Conrad Leonard

QIMR Berghofer Medical Research Institute

H指数:49

被引数:2.9万

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Explainable machine learning identifies features and thresholds predictive of immunotherapy response

可解释机器学习识别预测免疫治疗反应的特征和阈值

Scientific Reports

IF3.9

2026-05-230

OAAI

Multi-omics reveals key molecular and cellular features of advanced small cell lung cancers associated with distinct therapeutic opportunities

多组学揭示了与不同治疗机会相关联的晚期小细胞肺癌的关键分子和细胞特征

Genome Medicine

IF11.2

2026-03-170

OAAI

Katia Nones; Vanessa Lakis; Andrew J. Dalley; Kimberley Ryan; Haarika Chittoory; Kaltin Ferguson; Kate Fitzgerald; Felicity Newell; Lambros T. Koufariotis; Farzad Bashirzadeh; Jung Hwa Son; Mahendra Singh; Lakshmy Nandakumar; David Fairbairn; Margaret Cummings; Daniel Steinfort; Jemma J. Christie; Matthew Gibney; Jonathan P. Williamson; Andrew Pattison; Louise McIntosh; Carl Pahoff; Phan Tien Nguyen; Jelena Solujic; Michael Brown; Scott Twaddell; David Arnold; Christopher Grainge; Shailendra Gune; Oliver Holmes; Conrad Leonard; Scott Wood; John V. Pearson; Sunil R. Lakhani; Peter T. Simpson; Nicola Waddell; David Fielding

Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance (vol 40, pg 88, 2022)

多组学分析：检查点抑制剂治疗的黑色素瘤：识别应答和耐药的预测因子，以及生物学不一致性的标志物（卷40，页88，2022）

CANCER CELL

IF44.5

2025-02-010

PRE

Newell, Felicity; da Silva, Ines Pires; Johansson, Peter A.; Menzies, Alexander M.; Wilmott, James S.; Addala, Venkateswar; Carlino, Matteo S.; Rizos, Helen; Nones, Katia; Edwards, Jarem J.; Lakis, Vanessa; Kazakoff, Stephen H.; Mukhopadhyay, Pamela; Ferguson, Peter M.; Leonard, Conrad; Koufariotis, Lambros T.; Wood, Scott; Blank, Christian U.; Thompson, John F.; Spillane, Andrew J.; Saw, Robyn P. M.; Shannon, Kerwin F.; Pearson, John, V; Mann, Graham J.; Hayward, Nicholas K.; Scolyer, Richard A.; Waddell, Nicola; Long, Georgina, V

Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology

使用牛津纳米孔测序技术在肺癌中体细胞结构变异调用的性能

BMC GENOMICS

IF3.7

2024-09-300

OAAI

The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants-a multi-site prospective cohort study

全基因组测序检测癌症易感性变异的临床效用和成本 -- 一项多中心前瞻性队列研究

GENOME MEDICINE

IF11.2

2023-09-194

OAAI

Davidson, Aimee L.; Dressel, Uwe; Norris, Sarah; Canson, Daffodil M.; Glubb, Dylan M.; Fortuno, Cristina; Hollway, Georgina E.; Parsons, Michael T.; Vidgen, Miranda E.; Holmes, Oliver; Koufariotis, Lambros T.; Lakis, Vanessa; Leonard, Conrad; Wood, Scott; Xu, Qinying; Reed, Amy E. McCart; Pickett, Hilda A.; Al-Shinnag, Mohammad K.; Austin, Rachel L.; Burke, Jo; Cops, Elisa J.; Nichols, Cassandra B.; Goodwin, Annabel; Harris, Marion T.; Higgins, Megan J.; Ip, Emilia L.; Kiraly-Borri, Catherine; Lau, Chiyan; Mansour, Julia L.; Millward, Michael W.; Monnik, Melissa J.; Pachter, Nicholas S.; Ragunathan, Abiramy; Susman, Rachel D.; Townshend, Sharron L.; Trainer, Alison H.; Troth, Simon L.; Tucker, Katherine M.; Wallis, Mathew J.; Walsh, Maie; Williams, Rachel A.; Winship, Ingrid M.; Newell, Felicity; Tudini, Emma; Pearson, John V.; Poplawski, Nicola K.; Mar Fan, Helen G.; James, Paul A.; Spurdle, Amanda B.; Waddell, Nicola; Ward, Robyn L.

Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy

NATURE COMMUNICATIONS

IF15.7

2023-05-319

OAAI

Naeini, Marjan M.; Newell, Felicity; Aoude, Lauren G.; Bonazzi, Vanessa F.; Patel, Kalpana; Lampe, Guy; Koufariotis, Lambros T.; Lakis, Vanessa; Addala, Venkateswar; Kondrashova, Olga; Johnston, Rebecca L.; Sharma, Sowmya; Brosda, Sandra; Holmes, Oliver; Leonard, Conrad; Wood, Scott; Xu, Qinying; Thomas, Janine; Walpole, Euan; Mai, G. Tao; Ackland, Stephen P.; Martin, Jarad; Burge, Matthew; Finch, Robert; Karapetis, Christos S.; Shannon, Jenny; Nott, Louise; Bohmer, Robert; Wilson, Kate; Barnes, Elizabeth; Zalcberg, John R.; Smithers, B. Mark; Simes, John; Price, Timothy; Gebski, Val; Nones, Katia; Watson, David I.; Pearson, John V.; Barbour, Andrew P.; Waddell, Nicola

Analysis of hereditary cancer gene variant classifications from ClinVar indicates a need for regular reassessment of clinical assertions

ClinVar对遗传性癌症基因变异分类的分析表明，需要定期重新评估临床断言

HUMAN MUTATION

IF3.7

2022-10-025

Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes

比较基因组学提供了对黑色素瘤亚型的病因学和生物学见解

CANCER DISCOVERY

IF33.3

2022-09-1338

OAAI

Newell, Felicity; Johansson, Peter A.; Wilmott, James S.; Nones, Katia; Lakis, Vanessa; Pritchard, Antonia L.; Lo, Serigne N.; Rawson, Robert, V; Kazakoff, Stephen H.; Colebatch, Andrew J.; Koufariotis, Lambros T.; Ferguson, Peter M.; Wood, Scott; Leonard, Conrad; Law, Matthew H.; Brooks, Kelly M.; Broit, Natasa; Palmer, Jane M.; Couts, Kasey L.; Vergara, Ismael A.; Long, Georgina, V; Barbour, Andrew P.; Nieweg, Omgo E.; Shivalingam, Brindha; Robinson, William A.; Stretch, Jonathan R.; Spillane, Andrew J.; Saw, Robyn P. M.; Shannon, Kerwin F.; Thompson, John F.; Mann, Graham J.; Pearson, John, V; Scolyer, Richard A.; Waddell, Nicola; Hayward, Nicholas K.

Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels

全基因组测序、基于计算机的全外显子组测序及突变Panel在癌症基因组中检测到的可靶向事件比较

ESMO OPEN

IF8.3

2022-08-0112

OAAI

Ramarao-Milne, P.; Kondrashova, O.; Patch, A. -M.; Nones, K.; Koufariotis, L. T.; Newell, F.; Addala, V.; Lakis, V.; Holmes, O.; Leonard, C.; Wood, S.; Xu, Q.; Mukhopadhyay, P.; Naeini, M. M.; Steinfort, D.; Williamson, J. P.; Bint, M.; Pahoff, C.; Nguyen, P. T.; Twaddell, S.; Arnold, D.; Grainge, C.; Basirzadeh, F.; Fielding, D.; Dalley, A. J.; Chittoory, H.; Simpson, P. T.; Aoude, L. G.; Bonazzi, V. F.; Patel, K.; Barbour, A. P.; Fennell, D. A.; Robinson, B. W.; Creaney, J.; Hollway, G.; Pearson, J. V.; Waddell, N.

Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma

全面的基因组和肿瘤免疫分析揭示了恶性胸膜间皮瘤的潜在治疗靶点

GENOME MEDICINE

IF11.2

2022-05-3029

OAAI

Creaney, Jenette; Patch, Ann-Marie; Addala, Venkateswar; Sneddon, Sophie A.; Nones, Katia; Dick, Ian M.; Lee, Y. C. Gary; Newell, Felicity; Rouse, Ebony J.; Naeini, Marjan M.; Kondrashova, Olga; Lakis, Vanessa; Nakas, Apostolos; Waller, David; Sharkey, Annabel; Mukhopadhyay, Pamela; Kazakoff, Stephen H.; Koufariotis, Lambros T.; Davidson, Aimee L.; Ramarao-Milne, Priya; Holmes, Oliver; Xu, Qinying; Leonard, Conrad; Wood, Scott; Grimmond, Sean M.; Bueno, Raphael; Fennell, Dean A.; Pearson, John, V; Robinson, Bruce W.; Waddell, Nicola

Considerations for using population frequency data in germline variant interpretation: Cancer syndrome genes as a model

在种系变异解释中使用群体频率数据的考虑因素: 癌症综合征基因作为模型

HUMAN MUTATION

IF3.7

2021-03-019

OAAI

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

DNA甲基化模式识别与临床相关的胰腺神经内分泌肿瘤亚组

COMMUNICATIONS BIOLOGY

IF5.1

2021-02-0331

OAAI

Lakis, Vanessa; Lawlor, Rita T.; Newell, Felicity; Patch, Ann-Marie; Mafficini, Andrea; Sadanandam, Anguraj; Koufariotis, Lambros T.; Johnston, Rebecca L.; Leonard, Conrad; Wood, Scott; Rusev, Borislav; Corbo, Vincenzo; Luchini, Claudio; Cingarlini, Sara; Landoni, Luca; Salvia, Roberto; Milella, Michele; Chang, David; Bailey, Peter; Jamieson, Nigel B.; Duthie, Fraser; Gingras, Marie-Claude; Muzny, Donna M.; Wheeler, David A.; Gibbs, Richard A.; Milione, Massimo; Pederzoli, Paolo; Samra, Jaswinder S.; Gill, Anthony J.; Johns, Amber L.; Pearson, John, V; Biankin, Andrew, V; Grimmond, Sean M.; Waddell, Nicola; Nones, Katia; Scarpa, Aldo

Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity

NATURE COMMUNICATIONS

IF15.7

2020-10-16118

OAAI

Newell, Felicity; Wilmott, James S.; Johansson, Peter A.; Nones, Katia; Addala, Venkateswar; Mukhopadhyay, Pamela; Broit, Natasa; Amato, Carol M.; Van Gulick, Robert; Kazakoff, Stephen H.; Patch, Ann-Marie; Koufariotis, Lambros T.; Lakis, Vanessa; Leonard, Conrad; Wood, Scott; Holmes, Oliver; Xu, Qinying; Lewis, Karl; Medina, Theresa; Gonzalez, Rene; Saw, Robyn P. M.; Spillane, Andrew J.; Stretch, Jonathan R.; Rawson, Robert V.; Ferguson, Peter M.; Dodds, Tristan J.; Thompson, John F.; Long, Georgina V.; Levesque, Mitchell P.; Robinson, William A.; Pearson, John V.; Mann, Graham J.; Scolyer, Richard A.; Waddell, Nicola; Hayward, Nicholas K.

