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Open-Label Study Assessing Relative and Absolute Bioavailability of Oral Camizestrant Formulations and Food Effects in Healthy Postmenopausal Women Sykes, Andy; Engman, Helena; Taylor, Nigel; Brier, Tim; Maudsley, Rhiannon; Kirova, Bistra; Mathewson, Alastair M.; Bragg, Ryan A.; Granfors, Malin; Gangl, Eric T.; Klinowska, Teresa; Li, Yan; Menakuru, Somasekhar R.; Roe, Chris; Mcdermott, John; Lindemann, Justin P. O. 分享 收藏
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CAMBRIA-1 & CAMBRIA-2 phase III trials: camizestrant versus standard endocrine therapy in ER+/HER2-early breast cancer Hamilton, Erika P.; Loibl, Sibylle; Bachelot, Thomas; Gnant, Michael; Niikura, Naoki; Park, Yeon Hee; Tolaney, Sara M.; Pistilli, Barbara; Rastogi, Priya; Saini, Kamal S.; Gioni, Ioanna; Johnston, Simon; Nunes, Raquel; Quintana, Angela; Stuart, Mary; Syta, Emilia; Walding, Andrew; Klinowska, Teresa; Mayer, Ingrid A. 分享 收藏
A phase I dose escalation and expansion trial of the next-generation oral SERD camizestrant in women with ER-positive, HER2-negative advanced breast cancer: SERENA-1 monotherapy results 在ER阳性，HER2-negative晚期乳腺癌女性中，下一代口服SERD camizestrant的I期剂量递增和扩展试验: SERENA-1单药治疗结果 Hamilton, E.; Oliveira, M.; Turner, N.; Garcia-Corbacho, J.; Hernando, C.; Ciruelos, E. M.; Kabos, P.; Ruiz-Borrego, M.; Armstrong, A.; Patel, M. R.; Vaklavas, C.; Twelves, C.; Boni, V.; Incorvati, J.; Brier, T.; Gibbons, L.; Klinowska, T.; Lindemann, J. P. O.; Morrow, C. J.; Sykes, A.; Baird, R. D. 分享 收藏
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Metabolism-driven in vitro/in vivo disconnect of an oral ERα VHL-PROTAC Hayhow, Thomas G.; Williamson, Beth; Lawson, Mandy; Cureton, Natalie; Braybrooke, Erin L.; Campbell, Andrew; Carbajo, Rodrigo J.; Cheraghchi-Bashi, Azadeh; Chiarparin, Elisabetta; Diene, Coura R.; Fallan, Charlene; Fisher, David I.; Goldberg, Frederick W.; Hopcroft, Lorna; Hopcroft, Philip; Jackson, Anne; Kettle, Jason G.; Klinowska, Teresa; Kuenzel, Ulrike; Lamont, Gillian; Lewis, Hilary J.; Maglennon, Gareth; Martin, Scott; Gutierrez, Pablo Morentin; Morrow, Christopher J.; Nikolaou, Myria; Nissink, J. Willem M.; O'Shea, Patrick; Polanski, Radoslaw; Schade, Markus; Scott, James S.; Smith, Aaron; Weber, Judith; Wilson, Joanne; Yang, Bin; Crafter, Claire 分享 收藏
A Phase 3, randomized, open-label study of upfront camizestrant vs standard endocrine therapy as adjuvant treatment for ER-positive/HER2negative early breast cancer with intermediate-high or high risk of recurrence (CAMBRIA-2) Loibl, Sibylle; Park, Yeon; Tolaney, Sara; Gioni, Ioanna; Johnston, Simon; Klinowska, Teresa; Mayer, Ingrid A.; Nunes, Raquel; Pistilli, Barbara; Stuart, Mary; Quintana, Angela; Walding, Andrew; Gnant, Michael 分享 收藏
A phase 3 randomized open-label study of extended adjuvant therapy with camizestrant vs standard endocrine therapy in patients with ER+/HER2-early breast cancer and an intermediate or high risk of recurrence (CAMBRIA 1) Hamilton, Erika; Loibl, Sibylle; Niikura, Naoki; Rastogi, Priya; Saini, Kamal S.; Gioni, Ioanna; Klinowska, Teresa; Mayer, Ingrid A.; Stuart, Mary; Syta, Emilia; Walding, Andrew; Bachelot, Thomas 分享 收藏
SERENA-3: A randomized pre-surgical window of opportunity study assessing dose and duration of camizestrant treatment in post-menopausal women with ER-positive, HER2-negative primary breast cancer Robertson, John; Gogitidze, Teimuraz; Katashvili, Zaza; Rocha, Juan Enrique Bargallo; Arkania, Ekaterine; Moppett, Iain; Cheung, Kwok-Leung; Nemsadze, Gia; Ajimi, Maxine; Irurzun-Arana, Itziar; Lindemann, Justin; Klinowska, Teresa; Mathewson, Alastair; Morrow, Christopher; Nikolaou, Myria; Dzagnidze, Giorgi 分享 收藏
