未登录 UPDATED RESULTS OF PHASE 3 STELLAR TRIAL: EFLORNITHINE IMPROVES OVERALL SURVIVAL AND BLINDED INDEPENDENT CENTRAL REVIEW DETERMINED PROGRESSION FREE SURVIVAL IN PATIENTS WITH RECURRENT WHO 2021 GRADE 3 IDH-MUTANT ASTROCYTOMA 更新后的III期STELLAR试验结果：依氟鸟氨酸改善2021年WHO分级3级IDH突变型星形细胞瘤患者的总生存期和盲态独立中央审查确定的无进展生存期 Colman, Howard; Lombardi, Giuseppe; Wong, Eric; Walbert, Tobias; Eoli, Marica; Lassman, Andrew; Peereboom, David; Kizilbash, Sani; Kamiya-Matsuoka, Carlos; Pitz, Marshall; Strowd, Roy; Desjardins, Annick; Kumthekar, Priya; Mason, Warren; Pellerino, Alessia; Soffietti, Riccardo; Butowski, Nicholas; Forsyth, Peter; Hamza, Mohamed; Hau, Peter; Lallana, Enrico; Nabors, Burt; Piccioni, David; Uhlmann, Erik; Welsh, Liam; Wen, Patrick; Dietrich, Jorg; Levin, Victor 分享 收藏
Volumetric (3D) compared with traditional bidirectional (2D) assessment in patients with Grade 2, isocitrate dehydrogenase 1/2 mutant (mIDH1/2) glioma receiving vorasidenib or placebo in the Phase 3 INDIGO trial 与接受vorasidenib或安慰剂治疗的Grade 2，异柠檬酸脱氢酶1/2突变（mIDH1/2）胶质瘤患者中，体素（3D）评估相较于传统双向（2D）评估在INDIGO III期试验中的比较 Ellingson, Benjamin M.; Mellinghoff, Ingo; Van Den Bent, Martin J.; Blumenthal, Deborah T.; Touat, Mehdi; Peters, Katherine B.; Clarke, Jennifer L.; Mendez, Joe; Yust-Katz, Shlomit; Welsh, Liam; Mason, Warren P.; Ducray, Francois; Umemura, Yoshie; Nabors, Burt; Holdhoff, Matthias; Hottinger, Andreas F.; Arakawa, Yoshiki; Sepulveda, Juan M.; Wick, Wolfgang; Soffietti, Riccardo; Perry, James; Giglio, Pierre; De La Fuente, Macarena, I; Maher, Elizabeth; Zhao, Dan; Pandya, Shuchi S.; Steelman, Lori; Hassan, Islam; Wen, Patrick Y.; Cloughesy, Timothy F. 分享 收藏
Volumetric tumor growth rate (TGR) modeling predicts clinical outcomes in patients with Grade 2, isocitrate dehydrogenase 1/2 mutant (mIDH1/2) glioma receiving vorasidenib or placebo in the Phase 3 INDIGO trial 体积肿瘤生长率（TGR）建模预测了在INDIGO三期试验中，接受vorasidenib或安慰剂治疗的Grade 2、异柠檬酸脱氢酶1/2突变（mIDH1/2）胶质瘤患者的临床结局。 Ellingson, Benjamin M.; Mellinghoff, Ingo; Van Den Bent, Martin J.; Blumenthal, Deborah T.; Touat, Mehdi; Peters, Katherine B.; Clarke, Jennifer L.; Mendez, Joe; Yust-Katz, Shlomit; Welsh, Liam; Mason, Warren P.; Ducray, Francois; Umemura, Yoshie; Nabors, Burt; Holdhoff, Matthias; Hottinger, Andreas F.; Arakawa, Yoshiki; Sepulveda, Juan M.; Wick, Wolfgang; Soffietti, Riccardo; Perry, James; Giglio, Pierre; De La Fuente, Macarena, I; Maher, Elizabeth; Zhao, Dan; Pandya, Shuchi S.; Steelman, Lori; Hassan, Islam; Wen, Patrick Y.; Cloughesy, Timothy F. 分享 收藏
