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PHASE 2 TRIAL USING INDOXIMOD-BASED CHEMO-IMMUNOTHERAPY FOR PATIENTS WITH CHILDHOOD BRAIN CANCER: INTERIM ANALYSIS OF THE GCC1949 STUDY (NCT04049669) Johnson, Theodore S.; Pacholczyk, Rafal; Ring, Eric K.; Aguilera, Dolly; Castellino, Robert C.; Fangusaro, Jason R.; Eaton, Bree R.; Chi, Susan; Yeo, Kee Kiat; Hummel, Trent R.; Berrong, Zuzana; Creager, Julianne; Ingerski, Lisa; Schniederjan, Matthew; Huang, Chenbin; Satpathy, Sarthak; Thomas, Beena E.; Sadek, Ramses F.; Kennedy, Eugene P.; Bhasin, Manoj K.; Macdonald, Tobey J.; Munn, David H. 分享 收藏
Stereotactic body radiotherapy plus rucosopasem in locally advanced or borderline resectable pancreatic cancer: GRECO-2 phase II study design Hoffe, Sarah E.; Aguilera, Todd A.; Parikh, Parag J.; Ghaly, Maged M.; Herman, Joseph M.; Caster, Joseph M.; Kim, Dae Won; Costello, James; Malafa, Mokenge P.; Moser, Elizabeth C.; Kennedy, Eugene P.; Terry, Kara; Kurman, Michael 分享 收藏
Meta-analysis of two placebo-controlled trials of avasopasem manganese (AVA) in patients with locally advanced, head & neck cancer (LAHNC) Dunlap, N.; Anderson, C.; Lee, C.; Kelley, J.; Walker, G.; Bar-Ad, V.; Miller, D.; King, V.; Peddada, A.; Ciuba, D.; Vincent, F.; Muzyka, B.; Gillespie-Twardy, A.; Sonis, S.; Kennedy, E.; Saunders, D. 分享 收藏
Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial Johnson, Theodore S.; MacDonald, Tobey J.; Pacholczyk, Rafal; Aguilera, Dolly; Al-Basheer, Ahmad; Bajaj, Manish; Bandopadhayay, Pratiti; Berrong, Zuzana; Bouffet, Eric; Castellino, Robert C.; Dorris, Kathleen; Eaton, Bree R.; Esiashvili, Natia; Fangusaro, Jason R.; Foreman, Nicholas; Fridlyand, Diana; Giller, Cole; Heger, Ian M.; Huang, Chenbin; Kadom, Nadja; Kennedy, Eugene P.; Manoharan, Neevika; Martin, William; McDonough, Colleen; Parker, Rebecca S.; Ramaswamy, Vijay; Ring, Eric; Rojiani, Amyn; Sadek, Ramses F.; Satpathy, Sarthak; Schniederjan, Matthew; Smith, Amy; Smith, Christopher; Thomas, Beena E.; Vaizer, Rachel; Yeo, Kee Kiat; Bhasin, Manoj K.; Munn, David H. 分享 收藏
Treatment Response in First-Line Metastatic Pancreatic Ductal Adenocarcinoma Is Stratified By a Composite Index of Tumor Proliferation and CD8 T-Cell Infiltration 一线转移性胰腺导管腺癌的治疗反应由肿瘤增殖和CD8 T细胞浸润的综合指数分层 Beatty, Gregory L.; Delman, Devora; Yu, Jiayi; Liu, Mingen; Li, Joey H.; Zhang, Liti; Lee, Jae W.; Chang, Renee B.; Bahary, Nathan; Kennedy, Eugene P.; Wang-Gillam, Andrea; Rossi, Gabriela R.; Garrido-Laguna, Ignacio 分享 收藏
INTERIM ANALYSIS OF THE GCC1949 PHASE 2 TRIAL USING INDOXIMOD-BASED CHEMO-IMMUNOTHERAPY FOR PATIENTS WITH PEDIATRIC BRAIN TUMORS Johnson, Theodore S.; Pacholczyk, Rafal; Aguilera, Dolly; Berrong, Zuzana; Castellino, Robert C.; Chi, Susan; Creager, Julianne; Eaton, Bree R.; Fangusaro, Jason R.; Huang, Chenbin; Hummel, Trent; Ingerski, Lisa; Kennedy, Eugene P.; Ring, Eric; Sadek, Ramses F.; Satpathy, Sarthak; Schniederjan, Matthew; Thomas, Beena E.; Yeo, Kee Kiat; Bhasin, Manoj; MacDonald, Tobey J.; Munn, David H. 分享 收藏
Indoximod or ibrutinib/indoximod based clinical chemo-immunotherapy drives conversion of extra-tumoral circulating stem-like precursor CD8+T cells into clonally expanded, rejuvenated effector cells Johnson, Theodore S.; Pacholczyk, Rafal; Berrong, Zuzana; Huang, Chenbin; Kennedy, Eugene P.; Ring, Eric; Sadek, Ramses F.; Satpathy, Sarthak; Thomas, Beena E.; MacDonald, Tobey J.; Bhasin, Manoj; Munn, David H. 分享 收藏
Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity Sharma, Madhav D.; Pacholczyk, Rafal; Shi, Huidong; Berrong, Zuzana J.; Zakharia, Yousef; Greco, Austin; Chang, Chang-Sheng S.; Eathiraj, Sudharshan; Kennedy, Eugene; Cash, Thomas; Bollag, Roni J.; Kolhe, Ravindra; Sadek, Ramses; McGaha, Tracy L.; Rodriguez, Paulo; Mandula, Jessica; Blazar, Bruce R.; Johnson, Theodore S.; Munn, David H. 分享 收藏
