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A fully automatic method yielding initial models from high-resolution cryo-electron microscopy maps
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DOI：10.1038/s41592-018-0173-1.png)
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摘要
En 中文
We report a fully automated procedure for the optimization and interpretation of reconstructions from cryo-electron microscopy (cryo-EM) data, available in Phenix as phenix. map_to_model. We applied our approach to 476 datasets with resolution of 4.5 angstrom or better, including reconstructions of 47 ribosomes and 32 other protein-RNA complexes. The median fraction of residues in the deposited structures reproduced automatically was 71% for reconstructions determined at resolutions of 3 angstrom or better and 47% for those at resolutions worse than 3 angstrom.
Keyword:
CRYO-EM STRUCTURE
SEQUENCE ASSIGNMENT
REFINEMENT
COMPLEX
SYSTEM
PHENIX
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期刊
IF:
32.1
论文数:
7.2K
被引数:
12.7W
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引用论文
De novo protein structure determination from near-atomic-resolution cryo-EM maps.png)
NATURE METHODSOAAI
NATURE METHODSIF32.1
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