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H

Hector C. Keun

imperial college london

60H指数
371论文数
1.4W被引数
收录论文 140
发表时间
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Altered Sphingolipid Metabolism is Associated with Osimertinib Resistance in Nonsmall-Cell Lung Cancer改变的鞘脂代谢与奥希替尼耐药性在非小细胞肺癌中的关联
errJournal of Proteome Research
IF3.6
err2026-04-16
err0
errOAAI
errJulia Babuta; Aleksandra Gruevska; Chiharu Wickremesinghe; Alex Montoya; Georgia Roumelioti; Pavel Shliaha; Cristina Balcells; Flora McKinney; Chandler Bray; Toby Athersuch; Matthew Martin; Hector Keun; Zoe Hall
err分享
err收藏
Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders
errCell Reports
IF6.9
err2026-01-08
err0
errOAAI
errYurui Ma; Evon Poon; Chenchen Jin; Barbara Martins da Costa; Yuewei Xu; Sadiya Quazi; Nikolaos Zourdoumis; Chiharu Wickremesinghe; Louis Chesler; Hector C. Keun; Anke Nijhuis
err分享
err收藏
RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combinationRAS/PI3K通路突变使上皮性卵巢癌细胞对PARP/NAMPT抑制剂组合产生敏感性
errCommunications Biology
IF5.1
err2025-12-19
err0
errOAAI
errMichael Gruet; Yitao Xu; Lyutong An; Yurui Ma; Cristina Balcells; Katie Tyson; Laila C. Evangelista; Sarah Spear; Yuewei Xu; Flora McKinney; Julia Babuta; Chandler Bray; Chiharu Wickremesinghe; Alexandros P. Siskos; Anke M. Nijhuis; Edward W. Tate; Iain A. McNeish; Adrian Benito; Hector C. Keun
err分享
err收藏
The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis幼稚多能性退出过程中包含一个由代谢诱导的端粒稳态检查点。
errCell Reports
IF6.9
err2025-12-11
err0
errOAAI
errRoshni A. de Souza; David Barneda; Donja Karimlou; Nick G.P. Bovee; Yuhan Zheng; Eveline J.E.M. Kahlman; Clara Lopes Novo; James K. Ellis; Bryony J. Leeke; Songyang Li; Megha Prakash Bangalore; Zijing Liu; Bebiana C. Sousa; Andrea F. Lopez-Clavijo; Joop H. Jansen; Mauricio Barahona; Michelle Percharde; Hector C. Keun; Mark Christian; Hendrik Marks
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Early-life exposome and health-related immune signatures in childhood生命早期暴露组与儿童健康相关的免疫特征
errEnvironment International
IF9.7
err2025-07-05
err0
errOAAI
errInes Amine; Augusto Anguita-Ruiz; Alicia Guillien; Xavier Basagaña; Mariona Bustamante; Eva Borràs; Marta Cirach; Audrius Dedele; Carlota Dobaño; Judith Garcia-Aymerich; Berit Granum; Regina Grazuleviciene; Juan Ramón González; Jordi Julvez; Hector Keun; Mónica López-Vicente; Rosemary McEachan; Gemma Moncunill; Mark Nieuwenhuijsen; Eduard Sabidó; Léa Maitre
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err收藏
Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweightMeet-in-the-middle方法结合多组学技术，识别环境因素驱动儿童超重的分子标志物
errEnvironment International
IF9.7
err2025-06-23
err0
errOAAI
errCongrong Wang; Brigitte Reimann; Tim S Nawrot; Dries S Martens; John Wright; Rosemary McEachan; Johanna Lepeule; Wenlun Yuan; Leda Chatzi; Marina Vafeiadi; Regina Grazuleviciene; Sandra Andrusaityte; Oliver Robinson; Jordi Sunyer; Hector Keun; Chung-Ho E. Lau; Alexandros P. Siskos; Muireann Coen; Eva Borràs; Eduard Sabidó; Rossella Alfano
