José Antonio Ortega - Publications, H-index & Citations

José Antonio Ortega

Istituto Italiano di Tecnologia

44H指数

324论文数

8.5K被引数

收录论文 33

发表时间

Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-06-12

OAAI

Brindani, Nicoletta; Vuong, Linh M.; La Serra, Maria Antonietta; Salvador, Noel; Menichetti, Andrea; Acquistapace, Isabella Maria; Ortega, Jose Antonio; Veronesi, Marina; Bertozzi, Sine Mandrup; Summa, Maria; Girotto, Stefania; Bertorelli, Rosalia; Armirotti, Andrea; Ganesan, Anand K.; De Vivo, Marco

Abatement and transaction costs of water reallocation

JOURNAL OF HYDROLOGY

IF6.3

2024-05-01

OAAI

Perez-Blanco, C. Dionisio; Loch, Adam; Mejino-Lopez, Juan; Gil-Garcia, Laura; Adamson, David; Saiz-Santiago, Pablo; Ortega, Jose Antonio

Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-12-01

OAAI

Basagni, Filippo; Ortega, Jose A.; Bertozzi, Sine M.; Armirotti, Andrea; Summa, Maria; Bertorelli, Rosalia; Bartolini, Manuela; Mellor, Ian R.; Bedeschi, Martina; Bottegoni, Giovanni; Lembo, Vittorio; Minarini, Anna; Cavalli, Andrea; Rosini, Michela

Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-04-07

OAAI

Brindani, Nicoletta; Vuong, Linh M.; Acquistapace, Isabella Maria; La Serra, Maria Antonietta; Ortega, Jose Antonio; Veronesi, Marina; Bertozzi, Sine Mandrup; Summa, Maria; Girotto, Stefania; Bertorelli, Rosalia; Armirotti, Andrea; Ganesan, Anand K.; De Vivo, Marco

Climate-sensitive hydrological drought insurance for irrigated agriculture under deep uncertainty. Insightful results from the Cega River Basin in Spain

AGRICULTURAL WATER MANAGEMENT

IF6.5

2022-12-01

OAAI

Agudo-Dominguez, Alberto; Dionisio Perez-Blanco, C.; Gil-Garcia, Laura; Antonio Ortega, Jose; Dasgupta, Shouro

Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2022-07-28

OAAI

Bagnolini, Greta; Balboni, Beatrice; Schipani, Fabrizio; Gioia, Dario; Veronesi, Marina; De Franco, Francesca; Kaya, Cansu; Jumde, Ravindra P.; Ortega, Jose Antonio; Girotto, Stefania; Hirsch, Anna K. H.; Roberti, Marinella; Cavalli, Andrea

Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer

CELL REPORTS

IF6.9

2022-04-01

OAAI

Jahid, Sohail; Ortega, Jose A.; Vuong, Linh M.; Acquistapace, Isabella Maria; Hachey, Stephanie J.; Flesher, Jessica L.; La Serra, Maria Antonietta; Brindani, Nicoletta; La Sala, Giuseppina; Manigrasso, Jacopo; Arencibia, Jose M.; Bertozzi, Sine Mandrup; Summa, Maria; Bertorelli, Rosalia; Armirotti, Andrea; Jin, Rongsheng; Liu, Zheng; Chen, Chi-Fen; Edwards, Robert; Hughes, Christopher C. W.; De Vivo, Marco; Ganesan, Anand K.

Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer (vol 39, 110641, 2022)

CELL REPORTS

IF6.9

2022-04-01

OAAI

ARN25068, a versatile starting point towards triple GSK-3β/FYN/ DYRK1A inhibitors to tackle tau-related neurological disorders

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-02-01

OAAI

Demuro, Stefania; Sauvey, Conall; Tripathi, Shailesh K.; Di Martino, Rita M. C.; Shi, Da; Ortega, Jose A.; Russo, Debora; Balboni, Beatrice; Giabbai, Barbara; Storici, Paola; Girotto, Stefania; Abagyan, Ruben; Cavalli, Andrea

