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Benchmarking single-cell multi-modal data integrations

delete2025-07-10
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AI
傅沙镠 封面图
傅沙镠 (Shaliu Fu)
S
Shu-Guang Wang
D
Duanmiao Si
G
Gaoyang Li
高亚威 封面图
高亚威 (Yawei Gao)
刘琦 封面图
刘琦 (Qi Liu) *
DOI:10.1038/s41592-025-02737-9delete
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摘要

摘要

En 中文
近期进展已经能够生成无配对(单独分析)和配对(同时测量)的单细胞多模态数据集,推动了单细胞多模态整合工具的快速发展。然而,迫切需要建立全面的基准来评估在不同整合数据集类型、整合模态、数据集规模和数据质量下的算法性能。本文介绍了一个系统性的基准测试,涉及40种单细胞多模态整合算法,涵盖了DNA、RNA、蛋白质和空间组学模态,适用于配对、无配对和马赛克数据集(混合配对和无配对数据集)。我们评估了这些算法的实用性、准确性和鲁棒性,以帮助研究人员选择适合其数据集和应用场景的整合方法。本基准为单细胞多组学这一持续发展的领域提供了有价值的指导。本注册报告呈现了对单细胞多模态数据整合方法的全面基准测试分析。

期刊

Nature Methods 封面图
Nature Methods
IF:
32.1
论文数:
7.2K
被引数:
12.7W

机构

S
School of Life Sciences and Technology
学者数:
205
论文数: 53
被引数: 0
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