kiuchi, Yuji; Yoshimura, Kiyoshi
Promotive clinical effects of pembrolizumab with necitumumab in patients having advanced non-small cell lung cancer with PD-L1 expression of 50% or higher in a phase II study (K-TAIL-202)
CANCER RESEARCH
IF16.6
2024-04-050
PRE
Horiike, Atsushi; Wakui, Hiroshi; Sugawara, Shunichi; Minegishi, Yuji; Tasaka, Sadatomo; Kusumoto, Sojiro; Sakatani, Toshio; Suzuki, Hiroyuki; Hosomi, Yukio; Tambo, Yuichi; Shimokawa, Tsuneo; Ishida, Hiroo; Miyauchi, Eisaku; Naoki, Katsuhiko; Fukuhara, Tatsuro; Mura, Emiko; Tsurui, Toshiaki; Suzuki, Risako; Iriguchi, Nana; Ishiguro, Tomoyuki; Hirasawa, Yuya; Manabe, Ryo; Shimokawa, Masahiro; Ohkuma, Ryotaro; Ariizumi, Hirotsugu; Kubota, Yutaro; Hamada, Kazuyuki; Takenoshita, Sachiko; Ryu, Kakei; Sambe, Takehiko; Inoue, Eisuke; Wada, Satoshi; Yoshimura, Kiyoshi; Sagara, Hironori; Kobayashi, Shinichi; Tsunoda, Takuya
Novel quantitative immunohistochemical analysis for evaluating PD-L1 expression with phosphor-integrated dots for predicting the efficacy of patients with cancer treated with immune checkpoint inhibitors

用荧光整合点评估PD-L1表达的新型定量免疫组织化学分析预测免疫检查点抑制剂治疗的癌症患者的疗效

FRONTIERS IN IMMUNOLOGY
IF5.9
2023-09-180
OAAI
Ohkuma, Ryotaro; Miura, Sakiko; Muto, Satoshi; Toyomasu, Yoshitaka; Fujimoto, Yuki; Ieguchi, Katsuaki; Onishi, Nobuyuki; Shimizu, Takashi; Watanabe, Makoto; Takayanagi, Daisuke; Goshima, Tsubasa; Horiike, Atsushi; Hamada, Kazuyuki; Ariizumi, Hirotsugu; Shimokawa, Masahiro; Hirasawa, Yuya; Ishiguro, Tomoyuki; Suzuki, Risako; Iriguchi, Nana; Tsurui, Toshiaki; Mura, Emiko; Takenoshita, Sachiko; Numajiri, Kazuki; Okabe, Naoyuki; Yoshimura, Kiyoshi; Tsuji, Mayumi; Kiuchi, Yuji; Yajima, Toshiki; Ishida, Hideyuki; Suzuki, Hiroyuki; Yamochi, Toshiko; Kobayashi, Shinichi; Tsunoda, Takuya; Wada, Satoshi

研究方向

暂未获取到该数据
K
Kiyoshi Yoshimura
H 指数:34论文数:220被引数:3,559
Y
Yutaro Kubota
H 指数:24论文数:215被引数:3,144
H
Hirotsugu Ariizumi
H 指数:15论文数:101被引数:637
Y
Yuya Hirasawa
H 指数:13论文数:94被引数:510
T
Tomoyuki Ishiguro
H 指数:11论文数:68被引数:424
S
Satoshi Wada
H 指数:30论文数:131被引数:2,631
R
Risako Suzuki
H 指数:8论文数:66被引数:261
T
Takuya Tsunoda
H 指数:39论文数:290被引数:4,476
T
Toshiaki Tsurui
H 指数:6论文数:40被引数:189
A
Atsushi Horiike
H 指数:34论文数:207被引数:6,450