err分享
err收藏
The multi-omics signatures of telomere length in childhood儿童端粒长度的多组学特征
errBMC GENOMICS
IF3.7
err2025-01-27
err0
errOAAI
errWang, Congrong; Martens, Dries S.; Bustamante, Mariona; Alfano, Rossella; Plusquin, Michelle; Maitre, Lea; Wright, John; Mceachan, Rosemary R. C.; Lepeule, Johanna; Slama, Remy; Vafeiadi, Marina; Chatzi, Leda; Grazuleviciene, Regina; Gutzkow, Kristine B.; Keun, Hector; Borras, Eva; Sabido, Eduard; Carracedo, Angel; Escarami, Georgia; Anguita-Ruiz, Augusto; Pelegri-Siso, Dolors; Gonzalez, Juan R.; Vrijheid, Martine; Nawrot, Tim S.
err分享
err收藏
PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
errCANCER RESEARCH
IF16.6
err2024-08-26
err0
errOAAI
errSpear, Sarah; Le Saux, Olivia; Mirza, Hasan B.; Iyer, Nayana; Tyson, Katie; Freile, Fabio Grundland; Walton, Josephine B.; Woodman, Chloe; Jarvis, Sheba; Ennis, Darren P.; Hernandez, Carmen Aguirre; Xu, Yuewei; Spiliopoulou, Pavlina; Brenton, James D.; Costa-Pereira, Ana P.; Cook, David P.; Vanderhyden, Barbara C.; Keun, Hector C.; Triantafyllou, Evangelos; Arnold, James N.; Mcneish, Iain A.
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err收藏
Editorial overview: Recent advances in metabolomics
errCURRENT OPINION IN CHEMICAL BIOLOGY
IF6.1
err2024-08-01
err0
PREAI
errMcCullagh, James S. O.; Keun, Hector C.
err分享
err收藏
Machine learning-based health environmental-clinical risk scores in European children基于机器学习的欧洲儿童健康环境临床风险评分
errCOMMUNICATIONS MEDICINE
IF6.3
err2024-05-23
err1
errOAAI
errGuimbaud, Jean-Baptiste; Siskos, Alexandros P.; Sakhi, Amrit Kaur; Heude, Barbara; Sabido, Eduard; Borras, Eva; Keun, Hector; Wright, John; Julvez, Jordi; Urquiza, Jose; Gutzkow, Kristine Bjerve; Chatzi, Leda; Casas, Maribel; Bustamante, Mariona; Nieuwenhuijsen, Mark; Vrijheid, Martine; Lopez-Vicente, Monica; Pascual, Montserrat de Castro; Stratakis, Nikos; Robinson, Oliver; Grazuleviciene, Regina; Slama, Remy; Alemany, Silvia; Basagana, Xavier; Plantevit, Marc; Cazabet, Remy; Maitre, Lea
err分享
err收藏
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition
errARCHIVES OF TOXICOLOGY
IF6.9
err2024-05-17
err0
errOAAI
errFogal, Valentina; Michopoulos, Filippos; Jarnuczak, Andrew F.; Hamza, Ghaith M.; Harlfinger, Stephanie; Davey, Paul; Hulme, Heather; Atkinson, Stephen J.; Gabrowski, Piotr; Cheung, Tony; Grondine, Michael; Hoover, Clare; Rose, Jonathan; Bray, Chandler; Foster, Alison J.; Askin, Sean; Majumder, Muntasir Mamun; Fitzpatrick, Paul; Miele, Eric; Macdonald, Ruth; Keun, Hector C.; Coen, Muireann
err分享
err收藏
Targeting RNA splicing factor RBM39 improves therapy responses in ovarian high-grade serous carcinoma
errCANCER RESEARCH
IF16.6
err2024-03-04
err0
PREAI
