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S

Sareena Rana

Novartis
H指数:17
被引数:2,485

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工作经历

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荣誉奖项

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Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2

Pi3kαras结合域的共价抑制剂会损害RAS和HER2驱动的肿瘤生长

SCIENCE
IF45.8
2025-11-130
PRE
Klebba, Joseph E.; Roy, Nilotpal; Bernard, Steffen M.; Grabow, Stephanie; Hoffman, Melissa A.; Miao, Hui; Tamiya, Junko; Wang, Jinwei; Berry, Cynthia; Esparza-Oros, Antonio; Lin, Richard; Liu, Yongsheng; Pariollaud, Marie; Parker, Holly; Mochalkin, Igor; Rana, Sareena; Snead, Aaron N.; Walton, Eric J.; Wyrick, Taylor E.; Aitichson, Erick; Bedke, Karl; Brannon, Jacyln C.; Chick, Joel M.; Hee, Kenneth; Horning, Benjamin D.; Ismail, Mohamed; Lamb, Kelsey N.; Lin, Wei; Lu, Justine; Pastuszka, Martha K.; Pollock, Jonathan; Sigler, John J.; Tomaschko, Mona; Tran, Eileen; Yue, Chanyu; Kinsella, Todd M.; Molina-Arcas, Miriam; Cook, Brian N.; Simon, Gabriel M.; Weinstein, David S.; Downward, Julian; Patricelli, Matthew P.
Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses
SCIENCE ADVANCES
IF12.5
2024-11-010
OAAI
Cole, Megan; Anastasiou, Panayiotis; Lee, Claudia; Yu, Xiaofei; de Castro, Andrea; Roelink, Jannes; Moore, Chris; Mugarza, Edurne; Jones, Martin; Valand, Karishma; Rana, Sareena; Colliver, Emma; Angelova, Mihaela; Enfield, Katey S. S.; Magness, Alastair; Mullokandov, Asher; Kelly, Gavin; de Gruijl, Tanja D.; Molina-Arcas, Miriam; Swanton, Charles; Downward, Julian; van Maldegem, Febe
CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

CRISPR-Cas9筛查确定KRAS诱导的COX2是肺癌免疫治疗耐药的驱动因素

CANCER RESEARCH
IF16.6
2024-04-181
OAAI
Boumelha, Jesse; de Castro, Andrea; Bah, Nourdine; Cha, Hongui; Trecesson, Sophie de Carne; Rana, Sareena; Tomaschko, Mona; Anastasiou, Panayiotis; Mugarza, Edurne; Moore, Christopher; Goldstone, Robert; East, Phil; Litchfield, Kevin; Lee, Se-Hoon; Molina-Arcas, Miriam; Downward, Julian
An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
CANCER RESEARCH
IF16.6
2022-08-0531
OAAI
Boumelha, Jesse; Trecesson, Sophie de Carne; Law, Emily K.; Romero-Clavijo, Pablo; Coelho, Matthew A.; Ng, Kevin W.; Mugarza, Edurne; Moore, Christopher; Rana, Sareena; Caswell, Deborah R.; Murillo, Miguel; Hancock, David C.; Argyris, Prokopios P.; Brown, William L.; Durfee, Cameron; Larson, Lindsay K.; Vogel, Rachel, I; Suarez-Bonnet, Alejandro; Priestnall, Simon L.; East, Philip; Ross, Sarah J.; Kassiotis, George; Molina-Arcas, Miriam; Swanton, Charles; Harris, Reuben; Downward, Julian
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers

治疗性KRASG12C抑制在免疫原性肺癌中驱动有效的干扰素介导的抗肿瘤免疫

SCIENCE ADVANCES
IF12.5
2022-07-2259
OAAI
Mugarza, Edurne; van Maldegem, Febe; Boumelha, Jesse; Moore, Christopher; Rana, Sareena; Sopena, Miriam Llorian; East, Philip; Ambler, Rachel; Anastasiou, Panayiotis; Romero-Clavijo, Pablo; Valand, Karishma; Cole, Megan; Molina-Arcas, Miriam; Downward, Julian
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

致癌RAS信号通过稳定PD-L1 mRNA促进肿瘤免疫抵抗

IMMUNITY
IF26.3
2017-12-01481
OAAI
Coelho, Matthew A.; Trecesson, Sophie de Carne; Rana, Sareena; Zecchin, Davide; Moore, Christopher; Molina-Arcas, Miriam; East, Philip; Spencer-Dene, Bradley; Nye, Emma; Barnouin, Karin; Snijders, Ambrosius P.; Lai, Wi S.; Blackshear, Perry J.; Downward, Julian

研究方向

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J
Julian Downward
H 指数:114论文数:667被引数:6.2万
C
Christopher Moore
H 指数:29论文数:163被引数:3,432
E
Edurne Mugarza
H 指数:9论文数:72被引数:695
M
Míriam Molina‐Arcas
H 指数:33论文数:197被引数:4,558
F
Febe van Maldegem
H 指数:16论文数:71被引数:2,038
J
Jesse Boumelha
H 指数:11论文数:94被引数:1,479
M
Mona Tomaschko
H 指数:4论文数:53被引数:175
P
Panayiotis Anastasiou
H 指数:9论文数:86被引数:715
M
Míriam Molina‐Arcas
H 指数:0论文数:1被引数:11
R
Richard Marais
H 指数:98论文数:624被引数:4.8万