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AFFINITY PROBES FOR THE AVERMECTIN BINDING-PROTEINS
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DOI：10.1021/jm00099a015.png)
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摘要
En 中文
The design and synthesis of a series of avermectin affinity probes used in the identification and purification of the avermectin binding proteins is described. These modified avermectins fall into two design classes: ligands to covalently modify specific avermectin binding proteins [an I-125-labeled aryl azide photoprobe (15) and a tritiated aziridine analog (6)] and ligands for affinity chromatography applications [three biotinylated compounds (10, 12, and 13) and one resin-bound derivative(9)]. The binding affinities of these compounds for the Caenorhabditis elegans avermectin binding protein is presented as well as their biological activities against C. elegans and Artemia salina.
Keyword:
CAENORHABDITIS-ELEGANS
MUSCLE
RECEPTOR
ANALOGS
SITE
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