errXu, Yuewei; Spear, Sarah; Ma, Yurui; Lorentzen, Marc; Gruet, Michael; McKinney, Flora; Xu, Yitao; Wickremesinghe, Chiharu; McNeish, Iain; Keun, Hector; Nijhuis, Anke
err分享
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In-utero and childhood chemical exposome in six European mother-child cohorts ( vol 121 , pg 751-763 , 2018 )六个欧洲母子队列中的子宫内和儿童化学暴露组 (121卷，751至763页，2018)
errENVIRONMENT INTERNATIONAL
IF9.7
err2024-03-01
err0
errOAAI
errHaug, Line Smastuen; Sakhi, Amrit Kaur; Cequier, Enrique; Casas, Maribel; Maitre, Lea; Basagana, Xavier; Andrusaityte, Sandra; Chalkiadaki, Georgia; Chatzi, Leda; Coen, Muireann; de Bont, Jeroen; Dedele, Audrius; Ferrand, Joane; Grazuleviciene, Regina; Gonzalez, Juan Ramon; Gutzkow, Kristine Bjerve; Keun, Hector; McEachan, Rosie; Meltzer, Helle Margrete; Petraviciene, Inga; Robinson, Oliver; Saulnier, Pierre -Jean; Slama, Remy; Sunyer, Jordi; Urquiza, Jose; Vafeiadi, Marina; Wright, John; Vrijheid, Martine; Thomsen, Cathrine
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Hyperacetylated histone H4 is a source of carbon contributing to lipid synthesis
errEMBO JOURNAL
IF8.3
err2024-02-21
err2
errOAAI
errCharidemou, Evelina; Noberini, Roberta; Ghirardi, Chiara; Georgiou, Polymnia; Marcou, Panayiota; Theophanous, Andria; Strati, Katerina; Keun, Hector; Behrends, Volker; Bonaldi, Tiziana; Kirmizis, Antonis
err分享
err收藏
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
errCURRENT OPINION IN CHEMICAL BIOLOGY
IF6.1
err2024-02-01
err2
errOAAI
errBalcells, Cristina; Xu, Yitao; Gil-Solsona, Ruben; Maitre, Lea; Gago-Ferrero, Pablo; Keun, Hector C.
err分享
err收藏
Chemical tools for profiling the intracellular ADP-ribosylated proteome
errRSC CHEMICAL BIOLOGY
IF3.1
err2024-01-01
err0
errOAAI
errDraganov, Simeon D.; Gruet, Michael J.; Conole, Daniel; Balcells, Cristina; Siskos, Alexandros P.; Keun, Hector C.; Haskard, Dorian O.; Tate, Edward W.
err分享
err收藏
RBM39: A druggable metabolic sensor linking RNA splicing, transcriptional regulation, and metabolic reprogramming in cancer
errMOLECULAR CELL
IF16.6
err2023-12-01
err0
errOAAI
errKeun, Hector C.; Nijhuis, Anke
err分享
err收藏
Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
errCELL REPORTS
IF6.9
err2023-10-01
err10
errOAAI
errXu, Yuewei; Spear, Sarah; Ma, Yurui; Lorentzen, Marc P.; Gruet, Michael; Mckinney, Flora; Xu, Yitao; Wickremesinghe, Chiharu; Shepherd, Madelen R.; Mcneish, Iain; Keun, Hector C.; Nijhuis, Anke
err分享
err收藏
The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality靶向MTAP阴性癌症超出合成致死率的潜力和挑战
errFRONTIERS IN ONCOLOGY
IF3.3
err2023-09-19
err17
errOAAI
errBray, Chandler; Balcells, Cristina; Mcneish, Iain A.; Keun, Hector C.
err分享
err收藏
Editorial: Metabolomics and the exposome
errFRONTIERS IN PUBLIC HEALTH
IF3.4
err2023-06-28
err2
errOAAI
errSiskos, Alexandros P.; Keun, Hector C.; Warth, Benedikt; Kelly, Rachel S.; Maitre, Lea
err分享
err收藏

研究方向

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