FIRST-IN-CHILDREN PHASE 1B STUDY USING THE IDO PATHWAY INHIBITOR INDOXIMOD IN COMBINATION WITH RADIATION AND CHEMOTHERAPY FOR CHILDREN WITH NEWLY DIAGNOSED DIPG (NCT02502708, NLG2105) Johnson, Theodore S.; Pacholczyk, Rafal; Aguilera, Dolly; Al-Basheer, Ahmad; Bajaj, Manish; Berrong, Zuzana; Castellino, Robert C.; Eaton, Bree R.; Esiashvili, Natia; Foreman, Nicholas; Heger, Ian M.; Kennedy, Eugene P.; Martin, William; Ring, Eric; Sadek, Ramses F.; Smith, Amy; Smith, Chris; Vaizer, Rachel; MacDonald, Tobey J.; Munn, David H. 分享 收藏
Results of a phase II double-blinded, randomized, placebo-controlled clinical trial of Indoximod, an Indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, in combination with Taxane chemotherapy in metastatic breast cancer (MBC) Mariotti, Veronica; Tang, Shou-Ching; Dillon, Patrick; Montero, Alberto; Poklepovic, Andrew; Melin, Susan; Nuhad, Ibrahim; Nikolinakos, Petros; Kennedy, Eugene; Han, Hyo; Ismail-Khan, Roohi; Bruetman, Daniel; Danciu, Oana; Gilman, Paul; Karaszewska, Boguslawa; Lesniewski-Kmak, Krzysztof; Panella, Timothy; Patel, Dhimant; Suszko-Kazarnowicz, Malgorzata; Volterra, Fabio; Soliman, Hatem 分享 收藏
A Phase II study of NLG207 (formerly CRLX101) in combination with weekly paclitaxel in patients with recurrent or persistent epithelial ovarian, fallopian tube or primary peritoneal cancer Duska, Linda; O'Malley, David M.; Krasner, Carolyn; Schilder, Russell J.; Mathews, Cara; Moore, Kathleen; Thaker, Premal; Miller, Austin; Purdy, Christopher; Leyco, A. J.; Smith, Christopher; Mercier, Deborah; Tennant, Lucinda; Kennedy, Eugene; Vahanian, Nicholas; Link, Charles 分享 收藏
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Front-line therapy of DIPG using the IDO pathway inhibitor indoximod in combination with radiation and chemotherapy Johnson, Theodore S.; Aguilera, Dolly; Al-Basheer, Ahmad; Castellino, Robert C.; Eaton, Bree R.; Esiashvili, Natia; Foreman, Nicholas; Heger, Ian M.; Kennedy, Eugene P.; Link, Charles J.; Martin, William; Ring, Eric K.; Sadek, Ramses F.; Smith, Amy; Vahanian, Vahanian N.; MacDonald, Tobey J.; Munn, David H. 分享 收藏
Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors Nayak-Kapoor, Asha; Hao, Zhonglin; Sadek, Ramses; Dobbins, Robin; Marshall, Lisa; Vahanian, Nicholas N.; Ramsey, W. Jay; Kennedy, Eugene; Mautino, Mario R.; Link, Charles J.; Lin, Ray S.; Royer-Joo, Stephanie; Liang, Xiaorong; Salphati, Laurent; Morrissey, Kari M.; Mahrus, Sami; McCall, Bruce; Pirzkall, Andrea; Munn, David H.; Janik, John E.; Khleif, Samir N. 分享 收藏
Interim analysis of the Phase 2 clinical trial of the IDO pathway inhibitor indoximod in combination with pembrolizumab for patients with advanced melanoma Zakharia, Yousef; McWilliams, Robert; Shaheen, Monaster; Grossman, Kenneth; Drabick, Joseph; Milhem, Mohammed; Rixie, Olivier; Khleif, Samir; Lott, Ryan; Kennedy, Eugene; Munn, David; Vahanian, Nicholas; Link, Charles 分享 收藏
Phase II trial of theilndoleamine 2, 3-dioxygenase pathway (IDO) inhibitor indoximod plus immune checkpoint inhibitors for the treatment of unresectable stage 3 or 4 melanoma Zakharia, Yousef; Drabick, Joseph; Khleif, Samir; Munn, David; Link, Charles; Vahanian, Nicholas; Kennedy, Eugene; Shaheen, Montaser; Rixe, Olivier; Milhem, Mohammed 分享 收藏
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Results of Phase 1b trial of the Indoleamine 2,3-dioxygenase (IDO) Pathway Inhibitor Indoximod plus Ipilimumab for the treatment of unresectable stage III or IV melanoma Zakharia, Y.; Drabick, J.; Khleif, S.; Munn, D.; Link, C.; Vahanian, N.; Kennedy, E.; Rixe, O.; Milhem, M. 分享 收藏
Phase 1a study of the safety, pharmacokinetics, and pharmacodynamics of GDC-0919 in patients with recurrent/advanced solid tumors Nayak, A.; Hao, Z.; Sadek, R.; Dobbins, R.; Marshall, L.; Vahanian, N.; Ramsey, J.; Kennedy, E.; Mautino, M.; Link, C.; Lin, R.; Royer-Joo, S.; Morrissey, K.; Mahrus, S.; McCall, B.; Pirzkall, A.; Munn, D.; Janik, J.; Khleif, S. 分享 收藏
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