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-09-01

OAAI

Di Fruscia, Paolo; Carbone, Anna; Bottegoni, Giovanni; Berti, Francesco; Giacomina, Francesca; Ponzano, Stefano; Pagliuca, Chiara; Fiasella, Annalisa; Pizzirani, Daniela; Ortega, Jose Antonio; Nuzzi, Andrea; Tarozzo, Glauco; Mengatto, Luisa; Giampa, Roberta; Penna, Ilaria; Russo, Debora; Romeo, Elisa; Summa, Maria; Bertorelli, Rosalia; Armirotti, Andrea; Bertozzi, Sine Mandrup; Reggiani, Angelo; Bandiera, Tiziano; Bertozzi, Fabio

Synthetic Lethality through the Lens of Medicinal Chemistry

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-11-02

OAAI

Myers, Samuel H.; Ortega, Jose Antonio; Cavalli, Andrea

Analytical Solution of Mixed Electroosmotic/Pressure Driven Flow of Viscoelastic Fluids between a Parallel Flat Plates Micro-Channel: The Maxwell Model Using the Oldroyd and Jaumann Time Derivatives

MICROMACHINES

IF3

2020-10-31

OAAI

Casas, Laura; Ortega, Jose A.; Gomez, Aldo; Escandon, Juan; Vargas, Rene O.

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-10-20

OAAI

Ortega, Jose Antonio; Arencibia, Jose M.; Minniti, Elirosa; Byl, Jo Ann W.; Franco-Ulloa, Sebastian; Borgogno, Marco; Genna, Vito; Summa, Maria; Bertozzi, Sine Mandrup; Bertorelli, Rosalia; Armirotti, Andrea; Minarini, Anna; Sissi, Claudia; Osheroff, Neil; De Vivo, Marco

Structure-based design of CDC42/RHOJ effector inhibitors for the treatment of cancer

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Flesher, Jessica L.; Jahid, Sohail; Ortega, Jose A.; La Sala, Giuseppina; Brindani, Nicoletta; Arencibia, Jose M.; Manigrasso, Jacopo; Hachey, Stephanie; Chen, Chi-Fen; Hughes, Chris; De Vivo, Marco; Ganesan, Anand K.

Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders

CHEM

IF19.6

2020-08-01

OAAI

Savardi, Annalisa; Borgogno, Marco; Narducci, Roberto; La Sala, Giuseppina; Ortega, Jose Antonio; Summa, Maria; Armirotti, Andrea; Bertorelli, Rosalia; Contestabile, Andrea; De Vivo, Marco; Cancedda, Laura

Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-11-09

OAAI

Ortega, Jose Antonio; Riccardi, Laura; Minniti, Elirosa; Borgogno, Marco; Arencibia, Jose M.; Greco, Maria L.; Minarini, Anna; Sissi, Claudia; De Vivo, Marco

Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-06-27

OAAI

Ortega, Jose Antonio; Arencibia, Jose M.; La Sala, Giuseppina; Borgogno, Marco; Bauer, Inga; Bono, Luca; Braccia, Clarissa; Armirotti, Andrea; Girotto, Stefania; Ganesan, Anand; De Vivo, Marco

Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2016-03-01

OAAI

Nuzzi, Andrea; Fiasella, Annalisa; Ortega, Jose Antonio; Pagliuca, Chiara; Ponzano, Stefano; Pizzirani, Daniela; Bertozzi, Sine Mandrup; Ottonello, Giuliana; Tarozzo, Glauco; Reggiani, Angelo; Bandiera, Tiziano; Bertozzi, Fabio; Piomelli, Daniele

Use of circulating tumor cells as response evaluation criteria to erlotinib treatment in EGFR wild-type metastatic lung cancer patients

EUROPEAN JOURNAL OF CANCER

IF7.1

2015-09-01

PREAI

Jurado, J. M.; Serrano, M. J.; Valdivia, J.; Mellado, M.; Lorente, J. A.; Delgado, J. R.; Ortega, J. A.; Exposito, J.; Suarez, L.; Garcia-Puche, J. L.

Clinical outcome and impact of lymph node level assessment in biliary tract cancers

ANNALS OF ONCOLOGY

IF65.4

2015-06-01

OAAI

Martinez-Galan, J.; Gonzalez-Rivas, C.; Conde, V.; Ruiz-Vozmediano, J.; Castillo, L.; Ochoa, L.; Amezcua, V.; Garcia-Garcia, J.; Ortega, J. A.; Gonzalez-Flores, E.; Delgado, J. R.

研究方向