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A PHASE 2 STUDY OF PEMIGATINIB FOR PRE-TREATED GLIOBLASTOMA OR OTHER GLIOMAS WITH ACTIVATING FGFR1-3 ALTERATIONS: FINAL RESULTS FROM FIGHT-209 一项关于佩米加替尼治疗经治胶质母细胞瘤或其他携带激活性FGFR1-3变异的胶质瘤的II期研究：FIGHT-209的最终结果 Franceschi, E.; van den Bent, M.; Sanson, M.; Lassman, A. B.; Lombardi, G.; Gomez, D.; Strowd, R. E.; Sepulveda Sanchez, J. M.; McBain, C.; Welsh, L.; Lobbous, M.; Dahlrot, R.; Pineda, E.; Larrieu, D.; Pellerino, A.; Narita, Y.; Bagley, S.; Oliveira, N.; Guo, Y.; Veronese, L.; Viviers, L.; Yogendran, L.; Ahluwalia, M. S. 分享 收藏
EARLY TUMOR VOLUME CHANGES PREDICT CLINICAL OUTCOMES IN MIDH1/2 GLIOMA: POST-HOC RESULTS FROM THE PHASE 3 INDIGO TRIAL 早期肿瘤体积变化预测Midh1/2胶质瘤的临床结局：INDIGO III期试验的事后分析结果 Ellingson, B. M.; Mellinghoff, I. K.; van den Bent, M. J.; Blumenthal, D. T.; Touat, M.; Peters, K. B.; Clarke, J. L.; Mendez, J.; Yust-Katz, S.; Welsh, L.; Mason, W. P.; Ducray, F.; Umemura, Y.; Nabors, B.; Holdhoff, M.; Hottinger, A. F.; Arakawa, Y.; Sepulveda, J. M.; Wick, W.; Soffietti, R.; Perry, J.; Giglio, P.; de la Fuente, M.; Maher, E.; Zhao, D.; Pandya, S. S.; Steelman, L.; Hassan, I; Wen, P. Y.; Cloughesy, T. F. 分享 收藏
EXPLORATORY ANALYSES FROM PHASE 3 INDIGO STUDY SUGGEST POTENTIAL MECHANISM OF SEIZURE CONTROL THROUGH TUMOR VOLUME REDUCTION UNDER TREATMENT WITH VORASIDENIB 来自INDIGO研究第3阶段的探索性分析表明，在VORASIDENIB治疗下，通过肿瘤体积减小可能存在控制癫痫发作的潜在机制。 Wick, W.; Mellinghoff, I. K.; van den Bent, M. J.; Blumenthal, D. T.; Touat, M.; Peters, K. B.; Clarke, J. L.; Mendez, J.; Welsh, L.; Mason, W. P.; Hottinger, A. F.; Sepulveda, J. M.; Soffietti, R.; Zhao, D.; Yi, D.; Weidl, D.; Steelman, L.; Hassan, I; Wen, P. Y.; Cloughesy, T. F. 分享 收藏
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Health-related quality of life and cognitive functioning in survivors of oligodendroglioma: An international cross-sectional investigation 健康相关生活质量及认知功能在寡形胶质细胞瘤幸存者中的表现：一项国际横断面调查 Boele, Florien W.; Frances, Se M.; Darlix, Amelie; Ducray, Francois; Cartalat, Stephanie; Guerdoux, Estelle; Tabouret, Emeline; Burger, Michael C.; Ryden, Isabelle; Malmstrom, Annika; Vauleon, Elodie; Kazda, Tomas; Renovanz, Mirjam; Werner, Jan-Michael; Welsh, Liam; Sanghera, Paul; Dehais, Caroline; Desideri, Isacco; McBain, Catherine; Mehta, Shaveta; Lord, Hannah; Jena, Rajesh; Foweraker, Karen; Ashkan, Keyoumars; Engelhardt, Julien; Bourg, Veronique; Herrlinger, Ulrich; Lawson McLean, Aaron; Hertler, Caroline; Haldbo-Classen, Lene; Dahlrot, Rikke H.; Noel, Georges; Durando, Xavier; Hrab, Ioana; Razis, Evangelia; Weller, Michael; Muhic, Aida; Klein, Martin 分享 收藏