SERENA-1: Results from a Phase 1 study (Parts I/J) testing the next-generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) in combination with capivasertib in women with ER+, HER2 advanced breast cancer SERENA-1: 1期研究 (I/J部分) 的结果，该研究测试了ER，HER2晚期乳腺癌女性的下一代口服选择性雌激素受体降解剂 (SERD) camizestrant (AZD9833) 与capivasertib的组合 Vaklavas, Christos; Oliveira, Mafalda; Armstrong, Anne; Moreno, Irene; Twelves, Chris; Ruiz, Ivan Victoria; Bermejo, Begona; Ajimi, Maxine; Brier, Tim; Ciardullo, Carmela; Gibbons, Lisa; Irurzun-Arana, Itziar; Jack, Tony; Klinowska, Teresa; Lindemann, Justin; Mathewson, Alastair; Morrow, Christopher; Sykes, Andy; Baird, Richard 分享 收藏
A phase III randomised open-label study of extended adjuvant therapy with camizestrant vs standard endocrine therapy (ET) in patients with ER+/HER2-early breast cancer (BC) and an intermediate or high risk of recurrence (CAMBRIA-1) Hamilton, E.; Loibl, S.; Niikura, N.; Rastogi, P.; Saini, K. S.; Gioni, I.; Klinowska, T.; Mayer, I.; Stuart, M.; Syta, E.; Walding, A.; Bachelot, T. 分享 收藏
The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance 下一代口服选择性雌激素受体降解剂Camizestrant (AZD9833) 抑制ER乳腺癌生长并克服内分泌和CDK4/6抑制剂抗性 Lawson, Mandy; Cureton, Natalie; Ros, Susana; Cheraghchi-Bashi, Azadeh; Urosevic, Jelena; D'Arcy, Sophie; Delpuech, Oona; Dupont, Michelle; Fisher, David I.; Gangl, Eric T.; Lewis, Hilary; Trueman, Dawn; Wali, Neha; Williamson, Stuart C.; Moss, Jennifer; Montaudon, Elodie; Derrien, Heloise; Marangoni, Elisabetta; Miragaia, Ricardo J.; Gagrica, Sladjana; Morentin-Gutierrez, Pablo; Moss, Thomas A.; Maglennon, Gareth; Sutton, Daniel; Polanski, Radoslaw; Rosen, Alan; Cairns, Jonathan; Zhang, Pei; Sanchez-Guixe, Monica; Serra, Violeta; Critchlow, Susan E.; Scott, James S.; Lindemann, Justin P. O.; Barry, Simon T.; Klinowska, Teresa; Morrow, Christopher J.; Carnevalli, Larissa 分享 收藏
The next generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) is active against wild type and mutant estrogen receptor α Morrow, Christopher; Carnevalli, Larissa; Baird, Richard D.; Brier, Tim; Ciardullo, Carmela; Cureton, Natalie; Lawson, Mandy; McEwen, Robert; Nikolaou, Myria; Armstrong, Anne; Bermejo, Begona; Calvo, Emiliano; Ciruelos, Eva; Garcia-Corbacho, Javier; Hamilton, Erika; Incorvati, Jason; Kabos, Peter; Oliveira, Mafalda; Patel, Manish R.; Ruiz-Borrego, Manuel; Turner, Nicholas; Twelves, Chris; Vaklavas, Christos; Carroll, Danielle; Ching, Steven; Cvetesic, Nevena; DuPont, Michelle; Gibbons, Lisa; Mathewson, Alastair; Maudsley, Rhiannon; Gutierrez, Pablo Morentin; Reddy, Avinash; Rodriguez-Canales, Jaime; Ros, Susana; Sudhan, Dhivya; Sykes, Andy; Whitson, David; Klinowska, Teresa; Lindemann, Justin 分享 收藏
SERENA-1: Updated analyses from a Phase 1 study of the next generation oral selective estrogen receptor degrader camizestrant (AZD9833) combined with abemaciclib, in women with ER-positive, HER2-negative advanced breast cancer Turner, Nicholas; Vaklavas, Christos; Calvo, Emiliano; Garcia-Corbacho, Javier; Incorvati, Jason; Borrego, Manuel Ruiz; Twelves, Chris; Armstrong, Anne; Bermejo, Begona; Hamilton, Erika; Oliveira, Mafalda; Ciruelos, Eva; Kabos, Peter; Patel, Manish R.; Borrell, Maria; Burris, Howard; de Paula, Bruno; Falcon, Alejandro; Hernando, Cristina; Moreno, Irene; O'Brien, Ciara S.; Shagisultanova, Elena; Ruiz, Ivan Victoria; Wang, Judy S.; Wei, Mei; Brier, Tim; Carroll, Danielle; Ciardullo, Carmela; Gibbons, Lisa; Irurzun-Arana, Itziar; Jack, Tony; Kirova, Bistra; Klinowska, Teresa; Lindemann, Justin; Maidment, Julie; Mathewson, Alastair; Maudsley, Rhiannon; McEwen, Robert; Morrow, Christopher; Sykes, Andy; Baird, Richard D. 分享 收藏
