未登录 Indazole to 2-Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity Sun, Shan; Ginn, John; Kochanczyk, Tomasz; Arango, Nancy; Jiang, Xiuju; Huggins, David J.; Bean, James; Michino, Mayako; Baxt, Leigh; Liverton, Nigel; Meinke, Peter T.; Bryk, Ruslana 分享 收藏
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Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055 Michino, Mayako; Khan, Tanweer A.; Miller, Michael W.; Fukase, Yoshiyuki; Vendome, Jeremie; Adura, Carolina; Glickman, J. Fraser; Liu, Yiman; Wan, Liling; Allis, C. David; Stamford, Andrew W.; Meinke, Peter T.; Renzetti, Louis M.; Kargman, Stacia; Liverton, Nigel J.; Huggins, David J. 分享 收藏
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T.; Huggins, David J. 分享 收藏
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T.; Huggins, David J. 分享 收藏
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential (vol 13, 1013845, 2022) Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Buck, Hannes; Steegborn, Clemens; Myers, Robert W.; Meinke, Peter T.; Levin, Lonny R.; Buck, Jochen 分享 收藏
On-demand male contraception via acute inhibition of soluble adenylyl cyclase Balbach, Melanie; Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Ritagliati, Carla; Myers, Robert W. W.; Huggins, David J. J.; Steegborn, Clemens; Miranda, Ileana C. C.; Meinke, Peter T. T.; Buck, Jochen; Levin, Lonny R. R. 分享 收藏
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors-Part II Zhang, Hao; Ginn, John; Zhan, Wenhu; Leung, Annie; Liu, Yi J.; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Michino, Mayako; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K.; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J.; Cooper, Roland A.; Liverton, Nigel; Foley, Michael; Meinke, Peter T.; Nathan, Carl F.; Kirkman, Laura A.; Lin, Gang 分享 收藏
Design, Synthesis, and Pharmacological Evaluation of Second- Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates Miller, Michael; Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Balbach, Melanie; Kaur, Navpreet; Levin, Lonny R.; Buck, Jochen; Kehr, Maria; Coquille, Sandrine; Heuvel, Joop van den; Steegborn, Clemens; Fushimi, Makoto; Finkin-Groner, Efrat; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel J.; Huggins, David J.; Meinke, Peter T. 分享 收藏
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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia Liu, Yiman; Li, Qinglan; Alikarami, Fatemeh; Barrett, Declan R.; Mahdavi, Leila; Li, Hangpeng; Tang, Sylvia; Khan, Tanweer A.; Michino, Mayako; Hill, Connor; Song, Lele; Yang, Lu; Li, Yuanyuan; Pokharel, Sheela Pangeni; Stamford, Andrew W.; Liverton, Nigel; Renzetti, Louis M.; Taylor, Simon; Watt, Gillian F.; Ladduwahetty, Tammy; Kargman, Stacia; Meinke, Peter T.; Foley, Michael A.; Shi, Junwei; Li, Haitao; Carroll, Martin; Chen, Chun-Wei; Gardini, Alessandro; Maillard, Ivan; Huggins, David J.; Bernt, Kathrin M.; Wan, Liling 分享 收藏
Mayako Michino-Jeremie Vendome Zhang, Hao; Ginn, John; Zhan, Wenhu; Liu, Yi J.; Leung, Annie; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Yukawa, Takafumi; Michino, Mayako; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Meinke, Peter T.; Nathan, Carl F.; Kirkman, Laura A.; Lin, Gang 分享 收藏
A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors Liang, Rui; Tomita, Daisuke; Sasaki, Yusuke; Ginn, John; Michino, Mayako; Huggins, David J.; Baxt, Leigh; Kargman, Stacia; Shahid, Maaz; Aso, Kazuyoshi; Duggan, Mark; Stamford, Andrew W.; DeStanchina, Elisa; Liverton, Nigel; Meinke, Peter T.; Foley, Michael A.; Phillips, Richard E. 分享 收藏
Soluble adenylyl cyclase inhibition prevents human sperm function essential for fertilization Balbach, Melanie; Ghanem, Lubna; Rossetti, Thomas; Kaur, Navpreet; Ritagliati, Carla; Ferreira, Jacob; Krapf, Dario; Molina, Lis C. Puga; Santi, Celia Maria; Hansen, Jan Niklas; Wachten, Dagmar; Fushimi, Makoto; Meinke, Peter T.; Buck, Jochen; Levin, Lonny R. 分享 收藏
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) Fushimi, Makoto; Buck, Hannes; Balbach, Melanie; Gorovyy, Anna; Ferreira, Jacob; Rossetti, Thomas; Kaur, Navpreet; Levin, Lonny R.; Buck, Jochen; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Finkin-Groner, Efrat; Kargman, Stacia; Michino, Mayako; Foley, Michael A.; Miller, Michael; Liverton, Nigel J.; Huggins, David J.; Meinke, Peter T. 分享 收藏
Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome Zhang, Hao; Hsu, Hao-Chi; Kahne, Shoshanna C.; Hara, Ryoma; Zhan, Wenhu; Jiang, Xiuju; Burns-Huang, Kristin; Ouellette, Tierra; Imaeda, Toshihiro; Okamoto, Rei; Kawasaki, Masanori; Michino, Mayako; Wong, Tzu-Tshin; Toita, Akinori; Yukawa, Takafumi; Moraca, Francesca; Vendome, Jeremie; Saha, Priya; Sato, Kenjiro; Aso, Kazuyoshi; Ginn, John; Meinke, Peter T.; Foley, Michael; Nathan, Carl F.; Darwin, K. Heran; Li, Huilin; Lin, Gang 分享 收藏
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice 在人源化小鼠中开发具有抗疟疾活性的高选择性恶性疟原虫蛋白酶体抑制剂 Zhan, Wenhu; Zhang, Hao; Ginn, John; Leung, Annie; Liu, Yi J.; Michino, Mayako; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K.; Lafuente-Monasterio, Maria Jose; Martinez-Martinez, Maria Santos; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J.; Cooper, Roland A.; Meinke, Peter T.; Nathan, Carl F.; Kirkman, Laura A.; Lin, Gang 分享 收藏
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules Singh, Kamini; Lin, Jianan; Lecomte, Nicolas; Mohan, Prathibha; Gokce, Askan; Sanghvi, Viraj R.; Jiang, Man; Grbovic-Huezo, Olivera; Burcul, Antonija; Stark, Stefan G.; Romesser, Paul B.; Chang, Qing; Melchor, Jerry P.; Beyer, Rachel K.; Duggan, Mark; Fukase, Yoshiyuki; Yang, Guangli; Ouerfelli, Ouathek; Viale, Agnes; de Stanchina, Elisa; Stamford, Andrew W.; Meinke, Peter T.; Raetsch, Gunnar; Leach, Steven D.; Ouyang, Zhengqing; Wendel, Hans-Guido 分享 收藏
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions Ginn, John; Jiang, Xiuju; Sun, Shan; Michino, Mayako; Huggins, David J.; Mbambo, Zodwa; Jansen, Robert; Rhee, Kyu Y.; Arango, Nancy; Lima, Christopher D.; Liverton, Nigel; Imaeda, Toshihiro; Okamoto, Rei; Kuroita, Takanobu; Aso, Kazuyoshi; Stamford, Andrew; Foley, Michael; Meinke, Peter T.; Nathan, Carl; Bryk, Ruslana 分享 收藏
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