Using whole-genome sequencing data to derive the homologous recombination deficiency scores

使用全基因组测序数据得出同源重组缺陷评分

NPJ BREAST CANCER

IF7.6

2020-08-0719

OAAI

Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

葡萄膜黑色素瘤的全基因组景观在虹膜肿瘤中显示出紫外线辐射特征

NATURE COMMUNICATIONS

IF15.7

2020-05-1592

OAAI

Johansson, Peter A.; Brooks, Kelly; Newell, Felicity; Palmer, Jane M.; Wilmott, James S.; Pritchard, Antonia L.; Broit, Natasa; Wood, Scott; Carlino, Matteo S.; Leonard, Conrad; Koufariotis, Lambros T.; Nathan, Vaishnavi; Beasley, Aaron B.; Howlie, Madeleine; Dawson, Rebecca; Rizos, Helen; Schmidt, Chris W.; Long, Georgina, V; Hamilton, Hayley; Kiilgaard, Jens F.; Isaacs, Timothy; Gray, Elin S.; Rolfe, Olivia J.; Park, John J.; Stark, Andrew; Mann, Graham J.; Scolyer, Richard A.; Pearson, John, V; van Baren, Nicolas; Waddell, Nicola; Wadt, Karin W.; McGrath, Lindsay A.; Warrier, Sunil K.; Glasson, William; Hayward, Nicholas K.

Detection of actionable variants in various cancer types reveals value of whole-genome sequencing over in-silico whole-exome and hotspot panel sequencing

ANNALS OF ONCOLOGY

IF65.4

2019-11-012

OAAI

Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

粘膜黑色素瘤的全基因组景观揭示了不同的驱动因素和治疗靶点

NATURE COMMUNICATIONS

IF15.7

2019-07-18214

OAAI

Newel, Felicity; Kong, Yan; Wilmott, James S.; Johansson, Peter A.; Ferguson, Peter M.; Cui, Chuanliang; Li, Zhongwu; Kazakoff, Stephen H.; Burke, Hazel; Dodds, Tristan J.; Patch, Ann-Marie; Nones, Katia; Tembe, Varsha; ShanG, Ping; van der Weyden, Louise; WongH, Kim; Holmes, Oliver; Lo, Serigne; Leonardl, Conrad; Wood, Scott; Xu, Qinying; Rawson, Robert, V; Mukhopadhyay, Pamela; Dummer, Reinhard; Levesque, Mitchell P.; Jonsson, Goran; Wang, Xuan; Yeh, Iwei; Wu, Hong; Joseph, Nancy; Bastian, Boris C.; Long, Georgina, V; Spillane, Andrew J.; Shannon, Kerwin F.; Thompson, John F.; Saw, Robyn P. M.; Adams, David J.; Si, Lu; Pearson, John, V; Hayward, Nicholas K.; Waddell, Nicola; Mann, Graham J.; Guo, Jun; Scolyer, Richard A.

Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

ANNALS OF ONCOLOGY

IF65.4

2019-07-0151

OAAI

Using whole genome sequencing and somatic mutation signatures to unravel insight into familial breast cancer aetiology

CANCER RESEARCH

IF16.6

2019-02-150

PRE

Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications

化生性乳腺癌的表型和分子解剖及其预后意义

JOURNAL OF PATHOLOGY

IF5.2

2018-12-2066

OAAI

McCart Reed, Amy Ellen; Kalaw, Emarene; Nones, Katia; Bettington, Mark; Lim, Malcolm; Bennett, James; Johnstone, Kate; Kutasovic, Jamie Rose; Saunus, Jodi Marie; Kazakoff, Stephen; Xu, Qinying; Wood, Scott; Holmes, Oliver; Leonard, Conrad; Reid, Lynne Estelle; Black, Debra; Niland, Colleen; Ferguson, Kaltin; Gresshoff, Irma; Raghavendra, Ashwini; Harvey, Kate; Cooper, Caroline; Liu, Cheng; Kalinowski, Lauren; Reid, Andrew Scott; Davidson, Morgan; Pearson, John V.; Pathmanathan, Nirmala; Tse, Gary; Papadimos, David; Pathmanathan, Rajadurai; Harris, Gavin; Yamaguchi, Rin; Tan, Puay Hoon; Fox, Stephen B.; O'Toole, Sandra A.; Simpson, Peter Thomas; Waddell, Nicola; Lakhani, Sunil R.

Conrad Leonard

个人简介

教育背景

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