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Noboru Ishiyama

university of toronto

H指数:29

被引数:3,205

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Afadin loss induces breast cancer metastasis through destabilisation of E-cadherin to F-actin linkage

Afadin缺失通过破坏E-钙黏蛋白与F-肌动蛋白的连接来诱导乳腺癌转移

JOURNAL OF PATHOLOGY

IF5.2

2025-03-030

OAAI

α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure

JOURNAL OF CELL BIOLOGY

IF6.4

2025-01-090

PRE

Current and emerging therapies for Achondroplasia: The dawn of precision medicine

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2023-05-017

PRE

Preclinical characterization of a brain penetrant RAF inhibitor, BDTX-4933, targeting oncogenic BRAF Class I/II/III and RAS mutations

CANCER RESEARCH

IF16.6

2023-04-043

PRE

Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects

CANCER RESEARCH

IF16.6

2022-05-033

OAAI

Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin

力诱导的 α-catenin构象变化独立于vinculin稳定血管连接

JOURNAL OF CELL SCIENCE

IF3.6

2021-12-2210

OAAI

Pre-clinical evaluation of next-generation inhibitor targeting a wide spectrum of oncogenic BRAF dimers

MOLECULAR CANCER THERAPEUTICS

IF5.5

2021-12-010

PRE

Pre-clinical evaluation of potent and orally bioavailable next-generation inhibitors targeting the family of mutants that drive oncogenic BRAF dimer formation

ANNALS OF ONCOLOGY

IF65.4

2021-03-010

OA

Discovery and characterization of selective, FGFR1-sparing, inhibitors of FGFR2/3 oncogenic mutations for the treatment of cancers

ANNALS OF ONCOLOGY

IF65.4

2021-03-011

OA

Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety

SCIENCE SIGNALING

IF6.6

2020-03-3126

PREAI

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

NATURE COMMUNICATIONS

IF15.7

2018-11-3084

OAAI

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity

SCIENCE SIGNALING

IF6.6

2017-10-3143

OAAI

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

NATURE COMMUNICATIONS

IF15.7

2017-10-2325

OAAI

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion

JOURNAL OF CELL BIOLOGY

IF6.4

2017-09-0522

OAAI

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions

cold spring harbor perspectives in medicine

IF8.4

2017-01-17177

OAAI

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

NATURE CELL BIOLOGY

IF19.1

2016-10-0341

PREAI

Structural Determinants of the Mechanical Stability of α-Catenin

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-07-0131

OAAI

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism

JOURNAL OF CELL SCIENCE

IF3.6

2015-01-0148

OAAI

Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin ( mTOR)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-05-0119

OAAI

An Autoinhibited Structure of α-Catenin and Its Implications for Vinculin Recruitment to Adherens Junctions

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-05-01124

OAAI