Alan Brown - Publications, H-index & Citations

Alan Brown

Harvard Medical School

64H指数

261论文数

1.5W被引数

收录论文 52

发表时间

Atomic models of the Toxoplasma cell invasion machinery 弓形虫细胞入侵机器的原子模型

Nature Structural & Molecular Biology

IF10.1

2025-12-09

OAAI

Jianwei Zeng; Yong Fu; Pengge Qian; Wei Huang; Qingwei Niu; Wandy L. Beatty; Alan Brown; L. David Sibley; Rui Zhang

A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia 从纤毛中回收泛素化蛋白的一种保守机制

Cell

IF42.5

2025-08-20

PREAI

Sven M. Lange; Jeremy A. Bennett; Robyn J. Eisert; Alan Brown

Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors 发现一种新型，高效且可口服生物利用的吡咯烷酮吲哚系列不可逆髓过氧化物酶 (MPO) 抑制剂

BIOCHEMICAL PHARMACOLOGY

IF5.6

2023-03-01

PREAI

Regard, Jean B.; Harrison, Tyler J.; Axford, Jake; Axford, Laura; Lee, Lac; Ren, Xianglin; Deng, Lin; Reynolds, Aimee; Mao, Justin; Liu, Qian; Patnaik, Anup; Cohick, Evan; Hollis-Symynkywicz, Micah; Loi, Sally; Riek, Simone; McKeever, Una; Dunstan, David; Sung, MooJe; Ware, Nathaniel F.; Brown, Alan P.; Hamann, Lawrence G.; Marcinkeviciene, Jovita; Patterson, Andrew W.; Marro, Martin L.

Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes

ELIFE

IF0

2022-10-20

OAAI

Juette, Manuel F.; Carelli, Jordan D.; Rundlet, Emily J.; Brown, Alan; Shao, Sichen; Ferguson, Angelica; Wasserman, Michael R.; Holm, Mikael; Taunton, Jack; Blanchard, Scott C.

SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-10-03

OAAI

Gui, Miao; Croft, Jacob T.; Zabeo, Davide; Acharya, Vajradhar; Kollman, Justin M.; Burgoyne, Thomas; Hoog, Johanna L.; Brown, Alan

Editorial overview: Modern and future methods for studying macromolecular assemblies in action

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2022-08-01

PREAI

Brown, Alan; Fraternali, Franca

Ciliary central apparatus structure reveals mechanisms of microtubule patterning

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-05-16

OAAI

Gui, Miao; Wang, Xiangli; Dutcher, Susan K.; Brown, Alan; Zhang, Rui

Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates

NUCLEIC ACIDS RESEARCH

IF13.1

2021-12-01

OAAI

Zhou, Haixia; Zaher, Manal S.; Walter, Johannes C.; Brown, Alan

Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins (vol 12, 3065, 2021)

NATURE COMMUNICATIONS

IF15.7

2021-06-25

OAAI

Wang, Xiangli; Fu, Yong; Beatty, Wandy L.; Ma, Meisheng; Brown, Alan; Sibley, L. David; Zhang, Rui

Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins

NATURE COMMUNICATIONS

IF15.7

2021-05-24

OAAI

Wang, Xiangli; Fu, Yong; Beatty, Wandy L.; Ma, Meisheng; Brown, Alan; Sibley, L. David; Zhang, Rui

Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2021-02-25

OAAI

Zhang, Meng; Gui, Miao; Wang, Zi-Fu; Gorgulla, Christoph; Yu, James J.; Wu, Hao; Sun, Zhen-yu J.; Klenk, Christoph; Merklinger, Lisa; Morstein, Lena; Hagn, Franz; Pluckthun, Andreas; Brown, Alan; Nasr, Mahmoud L.; Wagner, Gerhard

Structure of a microtubule-bound axonemal dynein

NATURE COMMUNICATIONS

IF15.7

2021-01-20

OAAI

Walton, Travis; Wu, Hao; Brown, Alan

Structures of radial spokes and associated complexes important for ciliary motility

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2020-12-14

OAAI

Gui, Miao; Ma, Meisheng; Sze-Tu, Erica; Wang, Xiangli; Koh, Fujiet; Zhong, Ellen D.; Berger, Bonnie; Davis, Joseph H.; Dutcher, Susan K.; Zhang, Rui; Brown, Alan

Primary Cilia: A Closer Look at the Antenna of Cells

CURRENT BIOLOGY

IF7.5

2020-12-01

OAAI

Brown, Alan; Zhang, Rui

New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2020-06-11

PREAI

Walles, Markus; Brown, Alan P.; Zimmerlin, Alfred; End, Peter

Structure and activation mechanism of the BBSome membrane protein trafficking complex

ELIFE

IF0

2020-01-15

OAAI

Singh, Sandeep K.; Gui, Miao; Koh, Fujiet; Yip, Matthew C. J.; Brown, Alan

Mechanism of ribosome stalling during translation of a poly(A) tail

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2019-11-25

173

OAAI

Chandrasekaran, Viswanathan; Juszkiewicz, Szymon; Choi, Junhong; Puglisi, Joseph D.; Brown, Alan; Shao, Sichen; Ramakrishnan, V.; Hegde, Ramanujan S.

Mortality Associated With Opioid Overdose: A Review of Clinical Characteristics and Health Services Received in the Year Prior to Death

PSYCHIATRIC SERVICES

IF3.2

2019-02-01

OAAI

Rose, Christian; Shahanaghi, Abtin; Romero-Gonzalez, Mauricio; Yarzebski, Jorge; Andre, Michael; DiGirolamo, Gregory J.; Brown, Alan P.; Gonzalez, Gerardo

Tiny crystals, big potential

NATURE

IF48.5

2018-12-17

OAAI

Brown, Alan; Clardy, Jon

Structural Patching Fosters Divergence of Mitochondrial Ribosomes

MOLECULAR BIOLOGY AND EVOLUTION

IF5.3

2018-12-04

OAAI

Petrov, Anton S.; Wood, Elizabeth C.; Bernier, Chad R.; Norris, Ashlyn M.; Brown, Alan; Amunts, Alexey

研究方向