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HEALTH-RELATED QUALITY OF LIFE AND COGNITIVE FUNCTIONING IN SURVIVORS OF OLIGODENDROGLIOMA: AN INTERNATIONAL CROSS-SECTIONAL INVESTIGATION Boele, Florien; Frances, Se; Darlix, Amelie; Ducray, Francois; Tabouret, Emeline; Burger, Michael; Ryden, Isabelle; Malmstrom, Annika; Vauleon, Elodie; Kazda, Tomas; Renovanz, Mirjam; Werner, Jan-Michael; Welsh, Liam; Sanghera, Paul; Dehais, Caroline; Desideri, Isacco; Mcbain, Catherine; Mehta, Shaveta; Lord, Hannah; Jena, Rajesh; Foweraker, Karen; Ashkan, Keyoumars; Engelhardt, Julien; Bourg, Veronique; Herrlinger, Ulrich; Mclean, Aaron Lawson; Hertler, Caroline; Haldbo-Classen, Lene; Dahlrot, Rikke; Noel, Georges; Durando, Xavier; Hrab, Ioana; Razis, Evangelia; Muhic, Aida; Klein, Martin 分享 收藏
PHASE 3 STELLAR STUDY SHOWS EFLORNITHINE IMPROVES OVERALL SURVIVAL (OS) AND PROGRESSION FREE SURVIVAL (PFS) IN PATIENTS WITH RECURRENT 2021 WHO ASTROCYTOMA, IDH-MUTANT GRADE 3 Colman, Howard; Lombardi, Giuseppe; Wong, Eric; Walbert, Tobias; Eoli, Marica; Lassman, Andrew; Peereboom, David; Kizilbash, Sani; Kamiya-Matsuoka, Carlos; Pitz, Marshall; Strowd, Roy; Desjardins, Annick; Kumthekar, Priya; Mason, Warren; Pellerino, Alessia; Soffietti, Ricardo; Butowski, Nicholas; Forsyth, Peter; Hamza, Mohamed; Hau, Peter; Lallana, Enrico; Nabors, Burt; Piccioni, David; Uhlmann, Erik; Welsh, Liam; Wen, Patrick; Dietrich, Jorg; Levin, Victor 分享 收藏
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HEALTH-RELATED QUALITY OF LIFE AND COGNITIVE FUNCTIONING IN SURVIVORS OF OLIGODENDROGLIOMA: AN INTERNATIONAL CROSS-SECTIONAL INVESTIGATION Boele, F. W.; Frances, S. . M.; Darlix, A.; Ducray, F.; Tabouret, E.; Burger, M. . C.; Ryden, I; Malmstrom, A.; Vauleon, E.; Kazda, T.; Renovanz, M.; Werner, J.; Welsh, L.; Sanghera, P.; Dehais, C.; Desideri, I; Mcbain, C.; Mehta, S.; Lord, H.; Jena, R.; Foweraker, K.; Ashkan, K.; Engelhardt, J.; Bourg, V; Herrlinger, U.; A Lawson, McLean; Hertler, C.; Haldbo-Classen, L.; Dahlrot, R. H.; Noel, G.; Durando, X.; Hrab, I; Razis, E.; Muhic, A.; Klein, M. 分享 收藏
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IDH- AND H3-WILDTYPE HIGH-GRADE GLIOMAS OCCURRING IN TEENAGERS AND YOUNG ADULT PATIENTS COMPRISE NOVEL MOLECULAR SUBGROUPS 在青少年和年轻成人患者中发生的IDH和H3-WILDTYPE高级别神经胶质瘤包括新的分子亚组 Pereira, Rita; Mackay, Alan; Grabovska, Yura; Clarke, Amelia; Bloom, Tabitha; Nicoll, James; Boche, Delphine; Procter, John; Moore, Andrew; Schagen, Johanna; Walker, Liam; Roncaroli, Federico; Ogunbigi, Olumide; van Dalen, Thijs; Ziegler, David; Shi, Zhi-Feng; Hargrave, Darren; Jacques, Thomas S.; Zebian, Bassel; Bleil, Cristina; Yates, Joseph; Norton, Emma; Mandeville, Henry; Creak, Antonia; Welsh, Liam; Marshall, Lynley; Carceller, Ferndando; Reisz, Zita; Al-Sarraj, Safa; Mastronuzzi, Angela; Carai, Andrea; Vinci, Maria; Kurian, Kathreena; Ng, Ho-Keung; Brandner, Sebastian; Jones, Chris; Clarke, Matthew 分享 收藏
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