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J

Julian Downward

the francis crick institute
H指数:114
被引数:6.2万

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Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

撤稿注意: 针对内源性逆转录病毒的抗体促进肺癌免疫治疗

Nature
IF48.5
2026-01-140
OAAI
Kevin W. Ng; Jesse Boumelha; Katey S. S. Enfield; Jorge Almagro; Hongui Cha; Oriol Pich; Takahiro Karasaki; David A. Moore; Roberto Salgado; Monica Sivakumar; George Young; Miriam Molina-Arcas; Sophie de Carné Trécesson; Panayiotis Anastasiou; Annika Fendler; Lewis Au; Scott T. C. Shepherd; Carlos Martínez-Ruiz; Clare Puttick; James R. M. Black; Thomas B. K. Watkins; Hyemin Kim; Seohee Shim; Nikhil Faulkner; Jan Attig; Selvaraju Veeriah; Neil Magno; Sophia Ward; Alexander M. Frankell; Maise Al Bakir; Emilia L. Lim; Mark S. Hill; Gareth A. Wilson; Daniel E. Cook; Nicolai J. Birkbak; Axel Behrens; Nadia Yousaf; Sanjay Popat; Allan Hackshaw; Crispin T. Hiley; Kevin Litchfield; Nicholas McGranahan; Mariam Jamal-Hanjani; James Larkin; Se-Hoon Lee; Samra Turajlic; Charles Swanton; Julian Downward; George Kassiotis
Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2

Pi3kαras结合域的共价抑制剂会损害RAS和HER2驱动的肿瘤生长

SCIENCE
IF45.8
2025-11-130
PRE
Klebba, Joseph E.; Roy, Nilotpal; Bernard, Steffen M.; Grabow, Stephanie; Hoffman, Melissa A.; Miao, Hui; Tamiya, Junko; Wang, Jinwei; Berry, Cynthia; Esparza-Oros, Antonio; Lin, Richard; Liu, Yongsheng; Pariollaud, Marie; Parker, Holly; Mochalkin, Igor; Rana, Sareena; Snead, Aaron N.; Walton, Eric J.; Wyrick, Taylor E.; Aitichson, Erick; Bedke, Karl; Brannon, Jacyln C.; Chick, Joel M.; Hee, Kenneth; Horning, Benjamin D.; Ismail, Mohamed; Lamb, Kelsey N.; Lin, Wei; Lu, Justine; Pastuszka, Martha K.; Pollock, Jonathan; Sigler, John J.; Tomaschko, Mona; Tran, Eileen; Yue, Chanyu; Kinsella, Todd M.; Molina-Arcas, Miriam; Cook, Brian N.; Simon, Gabriel M.; Weinstein, David S.; Downward, Julian; Patricelli, Matthew P.
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α (vol 13, 1889, 2023)
SCIENTIFIC REPORTS
IF3.9
2025-03-130
OAAI
Ismail, Mohamed; Martin, Stephen R.; George, Roger; Houghton, Francesca; Kelly, Geoff; Chaleil, Raphael A. G.; Anastasiou, Panayiotis; Wang, Xinyue; O'Reilly, Nicola; Federico, Stefania; Joshi, Dhira; Nagaraj, Hemavathi; Cooley, Rachel; Hui, Ning Sze; Molina-Arcas, Miriam; Hancock, David C.; Tavassoli, Ali; Downward, Julian
Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses
SCIENCE ADVANCES
IF12.5
2024-11-010
OAAI
Cole, Megan; Anastasiou, Panayiotis; Lee, Claudia; Yu, Xiaofei; de Castro, Andrea; Roelink, Jannes; Moore, Chris; Mugarza, Edurne; Jones, Martin; Valand, Karishma; Rana, Sareena; Colliver, Emma; Angelova, Mihaela; Enfield, Katey S. S.; Magness, Alastair; Mullokandov, Asher; Kelly, Gavin; de Gruijl, Tanja D.; Molina-Arcas, Miriam; Swanton, Charles; Downward, Julian; van Maldegem, Febe
CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

CRISPR-Cas9筛查确定KRAS诱导的COX2是肺癌免疫治疗耐药的驱动因素

CANCER RESEARCH
IF16.6
2024-04-181
OAAI
Boumelha, Jesse; de Castro, Andrea; Bah, Nourdine; Cha, Hongui; Trecesson, Sophie de Carne; Rana, Sareena; Tomaschko, Mona; Anastasiou, Panayiotis; Mugarza, Edurne; Moore, Christopher; Goldstone, Robert; East, Phil; Litchfield, Kevin; Lee, Se-Hoon; Molina-Arcas, Miriam; Downward, Julian
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer

骨髓和T细胞的空间结构协调肺癌的免疫逃避和临床结果

CANCER DISCOVERY
IF33.3
2024-04-1211
OAAI
Enfield, Katey S. S.; Colliver, Emma; Lee, Claudia; Magness, Alastair; Moore, David A.; Sivakumar, Monica; Grigoriadis, Kristiana; Pich, Oriol; Karasaki, Takahiro; Hobson, Philip S.; Levi, Dina; Veeriah, Selvaraju; Puttick, Clare; Nye, Emma L.; Green, Mary; Dijkstra, Krijn K.; Shimato, Masako; Akarca, Ayse U.; Marafioti, Teresa; Salgado, Roberto; Hackshaw, Allan; Jamal-Hanjani, Mariam; van Maldegem, Febe; Mcgranahan, Nicholas; Glass, Benjamin; Pulaski, Hanna; Walk, Eric; Reading, James L.; Quezada, Sergio A.; Hiley, Crispin T.; Downward, Julian; Sahai, Erik; Swanton, Charles; Angelova, Mihaela
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
NATURE GENETICS
IF31.8
2023-12-0419
OAAI
Caswell, Deborah R.; Gui, Philippe; Mayekar, Manasi K.; Law, Emily K.; Pich, Oriol; Bailey, Chris; Boumelha, Jesse; Kerr, D. Lucas; Blakely, Collin M.; Manabe, Tadashi; Martinez-Ruiz, Carlos; Bakker, Bjorn; Villcas, Juan De Dios Palomino; I. Vokes, Natalie; Dietzen, Michelle; Angelova, Mihaela; Gini, Beatrice; Tamaki, Whitney; Allegakoen, Paul; Wu, Wei; Humpton, Timothy J.; Hill, William; Tomaschko, Mona; Lu, Wei-Ting; Haderk, Franziska; Al Bakir, Maise; Nagano, Ai; Gimeno-Valiente, Francisco; Trecesson, Sophie de Carne; Vendramin, Roberto; Barbe, Vittorio; Mugabo, Miriam; Weeden, Clare E.; Rowan, Andrew; McCoach, Caroline E.; Almeida, Bruna; Green, Mary; Gomez, Carlos; Nanjo, Shigeki; Barbosa, Dora; Moore, Chris; Przewrocka, Joanna; Black, James R. M.; Gronroos, Eva; Suarez-Bonnet, Alejandro; Priestnall, Simon L.; Zverev, Caroline; Lighterness, Scott; Cormack, James; Olivas, Victor; Cech, Lauren; Andrews, Trisha; Rule, Brandon; Jiao, Yuwei; Zhang, Xinzhu; Ashford, Paul; Durfee, Cameron; Venkatesan, Subramanian; Temiz, Nuri Alpay; Tan, Lisa; Larson, Lindsay K.; Argyris, Prokopios P.; Brown, William L.; Yu, Elizabeth A.; Rotow, Julia K.; Guha, Udayan; Roper, Nitin; Yu, Johnny; Vogel, Rachel I.; Thomas, Nicholas J.; Marra, Antonio; Selenica, Pier; Yu, Helena; Bakhoum, Samuel F.; Chew, Su Kit; Reis-Filho, Jorge S.; Jamal-Hanjani, Mariam; Vousden, Karen H.; McGranahan, Nicholas; Van Allen, Eliezer M.; Kanu, Nnennaya; Harris, Reuben S.; Downward, Julian; Bivona, Trever G.; Swanton, Charles
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4
NATURE COMMUNICATIONS
IF15.7
2023-04-2515
OAAI
Chauhan, Jitesh; Grandits, Melanie; Palhares, Lais C. G. F.; Mele, Silvia; Nakamura, Mano; Lopez-Abente, Jacobo; Crescioli, Silvia; Laddach, Roman; Romero-Clavijo, Pablo; Cheung, Anthony; Stavraka, Chara; Chenoweth, Alicia M. M.; Sow, Heng Sheng; Chiaruttini, Giulia; Gilbert, Amy E. E.; Dodev, Tihomir; Koers, Alexander; Pellizzari, Giulia; Ilieva, Kristina M. M.; Man, Francis; Ali, Niwa; Hobbs, Carl; Lombardi, Sara; Lionarons, Daniel A.; Gould, Hannah J. J.; Beavil, Andrew J. J.; Geh, Jenny L. C.; Ross, Alastair D. MacKenzie D.; Healy, Ciaran; Calonje, Eduardo; Downward, Julian; Nestle, Frank O. O.; Tsoka, Sophia; Josephs, Debra H. H.; Blower, Philip J. J.; Karagiannis, Panagiotis; Lacy, Katie E. E.; Spicer, James; Karagiannis, Sophia N. N.; Bax, Heather J. J.
RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
Nature
IF48.5
2023-04-120
OAAI
Kevin W. Ng; Jesse Boumelha; Katey S. S. Enfield; Jorge Almagro; Hongui Cha; Oriol Pich; Takahiro Karasaki; David A. Moore; Roberto Salgado; Monica Sivakumar; George Young; Miriam Molina-Arcas; Sophie de Carné Trécesson; Panayiotis Anastasiou; Annika Fendler; Lewis Au; Scott T. C. Shepherd; Carlos Martínez-Ruiz; Clare Puttick; James R. M. Black; Thomas B. K. Watkins; Hyemin Kim; Seohee Shim; Nikhil Faulkner; Jan Attig; Selvaraju Veeriah; Neil Magno; Sophia Ward; Alexander M. Frankell; Maise Al Bakir; Emilia L. Lim; Mark S. Hill; Gareth A. Wilson; Daniel E. Cook; Nicolai J. Birkbak; Axel Behrens; Nadia Yousaf; Sanjay Popat; Allan Hackshaw; Crispin T. Hiley; Kevin Litchfield; Nicholas McGranahan; Mariam Jamal-Hanjani; James Larkin; Se-Hoon Lee; Samra Turajlic; Charles Swanton; Julian Downward; George Kassiotis

研究方向

暂未获取到该数据
D
David C. Hancock
H 指数:33论文数:116被引数:7,573
C
Charles Swanton
H 指数:137论文数:1,245被引数:10.9万
P
Patricia H. Warne
H 指数:25论文数:74被引数:8,746
S
Sareena Rana
H 指数:17论文数:101被引数:2,467
C
Christopher Moore
H 指数:29论文数:163被引数:3,414
M
Míriam Molina‐Arcas
H 指数:0论文数:1被引数:0
M
Míriam Molina‐Arcas
H 指数:33论文数:197被引数:4,547
P
Philip East
H 指数:42论文数:154被引数:7,147
王
王益华
H 指数:44论文数:492被引数:1.0万
O
Olivier E. Pardo
H 指数:27论文数:87被引数:3,452