Camizestrant, a next generation oral SERD vs fulvestrant in post-menopausal women with advanced ER-positive HER2-negative breast cancer: Results of the randomized, multi-dose Phase 2 SERENA-2 trial Oliveira, Mafalda; Pominchuck, Denys; Nowecki, Zbigniew; Hamilton, Erika; Kulyaba, Yaroslav; Andabekov, Timur; Hotko, Yevhen; Melkadze, Tamar; Nemsadze, Gia; Neven, Patrick; Semegen, Yuriy; Vladmirov, Vladmir; Zamagni, Claudio; Denys, Hannelore; Forget, Frederic; Horvath, Zsolt; Nesterova, Alfiya; Bennett, Maxine; Kirova, Bistra; Klinowska, Teresa; Lindemann, Justin; Lissa, Delphine; Mathewson, Alastair; Morrow, Christopher; Traugottova, Zuzana; Van Zyl, Ruaan; Arkania, Ekaterine 分享 收藏
Combination of the next generation oral SERD camizestrant (AZD9833) with CDK4/6 and mTOR/AKT inhibitors delivers robust efficacy in a broad range of ER plus breast tumors Carnevalli, Larissa; Ros, Susana; Urosevic, Jelena; Cureton, Natalie; Darcy, Sophie; Lawson, Mandy; Williamson, Stuart; Gutierrez, Pablo Morentin; Bashi, Azadeh; Moss, Jennifer; Morrow, Christopher; Simon, Barry; Klinowska, Teresa 分享 收藏
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists Scott, James S.; Stead, Darren; Barlaam, Bernard; Breed, Jason; Carbajo, Rodrigo J.; Chiarparin, Elisabetta; Cureton, Natalie; Davey, Paul R. J.; Fisher, David I.; Gangl, Eric T.; Grebe, Tyler; Greenwood, Ryan D.; Hande, Sudhir; Hatoum-Mokdad, Holia; Hughes, Samantha J.; Hunt, Thomas A.; Johnson, Tony; Kavanagh, Stefan L.; Klinowska, Teresa C. M.; Larner, Carrie J. B.; Lawson, Mandy; Lister, Andrew S.; Longmire, David; Marden, Stacey; McGuire, Thomas M.; McMillan, Caroline; McMurray, Lindsay; Morrow, Christopher J.; Nissink, J. Willem M.; Moss, Thomas A.; O'Donovan, Daniel H.; Polanski, Radoslaw; Stokes, Stephen; Thakur, Kumar; Trueman, Dawn; Truman, Caroline; Tucker, Michael J.; Wang, Haixia; Whalley, Nicky; Wu, Dedong; Wu, Ye; Yang, Bin; Yang, Wenzhan 分享 收藏
Serial monitoring of genomic alterations in circulating tumor cells of ER-positive/HER2-negative advanced breast cancer: feasibility of precision oncology biomarker detection ER阳性/HER2-negative晚期乳腺癌循环肿瘤细胞基因组改变的系列监测: 精确肿瘤生物标志物检测的可行性 Cani, Andi K.; Dolce, Emily M.; Darga, Elizabeth P.; Hu, Kevin; Liu, Chia-Jen; Pierce, Jackie; Bradbury, Kieran; Kilgour, Elaine; Aung, Kimberly; Schiavon, Gaia; Carroll, Danielle; Carr, T. Hedley; Klinowska, Teresa; Lindemann, Justin; Marshall, Gayle; Rowlands, Vicky; Harrington, Elizabeth A.; Barrett, J. Carl; Sathiyayogan, Nitharsan; Morrow, Christopher; Sero, Valeria; Armstrong, Anne C.; Baird, Richard; Hamilton, Erika; Im, Seock-Ah; Jhaveri, Komal; Patel, Manish R.; Dive, Caroline; Tomlins, Scott A.; Udager, Aaron M.; Hayes, Daniel F.; Paoletti, Costanza 分享 收藏
Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition Carnevalli, Larissa S.; Taylor, Molly A.; King, Matthew; Coenen-Stass, Anna M. L.; Hughes, Adina M.; Bell, Sigourney; Proia, Theresa A.; Wang, Yanjun; Ramos-Montoya, Antonio; Wali, Neha; Carroll, Danielle; Singh, Maneesh; Moschetta, Michele; Gutierrez, Pablo Morentin; Gardelli, Cristina; Critchlow, Susan E.; Klinowska, Teresa; Fawell, Stephen E.; Barry, Simon T. 分享 收藏
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CANCER RESEARCH